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  1 / 1522238 MEDLINE  
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[PMID]:29524382
[Au] Autor:Asada M; Nishimura T; Ifuku K; Mino H
[Ad] Endereço:Division of Material Science (Physics), Graduate school of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
[Ti] Título:Location of the extrinsic subunit PsbP in photosystem II studied by pulsed electron-electron double resonance.
[So] Source:Biochim Biophys Acta;, 2018 Mar 07.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The binding site of the extrinsic protein PsbP in plant photosystem II was mapped by pulsed electron-electron double resonance, using mutant spinach PsbP (Pro20Cys, Ser82Cys, Ala111Cys, and Ala186Cys) labeled with 4-maleimido-TEMPO (MSL) spin label. The distances between the spin label and the Tyr160 neutral radical (Y ) in PsbD, the D2 subunit of plant photosystem II, were 50.8 ±â€¯3.5 Å, 54.9 ±â€¯4.0 Å, 57.8 ±â€¯4.9 Å, and 58.4 ±â€¯14.1 Å, respectively. The geometry inferred from these distances was fitted to the PsbP crystal structure (PDB: 4RTI) to obtain the coordinates of Y relative to PsbP. These coordinates were then fitted under boundary conditions to the structure of cyanobacterial photosystem II (PDB: 4UB6), by rotating on Euler angles centered at fixed Y coordinates. The result proposed two models which show possible acidic amino acid residues in CP43, CP47 and D2 that can bind the basic amino acids Arg48, Lys143, and Lys160 in PsbP.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[St] Status:Publisher


  2 / 1522238 MEDLINE  
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[PMID]:29481954
[Au] Autor:Hassan EA; Fadel SM; Hassan ML
[Ad] Endereço:Cellulose and Paper Department, National Research Centre, 33 Behouth street, Dokki, Giza 12622, Egypt. Electronic address: ea.elgarhy@nrc.sci.eg.
[Ti] Título:Influence of TEMPO-oxidized NFC on the mechanical, barrier properties and nisin release of hydroxypropyl methylcellulose bioactive films.
[So] Source:Int J Biol Macromol;113:616-622, 2018 Feb 23.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bioactive films from hydroxypropyl methylcellulose (HPMC), nisin (N), and different percentage (5% to 75%) of TEMPO-oxidized nanofibrillated cellulose (NFC) isolated from rice straw pulp were prepared by solution casting technique and their properties were studied. Scanning electron microscope images (SEM) of films showed homogeneous surface with absence of nanofibers agglomeration. The mechanical and barrier properties were evaluated by measuring their tensile strength, tensile modulus, strain at maximum load, dynamic mechanical thermal properties (DMTA), and water vapor permeability (WVP). In all films, there was an improvement in the mechanical, thermomechanical, and moisture barrier properties as a result of presence of NFC. The molecular structure of the films was studied by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction patterns (XRD). Presence of NFC in HPMC films affected crystallinity of the later. The prepared HPMC/N, NFC/N, and HPMC/N/NFC films exhibited significant antimicrobial activities against Gram-positive bacteria Staphylococcus aureus with noticeable controlled release of nisin in case of films containing HPMC/NFC.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[St] Status:Publisher


  3 / 1522238 MEDLINE  
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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
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[PMID]:29362795
[Au] Autor:Foa EB; McLean CP; Zang Y; Rosenfield D; Yadin E; Yarvis JS; Mintz J; Young-McCaughan S; Borah EV; Dondanville KA; Fina BA; Hall-Clark BN; Lichner T; Litz BT; Roache J; Wright EC; Peterson AL; STRONG STAR Consortium
[Ad] Endereço:Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia.
[Ti] Título:Effect of Prolonged Exposure Therapy Delivered Over 2 Weeks vs 8 Weeks vs Present-Centered Therapy on PTSD Symptom Severity in Military Personnel: A Randomized Clinical Trial.
