Base de dados : MEDLINE
Pesquisa : dermatite and alérgica and de and contato [Palavras]
Referências encontradas : 10270 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1027 ir para página                         

  1 / 10270 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27775976
[Au] Autor:Grey KR; Warshaw EM
[Ad] Endereço:From the *University of Minnesota Medical School; †HCMC Parkside Occupational and Contact Dermatitis Clinic; ‡Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and §Department of Dermatology, University of Minnesota Medical School, Minneapolis.
[Ti] Título:Allergic Contact Dermatitis to Ophthalmic Medications: Relevant Allergens and Alternative Testing Methods.
[So] Source:Dermatitis;27(6):333-347, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Allergic contact dermatitis is an important cause of periorbital dermatitis. Topical ophthalmic agents are relevant sensitizers. Contact dermatitis to ophthalmic medications can be challenging to diagnose and manage given the numerous possible offending agents, including both active and inactive ingredients. Furthermore, a substantial body of literature reports false-negative patch test results to ophthalmic agents. Subsequently, numerous alternative testing methods have been described. This review outlines the periorbital manifestations, causative agents, and alternative testing methods of allergic contact dermatitis to ophthalmic medications.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Dermatoses Faciais/etiologia
Lubrificantes Oftálmicos/efeitos adversos
Soluções Oftálmicas/efeitos adversos
[Mh] Termos MeSH secundário: Administração Oftálmica
Agonistas de Receptores Adrenérgicos alfa 1/efeitos adversos
Antagonistas Adrenérgicos beta/efeitos adversos
Antibacterianos/efeitos adversos
Anti-Infecciosos Locais/efeitos adversos
Anti-Inflamatórios/efeitos adversos
Antineoplásicos/efeitos adversos
Antivirais/efeitos adversos
Inibidores da Anidrase Carbônica/efeitos adversos
Antagonistas Colinérgicos/efeitos adversos
Glaucoma/tratamento farmacológico
Antagonistas dos Receptores Histamínicos/efeitos adversos
Seres Humanos
Agonistas Muscarínicos/efeitos adversos
Antagonistas Muscarínicos/efeitos adversos
Prostaglandinas Sintéticas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic alpha-1 Receptor Agonists); 0 (Adrenergic beta-Antagonists); 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Carbonic Anhydrase Inhibitors); 0 (Cholinergic Antagonists); 0 (Histamine Antagonists); 0 (Lubricant Eye Drops); 0 (Muscarinic Agonists); 0 (Muscarinic Antagonists); 0 (Ophthalmic Solutions); 0 (Prostaglandins, Synthetic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27775977
[Au] Autor:Grey KR; Hanson JL; Hagen SL; Hylwa SA; Warshaw EM
[Ad] Endereço:From the *University of Minnesota Medical School; †Parkside Occupational and Contact Dermatitis Clinic, Hennepin County Medical Center; ‡Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and §Department of Dermatology, University of Minnesota Medical School, Minneapolis, MN.
[Ti] Título:Epidemiology and Co-Reactivity of Novel Surfactant Allergens: A Double-Blind Randomized Controlled Study.
[So] Source:Dermatitis;27(6):348-354, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surfactants are cleansing agents used in products such as shampoos and soaps. OBJECTIVES: The aims of this study were to identify positivity rates to 3 novel amide-containing surfactants (sodium lauroyl sarcosinate, isostearamidopropyl morpholine lactate, and disodium lauroamphodiacetate) and evaluate co-reactivity with other surfactants in patients with known surfactant sensitivity. METHODS: Previously patch-tested, surfactant-positive patients were identified via chart review and invited to participate. Participants were patch tested to screening surfactants (cocamidopropyl betaine, amidoamine, dimethylaminopropylamine, cocamide diethanolamine [DEA], oleamidopropyl dimethylamine, and decyl glucoside), as well as 3 novel surfactants: sodium lauroyl sarcosinate 0.5% and 1.0% aq, isostearamidopropyl morpholine lactate 0.5% and 1.0% aq, disodium lauroamphodiacetate 1.0 and 2.0% aq, and a hypoallergenic liquid cleanser (tested semiopen). Participants and clinicians were blinded. The order of tested allergens was randomized. RESULTS: Forty-seven participants completed the study. Excluding doubtful reactions, positive reactions were most common to oleamidopropyl dimethylamine (34%) and dimethylaminopropylamine (34%), followed by isostearamidopropyl morpholine lactate (23%). Reactivity was not associated with history of childhood eczema. Co-reactivity was high among oleamidopropyl dimethylamine, dimethylaminopropylamine, cocamidopropyl betaine, amidoamine, and isostearamidopropyl morpholine lactate. None of the participants who reacted to cocamide DEA reacted to an additional surfactant. CONCLUSIONS: Isostearamidopropyl morpholine lactate may be an important emerging allergen with sensitivity rates comparable with those of oleamidopropyl dimethylamine and dimethylaminopropylamine. Co-reactivity among surfactants was frequent except for cocamide DEA.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Dermatite Alérgica de Contato/etiologia
Tensoativos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Dermatite Alérgica de Contato/diagnóstico
Dermatite Alérgica de Contato/epidemiologia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Testes do Emplastro
Sarcosina/efeitos adversos
Sarcosina/análogos & derivados
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Allergens); 0 (Surface-Active Agents); 632GS99618 (sarkosyl); Z711V88R5F (Sarcosine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  3 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27775975
[Au] Autor:Huerth KA; Hawkes JE; Meyer LJ; Powell DL
[Ad] Endereço:From the *University at Buffalo School of Medicine, New York, NY; †The University of Utah Department of Dermatology, Salt Lake City; and ‡Veterans Administration Hospital, Salt Lake City, UT.
