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[PMID]:29499665
[Au] Autor:Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L
[Ad] Endereço:People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
[Ti] Título:Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis.
[So] Source:BMC Ophthalmol;18(1):65, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration.
[Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico
Substância Própria/metabolismo
Úlcera da Córnea/tratamento farmacológico
Reagentes para Ligações Cruzadas
Infecções Oculares Fúngicas/tratamento farmacológico
Fusariose/tratamento farmacológico
Fusarium/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Colágeno/metabolismo
Contagem de Colônia Microbiana
Úlcera da Córnea/metabolismo
Úlcera da Córnea/microbiologia
Modelos Animais de Doenças
Infecções Oculares Fúngicas/metabolismo
Infecções Oculares Fúngicas/microbiologia
Fusariose/metabolismo
Fusariose/microbiologia
Fusarium/isolamento & purificação
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0727-0


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[PMID]:29361927
[Au] Autor:Lin Z; Feng X; Zheng L; Moonasar N; Shen L; Wu R; Chen F
[Ad] Endereço:The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, No. 270 West College Road, Wenzhou, Zhejiang, 325027, China.
[Ti] Título:Incidence of endophthalmitis after 23-gauge pars plana vitrectomy.
[So] Source:BMC Ophthalmol;18(1):16, 2018 Jan 23.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Endophthalmitis is a rare but severe complication following PPV. The incidence of endophthalmitis varies between 20-gauge, 23-gauge, and 25-gauge incisions. The incidence and clinical features of endophthalmitis after 23-gauge PPV in an eye hospital in China was reported in this study. METHODS: Data of the eyes that underwent 23-gauge PPV from January 2011 to December 2014 at the Eye Hospital of Wenzhou Medical University was retrospectively collected. All the information was obtained from the electronic medical system. The exclusion criteria included: (1) preoperative diagnosis of endophthalmitis; (2) history of vitrectomy; (3) intraocular surgery within 6 months; (4) history of ocular penetrating trauma; (5) sutures for any of the 3 sclerotomy incisions; (6) patients with cancer, acquired immune deficiency syndrome, or taking drugs that may influence the immune system. The diagnosis of endophthalmitis was based on clinical characteristics and/or culture results from an operative sample. RESULTS: Three thousand nine hundred seventy nine eyes that underwent 23-gauge PPV surgery were included in this study. Among these eyes, 3 eyes developed endophthalmitis after surgery, giving an incidence of 0.075% (3/3979). The period in which endophthalmitis developed ranged from 1 to 5 days post-operation. The visual acuity decreased to hand motions or light perception postoperatively. The culture of aqueous and vitreous of the 2 eyes revealed Staphylococcus epidermidis and enterococcus faecalis respectively, however was negative for the third eye. All 3 eyes had a favorable response to the treatment of vitreous tap and intravitreal antibiotics injection. Two eyes gained visual acuity of 0.05 and 0.5, respectively at the final visit. CONCLUSIONS: Endophthalmitis is a rare but sight-threatening complication after 23-gauge pars plana vitrectomy. The peak duration of onset was within 5 days post-operation, with gram positive cocci being the common pathogenic organism.
