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[PMID]:29386167
[Au] Autor:Hässig M; Degen Aguayo Aparicio C; Nuss K
[Ad] Endereço:Abteilung AgroVet-Strickhof, Departement für Nutztiere, Universität Zürich.
[Ti] Título:[Correlation of a lameness scoring system and claw lesion].
[Ti] Título:Korrelation eines Lahmheit-Scoring- Systems und Klauenläsionen..
[So] Source:Schweiz Arch Tierheilkd;160(2):107-114, 2018 Feb.
[Is] ISSN:0036-7281
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Ab] Resumo:INTRODUCTION: The aim of this study was to investigate the relationship between lameness scoring and clinical findings. The lameness scoring and a gait assessment took place during drying off, the first week after calving and two months after calving in 29 lame and 27 free of lameness cows. In between the farmer scored the lamness. Most of the lameness occurred in the hind limbs and were most frequently caused by dermatitis digitalis, Mortellaro, Limax, and Rusterholz sole ulcer. The mean duration of lameness after treatment was 26 days (median 16 days) and was significantly longer in case of horn lesions than in skin lesions (including interdigital dermatitis). Lameness- free control animals were often affected by heel horn erosion and digital dermatitis. It was shown that the sensitivity of lameness (lameness is caused by a certain aetiology) for a certain cause of lameness (dermatitis interdigitalis, doble sole, purulent hollow wall, Limax, digital dermatitis, Rusterholz sole ulcer and sole contusion) increases along with the threshold (degree of lameness) but that the specificity (no lameness is not related to a certain aetiology) remained constant at the same time. The highest sensitivity was achieved in injuries, followed by interdigital hyperplasia. The receiver operating curve (ROC) showed that lameness was the best selecting symptom in white line lesions followed by claw injury. The positive predictive values varied between 38.8% in white line lesions and 0% in Rusterholz's sole ulcer. The negative predictive values varied between 99.1% in interdigital dermatitis and 82.3% in interdigital dermatitis. The ROC analysis shows which lameness is more related to a certain claw disease. The results demonstrate, that a lameness score cannot be linked to a certain claw disease.
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[St] Status:In-Process
[do] DOI:10.17236/sat00147


  2 / 9809 MEDLINE  
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[PMID]:29396189
[Au] Autor:de Vries M; Seppala LJ; Daams JG; van de Glind EMM; Masud T; van der Velde N; EUGMS Task and Finish Group on Fall-Risk-Increasing Drugs
[Ad] Endereço:Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam, The Netherlands.
[Ti] Título:Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: I. Cardiovascular Drugs.
[So] Source:J Am Med Dir Assoc;, 2018 Feb 12.
[Is] ISSN:1538-9375
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Use of certain medications is recognized as a major and modifiable risk factor for falls. Although the literature on psychotropic drugs is compelling, the literature on cardiovascular drugs as potential fall-risk-increasing drugs is conflicting. The aim of this systematic review and meta-analysis is to provide a comprehensive overview of the associations between cardiovascular medications and fall risk in older adults. METHODS: Design: A systematic review and meta-analysis. DATA SOURCES: Medline, Embase, and PsycINFO. Key search concepts were "fall," "aged," "causality," and "medication." Studies that investigated cardiovascular medications as risk factors for falls in participants ≥60 years old or participants with a mean age of 70 or older were included. A meta-analysis was performed using the generic inverse variance method, pooling unadjusted and adjusted odds ratios (ORs) separately. RESULTS: In total, 131 studies were included in the qualitative synthesis. Meta-analysis using adjusted ORs showed significant results (pooled OR [95% confidence interval]) for loop diuretics, OR 1.36 (1.17, 1.57), and beta-blocking agents, OR 0.88 (0.80, 0.97). Meta-analysis using unadjusted ORs showed significant results for digitalis, OR 1.60 (1.08, 2.36); digoxin, OR 2.06 (1.56, 2.74); and statins, OR 0.80 (0.65, 0.98). Most of the meta-analyses resulted in substantial heterogeneity that mostly did not disappear after stratification for population and setting. In a descriptive synthesis, consistent associations were not observed. CONCLUSION: Loop diuretics were significantly associated with increased fall risk, whereas beta-blockers were significantly associated with decreased fall risk. Digitalis and digoxin may increase the risk of falling, and statins may reduce it. For the majority of cardiovascular medication groups, outcomes were inconsistent. Furthermore, recent studies indicate that specific drug properties, such as selectivity of beta-blockers, may affect fall risk, and drug-disease interaction also may play a role. Thus, studies addressing these issues are warranted to obtain a better understanding of drug-related falls.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[St] Status:Publisher