[Ti] Título:The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis.
[So] Source:Dermatitis;27(6):372-381, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/diagnóstico
Dermatite por Toxicodendron/diagnóstico
Euphorbia/efeitos adversos
[Mh] Termos MeSH secundário: Criança
Dermatite Alérgica de Contato/etiologia
Diagnóstico Diferencial
Euphorbiaceae
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27775972
[Au] Autor:Zahir A; Kindred C; Blömeke B; Goebel C; Gaspari AA
[Ad] Endereço:From the *Department of Dermatology, School of Medicine, University of Maryland Baltimore; †Union Memorial Hospital, Baltimore, MD; ‡Department of Environmental Toxicology, University of Trier; and §The Procter & Gamble Company, Central Product Safety, Schwalbach am Taunus, Germany.
[Ti] Título:Tolerance to a Hair Dye Product Containing 2-Methoxymethyl-P-Phenylenediamine in an Ethnically Diverse Population of P-Phenylenediamine-Allergic Individuals.
[So] Source:Dermatitis;27(6):355-361, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergic contact dermatitis after exposure to p-phenylenediamine (PPD)-containing hair dye products is a common and important clinical problem. Because there is a high rate of cross-elicitation of allergic contact dermatitis to other important hair dye products (such as p-toluene diamine and other aminophenol hair dyes) in PPD-allergic patients, safer alternative dyes with excellent hair coloring options are needed. OBJECTIVE: This study aimed to study tolerance to Me-PPD in a PPD-allergic cohort. METHODS: Twenty ethnically diverse volunteers with a history of contact dermatitis to hair dyes or other PPD-containing chemicals and positive patch test results to 1% PPD in petrolatum were recruited to study their immediate and delayed skin reactivity to PPD, vehicle control, and 2-methoxy-methyl-PPD (Me-PPD) using the allergy alert test (simulating hair dyeing conditions) on volar forearm skin. This test is a short-contact open patch test. CONCLUSIONS: The Me-PPD may offer a safer alternative for PPD-allergic patients with an absent or reduced elicitation response in the allergy alert test simulating hair dye use conditions. The absent or reduced response to Me-PPD diagnosed using the allergy alert test has been shown to help reduce the possibility of moderate to severe cross-elicitation reactions among consumers during hair dyeing.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Grupos Étnicos
Tinturas para Cabelo/efeitos adversos
Fenilenodiaminas/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Afroamericanos
Idoso
Grupo com Ancestrais do Continente Asiático
Estudos de Coortes
Reações Cruzadas/imunologia
Dermatite Alérgica de Contato/epidemiologia
Dermatite Alérgica de Contato/etnologia
Dermatite Alérgica de Contato/imunologia
Grupo com Ancestrais do Continente Europeu
Feminino
Seres Humanos
Masculino
Meia-Idade
Testes do Emplastro
Fenilenodiaminas/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-methoxymethyl-p-phenylenediamine); 0 (Hair Dyes); 0 (Phenylenediamines); U770QIT64J (4-phenylenediamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27775966
[Au] Autor:de Groot A; Schmidt E
[Ad] Endereço:From acdegroot publishing, Wapserveen, The Netherlands.
[Ti] Título:Essential Oils, Part V: Peppermint Oil, Lavender Oil, and Lemongrass Oil.