[Mh] Termos MeSH primário: Endoftalmite/epidemiologia
Infecções Oculares Bacterianas/epidemiologia
Microcirurgia/efeitos adversos
Doenças Retinianas/cirurgia
Infecções Estafilocócicas/epidemiologia
Infecção da Ferida Cirúrgica/epidemiologia
Vitrectomia/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Humor Aquoso/microbiologia
China/epidemiologia
Endoftalmite/diagnóstico
Endoftalmite/microbiologia
Enterococcus faecalis/isolamento & purificação
Infecções Oculares Bacterianas/diagnóstico
Infecções Oculares Bacterianas/microbiologia
Feminino
Seguimentos
Infecções por Bactérias Gram-Positivas/diagnóstico
Infecções por Bactérias Gram-Positivas/epidemiologia
Infecções por Bactérias Gram-Positivas/microbiologia
Seres Humanos
Incidência
Masculino
Microcirurgia/instrumentação
Meia-Idade
Estudos Retrospectivos
Infecções Estafilocócicas/diagnóstico
Infecções Estafilocócicas/microbiologia
Staphylococcus epidermidis/isolamento & purificação
Infecção da Ferida Cirúrgica/microbiologia
Ultrassonografia
Acuidade Visual
Vitrectomia/instrumentação
Corpo Vítreo/diagnóstico por imagem
Corpo Vítreo/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0678-5


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[PMID]:29357839
[Au] Autor:Xie X; Hu J; Sun G; Ding B; Feng L
[Ad] Endereço:Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, People's Republic of China.
[Ti] Título:Orbital sparganosis in an 8-year boy: a case report.
[So] Source:BMC Ophthalmol;18(1):13, 2018 Jan 22.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sparganosis is one of the neglected but important food-borne parasitic zoonoses, with higher prevalence in Asian countries. The infection is commonly located in the subcutaneous tissue, brain, breast, and lung, but fewer reported infections involve the eye. Because the majority of patients with sparganosis are adults, it is likely to be missed in children. CASE PRESENTATION: An 8-year-old boy presented to our clinic complaining of a painless ocular mass in his right eye for 1 month. The boy had a history of eating frogs and frog poultice applications to his eyelids. The patient was checked for an elliptical mass near the medial wall of the right eye. Serodiagnosis testing was positive in an enzyme-linked immunosorbent assay. During surgical operation on the patient, calcified parasite eggs and foreign body granulomatous reaction were found using histological examination. Due to early detection and surgery, the patient fully recovered with no damage to his eyesight. CONCLUSIONS: Although rare, ocular sparganosis should be suspected in a mass of the eye when there is a history of eating frogs and frog poultice applications on eyelids. Early surgical resection is important for a good prognosis.
[Mh] Termos MeSH primário: Infecções Oculares Parasitárias/diagnóstico
Órbita/diagnóstico por imagem
Doenças Orbitárias/diagnóstico
Esparganose/diagnóstico
Plerocercoide/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Biópsia
Criança
Diagnóstico Diferencial
Ensaio de Imunoadsorção Enzimática
Infecções Oculares Parasitárias/parasitologia
Seres Humanos
Masculino
Órbita/parasitologia
Doenças Orbitárias/parasitologia
Esparganose/parasitologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0675-8


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[PMID]:29390262
[Au] Autor:Pan Q; Liu Y; Wang R; Chen T; Yang Z; Deng Y; Zhao Z; Hu X; Chen X; Wei W; Zhang Z; Wang Y; Zheng J; Ke Z
[Ad] Endereço:The Eye Hospital of Wenzhou Medical University, Wenzhou, China.
[Ti] Título:Treatment of Bacillus cereus endophthalmitis with endoscopy-assisted vitrectomy.
[So] Source:Medicine (Baltimore);96(50):e8701, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To evaluate the use of endoscopy-assisted vitrectomy in patients with sight-threatening Bacillus cereus endophthalmitis.A retrospective analysis was conducted in 15 eyes with Bacillus cereus endophthalmitis. Patients were divided into 2 groups: endoscopy-assisted vitrectomy (5 eyes) and conventional vitrectomy (10 eyes). The following clinical data were recorded and analyzed: sex, age, latent period, symptom duration, follow-up time, visual acuity pre- and postsurgery, recurrence of endophthalmitis, incidence of phithisis bulbi, and incidence of enucleation.In the conventional vitrectomy group, postoperative visual acuity ranged from no light perception in 5 patients (50%), light perception in 3 patients (30%), 20/1000 in 1 patient (10%), and 20/50 in 1 patient (10%). In the endoscopy-assisted vitrectomy group, postoperative visual acuity ranged from no light perception in 2 patients (40%), light perception in 1 patient (20%), and hand movements in 2 patients (40%). There was no statistically significant difference between the 2 groups in terms of the final postoperative visual acuity (F = 0.006, P = .937). There is no difference between the 2 groups in terms of the incidence of enucleation. The median symptom duration was 4 hours (range: 2-6 hours) in the conventional group and 9 hours (range: 7-11 hours) in the endoscopy-assisted vitrectomy group. The difference in the symptom duration between the 2 groups was statistically significant (P = .002).There is no statistical significant difference between the 2 groups in terms of visual acuity and incidence of enucleation. Therefore, endoscopy-assisted vitrectomy can be considered as an alternative treatment for treatment of B cereus endophthalmitis particularly for cases when symptom duration was more than 6 hours.