[So] Source:JAMA;319(4):354-364, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Effective and efficient treatment is needed for posttraumatic stress disorder (PTSD) in active duty military personnel. Objective: To examine the effects of massed prolonged exposure therapy (massed therapy), spaced prolonged exposure therapy (spaced therapy), present-centered therapy (PCT), and a minimal-contact control (MCC) on PTSD severity. Design, Setting, and Participants: Randomized clinical trial conducted at Fort Hood, Texas, from January 2011 through July 2016 and enrolling 370 military personnel with PTSD who had returned from Iraq, Afghanistan, or both. Final follow-up was July 11, 2016. Interventions: Prolonged exposure therapy, cognitive behavioral therapy involving exposure to trauma memories/reminders, administered as massed therapy (n = 110; 10 sessions over 2 weeks) or spaced therapy (n = 109; 10 sessions over 8 weeks); PCT, a non-trauma-focused therapy involving identifying/discussing daily stressors (n = 107; 10 sessions over 8 weeks); or MCC, telephone calls from therapists (n = 40; once weekly for 4 weeks). Main Outcomes and Measures: Outcomes were assessed before and after treatment and at 2-week, 12-week, and 6-month follow-up. Primary outcome was interviewer-assessed PTSD symptom severity, measured by the PTSD Symptom Scale-Interview (PSS-I; range, 0-51; higher scores indicate greater PTSD severity; MCID, 3.18), used to assess efficacy of massed therapy at 2 weeks posttreatment vs MCC at week 4; noninferiority of massed therapy vs spaced therapy at 2 weeks and 12 weeks posttreatment (noninferiority margin, 50% [2.3 points on PSS-I, with 1-sided α = .05]); and efficacy of spaced therapy vs PCT at posttreatment. Results: Among 370 randomized participants, data were analyzed for 366 (mean age, 32.7 [SD, 7.3] years; 44 women [12.0%]; mean baseline PSS-I score, 25.49 [6.36]), and 216 (59.0%) completed the study. At 2 weeks posttreatment, mean PSS-I score was 17.62 (mean decrease from baseline, 7.13) for massed therapy and 21.41 (mean decrease, 3.43) for MCC (difference in decrease, 3.70 [95% CI,0.72 to 6.68]; P = .02). At 2 weeks posttreatment, mean PSS-I score was 18.03 for spaced therapy (decrease, 7.29; difference in means vs massed therapy, 0.79 [1-sided 95% CI, -∞ to 2.29; P = .049 for noninferiority]) and at 12 weeks posttreatment was 18.88 for massed therapy (decrease, 6.32) and 18.34 for spaced therapy (decrease, 6.97; difference, 0.55 [1-sided 95% CI, -∞ to 2.05; P = .03 for noninferiority]). At posttreatment, PSS-I scores for PCT were 18.65 (decrease, 7.31; difference in decrease vs spaced therapy, 0.10 [95% CI, -2.48 to 2.27]; P = .93). Conclusions and Relevance: Among active duty military personnel with PTSD, massed therapy (10 sessions over 2 weeks) reduced PTSD symptom severity more than MCC at 2-week follow-up and was noninferior to spaced therapy (10 sessions over 8 weeks), and there was no significant difference between spaced therapy and PCT. The reductions in PTSD symptom severity with all treatments were relatively modest, suggesting that further research is needed to determine the clinical importance of these findings. Trial Registration: clinicaltrials.gov Identifier: NCT01049516.
[Mh] Termos MeSH primário: Terapia Implosiva/métodos
Militares/psicologia
Psicoterapia/métodos
Transtornos de Estresse Pós-Traumáticos/terapia
[Mh] Termos MeSH secundário: Adulto
Campanha Afegã de 2001-
Feminino
Seres Humanos
Guerra do Iraque 2003-2011
Modelos Lineares
Masculino
Índice de Gravidade de Doença
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.21242


  4 / 1522238 MEDLINE  
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[PMID]:29362786
[Au] Autor:Woloshin S; Schwartz LM; Bagley PJ; Blunt HB; White B
[Ad] Endereço:Center for Medicine in the Media, Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire.
[Ti] Título:Characteristics of Interim Publications of Randomized Clinical Trials and Comparison With Final Publications.
[So] Source:JAMA;319(4):404-406, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Editoração
Ensaios Clínicos Controlados Aleatórios como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Publicações
Projetos de Pesquisa
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.20653


  5 / 1522238 MEDLINE  
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[PMID]:28460138
[Au] Autor:Tucker MA; Morris CJ; Morgan A; Yang J; Myers S; Pierce JG; Stickgold R; Scheer FAJL
[Ad] Endereço:Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, MA.
[Ti] Título:The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation.
