Database : LILACS
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Id: lil-681743
Author: MUNAR, MARÍA ANGÉLICA; PANTOJA, JAIME ANDRÉS; SANTACRUZ, JUAN CAMILO; VILLATE, ANA MARÍA; BASTIDAS, ALIRIO RODRIGO; GIRALDO, LUIS FERNANDO.
Title: Terapia biológiaa en patología pulmonar: parte i generalidades y clasificaciónn parte ii: terapias específicas en asma, epoc, enfermedad pulmonar parinquematosa difusa, cáncer pulmonar / Terapiabiológicaa em patología pulmonar / Terapia biológica en patología pulmonar parte I: generalidades y clasificación parte II: terapias específicas en asma, EPOC, enfermedad pulmonar parinquematosa difusa, cáncer pulmonar
Source: Rev. MED;20(2):82-100, jul.-dic. 2012. ilus, tab.
Language: es.
Abstract: El avance de la investigación médica, en los campos de la biología molecular y la ingeniería genética, ha traído consigo el desarrollo de una serie de nuevos medicamentos dirigidos a bloquear diferentes vías de la respuesta inmune celular. La terapia biológica, nombre con el cual se reconoce a estos nuevos medicamentos, ofrece una nueva oportunidad terapéutica para el manejo de enfermedades crónicas progresivas. En las enfermedades pulmonares crónicas como el asma, la enfermedad pulmonar obstructiva crónica (EPOC), la enfermedad pulmonar parenquimatosa difusa (EPPD) y el cáncer de pulmón, el tratamiento con medicamentos biológicos ha aportado importantes avances para comprender con mayor claridad estas enfermedades y en algunos casos gracias a la eficacia de los mismos, mejorar la calidad de vida de los pacientes que las presentan. Debido al número cada vez mayor de medicamentos de terapia biológica y su aplicación terapéutica creciente en enfermedades inflamatorias crónicas y cáncer, creemos necesario revisar su estado actual en el manejo de la patología pulmonar crónica.

The advancement of medical research in molecular biology and genetic engineering has given rise to the development of new drugs aimed at blocking different pathways of cellular immune responses. Biological therapy is a new therapeutic option for progressive chronic disease management. In chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), diffuse parenchymal lung disease (DPLD) and lung cancer, treatment with biologics has made important advances in the understanding of these diseases, and in some cases, due to their effectiveness, has contributed to the improvement in life quality of patients who suffer them. Due to the increasing number of biological therapy drugs and their therapeutic application in chronic inflammatory diseases and cancer, it is relevant to review their current status in the management of chronic lung diseases.

O avanço da pesquisa médica, nos campos da biologia molecular e da engenharia genética, trouxe consigo o desenvolvimento de uma série de novos medicamentos dirigidos a bloquear diferentes vias da resposta imune celular. A terapia biológica, nome com o qual são conhecidos estes novos medicamentos, oferece uma nova oportunidade terapêutica para o tratamento de doenças cônicas progressivas. Nas doenças pulmonares crônicas como a asma, a doença pulmonar obstrutiva crônica (DPOC), a doença parenquimatosa difusa pulmonar (DPDP) e o câncer de pulmão, o tratamento com medicamentos biológicos tem contribuído com importantes avanços para compreender com maior claridade estas doenças e em alguns casos graças à eficácia dos mesmos, melhorar a qualidade de vida dos pacientes que as apresentam. Devido ao número cada vez maior de medicamentos de terapia biológica e sua aplicação terapêutica crescente em doenças inflamatórias crônicas e câncer, acreditamos que é necessário revisar seu estado atual no tratamento da patologia pulmonar Crônica.
Descriptors: Biological Factors
-Pulmonary Disease, Chronic Obstructive
Immunomodulation
Immunotherapy
Antibodies, Monoclonal
Limits: Humans
Publication Type: Classical Article
Responsable: CO87.1 - Biblioteca Médica


