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[PMID]: 29506510 [Au] Autor: Guo J; Tang W; Ye X; Wu H; Xu G; Liu W; Zhang Y [Ad] Endereço: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China. [Ti] Título: Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1. [So] Source: BMC Ophthalmol;18(1):69, 2018 Mar 05. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS: A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA. RESULTS: The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 µm in MT type 1 eyes and 252.43 ± 15.77 µm in contralateral eyes (Z = - 4.113, p < 0.001). The mean vessel density of the DCP was lower in MT type 1 eyes (47.25 ± 4.69%) than in contralateral eyes (53.93 ± 2.94%) and normal eyes (59.37 ± 2.50%) (Z = - 3.492, - 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with CMT (r = 0.682, p = 0.007), SCP density (r = - 0.652, p = 0.012), DCP density (r = - 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1 eyes. CONCLUSIONS: Decreased DCP density and the presence of DRIL may be predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central region were strongly associated with VA. [Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada Angiofluoresceinografia Telangiectasia Retiniana/diagnóstico por imagem Tomografia de Coerência Óptica Acuidade Visual/fisiologia [Mh] Termos MeSH secundário: Adulto Idoso Biomarcadores Feminino Seres Humanos Edema Macular/diagnóstico por imagem Masculino Meia-Idade Imagem Multimodal Telangiectasia Retiniana/fisiopatologia Vasos Retinianos/diagnóstico por imagem Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180307 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0737-y

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[PMID]: 29499665 [Au] Autor: Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L [Ad] Endereço: People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China. [Ti] Título: Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis. [So] Source: BMC Ophthalmol;18(1):65, 2018 Mar 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration. [Mh] Termos MeSH primário: Anti-Infecciosos/uso terapêutico Substância Própria/metabolismo Úlcera da Córnea/tratamento farmacológico Reagentes para Ligações Cruzadas Infecções Oculares Fúngicas/tratamento farmacológico Fusariose/tratamento farmacológico Fusarium/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais Colágeno/metabolismo Contagem de Colônia Microbiana Úlcera da Córnea/metabolismo Úlcera da Córnea/microbiologia Modelos Animais de Doenças Infecções Oculares Fúngicas/metabolismo Infecções Oculares Fúngicas/microbiologia Fusariose/metabolismo Fusariose/microbiologia Fusarium/isolamento & purificação Masculino Camundongos Camundongos Endogâmicos C57BL Fármacos Fotossensibilizantes/uso terapêutico Riboflavina/uso terapêutico Raios Ultravioleta [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180304 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0727-0

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[PMID]: 29377953 [Au] Autor: Waduthantri S; Zhou L; Chee SP [Ad] Endereço: Singapore Eye Research Institute, Singapore, Singapore. [Ti] Título: Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study. [So] Source: PLoS One;13(1):e0191850, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. DESIGN: Non-randomized, prospective, interventional clinical study. METHODS: Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment. RESULTS: There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11). CONCLUSION: Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%. TRIAL REGISTRATION: SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. [Mh] Termos MeSH primário: Segmento Anterior do Olho/patologia Antivirais/administração & dosagem Infecções por Citomegalovirus/tratamento farmacológico Ganciclovir/administração & dosagem [Mh] Termos MeSH secundário: Administração Oftálmica Adulto Idoso Idoso de 80 Anos ou mais Cromatografia Líquida Citomegalovirus/genética Feminino Seres Humanos Masculino Meia-Idade Projetos Piloto Estudos Prospectivos Reação em Cadeia da Polimerase em Tempo Real Espectrometria de Massas em Tandem [Pt] Tipo de publicação: CLINICAL STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antiviral Agents); P9G3CKZ4P5 (Ganciclovir) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180130 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191850

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[PMID]: 29211701 [Au] Autor: Zhong J; Deng Y; Zhang P; Li S; Huang H; Wang B; Zhang H; Peng L; Yang R; Xu J; Yuan J [Ad] Endereço: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. [Ti] Título: New Grading System for Limbal Dermoid: A Retrospective Analysis of 261 Cases Over a 10-Year Period. [So] Source: Cornea;37(1):66-71, 2018 Jan. [Is] ISSN: 1536-4798 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To establish a new scoring system for limbal dermoid, in order to unify the diagnostic criteria and assess the prognosis. METHODS: A retrospective study was conducted on 261 patients with limbal dermoid. The basic information, clinical features, and pathology of dermoids were recorded, and the prognosis at 1 year after keratoplasty was assessed at follow-up. A new visual scoring system was created for the area of corneal involvement, the area of conjunctival involvement, and the surface shape. RESULTS: There were 154 females and 107 males with mean age of 4 ± 3 years at surgery. After scoring, 59% (136) of patients were classified as grade I, 26% (60) as grade II, and 14% (33) as grade III. The pathological results were 124 dermoid cases, 76 lipodermoid, 5 complex choristoma, and 10 epibulbar osseous choristoma. Moreover, patients with lower clinical scores presented a better prognosis; the mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity in grade I patients was 0.38 ± 0.05, which was better than the grade II value of 0.61 ± 0.09 (P < 0.05) and the grade III value of 0.94 ± 0.11 (P < 0.001). CONCLUSIONS: New grading systems for limbal dermoid were useful for clinical diagnosis and may have prognostic value in predicting visual acuity. A lower-grade dermoid exhibited better vision postoperatively. [Mh] Termos MeSH primário: Doenças da Córnea/diagnóstico Cisto Dermoide/diagnóstico Neoplasias Oculares/diagnóstico Limbo da Córnea/patologia [Mh] Termos MeSH secundário: Pré-Escolar Doenças da Córnea/cirurgia Cisto Dermoide/cirurgia Neoplasias Oculares/cirurgia Feminino Seres Humanos Lactente Limbo da Córnea/cirurgia Masculino Gradação de Tumores Procedimentos Cirúrgicos Oftalmológicos Prognóstico Estudos Retrospectivos Acuidade Visual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171207 [St] Status: MEDLINE [do] DOI: 10.1097/ICO.0000000000001429

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[PMID]: 28465175 [Au] Autor: Malik A; Albogami S; Alsenaidy AM; Aldbass AM; Alsenaidy MA; Khan ST [Ad] Endereço: Department of Biochemistry. Protein Research Chair. College of Science. King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: amalik@ksu.edu.sa. [Ti] Título: Spectral and thermal properties of novel eye lens ζ-crystallin. [So] Source: Int J Biol Macromol;102:1052-1058, 2017 Sep. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Eye lenses are exposed to thermal, solar radiations, dryness that enhances cataractogenesis. Some animal lenses contain novel proteins in bulk quantities. ζ-crystallin occurred in three ecologically divergent species, but it's physiological role not known. The truncated variant of ζ-crystallin causes hereditary cataract. Guinea pig ζ-crystallin is temperature-sensitive and rapidly aggregates at 41°C. Camels adopted to survive above 50°C, which raises an interesting question about how it retains lens proteins in the soluble state? Here, we have optimized expression and purification of recombinant camel ζ-crystallin. We have studied thermodynamic and spectroscopic properties using orthogonal techniques. Dynamic multimode spectroscopy results showed that camel ζ-crystallin unfolds via single transition with T value of 60.8±0.1°C and van't Hoff enthalpy of 714.7±7.1kJ/mol. Thermal-shift assay calculates T value of 62°C at pH 7. Additionally, the conformational stability of ζ-crystallin increases with ionic-strength. The influence of pH on ζ-crystallin was evaluated where the protein was found to be stable in the pH range of 6-9, but its stability drastically decreases below pH 6. Our results also showed that quaternary structure of ζ-crystallin drastically changed as a result of lowering pH. This study provides significant understandings onto the conformational, thermodynamic and unfolding pathway of camel ζ-crystallin. [Mh] Termos MeSH primário: Cristalino/química Temperatura Ambiente zeta-Cristalinas/química [Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio Estabilidade Proteica Desdobramento de Proteína Análise Espectral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (zeta-Crystallins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE

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[PMID]: 29441913 [Ti] Título: Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: evidence and . [So] Source: Pharmazie;71(7):382-389, 2016 Jul 07. [Is] ISSN: 0031-7144 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The occurrence of bone defects can be due to a variety of factors not limited to bone fractures and tumours. Most diseased bone is removed and the patient fitted with prosthetics, prior to use of certain factors such as bone morphogenetic proteins (BMPs) to aid healing. Recently, the protein pigment epithelium-derived factor (PEDF) and the polysaccharide chitosan have been found to have promising effects on the regeneration of bone, with the major advantage of these agents being their safety to date. A study was performed to determine whether the combination of both chitosan and PEDF would enhance greater bone regeneration effects. Post-formulation, in silico tests (particle sizing and surface charge determination) were followed by several cell-based assays (microparticle cellular uptake, cytotoxicity, mitochondrial abundance, bone mineral formation, colony formation in matrigel, and colony formation in collagen I matrix), and finally in vivo testing where microparticles were injected periosteally in the hindlimb. Collectively, these findings support the idea that PEDF microencapsulated within chitosan promotes bone regeneration, and has potential for bone trauma management. Future studies will examine the ability of this promising bone regeneration microparticle to heal bone in disease states such as fracture and tumour-mediated osteolysis. [Mh] Termos MeSH primário: Regeneração Óssea/efeitos dos fármacos Proteínas do Olho/farmacologia Fatores de Crescimento Neural/farmacologia Serpinas/farmacologia [Mh] Termos MeSH secundário: Animais Densidade Óssea/efeitos dos fármacos Cápsulas Sobrevivência Celular/efeitos dos fármacos Quitosana/farmacologia Colágeno Tipo I/farmacologia Ensaio de Unidades Formadoras de Colônias Simulação por Computador Composição de Medicamentos Proteínas do Olho/administração & dosagem Proteínas do Olho/metabolismo Membro Posterior Seres Humanos Injeções Masculino Camundongos Camundongos Endogâmicos BALB C Mitocôndrias/efeitos dos fármacos Fatores de Crescimento Neural/administração & dosagem Fatores de Crescimento Neural/metabolismo Tamanho da Partícula Serpinas/administração & dosagem Serpinas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Capsules); 0 (Collagen Type I); 0 (Eye Proteins); 0 (Nerve Growth Factors); 0 (Serpins); 0 (pigment epithelium-derived factor); 9012-76-4 (Chitosan) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180215 [St] Status: MEDLINE [do] DOI: 10.1691/ph.2016.6010

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[PMID]: 29183023 [Au] Autor: Demirel S; Degirmenci MFK; Bilici S; Yanik Ö; Batioglu F; Özmert E; Alp N [Ad] Endereço: Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey. [Ti] Título: The Recovery of Microvascular Status Evaluated by Optical Coherence Tomography Angiography in Patients after Successful Macular Hole Surgery. [So] Source: Ophthalmic Res;59(1):53-57, 2018. [Is] ISSN: 1423-0259 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: PURPOSE: The aim of this study was to evaluate the optical coherence tomography angiography (OCTA) features of patients who underwent successful macular hole (MH) surgery. METHODS: Nineteen patients who underwent surgery in a single eye due to MH and 13 healthy subjects as a control group were included in the study. Vascular densities, flow indexes, and the foveal avascular zone (FAZ) area in superficial and deep retinal capillary plexuses were evaluated by OCTA in the right eyes of the control group, and both the surgical and healthy fellow eyes of the patients. RESULTS: The mean vascular densities of the superficial and deep capillary plexuses were significantly lower in the surgical eyes than in the control group (44.1 vs. 49.6%, p = 0.002, and 47.3 vs. 59.1%, p = 0.009, respectively). The mean superficial and deep capillary flow indexes were significantly lower in the surgical eyes than in the control group (0.85 vs. 1.35, p = 0.003, and 0.57 vs. 1.45, p = 0.001, respectively), while the mean superficial and deep FAZ area were significantly greater in the surgical eyes in comparison to the control group (0.55 vs. 0.32, p < 0.001, and 0.64 vs. 0.37, p = 0.001, respectively). There was no difference between the flow indexes of both layers of the healthy fellow eyes and the control group. CONCLUSIONS: These preliminary results may be an explanation for unsatisfactory visual gain after surgery, despite the successful anatomical closure of the MH. [Mh] Termos MeSH primário: Fóvea Central/irrigação sanguínea Microvasos/diagnóstico por imagem Perfurações Retinianas/patologia Vasos Retinianos/diagnóstico por imagem [Mh] Termos MeSH secundário: Idoso Estudos de Casos e Controles Feminino Angiofluoresceinografia/métodos Fóvea Central/diagnóstico por imagem Seres Humanos Macula Lutea/irrigação sanguínea Masculino Meia-Idade Perfurações Retinianas/cirurgia Estudos Retrospectivos Tomografia de Coerência Óptica/métodos Acuidade Visual [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171129 [St] Status: MEDLINE [do] DOI: 10.1159/000484092

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[PMID]: 28471106 [Au] Autor: Son BK; Kwak HW; Kim ES; Yu SY [Ad] Endereço: Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea. [Ti] Título: Comparison of Ranibizumab and Bevacizumab for Macular Edema Associated with Branch Retinal Vein Occlusion. [So] Source: Korean J Ophthalmol;31(3):209-216, 2017 Jun. [Is] ISSN: 2092-9382 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: PURPOSE: To assess the effectiveness and safety of intravitreal ranibizumab compared with bevacizumab for the treatment of macular edema associated with branch retinal vein occlusion (BRVO). METHODS: This was a retrospective study of 80 eyes with macular edema associated with BRVO. Patients received either 0.5 mg of ranibizumab (n = 24) or 1.25 mg of bevacizumab (n = 56) intravitreally. Both groups received three initial monthly injections followed by as-needed injections. The best-corrected visual acuity, central subfield thickness, mean number of injections, and retreatment rate were evaluated monthly for 6 months after the initial injection. RESULTS: The best-corrected visual acuity significantly improved from logarithm of the minimal angle of resolution (logMAR) 0.55 ± 0.26 at baseline to 0.24 ± 0.26 at 6 months in the ranibizumab group (p < 0.001) and from logMAR 0.58 ± 0.21 at baseline to 0.29 ± 0.25 at 6 months in the bevacizumab group (p < 0.001), which is not a statistically significant difference (p = 0.770). The mean reduction in central subfield thickness at 6 months was 236 ± 164 µm in the ranibizumab group (p < 0.001) and 219 ± 161 µm in the bevacizumab group (p < 0.001), which is not also a statistically significant difference (p = 0.698). The mean numbers of ranibizumab and bevacizumab injections were 3.25 ± 0.53 and 3.30 ± 0.53, respectively (p = 0.602). In addition, after the three initial monthly injections, the retreatment rates for ranibizumab and bevacizumab injections were 20.8% and 26.7%, respectively (p = 0.573). CONCLUSIONS: Both ranibizumab and bevacizumab were effective for the treatment of BRVO and produced similar visual and anatomic outcomes. In addition, the mean number of injections and the retreatment rates were not significantly different between the groups. [Mh] Termos MeSH primário: Bevacizumab/administração & dosagem Edema Macular/tratamento farmacológico Ranibizumab/administração & dosagem Oclusão da Veia Retiniana/complicações Acuidade Visual [Mh] Termos MeSH secundário: Inibidores da Angiogênese/administração & dosagem Relação Dose-Resposta a Droga Feminino Angiofluoresceinografia Seguimentos Fundo de Olho Seres Humanos Injeções Intravítreas Macula Lutea/patologia Edema Macular/diagnóstico Edema Macular/etiologia Masculino Meia-Idade Oclusão da Veia Retiniana/diagnóstico Oclusão da Veia Retiniana/tratamento farmacológico Estudos Retrospectivos Fatores de Tempo Tomografia de Coerência Óptica Resultado do Tratamento [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Angiogenesis Inhibitors); 2S9ZZM9Q9V (Bevacizumab); ZL1R02VT79 (Ranibizumab) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.3341/kjo.2015.0158

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[PMID]: 28471100 [Au] Autor: Kim JM; Kim JH; Chang YS; Kim JW; Kim CG; Lee DW [Ad] Endereço: Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea. [Ti] Título: Treatment of Bilateral Retinal Angiomatous Proliferation with Anti-vascular Endothelial Growth Factor: 12-Month Outcome. [So] Source: Korean J Ophthalmol;31(3):240-248, 2017 Jun. [Is] ISSN: 2092-9382 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate the 12-month outcome of intravitreal anti-vascular endothelial growth factor therapy in eyes with bilateral retinal angiomatous proliferation (RAP). METHODS: This retrospective observational study included 38 eyes of 19 patients with stage 1 or 2 bilateral RAP at diagnosis. The eyes of patients who exhibited different baseline best-corrected visual acuity (BCVA) values in both eyes were assigned to one of two groups-the better (n=13) and worse (n=13) visual acuity groups. The BCVA values in both groups were compared to those at baseline and at 12 months. In addition, the 12-month changes in BCVA were compared between the two groups. The association between the optical coherence tomography findings at diagnosis and the 12-month BCVA was also analyzed. RESULTS: The values of mean baseline and 12-month BCVA in the better visual acuity group (13 eyes) were 0.48 ± 0.19 and 0.58 ± 0.29, respectively, and those in the worse visual acuity group (13 eyes) were 0.83 ± 0.20 and 0.90 ± 0.31. The 12-month changes in BCVA were not significantly different between the two groups (p=0.786). Among the six patients with equivalent baseline BCVA in both eyes, four patients (66.7%) exhibited 1 to 2 lines or ≥3 lines of difference in BCVA between eyes at 12 months. Eyes without pigment epithelial detachment (PED) at diagnosis exhibited significantly better BCVA at 12 months than eyes with PED (p=0.021). CONCLUSIONS: Better baseline visual acuity was associated with better BCVA at 12 months posttreatment in patients with bilateral RAP. However, equivalent baseline visual acuity in both eyes might not guarantee similar treatment outcomes. In addition, the absence of PED is predictive of better visual outcome. [Mh] Termos MeSH primário: Bevacizumab/administração & dosagem Neovascularização de Coroide/tratamento farmacológico Degeneração Macular/tratamento farmacológico Ranibizumab/administração & dosagem Acuidade Visual [Mh] Termos MeSH secundário: Idoso Inibidores da Angiogênese/administração & dosagem Neovascularização de Coroide/diagnóstico Feminino Angiofluoresceinografia Seguimentos Fundo de Olho Seres Humanos Injeções Intravítreas Degeneração Macular/diagnóstico Masculino Epitélio Pigmentado da Retina Estudos Retrospectivos Fatores de Tempo Tomografia de Coerência Óptica Resultado do Tratamento Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Angiogenesis Inhibitors); 0 (Vascular Endothelial Growth Factor A); 2S9ZZM9Q9V (Bevacizumab); ZL1R02VT79 (Ranibizumab) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.3341/kjo.2016.0026

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[PMID]: 28457509 [Au] Autor: Fracasso NCA; de Andrade ES; Wiezel CEV; Andrade CCF; Zanão LR; da Silva MS; Marano LA; Donadi EA; C Castelli E; Simões AL; Mendes-Junior CT [Ad] Endereço: Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900, Ribeirão Preto-SP, Brazil. Electronic address: nadiadeaguiar@gmail.com. [Ti] Título: Haplotypes from the SLC45A2 gene are associated with the presence of freckles and eye, hair and skin pigmentation in Brazil. [So] Source: Leg Med (Tokyo);25:43-51, 2017 Mar. [Is] ISSN: 1873-4162 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: The Solute Carrier Family 45, Member 2 (SLC45A2) gene encodes the Membrane-Associated Transporter Protein (MATP), which mediates melanin synthesis by tyrosinase trafficking and proton transportation to melanosomes. At least two SLC45A2 coding SNPs [E272K (rs26722) and L374F (rs16891982)] were reported influencing normal variation of human pigmentation. Here we aimed at evaluating the influence of haplotypes of 12 SNPs within SLC45A2 in the determination of eye, hair and skin pigmentation in a highly admixed population sample and comparing their frequencies with the ones found in data retrieved from the 1000 Genomes Project. To achieve this goal, 12 SLC45A2 SNPs were evaluated in 288 unrelated individuals from the Ribeirão Preto city area, Southeastern Brazil. SNPs were genotyped by PCR-RFLP or Allele-specific PCR, followed by polyacrylamide gel electrophoresis. Haplotypes of each individual were inferred by two independent computational methods, PHASE and Partition-Ligation-Expectation-Maximization (PL-EM) algorithms, and 34 different haplotypes were identified. The hp9 haplotype was the most frequent (58.3%) and was associated with the presence of blond/red hair, pale skin, blue eyes and freckles. All haplotypes significantly associated with dark or light pigmentation features harbor the 374L and 374F alleles, respectively. These results emphasize the role played by haplotypes at SLC45A2 in the determination of pigmentation aspects of human populations and reinforce the relevance of SNP L374F in human pigmentation. [Mh] Termos MeSH primário: Cor de Olho/genética Cor de Cabelo/genética Haplótipos/genética Melanose/genética Pigmentação da Pele/genética [Mh] Termos MeSH secundário: Alelos Brasil Frequência do Gene Projeto Genoma Humano Seres Humanos Polimorfismo de Fragmento de Restrição [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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