[So] Source:Sleep;40(4), 2017 04 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: Sleep during the biological night facilitates memory consolidation. Here we determined the impact of sleep and wake on motor skill learning (acquisition) and subsequent off-line skill improvement (memory consolidation), independent of circadian phase, and compared this to the impact of the endogenous circadian system, independent of whether sleep occurred during the biological night or day. Methods: Participants completed two 8-day sleep laboratory visits, adhering on one visit to a circadian aligned ("normal") sleep schedule for the full duration of the protocol, and on the other to a circadian misaligned (12-hour inverted) schedule, with alignment during the first 3 days, a 12-hour 'slam shift' on Day 4, followed by circadian misalignment during the last 4 days of the protocol. Participants were repeatedly trained and tested on different versions of the finger-tapping motor sequence task across each visit. Results: Sleep facilitated offline memory consolidation regardless of whether it occurred during the biological day or night, while circadian phase had no significant impact. These sleep-related benefits remained after accounting for general motor speed, measured in the absence of learning. In addition, motor skill acquisition was facilitated when the training session followed shortly after sleep, without significant impact of circadian phase (biological morning vs. evening). This effect was largely driven by heightened acquisition in participants who slept during the day and were trained shortly thereafter, that is, when acquisition occurred during the biological evening. These benefits were also retained after controlling for general motor speed. Conclusions: Sleep benefits both the acquisition and consolidation of motor skill regardless of whether they occur during the biological day or night. After controlling for general motor speed, a critical adjustment that few studies perform, these sleep benefits remain intact. Our findings have clear implications for night shift workers who obtain their sleep during the day.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Consolidação da Memória/fisiologia
Destreza Motora/fisiologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Jornada de Trabalho em Turnos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx036


  6 / 1522238 MEDLINE  
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[PMID]:29524018
[Au] Autor:Becker SP; Willcutt EG
[Ad] Endereço:Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA. stephen.becker@cchmc.org.
[Ti] Título:Advancing the study of sluggish cognitive tempo via DSM, RDoC, and hierarchical models of psychopathology.
[So] Source:Eur Child Adolesc Psychiatry;, 2018 Mar 10.
[Is] ISSN:1435-165X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sluggish cognitive tempo (SCT) is separable from attention-deficit/hyperactivity disorder (ADHD) and other psychopathologies, and growing evidence demonstrates SCT to be associated with impairment in both children and adults. However, it remains unclear how SCT should optimally be conceptualized. In this article, we argue that multiple models of psychopathology should be leveraged to make substantive advances to our understanding of SCT. Both categorical and dimensional approaches should be used, including the Diagnostic and Statistical Manual of Mental Disorders (DSM) nosology, the Research Domain Criteria (RDoC) initiative, and hierarchical models of psychopathology. Studies are needed to determine whether individuals categorized with SCT can be reliably identified and differentiated from individuals without SCT in pathophysiological, neuropsychological, behavioral, and daily life functioning. Studies are also needed to evaluate the validity and utility of SCT as a transdiagnostic and dimensional construct. In considering SCT as a dimensional and potentially transdiagnostic construct, we describe ways in which SCT might be examined within the RDoC framework, including negative valence systems, cognitive systems, and arousal/regulatory systems, as well as within hierarchical models of psychopathology. Conceptualizing SCT within both categorical and dimensional models of psychopathology will help to better understand the causes, developmental pathways, and clinical implications of SCT, both as a construct in its own right and also in relation to other psychopathologies.
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[St] Status:Publisher
[do] DOI:10.1007/s00787-018-1136-x


  7 / 1522238 MEDLINE  
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[PMID]:29496804
[Au] Autor:Watkins RT; Conn LJ; Gellin RG; Gonzales TS; Hamil LM; Cayouette MJ; Schmidt MG
[Ad] Endereço:Dr. Watkins is Assistant Dean for Dental Education and Informatics, East Carolina University School of Dental Medicine; Dr. Conn is Associate Professor and Chair, Department of General Dentistry, East Carolina University School of Dental Medicine; Dr. Gellin is Professor and Chair, Department of Sto
[Ti] Título:Analyzing Dental Students' Clinic Production Using Time-Based Relative Value Units: Ten-Year Cross-Cohort Mapping.
[So] Source:J Dent Educ;82(3):260-268, 2018 Mar.