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Portela, Margareth Crisóstomo
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Id: biblio-839669
Author: Botelho, Janaina Furtado; Portela, Margareth Crisóstomo.
Title: Risco de interpretação falaciosa das internações por condições sensíveis à atenção primária em contextos locais, Itaboraí, Rio de Janeiro, Brasil, 2006-2011 / Riesgo de interpretación falaz de los internamientos por condiciones sensibles a la atención primaria en contextos locales, Itaboraí, Río de Janeiro, Brasil, 2006-2011 / Risk of misinterpretation of trends in hospital admissions for primary care sensitive conditions in local contexts: Itaboraí, Rio de Janeiro State, Brazil, 2006-2011
Source: Cad. saúde pública (Online);33(3):e00050915, 2017. tab, graf.
Language: pt.
Abstract: Resumo: Este artigo objetiva caracterizar as internações por condições sensíveis à atenção primária (ICSAP), identificar fatores associados e explorar o impacto sobre elas do fechamento de um hospital, entre residentes de Itaboraí, um município com elevadas taxas de ICSAP no Estado do Rio de Janeiro, Brasil, alimentando o debate sobre o uso indiscriminado do indicador para inferências acerca da expansão e qualidade da atenção primária. O estudo foi baseado em dados do Sistema de Informações Hospitalares do Sistema Único de Saúde. Associações entre a ocorrência de ICSAP com variáveis demográficas e inerentes aos hospitais foram analisadas com o teste χ2. Modelos de regressão logística averiguaram o comportamento das ICSAP ano a ano. As internações mais frequentes foram por insuficiência cardíaca, asma, gastroenterites, doença pulmonar obstrutiva crônica e diabetes mellitus. Suas chances de ocorrência foram maiores para o sexo masculino, pardos, nos extremos de idade e em hospitais privados e filantrópicos. A evolução das taxas de ICSAP no decorrer dos anos foi influenciada pelo fechamento de um hospital, sugerindo cautela na sua atribuição à melhoria da qualidade da atenção primária.

Resumen: Este artículo tiene por objetivo caracterizar los internamientos por condiciones sensibles a la atención primaria (ICSAP) entre residentes de Itaboraí, un municipio con elevadas tasas de estos internamientos en el Estado de Río de Janeiro, Brasil, identificar factores asociados y explorar el impacto sobre ellas del cierre de un hospital, alimentando el debate sobre el uso indiscriminado del indicador para inferencias acerca de la expansión y calidad de la atención primaria. El estudio se basó en datos del Sistema de Información Hospitalaria del Sistema Único de Salud. Asociación entre la ocurrencia de ICSAP con variables demográficas e inherentes a los hospitales fueron analizadas con el test χ2. Modelos de regresión logística averiguaron el comportamiento de los ICSAP año a año. Los internamientos más frecuentes fueron por insuficiencia cardíaca, asma, gastroenteritis, enfermedad pulmonar obstructiva crónica y diabetes mellitus. Sus oportunidades de ocurrencia fueron mayores en el sexo masculino, mestizos, en los extremos de edad y en hospitales privados y filantrópicos. La evolución de las tasas de ICSAP en el transcurso de los años fue influenciada por el cierre de un hospital, sugiriendo cautela en su atribución a la mejora de la calidad de la atención primaria.