[Mh] Termos MeSH primário: Bacillus cereus/isolamento & purificação
Endoftalmite/microbiologia
Endoftalmite/cirurgia
Endoscopia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Infecções Oculares Bacterianas/microbiologia
Infecções Oculares Bacterianas/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008701


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[PMID]:29422757
[Au] Autor:Varshney A; Das M; Chaudhary P; Kumari R; Yadav K
[Ad] Endereço:Department of Vitreoretina, C. L. Gupta Eye Institute, Moradabad, Uttar Pradesh, India.
[Ti] Título: as a Causative Agent for Postoperative Endophthalmitis.
[So] Source:Middle East Afr J Ophthalmol;24(4):213-215, 2017 Oct-Dec.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:We report a case of a 55-year-old female who presented with pain, redness, and profound visual loss in her right eye 2 weeks after cataract surgery. An ophthalmic examination showed light perception vision, corneal edema with severe anterior chamber reaction and hypopyon, exudative membranes on the anterior lens surface, and dense vitreous exudates. Under the impression of acute postoperative exogenous endophthalmitis, immediate pars plana vitrectomy with culture of vitreous aspirate and intravitreal antibiotic injections were performed. Bacterial growth was observed on culture plates and broths which were identified as by VITEK 2 compact system. So far, no report has been published regarding endophthalmitis due to . Here, we present the first report of isolated from the ocular specimen.
[Mh] Termos MeSH primário: Aeromonas salmonicida/isolamento & purificação
Endoftalmite/microbiologia
Infecções Oculares Bacterianas/microbiologia
Infecções por Bactérias Gram-Negativas/microbiologia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Amicacina/uso terapêutico
Antibacterianos/uso terapêutico
Extração de Catarata
Dexametasona/uso terapêutico
Quimioterapia Combinada
Endoftalmite/diagnóstico
Endoftalmite/tratamento farmacológico
Infecções Oculares Bacterianas/diagnóstico
Infecções Oculares Bacterianas/tratamento farmacológico
Feminino
Glucocorticoides/uso terapêutico
Infecções por Bactérias Gram-Negativas/diagnóstico
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Seres Humanos
Injeções Intravítreas
Implante de Lente Intraocular
Meia-Idade
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glucocorticoids); 7S5I7G3JQL (Dexamethasone); 84319SGC3C (Amikacin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_238_17


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[PMID]:29338030
[Au] Autor:Bhende M; Raman R; Jain M; Shah PK; Sharma T; Gopal L; Bhende PS; Srinivasan S; Jambulingam M; Sankara Nethralaya Vitreoretinal Study Group (SNVR-Study Group)
[Ad] Endereço:Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
[Ti] Título:Incidence, microbiology, and outcomes of endophthalmitis after 111,876 pars plana vitrectomies at a single, tertiary eye care hospital.
[So] Source:PLoS One;13(1):e0191173, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the incidence, risk factors, clinical presentation, causative organisms, and outcomes in patients with endophthalmitis following pars plana vitrectomy (20G and minimally invasive vitrectomy surgery (MIVS). METHODS: Of 111,876 vitrectomies (70,585 20-G 41,291 MIVS) performed, 45 cases developed acute-onset, postoperative endophthalmitis. RESULTS: The rate of culture positive and culture negative endophthalmitis was 0.021% (2.1/10,000 surgeries) and 0.019% (1.9/10,000 surgeries) overall, 0.031% (3.1/10,000 surgeries) and 0.025% (2.5/10,000 surgeries) in 20G, and 0.005% (0.5/10,000 surgeries) and 0.007% (0.7/10,000 surgeries) in the MIVS group respectively. Potential predisposing factors were as follows: diabetes, 46.7%; vitrectomy for vascular retinopathies, 44.4%; and vitrectomy combined with anterior segment surgeries, 35.5%. The culture proven rates were 53.3% overall, 55.0% for 20G and 40.0% for MIVS. The most common organism was Pseudomonas aeruginosa for 20G. Klebsiella and Staphylococcus aureus were isolated in the two culture positive cases in MIVS group. The follow-up period for the patients with endophthalmitis was 586.14 ± 825.15 days. Seven were lost to follow up beyond one week. Of the remaining 38, 13 (34.2%) cases had a favorable visual outcome (i.e., best-corrected visual acuity [BCVA] > 5/200) and 24 (63.2%) had unfavorable visual outcome (BCVA < 5/200). Group with culture test results negative had significantly better outcomes (P < 0.05) as compared to those with positive. CONCLUSIONS: MIVS does not increase the risk of endophthalmitis. Outcomes are poor despite appropriate treatment, particularly in cases with culture results positive.
[Mh] Termos MeSH primário: Endoftalmite/etiologia
Complicações Pós-Operatórias/etiologia
Vitrectomia/efeitos adversos
[Mh] Termos MeSH secundário: Endoftalmite/epidemiologia
Endoftalmite/microbiologia
Infecções Oculares Bacterianas/epidemiologia
Infecções Oculares Bacterianas/etiologia
Infecções Oculares Bacterianas/microbiologia
Feminino
Seres Humanos
Incidência
Índia/epidemiologia
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/microbiologia
Prognóstico
Fatores de Risco
Infecção da Ferida Cirúrgica/epidemiologia
Infecção da Ferida Cirúrgica/etiologia
Infecção da Ferida Cirúrgica/microbiologia
Centros de Atenção Terciária
Acuidade Visual
Vitrectomia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191173


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[PMID]:29390522
[Au] Autor:Ko J; Kim SK; Yong DE; Kim TI; Kim EK
[Ad] Endereço:Department of Ophthalmology, Corneal Dystrophy Research Institute, Institute of Vision Research, Yonsei University College of Medicine.
[Ti] Título:Delayed onset Mycobacterium intracellulare keratitis after laser in situ keratomileusis: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9356, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Infectious keratitis is a relatively uncommon but potentially sight-threatening complication of laser in situ keratomileusis (LASIK). Mycobacterial keratitis is usually regarded as late onset keratitis among post-LASIK keratitis. There has been no documented case of Mycobacterium intracellulare post-LASIK keratitis of a long-latent period. PATIENT CONCERNS: A 36-year-old man was referred to our out-patient clinic, for persistent corneal epithelial defect with intrastromal infiltration. He had undergone uneventful bilateral LASIK procedure 4 years before. He complained decreased vision, accompanied by ocular pain, photophobia, and redness in his left eye for 7 months. DIAGNOSIS: Lamellar keratectomy was taken using femtosecond laser. Bacterial culture with sequenced bacterial 16s ribosomal DNA confirmed the organism to be M intracellulare. INTERVENTIONS: After 3 months of administration of topical clarithromycin, amikacin, and moxifloxacin, the corneal epithelial defect was resolved and the infiltration was much improved. However, newly developed diffuse haziness with surrounding granular infiltration in the central cornea was noted. Drug toxicity was suspected and topical moxifloxacin was discontinued, resulting in resolution of the diffuse haze with infiltration. OUTCOME: The patient was followed up regularly without medication thereafter and recurrence was not found for 7 years. LESSONS: This case presents the first case of M intracellulare keratitis after LASIK. LASIK surgeons should aware that post-LASIK keratitis can develop long after the operation and careful suspicion of infectious disease with meticulous diagnostic test is needed.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Infecções Oculares Bacterianas/diagnóstico
Ceratite/microbiologia
Ceratomileuse Assistida por Excimer Laser In Situ/efeitos adversos
Complexo Mycobacterium avium/isolamento & purificação
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Amicacina/uso terapêutico
Claritromicina/uso terapêutico
Quimioterapia Combinada
Infecções Oculares Bacterianas/tratamento farmacológico
Infecções Oculares Bacterianas/etiologia
Fluoroquinolonas/uso terapêutico
Seguimentos
Seres Humanos
Ceratite/tratamento farmacológico
Ceratite/etiologia
Ceratomileuse Assistida por Excimer Laser In Situ/métodos
Masculino
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 84319SGC3C (Amikacin); H1250JIK0A (Clarithromycin); U188XYD42P (moxifloxacin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009356


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[PMID]:29433463
[Au] Autor:Todokoro D; Hoshino J; Yo A; Makimura K; Hirato J; Akiyama H
[Ad] Endereço:Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. dtodokor@gunma-u.ac.jp.
[Ti] Título:Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review.
[So] Source:BMC Ophthalmol;18(1):40, 2018 Feb 13.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye. After 3 months, he complained of ocular pain and hyperemia in his left eye. Examination showed a subtenon abscess in the site corresponding with the STTA injection. After incising the abscess, the smear revealed numerous conidia-like structures. Although we suspected fungal infection and started topical voriconazole (VRCZ) and levofloxacin, the inflammation of the eye worsened. Fungal culture revealed filamentous fungus growth. Subsequently, we added systemic VRCZ and performed surgical debridement of the infected sclera and Tenon's capsule. Pathology of the sclera showed fungal hyphae. The antifungal susceptibility test revealed low minimum inhibitory concentrations for micafungin, VRCZ and miconazole (0.06, 0.25 and 0.5 µg/mL, respectively). After 2 months, the ciliary injection subsided and VRCZ therapy was stopped. However, subtenon abscess recurred 1 month after discontinuation of topical VRCZ. Surgical debridement and topical VRCZ were resumed, with the eye finally improving after 5 months of management. The fungal species was identified as Scedosporium apiospermum sensu stricto morphologically and by DNA sequencing. CONCLUSIONS: This case was successfully treated by topical and systemic VRCZ and repeated surgical debridement. Infectious scleritis caused by SASC rarely develops after posterior STTA. SASC can produce conidia in the enclosed subtenon space. Late-onset infectious scleritis after a posterior STTA injection suggests the presence of a fungal infection, including SASC, thereby requiring extensive and prolonged medical and surgical treatment.
[Mh] Termos MeSH primário: Infecções Oculares Fúngicas/microbiologia
Imunossupressores/administração & dosagem
Micoses/microbiologia
Complicações Pós-Operatórias
Scedosporium/isolamento & purificação
Esclerite/microbiologia
Triancinolona Acetonida/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Antifúngicos/uso terapêutico
Terapia Combinada
Desbridamento
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/terapia
Seres Humanos
Injeções Intraoculares
Edema Macular/tratamento farmacológico
Imagem por Ressonância Magnética
Masculino
Testes de Sensibilidade Microbiana
Micoses/diagnóstico
Micoses/terapia
Esclerite/diagnóstico
Esclerite/terapia
Cápsula de Tenon/efeitos dos fármacos
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Immunosuppressive Agents); F446C597KA (Triamcinolone Acetonide); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0707-4


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[PMID]:29426303
[Au] Autor:Singh S; Shrivastav A; Agarwal M; Gandhi A; Mayor R; Paul L
[Ad] Endereço:Vitreoretina services, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Road, Daryaganj, New Delhi, 110002, India. drshalini15@gmail.com.
[Ti] Título:A rare case of scleral buckle infection with Curvularia species.
[So] Source:BMC Ophthalmol;18(1):35, 2018 Feb 09.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Scleral buckling is an established modality of treating retinal detachment. Being an external implant the buckle may be prone to infections. We report such a case with a delayed presentation and a rare etiology. CASE PRESENTATION: A 45 year old male presented with redness, foreign body sensation and discharge for one month in his right eye. The patient had undergone a retinal detachment surgery elsewhere 14 years back without any visual gain. Right eye demonstrated no perception of light and the best corrected visual acuity in the left eye was 6/6, N6. On downgaze an exposed and anteriorly displaced scleral buckle was identified with black deposits and mucopurulent material overlying the buckle. Scleral buckle removal was done. On microbiological examination Curvularia species was identified. Successful treatment with antifungals was done. CONCLUSIONS: Scleral buckle infection with dematiaceous fungi is a rare occurrence. To the best of our knowledge this is the first case report describing a buckle infection caused by the curvularia species.
[Mh] Termos MeSH primário: Ascomicetos/isolamento & purificação
Infecções Oculares Fúngicas/microbiologia
Micoses/microbiologia
Infecções Relacionadas à Prótese/microbiologia
Recurvamento da Esclera/efeitos adversos
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Antifúngicos/uso terapêutico
Ciprofloxacino/uso terapêutico
Quimioterapia Combinada
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/tratamento farmacológico
Fluconazol/uso terapêutico
Seres Humanos
Masculino
Meia-Idade
Micoses/diagnóstico
Micoses/tratamento farmacológico
Infecções Relacionadas à Prótese/diagnóstico
Infecções Relacionadas à Prótese/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 5E8K9I0O4U (Ciprofloxacin); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0695-4


  10 / 12139 MEDLINE  
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[PMID]:29402251
[Au] Autor:Kim JY; Lee JH; Lee CS; Lee SC
[Ad] Endereço:Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, South Korea.
[Ti] Título:Varicella zoster virus-associated Chorioretinitis: a case report.
[So] Source:BMC Ophthalmol;18(1):28, 2018 Feb 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution. CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Slit lamp biomicroscopy, funduscopy, OCT, and intraocular fluid analysis were performed. The right eye exhibited multiple inflammatory lesions at the posterior pole, macular edema, and disc swelling on the fundus examination. OCT revealed predominant involvement of the choroid and the retinal pigment epithelium (RPE). Intraocular fluid analysis showed positivity for VZV. The patient was admitted and treated with intravenous acyclovir. Additional oral prednisolone was used to reduce the inflammatory reaction. After 2 weeks of treatment with acyclovir, the lesion resolved, with undulation of the RPE. Her final visual acuity was 20/20. CONCLUSIONS: VZV-associated posterior uveitis may present as multifocal chorioretinitis. Intraocular fluid analysis is important to detect an infectious origin.
[Mh] Termos MeSH primário: Coriorretinite/virologia
Infecções Oculares Virais/virologia
Herpesvirus Humano 3/isolamento & purificação
Uveíte Posterior/virologia
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Administração Oral
Antivirais/uso terapêutico
Coriorretinite/diagnóstico
Coriorretinite/tratamento farmacológico
Terapia Combinada
Infecções Oculares Virais/diagnóstico
Infecções Oculares Virais/tratamento farmacológico
Feminino
Angiofluoresceinografia
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Prednisolona/uso terapêutico
Tomografia de Coerência Óptica
Uveíte Posterior/diagnóstico
Uveíte Posterior/tratamento farmacológico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0696-3



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