[Is] ISSN:1930-7837
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The analysis of dental students' clinical production/participation has been used to assess whether a prospective graduate is capable of unsupervised and independent practice (that is, competent to perform that practice). This method and others have inherent biases that may not accurately reflect whether the student has mastered the associated concepts and techniques required for dentistry. The aim of this study was to assess an informatics system that assigned curriculum meta-tags with time-based relative educational value units (ReVUs) to each clinical procedure performed by Medical University of South Carolina (MUSC) students. The system has been used since 1998, but for this study the complete data sets for the MUSC graduating classes of 2007 through 2016 were mapped using microcompetency codes for the dental procedures. In total, 421,494 procedures were formatted and analyzed using software developed to aggregate disparate data sets from clinical activities into a common format for evaluation. The results showed that the ten classes (cohorts) were very consistent with cohort high ReVUs averaging 7,317.1 points, cohort mean ReVUs being 5,180.2 points, and cohort low ReVUs averaging 3,381 points. A detailed analysis of student effort by dental subspecialty found that preventive activities represented 13.4%, patient assessment 32.6%, periodontology 2.8%, restorative dentistry 16.3%, prosthodontics 21.9%, endodontics 6.7%, and oral surgery 5.7% of the total points in the clinical part of the curriculum. In this system, point thresholds can be easily generated to monitor students' progress towards competence for each defined competency and thus assess their progress towards acquiring the skills required for unsupervised, independent practice.
[Mh] Termos MeSH primário: Estudantes de Odontologia/estatística & dados numéricos
[Mh] Termos MeSH secundário: Competência Clínica/normas
Competência Clínica/estatística & dados numéricos
Estudos de Coortes
Currículo/estatística & dados numéricos
Assistência Odontológica/normas
Assistência Odontológica/estatística & dados numéricos
Avaliação Educacional/métodos
Seres Humanos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180303
[St] Status:MEDLINE
[do] DOI:10.21815/JDE.018.025


  8 / 1522238 MEDLINE  
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[PMID]:29446298
[Au] Autor:Katamanova EV; Dyakovich MP; Kudaeva IV; Shevchenko OI; Eshchina IM; Rukavishnikov VS; Meshchakova NM
[Ti] Título:[Clinical and neurophysiological peculiarities of health disorders in workers in dependence on the vinyl chloride exposure load].
[So] Source:Gig Sanit;95(12):1167-71, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Results of the clinical and neurophysiological examinations of 42 workers with operating history at the chemical plant exposed to vinyl chloride (VC) are presented. The purpose of research was the identification ofpeculiarities of clinical manifestations and disorders of the functional activity of the brain in workers at the vinyl chloride production, with taking into account the exposure toxic load (ETL). There were made clinical and electroencephalographic examinations with the detection of cognitive evoked potentials (CEP) and statistical analysis of results with the use of the Mann-Whitney U-test, Fisher's F-test, calculation of Spearman's correlation coefficient. The features in clinical picture of the pathology of the nervous system were detected in the form of asthenic disorders with cognitive impairment and autonomic dysfunction syndrome. There was established the increase in the cognitive impairment rate (p = 0.03), the decline in a-EEG activity (p = 0.01) and the worsening of indices of the amplitude (p = 0.011) and latency (p = 0,05) of CEP in extremely high level of ETL in comparison with same indices in the group with moderately high ETL. In the first group there was revealed a statistically significant exceedance of the frequency of hypertension - by 1.6 times, skin diseases - by 9 times, chronic subatrophic rhino-pharyngitis by 1.4 times in comparison with cases from the second group. In the group with moderately high level of ETL there was established the statistically significant inverse correlationship between the ETL and the index of P300 amplitude from the left side (r = -0.38, p = 0.019) and in the group with extremely high level ETL - between ETL and index of the ß2 - rhythm (r = - 0.73, p = 0.0008).
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Indústria Manufatureira
Síndromes Neurotóxicas
Cloreto de Vinil
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Eletroencefalografia/métodos
Seres Humanos
Masculino
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Meia-Idade
Síndromes Neurotóxicas/diagnóstico
Síndromes Neurotóxicas/epidemiologia
Síndromes Neurotóxicas/etiologia
Síndromes Neurotóxicas/fisiopatologia
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Medição de Risco/métodos
Medição de Risco/estatística & dados numéricos
Fatores de Risco
Sibéria/epidemiologia
Fatores de Tempo
Cloreto de Vinil/análise
Cloreto de Vinil/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  9 / 1522238 MEDLINE  
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[PMID]:29446294
[Au] Autor:Efimova NV; Rukavishnikov VS; Pankov VA; Perezhogin AN; Shayakhmetov SF; Meshchakova NM; Lisetskaya LG
[Ti] Título:[Assessment of carcinogenic risks to workers of the main enterprises of the Irkutsk region].