Abstract: The study's objectives were to describe hospital admissions for primary care sensitive conditions (PCSCs) among residents of Itaboraí, a municipality in Rio de Janeiro State, Brazil, with a high rate of such admissions, to identify associated factors, and to explore the impact from closing a hospital. The ultimate aim was to contribute to the debate on the indicator's indiscriminate use for inferences on the expansion and quality of primary care. The study was based on data from the Hospital Information System of the Brazilian Unified National Health System. Associations between admissions for PCSCs and demographic and hospital-related variables were analyzed with the χ2 test. Logistic regression models verified the year-by-year behavior of admissions for PCSCs. The most frequent admissions were for heart failure, asthma, gastroenteritis, chronic obstructive pulmonary disease, and diabetes mellitus. The odds of hospital admissions were higher in males, brown individuals, at age extremes, and in private and charity hospitals. The trend in the admissions rates for PCSCs over the years was influenced by the closing of a hospital, suggesting caution in attributing changes in admissions rates to quality improvement in primary care.
Descriptors: Primary Health Care/statistics & numerical data
Hospitalization/trends
Hospitalization/statistics & numerical data
-Brazil
Risk Factors
Hospital Information Systems
National Health Programs
Limits: Humans
Male
Female
Infant
Child, Preschool
Child
Adolescent
Adult
Middle Aged
Aged
Aged, 80 and over
Young Adult
Responsable: BR1.1 - BIREME


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Id: biblio-1293296
Author: Vega-Briceño, Luis Enrique.
Title: Asma leve: un problema sanitario invisible / Mild asthma, an invisible health problem
Source: Neumol. pediátr. (En línea);16(2):90-91, 2021.
Language: es.
Descriptors: Asthma/epidemiology
Limits: Humans
Responsable: CL1.1 - Biblioteca Central


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Id: biblio-1293294
Author: Herrera G, María Elena; Herrera G, Ana María; Rojas C, Antonio; Muñoz P, Mariela; Clavero, María Jesús.
Title: Hipovitaminosis D y malnutrición por exceso en niños asmáticos hospitalizados / Hypovitaminosis D and malnutrition by excess in hospitalized asthmatic children
Source: Neumol. pediátr. (En línea);16(2):85-89, 2021. tab.
Language: es.
Abstract: La tasa de hospitalización por crisis de asma en niños chilenos se ha duplicado en los últimos años. Diversos estudios muestran una asociación entre hipovitaminosis D y crisis de asma. El objetivo principal del presente estudio fue describir la prevalencia de déficit e insuficiencia de vitamina D (vitD) en escolares asmáticos hospitalizados por crisis de asma y evaluar su estado nutricional. METODOLOGÍA: Estudio analítico, transversal, que incluyó a todos los pacientes de 5 años o más que se hospitalizaron por crisis de asma durante un año calendario en el Servicio de Pediatría del Hospital Clínico de la Universidad de Chile. Se aplicó una encuesta que incluyó datos sociodemográficos y clínicos, se evaluó el nivel de control del asma mediante el cuestionario Asthma Control Test (ACT), se determinó el estado nutricional y se midió la concentración de vitD. RESULTADOS: Se observó que 6 de cada 10 pacientes presentaba déficit o insuficiencia de vitD (22,8 ng/ml ± 10,5), encontrándose una asociación positiva entre concentración de vitD y ACT. La malnutrición por exceso estaba presente en casi la mitad de los pacientes. Aquellos pacientes que se hospitalizaron por más de 3 días tenían una concentración sérica de vitD significativamente menor. CONCLUSIONES: La hipovitaminosis D afectó a la mayoría de los niños hospitalizados por crisis de asma. Se encontró una asociación significativa entre concentración de vitD con días de hospitalización y control de la enfermedad medido por ACT.

Asthma hospitalization rates in Chilean children has doubled in recent years. Multiple studies show an association between hypovitaminosis D and asthma attacks. OBJECTIVES: To determine the prevalence of vitamin D (vitD) deficiency and insufficiency in asthmatic school age children hospitalized for asthma crisis and to evaluate their nutritional status. METHODS: Cross-sectional, analytical study that included patients 5 years of age or older hospitalized for asthma attacks during one calendar year, in the Pediatric Service of the University of Chile Clinical Hospital. A survey was conducted that included sociodemographic and clinical data, the level of asthma control was evaluated using the Asthma Control Test questionnaire (ACT), the nutritional status was determined and the concentration of vitD was measured. RESULTS: 6 out of 10 patients had either Vit D deficiency or insufficiency (22,8 ng/ml ± 10,5), showing a positive association between vitD concentration and ACT. Malnutrition due to excess was present in almost half of the patients. Children hospitalized for more than 3 days had a significantly lower vitD serum concentration. CONCLUSIONS: Most of the patients had hypovitaminosis D. An association was found between vitD concentration and hospital stay and between vitD concentration and asthma control, measured by ACT .
Descriptors: Status Asthmaticus/epidemiology
Vitamin D Deficiency/epidemiology
Overnutrition/epidemiology
-Child, Hospitalized
Nutritional Status
Prevalence
Cross-Sectional Studies
Surveys and Questionnaires
Limits: Humans
Male
Female
Child, Preschool
Child
Adolescent
Responsable: CL1.1 - Biblioteca Central


