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Pesquisa : histoplasmose [Palavras]
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[PMID]:28457513
[Au] Autor:Bonsignore A; Orcioni GF; Barranco R; De Stefano F; Ravetti JL; Ventura F
[Ad] Endereço:University of Genova, Department of Legal and Forensic Medicine, Via De Toni 12, Genova 16132, Italy.
[Ti] Título:Fatal disseminated histoplasmosis presenting as FUO in an immunocompetent Italian host.
[So] Source:Leg Med (Tokyo);25:66-70, 2017 Mar.
[Is] ISSN:1873-4162
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Histoplasmosis is a relatively rare infectious disease endemic to certain geographic areas such as East Africa, eastern and central United States, western Mexico, Central and South America. Disseminated histoplasmosis has been reported mainly in immunocompromised hosts and in AIDS patients. In this paper we report on a fatal case of undiagnosed disseminated histoplasmosis presenting as fever of unknown origin (FUO) in a 43-year-old Italian woman who, although splenectomized 5years earlier due to a motor vehicle accident, was otherwise immunocompetent. This case report highlights the fact that, even in Europe, histoplasmosis is an emerging sporadic infection which needs be considered in the differential diagnosis of given clinical scenarios. The proposed case is of blatant forensic concern as it addresses the hypothesis of professional responsibility due to a missed diagnosis of histoplasmosis. A timely diagnosis, with appropriate therapies, could have prevented death. The role of the forensic pathologist is also crucial because the post-mortem diagnosis of histoplasmosis (never considered in the differential diagnosis during prior hospitalization) highlights the importance of a meticulous and thorough autopsy to elucidate the cause of death.
[Mh] Termos MeSH primário: Diagnóstico Tardio
Febre de Causa Desconhecida/diagnóstico
Histoplasmose/diagnóstico
Histoplasmose/patologia
Hospedeiro Imunocomprometido
[Mh] Termos MeSH secundário: Adulto
Autopsia
Evolução Fatal
Feminino
Seres Humanos
Itália
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  2 / 4474 MEDLINE  
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[PMID]:29185961
[Au] Autor:Galli M; Antinori S; Atzeni F; Meroni L; Riva A; Scirè C; Adorni F; Quartuccio L; Sebastiani M; Airò P; Bazzichi L; Cristini F; Del Bono V; Manfredi A; Viapiana O; De Rosa F; Favalli E; Petrelli E; Salvarani C; Govoni M; Corcione S; Scrivo R; Sarmati L; Lazzarin A; Grassi W; Mastroianni C; Gaeta GB; Ferraccioli G; Cutolo M; De Vita S; Lapadula G; Matucci-Cerinic M; Armignacco O; Sarzi-Puttini P
[Ad] Endereço:Clinica delle Malattie Infettive, Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Italy. massimo.galli@unimi.it.
[Ti] Título:Recommendations for the management of pulmonary fungal infections in patients with rheumatoid arthritis.
[So] Source:Clin Exp Rheumatol;35(6):1018-1028, 2017 Nov-Dec.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Often life-threatening pulmonary fungal infections (PFIs) can occur in patients with rheumatoid arthritis (RA) receiving disease-modifying anti-rheumatic drugs (DMARDs). Most of the data concerning PFIs in RA patients come from case reports and retrospective case series. Of the ve most widely described PFIs, Pneumocystis jirovecii pneumonia (PJP) has rarely been seen outside Japan, pulmonary cryptococcosis has been diagnosed in only a small number of patients worldwide, pulmonary coccidioidomycosis has almost only been observed in endemic areas, the limited number of cases of pulmonary histoplasmosis have mainly occurred in the USA, and the rare cases of invasive pulmonary aspergillosis have only been encountered in leukopenic patients. Many aspects of the prophylaxis, diagnosis and treatment of PFIs in RA patients remain to be defined, as does the role of each DMARD in increasing the risk of infection, and the possibility of resuming biological and non-biological DMARD treatment after the infection has been cured. The recommendations for the management of PFIs described in this paper are the product of a consensus procedure promoted by the Italian group for the Study and Management of Infections in Patients with Rheumatic Diseases (the ISMIR group).