  3 / 9809 MEDLINE  
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[PMID]:29493058
[Au] Autor:Abdul-Rahim AH; Shen L; Rush CJ; Jhund PS; Lees KR; McMurray JJV; VICCTA-Heart Failure Collaborators
[Ad] Endereço:Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
[Ti] Título:Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction.
[So] Source:Eur J Heart Fail;, 2018 Mar 01.
[Is] ISSN:1879-0844
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To evaluate the effects of digoxin in patients with the newly described phenotype of heart failure (HF) and mid-range ejection fraction (HFmrEF), attributed to mild left ventricular systolic dysfunction. METHODS AND RESULTS: We carried out a retrospective analysis of the Digitalis Investigation Group (DIG) trial which had 7788 patients available for analysis with a left ventricular ejection fraction (LVEF) ranging between 3% and 85%. We compared the effect of digoxin to placebo in three mutually exclusive groups of patients defined by LVEF category: <40% (HF with reduced LVEF, HFrEF, n = 5874), 40-49% (HFmrEF, n = 1195) and ≥50% (HF with preserved LVEF, HFpEF, n = 719). The primary outcome was the composite of cardiovascular death or HF hospitalisation. Patients with HFmrEF resembled patients with HFrEF, more than those with HFpEF, with respect to age, sex and aetiology but were more like HFpEF patients with respect to blood pressure and the prevalence of hypertension. Event rates in patients with HFmrEF were similar to those in HFpEF and much lower than in HFrEF. Digoxin reduced the primary endpoint in patients with HFrEF, mainly due to reduced HF hospitalisation: the digoxin/placebo hazard ratio (HR) for HF hospitalisation was 0.71 [95% confidence interval (CI) 0.65-0.77]. The digoxin/placebo HR for HF hospitalisation in patients with HFmrEF was 0.80 (95% CI 0.63-1.03) and 0.85 (95% CI 0.62-1.17) in those with HFpEF. The digoxin/placebo HR for the composite of HF death or HF hospitalisation was 0.74 (95% CI 0.68-0.81) in HFrEF, 0.83 (95% CI 0.66-1.05) in HFmrEF and 0.88 (95% CI 0.65-1.19) in HFpEF. CONCLUSIONS: In this study, event rates in patients with HFmrEF were closer to those in HFpEF than HFrEF. Digoxin had most effect on HF hospitalisation in patients with HFrEF, an intermediate effect in HFmrEF, and the smallest effect in HFpEF.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[St] Status:Publisher
[do] DOI:10.1002/ejhf.1160


  4 / 9809 MEDLINE  
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[PMID]:29477502
[Au] Autor:Serge Barold S
[Ad] Endereço:Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States. Electronic address: ssbarold@aol.com.
[Ti] Título:Alternans during fascicular ventricular tachycardia due to digitalis toxicity.
[So] Source:J Electrocardiol;, 2018 Feb 08.
[Is] ISSN:1532-8430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This report describes a digitalis-induced regular fascicular ventricular tachycardia characterized by marked QRS alternans a manifestation not usually associated with this arrhythmia. The striking alternation of QRS configuration suggested alternating ventricular activation from either a single focus with two exits in distal branches of the left anterior fascicle or 2 different foci localized in the Purkinje-myocardial network of the left anterior fascicle.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[St] Status:Publisher


  5 / 9809 MEDLINE  
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[PMID]:29465109
[Au] Autor:Vale JA; Scadding JW
[Ad] Endereço:JA Vale, NPIS (Birmingham Unit), City Hospital, Birmingham B18 7QH, UK. Email: allistervale@npis.org.
[Ti] Título:In Carthage ruins: the illness of Sir Winston Churchill at Carthage, December 1943.
[So] Source:J R Coll Physicians Edinb;47(3):288-295, 2017 Sep.
[Is] ISSN:2042-8189
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:This paper reviews Churchill's illness in Carthage in December 1943. It was characterised by fever that lasted 6 days, left lower lobe pneumonia and two episodes of atrial fibrillation. He was managed in a private villa by Lord Moran, his personal physician, with the assistance of two nurses and the expert advice of colleagues. Sulphadiazine and digitalis leaf were prescribed and Churchill recovered. It is remarkable that, despite the severity of his illness, he continued to direct the affairs of State from his bed.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[St] Status:In-Data-Review
[do] DOI:10.4997/JRCPE.2017.316