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Id: biblio-1293286
Author: Álvarez G, Cecilia.
Title: Rol de la fracción espirada de oxido nítrico en el niño con diagnóstico de asma bronquial / Role of the exhaled fraction of nitric oxide in children with diagnosis of bronchial asthma
Source: Neumol. pediátr. (En línea);16(2):62-68, 2021. ilus, tab.
Language: es.
Abstract: El asma es la enfermedad respiratoria crónica pediátrica más frecuente. En la mayoría de los niños se caracteriza por inflamación de la vía aérea de tipo eosinofílica alérgica. La fracción espirada de óxido nítrico (FENO) es un biomarcador de inflamación eosinofílica de vía aérea, su medición es no invasiva y fácil de realizar y ha sido evaluado en los últimos años para su aplicación clínica en el diagnóstico y tratamiento del asma en niños y adultos. Esta revisión abordará el origen anatómico y bioquímico del FENO, aspectos prácticos de su medición, valores de referencia y su aplicación clínica en el diagnóstico y tratamiento del asma pediátrico.

Asthma is the most common pediatric chronic disease characterized in most children by allergic eosinophilic airway inflammation. The exhaled fraction of nitric oxide (FENO) is a biomarker of eosinophilic airway inflammation, constituting a non-invasive and easy-to-perform test that has been evaluated in recent years for its clinical application in the diagnosis and treatment of asthma in children and adults. This review will address the anatomical and biochemical origin of FENO, practical aspects of its measurement, reference values and its clinical application in the diagnosis and treatment of pediatric asthma.
Descriptors: Asthma/diagnosis
Nitric Oxide/analysis
-Asthma/metabolism
Breath Tests
Biomarkers
Exhalation
Eosinophilia
Inflammation
Nitric Oxide/metabolism
Limits: Humans
Publication Type: Review
Responsable: CL1.1 - Biblioteca Central


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Id: biblio-1148260
Author: González Díaz, Donel; Cantillano Vaquedano, Liliam; Díaz de Villega, Mahily Paz.
Title: Secuestro pulmonar intralobar: hallazgo clínico-radiológico. presentación de un caso / Intralobar pulmonary sequestration. presentation of the case
Source: Rev. inf. cient;99(6):577-584, 2020. ilus.
Language: es.
Abstract: Se presentó una mujer de 40 años con antecedentes de asma bronquial atendida en el Hospital Clínico Quirúrgico "Hermanos Ameijeiras" de La Habana. Refirió historia de un mes de evolución de tos seca, dolor torácico en hemitórax izquierdo, falta de aire y en dos ocasiones fiebre de 38 °C. Cumplió tratamiento para el proceso infeccioso respiratorio sin resolución. En la radiografía de tórax se evidenció una lesión radiopaca en el lóbulo inferior izquierdo y se confirmó el secuestro pulmonar intralobar con la angiotomografía pulmonar. En el secuestro pulmonar se requiere del uso adecuado de método clínico para su diagnóstico y la toma de decisiones terapéuticas definitivas(AU)

