Base de datos : IBECS
Búsqueda : A01.236.249 [Categoria DeCS]
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Fotocópia
Id: 161722
Autor: Presas, VY; Mastronardi, LM; Saucedo, S; Rojas Bilbao, E.
Título: Mama ectópica en la región inguinal / Ectopic breast in the inguinal region
Fuente: Clín. investig. ginecol. obstet. (Ed. impr.);44(2):89-92, abr.-jun. 2017. ilus.
Idioma: es.
Resumen: El tejido mamario tiene su origen hacia la cuarta semana del desarrollo fetal, aparecen engrosamientos ectodérmicos que se extienden a ambos lados desde las futuras axilas hasta la región inguinal, constituyendo las «líneas mamarias o lácteas». Durante la embriogénesis se produce una regresión espontánea de este tejido, a excepción del situado en la región torácica que da lugar a las mamas en el adulto. La regresión mamaria permite conservar solo una glándula a cada lado de la región pectoral. Cuando se produce un fallo en la regresión, se condiciona el desarrollo de estructuras mamarias ectópicas, las cuales tienen una presentación clínica variable. El caso de una mujer de 41 años, que presentó una tumoración inguinal derecha de un año de evolución, con crecimiento acelerado en los últimos meses. La biopsia confirmó que se trataba de una proliferación epitelial glandular benigna (AU)

The breast tissue originated in the fourth week of foetal development, comprising ectodermal thickening extending on both sides from the armpits to the inguinal region, i.e. the milk lines. During embryogenesis, spontaneous regression of this tissue occurs, except tissue located in the thoracic region, which gives rise to breast tissue in adults. Breast regression preserves only one gland on each side of the chest. Breast regression impairment leads to the development of ectopic breast tissue, the clinical presentation of which varies widely. We report the case of a 41-year-old woman who presented a right inguinal tumour of one year of development, with rapid growth in recent months. The biopsy confirmed that it was a benign glandular epithelial proliferation (AU)
Responsable: ES1.1
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  2 / 11 IBECS  
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Fotocópia
Id: 127067
Autor: Pistone Creydt, V; Fletcher, S. J; Giudice, J; Bruzzone, A; Chasseing, N. A; Gonzalez, E. G; Sacca, P. A; Calvo, J. C.
Título: Human adipose tissue from normal and tumoral breast regulaltes the behavior of mammary ephithelial cells
Fuente: Clin. transl. oncol. (Print);15(2):124-131, feb. 2013. ilus.
Idioma: en.
Resumen: INTRODUCTION: Stromal-epithelial interactions mediate both breast development and breast cancer progression. In the present work, we evaluated the effects of conditioned media (CMs) of human adipose tissue explants from normal (hATN) and tumor (hATT) breast on proliferation, adhesion, migration and metalloproteases activity on tumor (MCF-7 and IBH-7) and non-tumor (MCF-10A) human breast epithelial cell lines. MATERIALS AND METHODS: Human adipose tissues were obtained from patients and the conditioned medium from hATN and hATT collected after 24 h of incubation. MCF-10A, MCF-7 and IBH-7 cells were grown and incubated with CMs and proliferation and adhesion, as well as migration ability and metalloprotease activity, of epithelial cells after exposing cell cultures to hATN- or hATT-CMs were quantified. The statistical significance between different experimental conditions was evaluated by one-way ANOVA. Tukey's post hoc tests were performed. RESULTS: Tumor and non-tumor breast epithelial cells significantly increased their proliferation activity after 24 h of treatment with hATT-CMs compared to control-CMs. Furthermore, cellular adhesion of these two tumor cell lines was significantly lower with hATT-CMs than with hATN-CMs. Therefore, hATT-CMs seem to induce significantly lower expression or less activity of the components involved in cellular adhesion than hATN-CMs. In addition, hATT-CMs induced pro-MMP-9 and MMP-9 activity and increased the migration of MCF-7 and IBH-7 cells compared to hATN-CMs. CONCLUSIONS: We conclude that the microenvironment of the tumor interacts in a dynamic way with the mutated epithelium. This evidence leads to the possibility to modify the tumor behavior/phenotype through the regulation or modification of its microenvironment. We developed a model in which we obtained CMs from adipose tissue explants completely, either from normal or tumor breast. In this way, we studied the contribution of soluble factors independently of the possible effects of direct cell contact (AU)
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  3 / 11 IBECS  
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Fotocópia
Id: 123654
Autor: Espada, J; Calvo, M. B; Díaz-Prado, S; Medina, V.
Título: Wnt signalling and cancer stem cells
Fuente: Clin. transl. oncol. (Print);11(7):411-427, jul. 2009. tab, ilus.
Idioma: en.
Resumen: Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefl y reviewed (AU)
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  4 / 11 IBECS  
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Fotocópia
Id: 123557
Autor: Hergueta-Redondo, M; Palacios, J; Cano, A; Moreno-Bueno, G.
Título: "New" molecular taxonomy in breast cancer
Fuente: Clin. transl. oncol. (Print);10(12):777-785, dic. 2008.
Idioma: en.
Resumen: Advances in the analysis of expression profiles, using genomic techniques, have revealed the high heterogeneity present in breast cancers. These approaches have served to identify different breast cancer subgroups with specific molecular characteristics that could sub-classify these tumours as carcinomas expressing hormone receptors, denominated Luminal subtype, and tumours with negative expression of hormone receptors, the Basal and HER2+ phenotypes. Therefore, during recent years, identification of markers characteristic of each subtype has been the focus of many research groups. All of these breast tumour subtypes probably have specific clinical and morphological features; however, this hypothesis needs to be confirmed by analysing more homogenous series. Although this "new" classification has limitations, it could be useful in the clinical practice, allowing not only a more accurate prognosis in breast cancer patients but also a selective treatment for each predefined subtype (AU)