[So] Source:Dermatitis;27(6):325-332, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some aspects of peppermint oil, lavender oil, and lemongrass oil are discussed including their botanical origin, uses of the plants and the oils, chemical composition, contact allergy to and allergic contact dermatitis from these essential oils, and causative allergenic ingredients.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Óleos Voláteis/efeitos adversos
Óleos Vegetais/efeitos adversos
Terpenos/efeitos adversos
[Mh] Termos MeSH secundário: Seres Humanos
Óleos Voláteis/química
Óleos Vegetais/química
Terpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils); 0 (Terpenes); 5BIA40E9ED (lemongrass oil); AV092KU4JH (peppermint oil); ZBP1YXW0H8 (lavender oil)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27778425
[Au] Autor:Admani S; Goldenberg A; Jacob SE
[Ad] Endereço:Department of Dermatology, University of California, San Diego, La Jolla, California.
[Ti] Título:Contact Alopecia: Improvement of Alopecia with Discontinuation of Fluocinolone Oil in Individuals Allergic to Balsam Fragrance.
[So] Source:Pediatr Dermatol;34(1):e57-e60, 2017 Jan.
[Is] ISSN:1525-1470
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory scalp dermatoses can be associated with alopecia, which is nonscarring and reversible in its early stages. This association has been described in seborrheic dermatitis, psoriasis, and atopic dermatitis. We describe three girls with alopecia aggravated by contact allergy to balsam fragrances. All three had complete resolution with avoidance of balsam of Peru and other balsam derivatives (including discontinuation of fluocinolone oil, which contains balsam of pine).
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Alopecia/induzido quimicamente
Bálsamos/efeitos adversos
Dermatite Alérgica de Contato/etiologia
Perfumes/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Alopecia/diagnóstico
Pré-Escolar
Dermatite Alérgica de Contato/diagnóstico
Feminino
Seres Humanos
Testes do Emplastro
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Allergens); 0 (Balsams); 0 (Perfume); 8P5F881OCY (Peruvian balsam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/pde.13011


  7 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:29186266
[Au] Autor:Lazzarini R; Hafner MFS; Lopes ASA; Oliari CB
[Ad] Endereço:Dermatology Clinic, Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP) Brazil.
[Ti] Título:Allergy to hypoallergenic nail polish: does this exist?
[So] Source:An Bras Dermatol;92(3):421-422, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The main allergen responsible for contact dermatitis to nail polish is tosylamide-formaldehyde resin. The so-called hypoallergenic nail polishes are suposedly free of agents that commonly trigger reactions. The commercially available products and their compositions were studied. It was observed that most brands present at least one component capable of triggering the disease; therefore, allergic reaction may occur even when hypoallergenic polishes are used. There should be a proper investigation of the specific allergen through a patch test, because more than one component can cause an allergy, and we need to check the exact composition of each product.
[Mh] Termos MeSH primário: Cosméticos/efeitos adversos
Cosméticos/química
Dermatite Alérgica de Contato/etiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  8 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28747341
[Au] Autor:Suwanpradid J; Shih M; Pontius L; Yang B; Birukova A; Guttman-Yassky E; Corcoran DL; Que LG; Tighe RM; MacLeod AS
[Ad] Endereço:Department of Dermatology, Duke University, Durham, NC 27710.
[Ti] Título:Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
[So] Source:J Immunol;199(5):1827-1834, 2017 09 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes/macrophages (mono/MΦ), which renders those cells ineffectual in suppressing skin inflammation. Mice lacking Arg1 in MΦ develop increased CHS characterized by elevated ear thickening, mono/MΦ-dominated dermal inflammation, and increased iNOS and IL-6 expression compared with control mice. Treatment of Arg1 ; LysMCre mice with a selective NOS inhibitor or knockout of , encoding iNOS, significantly ameliorates CHS. Our findings suggest a critical role for Arg1 in mono/MΦ in suppressing CHS through dampening expression. These results support that increasing Arg1 may be a potential therapeutic avenue in treating allergic contact dermatitis.
[Mh] Termos MeSH primário: Arginase/metabolismo
Dermatite Alérgica de Contato/imunologia
Macrófagos/imunologia
Óxido Nítrico Sintase Tipo II/metabolismo
Pele/imunologia
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Animais
Arginase/genética
Células Cultivadas
Dermatite Alérgica de Contato/genética
Modelos Animais de Doenças
Feminino
Haptenos/imunologia
Seres Humanos
Imunidade Inata
Interleucina-6/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Óxido Nítrico Sintase Tipo II/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Allergens); 0 (Haptens); 0 (Interleukin-6); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 3.5.3.1 (Arg1 protein, mouse); EC 3.5.3.1 (Arginase); EC 3.5.3.1 (arginase I, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700739


  9 / 10270 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29210973
[Au] Autor:Harrison J
[Ad] Endereço:Jeanine Harrison, MN, BScN, ACNP, RN-EC, NP, is a Medical Aesthetic Nurse Practitioner and a practice expert in PRP techniques for face and hair at TH Medical Aesthetics, Thornhill, Ontario, Canada.
[Ti] Título:Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo.