[Mh] Termos MeSH primário: Artrite Reumatoide/complicações
Pneumopatias Fúngicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antirreumáticos/efeitos adversos
Coccidioidomicose/tratamento farmacológico
Criptococose/tratamento farmacológico
Histoplasmose/tratamento farmacológico
Seres Humanos
Pneumonia por Pneumocystis/tratamento farmacológico
Aspergilose Pulmonar/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antirheumatic Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  3 / 4474 MEDLINE  
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[PMID]:29287097
[Au] Autor:López LF; Muñoz CO; Cáceres DH; Tobón ÁM; Loparev V; Clay O; Chiller T; Litvintseva A; Gade L; González Á; Gómez BL
[Ad] Endereço:Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.
[Ti] Título:Standardization and validation of real time PCR assays for the diagnosis of histoplasmosis using three molecular targets in an animal model.
[So] Source:PLoS One;12(12):e0190311, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histoplasmosis is considered one of the most important endemic and systemic mycoses worldwide. Until now few molecular techniques have been developed for its diagnosis. The aim of this study was to develop and evaluate three real time PCR (qPCR) protocols for different protein-coding genes (100-kDa, H and M antigens) using an animal model. Fresh and formalin-fixed and paraffin-embedded (FFPE) lung tissues from BALB/c mice inoculated i.n. with 2.5x106 Histoplasma capsulatum yeast or PBS were obtained at 1, 2, 3, 4, 8, 12 and 16 weeks post-infection. A collection of DNA from cultures representing different clades of H. capsulatum (30 strains) and other medically relevant pathogens (36 strains of related fungi and Mycobacterium tuberculosis) were used to analyze sensitivity and specificity. Analytical sensitivity and specificity were 100% when DNAs from the different strains were tested. The highest fungal burden occurred at first week post-infection and complete fungal clearance was observed after the third week; similar results were obtained when the presence of H. capsulatum yeast cells was demonstrated in histopathological analysis. In the first week post-infection, all fresh and FFPE lung tissues from H. capsulatum-infected animals were positive for the qPCR protocols tested except for the M antigen protocol, which gave variable results when fresh lung tissue samples were analyzed. In the second week, all qPCR protocols showed variable results for both fresh and FFPE tissues. Samples from the infected mice at the remaining times post-infection and uninfected mice (controls) were negative for all protocols. Good agreement was observed between CFUs, histopathological analysis and qPCR results for the 100-kDa and H antigen protocols. We successfully standardized and validated three qPCR assays for detecting H. capsulatum DNA in fresh and FFPE tissues, and conclude that the 100-kDa and H antigen molecular assays are promising tests for diagnosing this mycosis.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Genes Fúngicos
Histoplasmose/diagnóstico
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Animais
DNA Fúngico/genética
DNA Fúngico/isolamento & purificação
Histoplasma/genética
Histoplasmose/genética
Pulmão/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Mycobacterium tuberculosis/genética
Mycobacterium tuberculosis/isolamento & purificação
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190311