Forty years old woman with a history of severe asthma assisted to the Hospital Clínico Quirúrgico "Hermanos Ameijeiras" in Havana, presenting the following symptoms: dry cough, chest pain in left hemithorax, shortness of breath and fever with a temperature of 38°C (100.4°F) twice in the month. The patient was under treatment to control a respiratory infection, with no resolution reported. Radiography of the thorax revealed a radiopaque lesion in the left lower lobe, and lung sequestration was confirmed by pulmonary angiography. An appropiate use of clinical methods is required to diagnose and undertake the right therapy decisions about the intralobar lung sequestration(AU)
Descriptors: Bronchopulmonary Sequestration/diagnosis
Bronchopulmonary Sequestration/diagnostic imaging
Limits: Humans
Female
Adult
Publication Type: Case Reports
Responsable: CU419.1 - Centro Provincial de Información de Ciencias Médicas de Guantánamo


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Id: biblio-1284148
Author: Brum A, Marcos; Lantmann, Caroline; Zocche Junior, Giovani; Rodrigues F, Ingrid; Santos, Amanda; Friedrich, Federico; Carollo F, Morgana; Jones, Marcus.
Title: Técnica de oscilações forçadas na avaliação e manejo de crianças asmáticas: uma revisão narrativa / Forced oscillation technique in the assessment and management of asthmatic children: a narrative review
Source: Neumol. pediátr. (En línea);16(1):5-10, 2021. ilus.
Language: pt.
Abstract: Asthma is considered the most prevalent chronic disease in children. The pulmonary function measurements are important in the evaluation of the disease, being able to confirm the diagnosis by demonstrating the reversibility of the obstruction as well as detecting risks of poor prognosis in the control of asthma. However, the most common methods for analyzing pulmonary function in this age group have restrictions on its applicability, especially due to the need for cooperation on the part of patients. The forced oscillation technique (FOT) is considered a modern tool capable of estimating measures of respiratory mechanics related to the lungs. This method is easily applicable due to the low need for patient cooperation, an important element in the assessment of children. The aim of this study is to review the clinical utility of the Forced Oscillation Technique in the pulmonary assessment of asthmatic children. The bibliographic search covered the years between 1950 and 2019, in the databases: Medical Literature Analysis and Retrieval System Online (MEDLINE) and Latin American and Caribbean Literature in Health Sciences (LILACS). It was used as a search strategy the combination of the following Medical Subject Headings (MeSH) terms: "asthma", "oscillometry" and "child" crossed through the AND and OR Boolean connectors. In asthmatic children, FOT showed greater accuracy in the evaluation of smaller caliber peripheral airways, which can be applied as a complementary method to spirometry to strengthen the diagnosis, enabling a better understanding of the disease and its progression.

A asma é considerada a doença crônica de maior incidência em crianças. As medidas de função pulmonar são importantes na avaliação da doença, podendo confirmar o diagnóstico pela demonstração de reversibilidade da obstrução assim como detectar riscos de mau prognóstico no controle da asma. Entretanto, os métodos mais usuais para análise da função pulmonar nesta faixa etária apresentam restrições em sua aplicabilidade, especialmente pela necessidade de cooperação por parte dos pacientes. A técnica de oscilações forçadas (FOT) é considerada uma ferramenta moderna capaz de estimar medidas da mecânica respiratória relativas aos pulmões. Este método apresenta fácil aplicabilidade pela baixa necessidade de cooperação do paciente, elemento importante na avaliação de crianças. O objetivo deste estudo é revisar a utilidade clínica da Técnica de Oscilações Forçadas na avaliação pulmonar de crianças asmáticas. A busca bibliográfica contemplou os anos entre 1950 e 2019, nas bases de dados: Medical Literature Analysis and Retrieval System Online (MEDLINE) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Foi utilizada como estratégia de busca a combinação dos seguintes Medical Subject Headings(MeSH) terms: "asthma", "oscillometry" e "child" cruzados por meio dos conectores booleanos AND e OR. Em crianças asmáticas, a FOT mostrou maior acurácia na avaliação de vias aéreas periféricas de menor calibre, podendo ser aplicada como método complementar a espirometria para encorpar o diagnóstico, possibilitando compreender melhor a doença e sua progressão.
Descriptors: Oscillometry/methods
Respiratory Function Tests/methods
Asthma/diagnosis
Asthma/physiopathology
-Spirometry
Respiratory Mechanics
Limits: Humans
Child
Publication Type: Review
Responsable: CL1.1 - Biblioteca Central