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  5 / 11 IBECS  
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Fotocópia
Id: 122400
Autor: Mills, Dixie; Gordon, Eva J; Casano, Ashley; Lahti, Sarah Michelle; Nguyen, Tinh; Preston, Alex; Tondre, Julie; Wu, Kuan; Yanase, Tiffany; Love, Susan M; Chan, Henry; Chia, David; Esfandiari, Mahtash; Himmel, Tiffany.
Título: The physiology of the normal human breast: an exploratory study
Fuente: J. physiol. biochem;67(4):621-627, dic. 2011.
Idioma: en.
Resumen: No disponible

The physiology of the nonlactating human breast likely plays a key role in factors that contribute to the etiology of breast cancer and other breast conditions. Although there has been extensive research into the physiology of lactation, few reports explore the physiology of the resting mammary gland, including mechanisms by which compounds such as hormones, drugs, and potential carcinogens enter the breast ducts. The purpose of this study was to explore transport of exogenous drugs into ductal fluid in nonlactating women and determine if their concentrations in the fluid are similar to those observed in the breast milk of lactating women. We selected two compounds that have been well characterized during lactation, caffeine and cimetidine. Caffeine passively diffuses into breast milk, but cimetidine is actively transported and concentrated in breast milk. After ingestion of caffeine and cimetidine, 14 nonlactating subjects had blood drawn and underwent ductal lavage at five time points over 12 h to measure drug levels in the fluid and blood. The concentrations of both caffeine and cimetidine in lavage fluid were substantially less than those observed in breast milk. Our results support recent evidence that the cimetidine transporter is not expressed in the nonlactating mammary gland, and highlight intriguing differences in the physiology and molecular transport of the lactating and nonlactating breast. The findings of this exploratory study warrant further exploration into the physiology of the nonlactating mammary gland to elucidate factors involved in disease initiation and progression (AU)
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  6 / 11 IBECS  
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Texto completo SciELO España
Id: 95541
Autor: Peña Cabús, G.
Título: Mastopexia tridimensional con anclaje efectivo. Una respuesta a la ptosis, alteraciones de volumen, flacidez y recidiva en las mamoplastias / 3D Mastopexy with a dependable anchoring site. A logical response to ptosis, volume alterations, flaccidity and relapse in mammaplasties
Fuente: Cir. plást. ibero-latinoam;36(3):203-213, jul.-sept. 2010. ilus.
Idioma: es.
Resumen: La mastopexia es la técnica quirúrgica común que la Cirugía Plástica realiza en las mamas. En la literatura, se han expuesto múltiples y muy buenas técnicas sin terminarla búsqueda del elemento que sea consistente y que provea la mayor permanencia de resultados. De manera habitual, la atención se ha enfocado hacia la modificación anatómica del polo inferior, tratando de rellenar el polo superior de la mama de manera indirecta, con la confusión generalmente establecida de que, en la mayoría delas técnicas descritas, se considera el sostenimiento como sinónimo de suspensión. De manera descriptiva, exponemos una alternativa de suspensión que resulta tan interesante como sencilla, produciendo los resultados esperados a largo plazo y simplificando la técnica al reducir de manera importante la falta de mantenimiento del relleno del polo superior de la mama, el tiempo operatorio y facilitar la reconstrucción del molde mamario. La detección de un punto anatómico de fusión entre la fascia superficial, que es una continuación de la glándula mamaria y la propia fascia pectoral en la pared torácica, de importancia quirúrgica para el anclaje de la glándula mamaria, y el desarrollo de una técnica simple de suspensión glandular, logran cambiar los conceptos acostumbrados de nuestra práctica. La remodelación de la glándula se vuelve más sencilla y se autonomiza el manejo de la cubierta cutánea, permitiendo reducir la longitud final de las cicatrices (AU)