  6 / 9809 MEDLINE  
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[PMID]:29365353
[Au] Autor:Jiratham-Opas J; Kanjanavanit R; Wongcharoen W; Punyawudho B; Arunmanakul P; Amaritakomol A; Topaiboon P; Gunaparn S; Phrommintikul A
[Ad] Endereço:Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Título:Can available mathematical models predict serum digoxin levels in Thai patients?
[So] Source:J Clin Pharm Ther;, 2018 Jan 24.
[Is] ISSN:1365-2710
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:WHAT IS KNOWN AND OBJECTIVE: Digoxin is commonly prescribed for heart failure patients with reduced ejection fraction (HFrEF) and patients with atrial fibrillation (AF). Due to digoxin's narrow therapeutic range, monitoring the serum digoxin concentration (SDC) is important. However, the SDC measurement is not widely available. Equations using clinical parameters can be employed to estimate the SDC but have never been studied in the Thai population. Therefore, we conducted this study to evaluate the correlation between the measured SDC and predicted digoxin level using 2 commonly used equations: the Konishi equation and the Koup and Jusko equation. METHODS: This report describes prospective, cross-sectional study conducted at Chiang Mai University. One hundred and fourteen patients were recruited in the study. All of the patients were diagnosed as having HFrEF, AF or both and had been receiving digoxin for at least 4 weeks. The SDC of each patient was measured at steady state and assigned to one of 3 groups according to the classifications of the Digitalis Investigation Group (DIG) trial: in the therapeutic range, over the therapeutic range and in the suboptimal range. RESULTS AND DISCUSSION: There were significant correlations between the measured and predicted SDCs using both the Konishi equation and the Koup and Jusko equation, which had correlation coefficients (R) of 0.69 and 0.31 (P < .05 for both), respectively. The percentages of patients with measured SDCs in the therapeutic range, over the therapeutic range and in the suboptimal range were 27.2%, 9.6% and 63.2%, respectively. The sensitivity and specificity of the Konishi equation in predicting SDCs in the over the therapeutic range were 72.73% (95% Confidence interval (CI): 39.03%-93.98%) and 80.58% (95% CI: 71.62%-87.72%), respectively. Of the 5 patients (4.4%) who were rehospitalized, 2 patients (0.01%) were readmitted due to acute decompensated heart failure (ADHF). One of the patients had an SDC that was over the therapeutic range. None of the readmitted patients had ventricular arrhythmia. WHAT IS NEW AND CONCLUSIONS: The Konishi equation yielded better predictions of the SDC, especially in the subgroup of HFrEF patients. Furthermore, the prediction of SDCs in the over the therapeutic range using this equation was superior to that of the Koup and Jusko equation. With further validation in a larger population, this equation should facilitate the detection of patients who are over the therapeutic range in clinical practice.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[St] Status:Publisher
[do] DOI:10.1111/jcpt.12667


  7 / 9809 MEDLINE  
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[PMID]:29437012
[Au] Autor:Kashkin VA; Shekunova EV; Egorov AY; Bagrov A
[Ad] Endereço:Valdman Institute of Pharmacology, Pavlov Medical University, St. Petersburg, 197022. Russian Federation.
[Ti] Título:Marinobufagenin in urine: a potential marker of predisposition to ethanol and a target for spironolactone.
[So] Source:Curr Hypertens Rev;, 2018 Feb 11.
[Is] ISSN:1875-6506
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Previously it was demonstrated that digitalis-like cardiotonic steroid, marinobufagenin (MBG), is implicated in the development of ethanol addiction in rats. We hypothesized that (i) levels of sodium pump ligand, MBG, would be negatively correlated with amount of ethanol consumed by rats, and (ii) that spironolactone would oppose the MBG induced ethanol-seeking behavior and blood pressure in rats. METHODS: Voluntary consumption of 9% alcohol (vs. water) during 10 days period by 11 adult male Wistar rats was studied. Eight weeks after the beginning of the experiment, the animals were divided into two treatment subgroups: high alcohol drinkers (HAD, n=6, daily consumption of ethanol > 4 g/kg) and low alcohol drinkers (LAD, n=5, daily consumption of ethanol < 4 g/kg) rats. Spironolactone treatment (7 days) was started following 3-day habituation to intragastric vehicle administration. Consumption of ethanol and blood pressure were recorded daily. RESULTS: Urinary MBG excretion at baseline was 11.2±0.6 pmoles in HAD rats and 19.1±2.9 pmoles (p<0.05) in LAD rats, respectively. Seven days of spironolactone treatment was associated with reduction in ethanol intake (2.9 g/kg/24 hr), reduction in systolic blood pressure (5 mm Hg), and increase in sodium excretion (1 mmol/24 hr). CONCLUSION: Levels of MBG may be a predisposing factor to voluntary ethanol intake. Spironolactone, along with antihypertensive effect, decreases ethanol intake.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[St] Status:Publisher
[do] DOI:10.2174/1573402114666180212115518