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Id: biblio-1153521
Author: Huang, Xue-peng; Qin, Cheng-yu; Gao, Yue-ming.
Title: miR-135a inhibits airway inflammatory response in asthmatic mice via regulating JAK/STAT signaling pathway
Source: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(3):e10023, 2021. graf.
Language: en.
Abstract: The objective of this study was to investigate the inhibitory effect of miR-135a in regulating JAK/STAT signaling pathway on airway inflammation in asthmatic mice. An asthma model was established by sensitization and stimulation with ovalbumin (OVA), and the corresponding drug intervention was given from the day of stimulation by means of nasal drops. Airway hyperresponsiveness was tested. The content of miR-135a in the lung tissue of mice was detected by RT-PCR. The pathological changes of lung tissue were evaluated by HE staining. Tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-5, and eotaxin in bronchoalveolar lavage fluid (BALF) and lung tissue were detected by ELISA and immunohistochemistry, respectively. The expression of JAK/STAT signaling pathway-related protein in lung tissue was detected by western blot. To further validate the effect of miR-135a overexpression on the JAK/STAT signaling pathway, pathway activators and inhibitors were added. Compared with the OVA group, the airway hyperresponsiveness of the mice was significantly decreased after treatment with the miR-135a agonist. The expression of miR-135a was significantly increased in the lung tissue and the pathological changes of the lung tissue were alleviated. The contents of TNF-α, IL-6, IL-5, and eotaxin in BALF and lung tissues were decreased. The expression of JAK/STAT signaling pathway-related proteins p-JAK3/JAK3, p-STAT1/STAT1, and p-STAT3/STAT3 were significantly reduced in lung tissue (P<0.05). Addition of JAK inhibitor AG490 reduced airway inflammation in asthmatic mice. miR-135a agonists inhibit airway inflammation in asthmatic mice by regulating the JAK/STAT signaling pathway.
Descriptors: Asthma/drug therapy
-Bronchoalveolar Lavage Fluid
Signal Transduction
Ovalbumin
MicroRNAs
Disease Models, Animal
Lung
Mice, Inbred BALB C
Limits: Animals
Rats
Responsable: BR1.1 - BIREME


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Id: biblio-1289357
Author: Torres Montes de Oca, Amy; Puente Téllez, Hugo; Ramírez López, Beatriz.
Title: Contradicción anestesiológica en una gestante con adenoma pleomórfico y alergia a los anestésicos locales / Anesthesiological contradiction in a pregnant woman with pleomorphic adenoma and allergy to local anesthetics
Source: Rev. cuba. anestesiol. reanim;20(2):e657, 2021. graf.
Language: es.
Abstract: Introducción: El adenoma del paladar blando es frecuente en mujeres, aunado a los cambios fisiológicos que suceden durante el embarazo, es de presumir que la gestante puede presentar una vía aérea difícil. Objetivo: Describir el abordaje de la vía aérea en una gestante con adenoma del paladar blando. Presentación del caso: Se trata de una gestante de 20 años de edad con antecedentes patológicos personales de asma bronquial, alergia a los anestésicos locales, que presenta un adenoma en el paladar blando que impide ver la estructura de la orofaringe, Mallampatti IV, anunciada para procedimiento quirúrgico de urgencia para realizarle cesárea segmentaria anterior. Conclusiones: La embarazada presenta mayor incidencia de vía aérea difícil comparado con la población general, debido a los cambios fisiológicos que presenta en este periodo, si a ello se le adiciona la presencia de un tumor oro faríngeo que imposibilita la manipulación de la vía aérea, la evaluación preoperatoria y trazar una estrategia multidisciplinaria, constituyen los pilares para evitar complicaciones potencialmente fatales(AU)