The elusive long term result in mastopexy, reveals the lack of an element that provides with certainty, an alternative that maintains the result surgically obtained. Although myriads of alternatives have been proposed in modern literature, most of them referred to lower poleanatomical molding as an indirect way to modify the upper pole as well, which is in fact the main target expectation for a good and sustained surgically outcome. There is a factor of confusion that has not been currently clarified; sustenance is not necessarily a synonym of suspension, being the latter our main objective that induced to present this technical proposal. The anatomical site of fusion of the superficial fascia which is in continuity with the mammary gland, and the proper pectoralis fascia, means that this structure can be used as a reinforced tissue that becomes as an anchoring site for the breastgland. An easily placement transglandular sutures stablishes the expected real suspension and the technical benefits derived from it, with the advantage of the use of non absorbable suture material that provides the occasion of change for a better good (AU)
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  7 / 11 IBECS  
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Texto completo SciELO España
Id: 93509
Autor: Palacín Casal, J. M.
Título: Mamoplastia transversal en mamas tuberosas / Transversal mammoplasty in tuberous breast
Fuente: Cir. plást. ibero-latinoam;37(3):205-214, jul.-sept. 2011. ilus.
Idioma: es.
Resumen: Con el nombre de mama tuberosa o constricción mamaria se define una malformación congénita de la glándula mamaria femenina, unilateral o bilateral, descrita en1976 por Rees y Aston y que puede presentarse con diferentes grados de severidad. Durante estos 40 años se han publicado y utilizado diversas técnica quirúrgicas de remodelación mamaria destinadas a recrear el polo inferior de la mama mediante colgajos glandulares o incisiones radiales. Este artículo describe la técnica quirúrgica diseñada por el autor mediante la realización de tres incisiones transversales que abarcan todo el espesor y anchura de la mama y consiguen aportar, al ser utilizadas conjuntamente con la colocación de prótesis anatómicas de gel cohesivo, suficiente volumen al polo inferior mamario para darle una forma correcta que permite corregir adecuadamente un gran porcentaje de mamas tuberosas hipoplásicas (AU)

Tuberous breast or constricted breast is a female mammary gland congenital malformation which can be unilateral or bilateral. It was first described by Rees and Aston in 1976. It can be present in different grades of severity.Numerous surgical techniques have been described during the last 40 years, and the main objective is the recreation of the lower pole by using glandular flaps or radialincisions.This article describes a personal surgical technique based on three transverse incisions that include the whole glandular thickness and together with anatomic cohesivegel mammary implants, provide enough volume to thelower pole, achieving a better shape and thus helping to improve a greater percentage of hypoplastic tuberous breast (AU)
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  8 / 11 IBECS  
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Fotocópia
Id: 88481
Autor: González González, J; Carbonero Celis, M. J; Juguera Rodríguez, I.
Título: Ectasia ductal mamaria. A propósito de dos casos / Duct ectasy. Two cases report
Fuente: Acta pediatr. esp;69(3):143-144, mar. 2011.
Idioma: es.
Responsable: ES1.1
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  9 / 11 IBECS  
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Fotocópia
Id: 43982
Autor: Petros, Ernesto; Azar Raed, Gustavo Adolfo.
Título: Tumor maligno de vaina nerviosa periférica (shwannoma maligno) de la glándula mamaria en una paciente con enfermedad de von Recklinhausen tipo I. Reporte y comunicación de un caso / Malignant peripheral nerve sheath tumor (malignant schwannoma) of the mammary gland in a patient with type I von Recklinhausen disease. Report and communication of one case
Fuente: Rev. esp. patol;38(3):179-182, jul.-sep. 2005. ilus.
Idioma: Es.
Resumen: Se presenta un caso de schwannoma maligno de la glándulamamaria, ubicación extraordinariamente inusual deeste tumor, en una paciente de 25 años de edad, de sexofemenino, con diagnóstico previo de Enfermedad de vonRecklinghausen tipo I

A breast malignant schwannoma is described. This is avery uncommon location for this tumor. It was observed inthe left breast of a female patient, 25 years old, previouslydiagnosed from type I von Recklinghausen's disease
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  10 / 11 IBECS  
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Fotocópia
Id: 41600
Autor: Díaz-Miguel, V; Tello, A; Sánchez-Rivera, M; Montero, J; García-Toro, E; Nieto, M; Alonso, E.
Título: Manifestación radiológica atípica de un galactocele secundario a un papiloma intraductal / Atypical radiological manifestation of a galactocele secondary to intraductal papilloma
Fuente: Prog. obstet. ginecol. (Ed. impr.);48(12):590-592, dic. 2005. ilus.
Idioma: Es.
Resumen: El hamartoma de mama es una lesión que, en ocasiones, muestra una imagen mamográfica típica, que muchos autores comparan a una "loncha de salami". En muy raras ocasiones, esta imagen tan característica se corresponde con otras enfermedades mamarias, tal es el caso del galactocele secundario a un papiloma intraductal que se expone

Hamartoma of the breast tends to have a typical mammographic presentation, which many authors compare to a "slice of salami". Exceptionally, this characteristic image can correspond to other breast lesions. We report a case of galactocele due to an intraductal papilloma requiring differential diagnosis between the two entities
Responsable: ES1.1
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