[So] Source:Plast Surg Nurs;37(4):154-157, 2017 Oct/Dec.
[Is] ISSN:1550-1841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options. This has been seen in the use of treatments, such as Manuka honey, for skin conditions and dermal injuries. It is often with off-label uses, or conditions resistant to other treatments, that then prompt the use of holistic products and the true value of the product is validated. As with the following case study, the example of the use of Manuka honey on a severe atopic contact dermatitis eczematous reaction provides further documentation and supportive evidence of the potential efficacy of the properties of this particular natural product.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/tratamento farmacológico
Dermatite Atópica/tratamento farmacológico
Mel
Naftoquinonas/efeitos adversos
Tatuagem/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Terapias Complementares/métodos
Dermatite Atópica/induzido quimicamente
Feminino
Seres Humanos
Prednisona/uso terapêutico
Silicones/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Naphthoquinones); 0 (Silicones); TLH4A6LV1W (lawsone); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1097/PSN.0000000000000207


  10 / 10270 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28935759
[Au] Autor:Karlsen TV; Reikvam T; Tofteberg A; Nikpey E; Skogstrand T; Wagner M; Tenstad O; Wiig H
[Ad] Endereço:From the Department of Biomedicine, University of Bergen, Norway (T.V.K., T.R., A.T., E.N., T.S., M.W., O.T., H.W.); and Departments of Medicine (E.N.) and Pathology (M.W.), Haukeland University Hospital, Bergen, Norway. tine.karlsen@uib.no helge.wiig@uib.no.
[Ti] Título:Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration.
[So] Source:Arterioscler Thromb Vasc Biol;37(11):2128-2135, 2017 Nov.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Lymphatic vessels play an important role in body fluid, as well as immune system homeostasis. Although the role of malfunctioning or missing lymphatics has been studied extensively, less is known on the functional consequences of a chronically expanded lymphatic network or lymphangiogenesis. APPROACH AND RESULTS: To this end, we used K14-VEGF-C (keratin-14 vascular endothelial growth factor-C) transgenic mice overexpressing the vascular endothelial growth factor C in skin and investigated the responses to inflammatory and fluid volume challenges. We also recorded interstitial fluid pressure, a major determinant of lymph flow. Transgenic mice had a strongly enhanced lymph vessel area in skin. Acute inflammation induced by lipopolysaccharide and chronic inflammation by delayed-type hypersensitivity both resulted in increased interstitial fluid pressure and reduced lymph flow, both to the same extent in wild-type and transgenic mice. Hyperplastic lymphatic vessels, however, demonstrated enhanced transport capacity after local fluid overload not induced by inflammation. In this situation, interstitial fluid pressure was increased to a similar extent in the 2 strains, thus, suggesting that the enhanced lymph vessel area facilitated initial lymph formation. The increased lymph vessel area resulted in an enhanced production of the chemoattractant CCL21 that, however, did not result in augmented dendritic cell migration after induction of local skin inflammation by fluorescein isothiocyanate. CONCLUSIONS: An expanded lymphatic network is capable of enhanced chemoattractant production, and lymphangiogenesis will facilitate initial lymph formation favoring increased clearance of fluid in situations of augmented fluid filtration.
[Mh] Termos MeSH primário: Quimiocina CCL21/metabolismo
Quimiotaxia
Células Dendríticas/metabolismo
Dermatite Alérgica de Contato/metabolismo
Linfa/metabolismo
Linfangiogênese
Vasos Linfáticos/metabolismo
Linfedema/metabolismo
[Mh] Termos MeSH secundário: Animais
Dermatite Alérgica de Contato/genética
Dermatite Alérgica de Contato/patologia
Dermatite Alérgica de Contato/fisiopatologia
Modelos Animais de Doenças
Líquido Extracelular/metabolismo
Feminino
Deslocamentos de Líquidos Corporais
Fluoresceína-5-Isotiocianato
Genótipo
Queratina-14/genética
Lipopolissacarídeos
Vasos Linfáticos/patologia
Vasos Linfáticos/fisiopatologia
Linfedema/genética
Linfedema/patologia
Linfedema/fisiopatologia
Masculino
Camundongos Endogâmicos C3H
Camundongos Transgênicos
Oxazolona
Fenótipo
Pressão
Regiões Promotoras Genéticas
Transdução de Sinais
Fatores de Tempo
Regulação para Cima
Fator C de Crescimento do Endotélio Vascular/genética
Fator C de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CCL21); 0 (Keratin-14); 0 (Lipopolysaccharides); 0 (Vascular Endothelial Growth Factor C); 15646-46-5 (Oxazolone); I223NX31W9 (Fluorescein-5-isothiocyanate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.309883



página 1 de 1027 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde