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Pesquisa : transtornos and da and pigmentação [Palavras]
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  1 / 8021 MEDLINE  
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[PMID]:29210541
[Au] Autor:Take N; Kido-Nakahara M; Furue M
[Ti] Título:Coexistence of Reticulate Acropigmentation of Kitamura and Dowling-Degos Disease.
[So] Source:Fukuoka Igaku Zasshi;107(4):85-5, 2016 Apr.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperpigmentação/complicações
Transtornos da Pigmentação/complicações
Dermatopatias Genéticas/complicações
Dermatopatias Papuloescamosas/complicações
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  2 / 8021 MEDLINE  
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[PMID]:29362773
[Au] Autor:Abalem MF; Rao PK; Rao RC
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine, University of São Paulo, Brazil.
[Ti] Título:Nystagmus and Platinum Hair.
[So] Source:JAMA;319(4):399-400, 2018 01 23.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Albinismo Oculocutâneo/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Albinismo Oculocutâneo/complicações
Diagnóstico Diferencial
Feminino
Fundo de Olho
Cor de Cabelo
Seres Humanos
Nistagmo Patológico/etiologia
Transtornos da Pigmentação/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.20673


  3 / 8021 MEDLINE  
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[PMID]:29249796
[Au] Autor:Farran Y; Padilla O; Chambers K; Philipovskiy A; Nahleh Z
[Ad] Endereço:Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA.
[Ti] Título:Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature.
[So] Source:Am J Case Rep;18:1347-1350, 2017 Dec 18.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences. CONCLUSIONS The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.
[Mh] Termos MeSH primário: Neoplasias da Mama/etiologia
Hemangiossarcoma/etiologia
Neoplasias Induzidas por Radiação
Transtornos da Pigmentação/etiologia
Radioterapia Adjuvante/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Neoplasias da Mama/patologia
Neoplasias da Mama/radioterapia
Carcinoma Ductal de Mama/radioterapia
Feminino
Hemangiossarcoma/patologia
Seres Humanos
Transtornos da Pigmentação/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


  4 / 8021 MEDLINE  
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[PMID]:29052871
[Au] Autor:Betz RC
[Ad] Endereço:Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.
[Ti] Título:A path through the reticulate pigmentation disorder jungle.
[So] Source:Br J Dermatol;177(4):893-894, 2017 10.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperpigmentação
Transtornos da Pigmentação
[Mh] Termos MeSH secundário: Seres Humanos
Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15805


  5 / 8021 MEDLINE  
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[PMID]:28930817
[Au] Autor:Wang J; Zhao L; Ma N; Che J; Li H; Cao B
[Ad] Endereço:Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Cronkhite-Canada syndrome associated with colon cancer metastatic to liver: A case report.
[So] Source:Medicine (Baltimore);96(38):e7466, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Although malignant colon and gastric cancer have been reported in CCS, reports of distant metastasis have been rare in CCS. PATIENT CONCERNS: A 58-year-old male was referred from a nearby hospital with diarrhea and weight loss. The patient was hypoproteinemia (17.9 g/L), and multiple polyps were observed in the large intestine. He also had alopecia, onychatrophia, and dysgeusia. DIAGNOSES: The presence of multiple polyps and associated symptoms of alopecia, onychatrophia, pigmentation, and dysgeusia informed the diagnosis of CCS. INTERVENTIONS: He was treated with 20mg dexamethasone acetate per day for about 3 months, 10 mg for about 9 month, 5 mg for about 1 year, and then maintained on 5 mg daily. Three years after starting treatment, colonoscopy revealed colon cancer and colon adenomas. A sigmoidectomy revealed 4 well-differentiated adenocarcinomas of the ulcerating type in the sigmoid colon, and tubularadenomas throughout the rest of the large intestine. He was treated with FOLFOX6 for 6 months. At this stage liver metastasis was found. A right hepatectomy was performed confirming hepatic metastasis of colonic adenocarcinoma, which was GPC-3(-), CD34(-), CK20(+), CDX-2(+), Hep(-), CK19(+), and CK8(+).The patient received 3 courses of hepatic arterial infusion chemotherapy. OUTCOMES: The patient's status has been stable for more than 2 years, and there was no tumor recurrence or metastasis occurred. LESSONS: CCS is a rare cause of multiple polyposis most often treated with hormone therapy. Regular follow-ups are very important to ensure discovery of malignant tumors at an early stage. Studies with longer-term observations and larger sample sizes will be required to confirm these observations. However, characterization of molecular markers for the early detection of malignant transformation that might allow less invasive and more cost-effective surveillance of colon cancer is urgently sought.
[Mh] Termos MeSH primário: Adenocarcinoma/secundário
Neoplasias do Colo/etiologia
Polipose Intestinal/complicações
Neoplasias Hepáticas/secundário
[Mh] Termos MeSH secundário: Alopecia/etiologia
Neoplasias do Colo/patologia
Pólipos do Colo/etiologia
Diarreia/etiologia
Disgeusia/etiologia
Seres Humanos
Masculino
Meia-Idade
Doenças da Unha/etiologia
Transtornos da Pigmentação/etiologia
Perda de Peso
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007466


  6 / 8021 MEDLINE  
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[PMID]:28918974
[Au] Autor:Dai J; Belum VR; Wu S; Sibaud V; Lacouture ME
[Ad] Endereço:Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Dermatology, Stanford University, Stanford, California.
[Ti] Título:Pigmentary changes in patients treated with targeted anticancer agents: A systematic review and meta-analysis.
[So] Source:J Am Acad Dermatol;77(5):902-910.e2, 2017 Nov.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The discovery of signaling networks that drive oncogenic processes has led to the development of targeted anticancer agents. The burden of pigmentary adverse events from these drugs is unknown. OBJECTIVE: To conduct a systematic review and meta-analysis of published clinical trials and determine the incidence and risk of development of targeted therapy-induced pigmentary changes. METHODS: A comprehensive search was conducted to identify studies reporting targeted therapy-induced pigmentary changes. The incidence and relative risk were calculated. Case reports and series were reviewed to understand clinical characteristics. RESULTS: A total of 8052 patients from 36 clinical trials were included. The calculated overall incidences of targeted cancer therapy-induced all-grade pigmentary changes in the skin and hair were 17.7% (95% confidence interval [CI], 11.9-25.4) and 21.5% (95% CI, 14.9-30.1), respectively. The relative risk of all-grade pigmentary changes of skin and hair were 93.7 (95% CI, 5.86-1497.164) and 20.1 (95% CI, 8.35-48.248). Across 53 case reports/series (N = 75 patients), epidermal growth factor receptor and breakpoint cluster region-abelson inhibitors were the most common offending agents. LIMITATIONS: Potential under-reporting and variability in oncologists reporting these events. CONCLUSION: There is a significant risk of development of pigmentary changes during treatment with targeted anticancer therapies. Appropriate counseling and management are critical to minimize psychosocial impairment and deterioration in quality of life.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Terapia de Alvo Molecular/efeitos adversos
Neoplasias/tratamento farmacológico
Transtornos da Pigmentação/induzido quimicamente
Transtornos da Pigmentação/patologia
Qualidade de Vida
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/fisiopatologia
Feminino
Seres Humanos
Masculino
Neoplasias/patologia
Transtornos da Pigmentação/epidemiologia
Prevalência
Prognóstico
Ensaios Clínicos Controlados Aleatórios como Assunto
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


  7 / 8021 MEDLINE  
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[PMID]:28877348
[Au] Autor:Karakatsanis A; Daskalakis K; Stålberg P; Olofsson H; Andersson Y; Eriksson S; Bergkvist L; Wärnberg F
[Ad] Endereço:Department of Surgical Sciences, Uppsala University Hospital, Uppsala Academic Hospital, Uppsala, Sweden.
[Ti] Título:Superparamagnetic iron oxide nanoparticles as the sole method for sentinel node biopsy detection in patients with breast cancer.
[So] Source:Br J Surg;104(12):1675-1685, 2017 Nov.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sentinel node biopsy (SNB) using superparamagnetic iron oxide (SPIO) nanoparticles is a novel method in breast cancer. Several studies have verified the non-inferiority of SPIO compared with the standard use of radioisotope Tc with or without blue dye. The aim of the MONOS study presented here was to evaluate the use of SPIO as a sole tracer and the efficacy of tracer injection in the preoperative setting. METHODS: This prospective cohort study was carried out in two hospitals, one using Tc and the other SPIO. Tc was injected in the morning of the day of surgery or the day before. SPIO was either injected before surgery in the outpatient clinic or 1 h before the operation. RESULTS: A total of 338 consecutive patients with breast cancer underwent 343 procedures; SPIO nanoparticles were used in 184 procedures and Tc-labelled tracer in 159. Detection rates for SPIO and Tc were 95·6 and 96·9 per cent respectively (P = 0·537). All nodes with SPIO uptake were coloured brown. Fewer nodes were retrieved with SPIO (mean 1·35 versus 1·89), regardless of whether blue dye was used (P < 0·001). Preoperative SPIO injection (58·7 per cent of procedures), a median of 16 (range 2-27) days before the procedure, was associated with a better tracer-specific detection rate (95·3 versus 86 per cent; P = 0·031) and retrieval of more nodes (mean 1·43 versus 1·03; P < 0·001) than perioperative administration. Skin staining was present in 39·9 per cent of patients, and was related to breast-conserving surgery and periareolar injection. CONCLUSION: The use of SPIO alone is a safe alternative, with results comparable to those of the standard dual technique using Tc and blue dye. The efficacy of injection in the preoperative setting simplifies logistics and improves performance. Skin staining can be prevented by a deeper peritumoral injection.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Neoplasias da Mama/cirurgia
Compostos Férricos
Linfonodos/patologia
Nanopartículas de Magnetita
Biópsia de Linfonodo Sentinela/métodos
[Mh] Termos MeSH secundário: Idoso
Corantes
Custos e Análise de Custo
Feminino
Compostos Férricos/efeitos adversos
Seres Humanos
Metástase Linfática
Nanopartículas de Magnetita/efeitos adversos
Mastectomia Segmentar
Meia-Idade
Satisfação do Paciente
Transtornos da Pigmentação/etiologia
Estudos Prospectivos
Cintilografia
Biópsia de Linfonodo Sentinela/economia
Agregado de Albumina Marcado com Tecnécio Tc 99m
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Ferric Compounds); 0 (Magnetite Nanoparticles); 0 (Technetium Tc 99m Aggregated Albumin); 1K09F3G675 (ferric oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10606


  8 / 8021 MEDLINE  
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[PMID]:28855495
[Au] Autor:Okamoto M; Takeshita J; Takahashi K; Tanaka A; Yoshida K; Kuriyama M
[Ad] Endereço:Department of Neurology, Brain Attack Center Ota Memorial Hospital.
[Ti] Título:Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: A case presented brain calcification and corpus callosum atrophy from over 10 years before the onset of dementia.
[So] Source:Rinsho Shinkeigaku;57(9):521-526, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 44-year-old man made many mistakes at work over a year. Eleven years prior, he had had medical examination with headache. He presented with symptoms consistent with frontal lobe dysfunction including cognitive decline, and bilateral pyramidal signs. Brain MRI showed cerebral atrophy, localized atrophy of corpus callosum, asymmetrical white matter lesions and multiple cystic lesions. CT images showed bilateral calcifications in the parietal subcortical white matter. Reconstructed sagittal CT images showed bilateral calcifications in the frontal white matter adjacent to the anterior horns of the lateral ventricles, which had a symmetrical "stepping stone appearance" in the frontal pericallosal regions. The brain MRI and CT images performed 11 years prior already showed evidence of similar findings including corpus callosum atrophy, multiple cystic lesions, and calcifications in the parietal subcortical white matter. Similar cystic lesions and calcifications were also observed in the frontal white matter adjacent to the anterior horns of the lateral ventricles However, the changes in the brain associated with atrophy and white matter lesions at this stage were mild. Genetic analysis revealed a novel mutation, p.R782C, in the exon 18 of the colony stimulating factor 1 receptor (CSF1R) gene. The CSF1R gene encodes the colony stimulating factor 1 receptor protein. This mutation was not observed in the patient's parents. Therefore, this mutation is considered to be a de novo mutation. He was diagnosed as having adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP).
[Mh] Termos MeSH primário: Axônios/patologia
Encefalopatias/patologia
Encéfalo/patologia
Calcinose/patologia
Corpo Caloso/patologia
Leucoencefalopatias/patologia
Neuroglia/patologia
Esferoides Celulares/patologia
[Mh] Termos MeSH secundário: Adulto
Atrofia
Encéfalo/diagnóstico por imagem
Encefalopatias/diagnóstico por imagem
Calcinose/diagnóstico por imagem
Corpo Caloso/diagnóstico por imagem
Diagnóstico Diferencial
Seres Humanos
Leucoencefalopatias/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Pigmentação
Fatores de Tempo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001072


  9 / 8021 MEDLINE  
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[PMID]:28847781
[Au] Autor:Burleigh A; Lam JM
[Ad] Endereço:Departments of Dermatology and Skin Science (Burleigh), Pediatrics (Lam) and Dermatology (Lam), Faculty of Medicine, The University of British Columbia, Vancouver, BC aburleigh@me.com.
[Ti] Título:Pediatric longitudinal melanonychia.
[So] Source:CMAJ;189(34):E1093, 2017 08 28.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças da Unha/diagnóstico
Unhas/patologia
Transtornos da Pigmentação/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
Melanócitos/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170256


  10 / 8021 MEDLINE  
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[PMID]:28833020
[Au] Autor:Stefanaki C; Stratigos A
[Ad] Endereço:Department of Dermatology-Venereology, National and Kapodestrian University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece.
[Ti] Título:Alopecia in Cronkhite-Canada syndrome.
[So] Source:Br J Dermatol;177(2):348-349, 2017 08.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Alopecia
Polipose Intestinal
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos da Pigmentação
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15611



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