[So] Source:Gig Sanit;95(12):1163-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose of research is the assessment of the individual cancer risk (ICR) for workers of the basic occupations in key branches of industry of the Irkutsk region. There was executed the calculation of ICR levels for workers of the basic occupations of the aircraft industry, aluminum smelters and vinyl chloride production plants. The estimation of the exposure for workers was carried out according to long-term time-weighted average concentrations in the air of the working area, for the population - on annual average concentrations in the ambient air. To assess the risk that is not associated with the profession, the dose was calculated for the period of life (70 years). When calculating the toxicant doses in the working area there were used the "standard" indices ofpulmonary ventilation for adults, body weight, the work experience in the contact with carcinogens of 30 years, the number of days in the contact of 240, the duration of the working time 8 or 12 hours (in accordance with the working hours) duration. ICR for the Irkutsk population amounted of 3.08E-04, in Shelekhov - 4.8E-05, Sayansk - 1.1E-05. The amount of risk depends on the content offormaldehyde in all territories and chromium VI in cities of Irkutsk and Shelekhov. ICR for workers of basic occupations of studied plants in dozens of times are higher than for the urban population. Priority carcinogens are: chromium VI, nickel, formaldehyde, silicon dioxide -for the aircraft plant employees; 1,2-dichloretan, vinyl chloride - for the workers of vinyl chloride production plant; benzopyrene - for the aluminum smelter workers.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Carcinogênese/induzido quimicamente
Cromo
Formaldeído
Indústria Manufatureira
Cloreto de Vinil
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Carcinógenos Ambientais/análise
Carcinógenos Ambientais/toxicidade
Cromo/análise
Cromo/toxicidade
Formaldeído/análise
Formaldeído/toxicidade
Seres Humanos
Indústria Manufatureira/métodos
Indústria Manufatureira/normas
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Medição de Risco/métodos
Medição de Risco/estatística & dados numéricos
Fatores de Risco
Sibéria/epidemiologia
Tempo
Cloreto de Vinil/análise
Cloreto de Vinil/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Carcinogens, Environmental); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 1HG84L3525 (Formaldehyde); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  10 / 1522238 MEDLINE  
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[PMID]:29446293
[Au] Autor:Beygel EA; Katamanova EV; Shayakhmetov SF; Ushakova OV; Pavlenko NA; Kuks AN; Voronin DA
[Ti] Título:[The impact of the long-term exposure of industrial aerosols on clinical and functional indices of the broncho-pulmonary system in aluminum smelter workers].
[So] Source:Gig Sanit;95(12):1160-3, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:It was found that the appearance of respiratory diseases among workers was established to be associated with the impact of aerosols with the complex chemical composition, exceeding corresponding MAC. Among respiratory diseases in workers there were detected predominantly chronic non-obstructive bronchitis - 59.15%, and chronic obstructive pulmonary disease (COPD) - in 35.2% of cases. In the analysis of spirometric indices of examined patients the vast majority (76.3%) of them showed disturbances of the bronchial patency of mild to moderate degree of the pronouncement. As a result of the implementation offlexible bronchoscopy there was established the presence of a diffuse lesion of bronchi with a predominance of subatrophic and atrophic processes in the mucosa. It was found that under the increase of the concentration of HF in the air of industrial premises the probability of bronchial obstruction and deterioration of the tracheobronchial patency in aluminum smelter workers was established to elevate.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Alumínio
Bronquite Crônica
Indústria Química
Doenças Profissionais
Doença Pulmonar Obstrutiva Crônica
[Mh] Termos MeSH secundário: Aerossóis/efeitos adversos
Aerossóis/análise
Aerossóis/química
Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Alumínio/análise
Alumínio/química
Bronquite Crônica/epidemiologia
Bronquite Crônica/etiologia
Bronquite Crônica/prevenção & controle
Indústria Química/métodos
Indústria Química/normas
Seres Humanos
Masculino
Meia-Idade
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Doença Pulmonar Obstrutiva Crônica/etiologia
Doença Pulmonar Obstrutiva Crônica/prevenção & controle
Sibéria/epidemiologia
Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Air Pollutants, Occupational); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE



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