  8 / 9809 MEDLINE  
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[PMID]:29429799
[Au] Autor:Zhao YT; Zhou H; Cui Y
[Ad] Endereço:Department of Cardiology, Aerospace Center Hospital, 15 Yuquan road, Beijing, 100049, People's Republic of China. Electronic address: raas@bjmu.edu.cn.
[Ti] Título:Accelerated idioventricular rhythm degenerating into bidirectional ventricular tachycardia following acute myocardial infarction.
[So] Source:Am J Emerg Med;, 2018 Jan 08.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bidirectional ventricular tachycardia (BVT) is a rare ventricular tachyarrhythmia. It is usually regular, demonstrating a beat-to-beat alternation in the QRS frontal axis that varies between -20° to -30° and +110°. The tachycardia rate is typically between 140 and 180 beats/min and the QRS is relatively narrow, with a duration of 120 to 150 ms. The etiology of published BVT cases is most commonly digitalis toxicity and, rarely, herbal aconitine poisoning, hypokalemic periodic paralysis, catecholaminergic polymorphic ventricular tachycardia (CPVT), myocarditis, and Andersen-Tawil syndrome. We report a case of accelerated idioventricular rhythm (AIVR) degenerating into BVT following acute myocardial infarction, and briefly discuss the proposed mechanisms underlying BVT.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[St] Status:Publisher


  9 / 9809 MEDLINE  
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[PMID]:29426556
[Au] Autor:Gutnik F
[Ad] Endereço:115, rue de Reuilly, 75012 Paris, France. Electronic address: fabrice.gutnik@free.fr.
[Ti] Título:[Homo digitalis and occupational health].
[Ti] Título:Homo numericus et santé au travail..
[So] Source:Rev Infirm;67(238):29-30, 2018 Feb.
[Is] ISSN:1293-8505
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Although the digital transformation is widely viewed as a lever for productivity, it is now also seen, in public occupational health policies, as a factor for the potential increase in occupational risks. This digital transformation can also provide possible solutions enabling the homo digitalis to avoid these risks.
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[St] Status:In-Data-Review


  10 / 9809 MEDLINE  
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[PMID]:29414149
[Au] Autor:Grzesk G; Stolarek W; Kasprzak M; Krzyzanowski M; Szadujkis-Szadurska K; Wicinski M; Grzesk E
[Ad] Endereço:Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
[Ti] Título:Therapeutic drug monitoring of digoxin- 20 years of experience.
[So] Source:Pharmacol Rep;70(1):184-189, 2017 Aug 30.
[Is] ISSN:1734-1140
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Digoxin is the oldest drug used in the pharmacotherapy of heart failure (HF). However, digoxin remains an important therapeutic option for patients with persistent symptoms of HF occurring despite the implementation of standard pharmacotherapy. Digoxin concentration serum (SCD) should equal 1-2 ng/ml. The aim of our study was to measure of SCD among the hospitalized patients as well as to determine the selected factors influencing the concentration of the digoxin in the blood. METHODS: The presented research was based on a retrospective analysis including 2149 patients treated with digoxin and hospitalized between 1980 and 2000. Was used for the determination of SCD automatic analyzer TDX ABBOTT GmbH - fluorescence polarization immunoassay (FPIA), with therapeutic range for digoxin of 0.8-2.0 ng/ml. RESULTS: Average SCD result in the study population was located within the therapeutic range and amounted 1.06 ng/ml (55.7% of patients). Statistically significant differences in digoxin level were observed depending on the way of medicine administration (p = 0.000001) and the daily amount (p = 0.001). Moreover, statistically significant differences in digoxin level were observed depending on sex (p = 0.00002). CONCLUSIONS: An elevated level of digoxin was observed in the case of patients who received the medication both orally and intravenously, together with an increase in the daily amount of digoxin doses. It was confirmed that an elevated digoxin level occurs in the course of treatment in the case of women.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[St] Status:Publisher



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