  4 / 4474 MEDLINE  
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[PMID]:29274666
[Au] Autor:Gaume M; Marie-Hardy L; Larousserie F; Lavielle M; Roux C; Leclerc P; Paugam A; Archambeau D; Eyrolle L; Gauzit R; Lortholary O; Anract P; Epelboin L; Salmon D
[Ad] Endereço:Département de chirurgie orthopédique, hôpital Cochin, université Paris Descartes, Sorbonne Paris Cité, Assistance publique-Hôpitaux de Paris, Paris, France. Electronic address: mathildegaume@hotmail.fr.
[Ti] Título:[Erratum to "Histoplasma capsulatum bone and joint infection" [Med. Mal. Infect. 47 (2017) 554-557]].
[Ti] Título:Erratum à « Histoplasmose ostéo-articulaire à Histoplasma capsulatum ¼ [Med. Mal. Infect. 47 (2017) 554­557]..
[So] Source:Med Mal Infect;48(1):81, 2018 Feb.
[Is] ISSN:1769-6690
[Cp] País de publicação:France
[La] Idioma:fre
[Pt] Tipo de publicação:PUBLISHED ERRATUM
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[St] Status:In-Data-Review


  5 / 4474 MEDLINE  
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[PMID]:29244019
[Au] Autor:Charalambous LT; Premji A; Tybout C; Hunt A; Cutshaw D; Elsamadicy AA; Yang S; Xie J; Giamberardino C; Pagadala P; Perfect JR; Lad SP
[Ad] Endereço:1​Department of Neurosurgery, Duke University Medical Center, NC, USA.
[Ti] Título:Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.
[So] Source:J Med Microbiol;67(2):215-227, 2018 Feb.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012. Patients with a primary diagnosis of cryptococcal, Coccidioides, Histoplasma, or Candida meningitis were included in the analysis. Data concerning healthcare resource utilization, prevalence and length of stay were collected for up to 5 years following the original diagnosis. RESULTS: Cryptococcal meningitis was the most prevalent type of fungal meningitis (70.1 % of cases over the duration of the study), followed by coccidioidomycosis (16.4 %), histoplasmosis (6.0 %) and candidiasis (7.6 %). Cryptococcal meningitis and candidiasis patients accrued the largest average charges ($103 236 and $103 803, respectively) and spent the most time in the hospital on average (70.6 and 79 days). Coccidioidomycosis and histoplasmosis patients also accrued substantial charges and time in the hospital ($82 439, 48.1 days; $78 609, 49.8 days, respectively). CONCLUSION: Our study characterizes the largest longitudinal cohort of fungal meningitis in the United States. Importantly, the health economic impact and long-term morbidity from these infections are quantified and reviewed. The healthcare resource utilization of fungal meningitis patients in the United States is substantial.
[Mh] Termos MeSH primário: Efeitos Psicossociais da Doença
Recursos em Saúde/utilização
Meningite Fúngica/epidemiologia
Meningite Fúngica/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Candidíase/economia
Candidíase/epidemiologia
Candidíase/microbiologia
Coccidioidomicose/economia
Coccidioidomicose/epidemiologia
Coccidioidomicose/microbiologia
Feminino
Histoplasmose/economia
Histoplasmose/epidemiologia
Histoplasmose/microbiologia
Seres Humanos
Masculino
Meningite Criptocócica/economia
Meningite Criptocócica/epidemiologia
Meningite Criptocócica/microbiologia
Meningite Fúngica/diagnóstico
Meningite Fúngica/economia
Meia-Idade
Prevalência
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000656


  6 / 4474 MEDLINE  
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[PMID]:29044310
[Au] Autor:Momesso GAC; Polo TOB; Lima VN; Sousa CA; Soubhia AMP; Jardim EG; Faverani LP
[Ad] Endereço:Divisão de Cirurgia Oral e Maxilofacial do Departamento de Cirurgia e Clínica Integrada, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista "Júlio de Mesquita Filho" - Araçatuba (SP), Brasil.
[Ti] Título:Oral histoplasmosis.
[Ti] Título:Histoplasmose oral..
[So] Source:Rev Bras Ter Intensiva;29(3):394-396, 2017 Jul-Sep.
[Is] ISSN:1982-4335
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[St] Status:In-Data-Review


  7 / 4474 MEDLINE  
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[PMID]:28953979
[Au] Autor:English BC; Van Prooyen N; Örd T; Örd T; Sil A
[Ad] Endereço:Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America.
[Ti] Título:The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum.
[So] Source:PLoS Pathog;13(9):e1006589, 2017 Sep.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability of intracellular pathogens to manipulate host-cell viability is critical to successful infection. Some pathogens promote host-cell survival to protect their replicative niche, whereas others trigger host-cell death to facilitate release and dissemination of the pathogen after intracellular replication has occurred. We previously showed that the intracellular fungal pathogen Histoplasma capsulatum (Hc) uses the secreted protein Cbp1 to actively induce apoptosis in macrophages; interestingly, cbp1 mutant strains are unable to kill macrophages and display severely reduced virulence in the mouse model of Hc infection. To elucidate the mechanism of Cbp1-induced host-cell death, we performed a comprehensive alanine scanning mutagenesis and identified all amino acid residues that are required for Cbp1 to trigger macrophage lysis. Here we demonstrate that Hc strains expressing lytic CBP1 alleles activate the integrated stress response (ISR) in infected macrophages, as indicated by an increase in eIF2α phosphorylation as well as induction of the transcription factor CHOP and the pseudokinase Tribbles 3 (TRIB3). In contrast, strains bearing a non-lytic allele of CBP1 fail to activate the ISR, whereas a partially lytic CBP1 allele triggers intermediate levels of activation. We further show that macrophages deficient for CHOP or TRIB3 are partially resistant to lysis during Hc infection, indicating that the ISR is critical for susceptibility to Hc-mediated cell death. Moreover, we show that CHOP-dependent macrophage lysis is critical for efficient spread of Hc infection to other macrophages. Notably, CHOP knockout mice display reduced macrophage apoptosis and diminished fungal burden and are markedly resistant to Hc infection. Together, these data indicate that Cbp1 is required for Hc to induce the ISR and mediate a CHOP-dependent virulence pathway in the host.
[Mh] Termos MeSH primário: Apoptose/imunologia
Genes Fúngicos/genética
Histoplasma/metabolismo
Histoplasmose/microbiologia
Macrófagos/metabolismo
Fator de Transcrição CHOP/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Ligação ao Cálcio/metabolismo
Células Cultivadas
Citoplasma/metabolismo
Feminino
Interações Hospedeiro-Patógeno/imunologia
Macrófagos/microbiologia
Camundongos
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium-Binding Proteins); 147336-12-7 (Transcription Factor CHOP)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006589