Introduction: Adenoma of soft palate is frequent in women, together with the physiological changes that occur during pregnancy. The pregnant woman is to be presumed to have a difficult airway. Objective: To describe the airway managment in a pregnant woman with adenoma of soft palate. Case presentation: This is a 20-year-old pregnant woman (Mallampati IV) with a personal pathological history of bronchial asthma and allergy to local anesthetics, who presents an adenoma of soft palate that avoids seeing the oropharynx structure, announced for emergency surgical procedure for an anterior segmental cesarean section. Conclusions: The pregnant woman has a higher incidence of difficult airway compared to the general population, due to the physiological changes that she presents in this period. If, apart from this situation, the presence is considered of an oropharyngeal tumor that makes it impossible to manipulate the airway, preoperative assessment and tracing a multidisciplinary strategy are the pillars to avoid potentially fatal complications(AU)
Descriptors: Oropharynx
Palate, Soft
Surgical Procedures, Operative
Adenoma, Pleomorphic
Surgical Clearance
-Adenoma/complications
Emergencies
Anesthetics, Local
Limits: Humans
Female
Pregnancy
Young Adult
Publication Type: Case Reports
Responsable: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-951970
Author: Reis, Manuella Verdinelli de Paula; Moura, Camilla Christian Gomes; Silva, Marcus Vinicius da; Souza, Maria Aparecida de; Soares, Priscilla Barbosa Ferreira; Soares, Carlos José.
Title: Effect of lectin (ScLL) on fibroblasts stimulated with LPS - an in vitro study
Source: Braz. oral res. (Online);30(1):e140, 2016. graf.
Language: en.
Abstract: Abstract: The lectin (ScLL) extracted from the Synadenium carinatum plant has been evaluated as an immunomodulator in diseases such as asthma, neosporosis and leishmaniasis. However, it has not yet been evaluated in the oral cavity. This study evaluated the effect of ScLL on viability, proliferation and release of IL-10 in human gingival fibroblasts (HGF) stimulated with lipopolysaccharide (LPS). HGF were stimulated with LPS 1 µg/ml and treated with ScLL in concentrations of 10, 5 and 2 µg/ml for 1 and 5 h, and evaluated by flow cytometry for viability, apoptosis (initial/advanced) and necrosis. The supernatant was collected to detect release of IL-10 by ELISA. The proliferation was assessed with the BrdU assay. Positive control consisted of cells maintained in Dulbecco's Modified Eagles Medium (DMEM), and the negative control, of those kept in tap water. Data were analyzed by ANOVA and Dunnett's test (α = 0.05). No significant difference was found for ScLL concentrations regarding viability or initial and advanced apoptosis (p=0.455). All the groups, including the positive control, had a significantly lower necrosis parameter than negative control at 5 h (p < 0.001). No difference was found for proliferation among the experimental groups (p = 0.832). ScLL at 5 and 2 µg/ml resulted in a lower release of IL-10 than positive and negative controls at 5 h (p = 0.047). The results indicated that ScLL concentrations tested were not cytotoxic, and had no effect on proliferation and release of IL-10 parameters. A thorough understanding of ScLL, regarding its immunomodulatory potential, may open the door to new perspectives for dentistry.
Descriptors: Lipopolysaccharides/pharmacology
Plant Lectins/pharmacology
Fibroblasts/drug effects
-Time Factors
Enzyme-Linked Immunosorbent Assay
Cell Survival/drug effects
Cells, Cultured
Analysis of Variance
Interleukin-10/analysis
Apoptosis/drug effects
Statistics, Nonparametric
Cell Proliferation/drug effects
Flow Cytometry
Gingiva/drug effects
Gingiva/chemistry
Limits: Humans
Publication Type: Evaluation Study
Responsable: BR1.1 - BIREME



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BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information