  8 / 4474 MEDLINE  
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[PMID]:28930505
[Au] Autor:Romano K; Pazo V; Qian X; Vaidya A; Maguire JH
[Ti] Título:The Road Less Traveled.
[So] Source:N Engl J Med;377(12):e16, 2017 Sep 21.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Histoplasma/isolamento & purificação
Histoplasmose/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Lavagem Broncoalveolar
Diagnóstico Diferencial
Feminino
Histoplasma/fisiologia
Histoplasmose/complicações
Histoplasmose/tratamento farmacológico
Seres Humanos
Itraconazol/uso terapêutico
Estágios do Ciclo de Vida
Pulmão/diagnóstico por imagem
Pulmão/patologia
Linfonodos/microbiologia
Linfonodos/patologia
Linfadenopatia/diagnóstico por imagem
Linfadenopatia/etiologia
Tomografia Computadorizada por Raios X
Viagem
[Pt] Tipo de publicação:INTERACTIVE TUTORIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMimc1616026


  9 / 4474 MEDLINE  
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[PMID]:28919390
[Au] Autor:Gaume M; Marie-Hardy L; Larousserie F; Lavielle M; Roux C; Leclerc P; Paugam A; Archambeau D; Eyrolle L; Gauzit R; Lortholary O; Anract P; Salmon D
[Ad] Endereço:Département de chirurgie orthopédique, hôpital Cochin, université Paris Descartes, Sorbonne Paris Cité, Assistance publique-Hôpitaux de Paris, Paris, France. Electronic address: mathildegaume@hotmail.fr.
[Ti] Título:[Histoplasma capsulatum bone and joint infection].
[Ti] Título:Histoplasmose ostéo-articulaire à Histoplasma capsulatum..
[So] Source:Med Mal Infect;47(8):554-557, 2017 Dec.
[Is] ISSN:1769-6690
[Cp] País de publicação:France
[La] Idioma:fre
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[St] Status:In-Data-Review


  10 / 4474 MEDLINE  
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[PMID]:28797398
[Au] Autor:Patterson J; Graham D; George A; Will M; Sutter D
[Ad] Endereço:Department of Pediatrics, San Antonio Military Medical Center, JBSA Fort Sam Houston, TX.
[Ti] Título:Right Middle Lobe Collapse and Pleural Effusion in an 18-Year-Old Man.
[So] Source:Chest;152(2):e33-e38, 2017 Aug.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 18-year-old African American male subject presented to an acute care clinic with 3 days of productive cough, chills, pleuritic right chest pain, sore throat with hoarseness, congestion, and intermittent shortness of breath. He recently relocated to Texas from Georgia to undergo basic military training. He denied any other recent travel or contact with persons with pulmonary TB or other respiratory illnesses. His medical history was significant for glucose-6-phosphate dehydrogenase deficiency and sickle cell trait.
[Mh] Termos MeSH primário: Histoplasmose/diagnóstico
Pneumopatias Fúngicas/diagnóstico
Mediastinite/microbiologia
Derrame Pleural/microbiologia
Atelectasia Pulmonar/microbiologia
Esclerose/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Histoplasma
Histoplasmose/diagnóstico por imagem
Seres Humanos
Pneumopatias Fúngicas/diagnóstico por imagem
Masculino
Mediastinite/diagnóstico por imagem
Derrame Pleural/diagnóstico por imagem
Atelectasia Pulmonar/diagnóstico por imagem
Esclerose/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE



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