Database : IBECS
Search on : G07.345.500.325.377.625.050.500.729 [DeCS Category]
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Id: 192443
Author: García Callejo, Francisco Javier; Oishi, Natsuki; López Sánchez, Isabel; Pallarés Martí, Beatriz; Rubio Fernández, Andrea; Gómez Gómez, María José.
Title: Incidencia de la hiperostosis esquelética difusa idiopática sobre un modelo clínico de disfagia / Incidence of diffuse idiopathic skeletal hyperostosis from a model of dysphagia
Source: Acta otorrinolaringol. esp;71(2):78-82, mar.-abr. 2020. ilus.
Language: es.
Abstract: OBJETIVO: Relacionar la clínica de disfagia con la enfermedad de Forestier-Rotes-Querol o hiperostosis esquelética difusa idiopática (HEDI), desorden por osificación del ligamento cervical anterior común y calcificaciones en otras articulaciones. PACIENTES Y MÉTODOS: Revisión del historial clínico-radiológico de 455 pacientes que en 5 años consultaron en nuestro centro por disfagia, remitidos desde Atención Primaria o diferentes especialidades. El diagnóstico de HEDI se estableció en función de los criterios descritos por Resnick. RESULTADOS: Sobre un volumen total de 32.544 pacientes atendidos, el 1,4% consultó por disfagia alta. En 51 casos con esta sintomatología -el 11,2% de los sujeto- pudieron verificarse datos congruentes con los hallazgos radiológicos diagnósticos de HEDI. La incidencia observada fue de 7:100.000 habitantes-año. Dos casos con disfagia severa mejoraron con la retirada del hueso cervical neoformado. CONCLUSIONES: La HEDI supone una osificación interarticular anquilosante habitualmente sistémica pero asintomática. Al manifestarse, distorsiona principalmente las funciones de cuello y vías altas, generando sobre todo disfagia. Unos pocos casos requieren cirugía liberadora de estas calcificaciones

OBJECTIVE: To relate symptoms of dysphagia to Forestier-Rotes Querol disease or diffuse idiopathic skeletal hyperostosis (DISH), a disorder due to ossification in the anterior longitudinal ligament and calcifications in other entheses. PATIENTS AND METHODS: Review of clinical and radiological findings in 455 outpatients attended at our Centre with dysphagia, for 5 years, referred from dental, trauma, neurological or primary health care. A diagnosis of DISH was established using Resnick's criteria. RESULTS: We detected 51 cases with dysphagia consistent with DISH diagnostic criteria - 11.2% of subjects suffering this symptom- out of 32544 outpatients attended. An incidence of 7:100000 inhabitants per year was observed. Two cases showed significant improvement after removing the new bone in the spine. CONCLUSIONS: DISH is an ankylosing ossification between the joints, frequently systemic but showing no clinical symptoms. When symptoms manifest, neck movements and upper airways are involved, mainly dysphagia. A few cases need surgery to relieve the calcification processes
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Id: 192237
Author: Witek, Lukasz; Alifarag, Adham M; Tovar, Nick; Lopez, Christopher D; Gil, Luiz F; Gorbonosov, Michelle; Hannan, Kaitlin; Neiva, Rodrigo; Coelho, Paulo G.
Title: Osteogenic parameters surrounding trabecular tantalum metal implants in osteotomies prepared via osseodensification drilling
Source: Med. oral patol. oral cir. bucal (Internet);24(6):e764-e769, nov. 2019. ilus, graf.
Language: en.
Abstract: BACKGROUND: Surgical fixation of implants into bone for the correction of bone deformities or defects is a traditional approach for skeletal stabilization. Important measures of efficacy of implants include implant stability and osseo integration-the direct interaction between living bone and an implant. Osseointegration depends on successful implant placement and subsequent bone remodeling. This study utilized osseo densification drilling (OD) in a low bone density model using trabecular metal (TM) implants. MATERIAL AND METHODS: Three osteotomy sites, Regular, OD-CW (clockwise), and OD-CCW (counterclockwise), were prepared in each ilium of three female sheep. Drilling was performed at 1100rpm with saline irrigation. Trabecular metal (TM) (Zimmer(R), Parsippany, NJ, USA) implants measuring 3.7mm in diameter X 10mm length were placed into respective osteotomies. A three-week period post-surgery was given to allow for healing to take place after which all three sheep were euthanized and the ilia were collected. Samples were prepared, qualitatively and quantitatively analyzed using histology micrographs and image analysis software (ImageJ, NIH, Bethesda, MD). Bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) were quantified to evaluate the osseointegration parameters. RESULTS: All implants exhibit successful bone formation in the peri-implant environment as well as within the open spaces of the trabecular network. Osseointegration within the TM (quantified by %BIC) as a function of drilling technique was more pronounced in OD samples (p > 0.05). The %BAFO however shows a significant difference (p = 0.036) between the CCW and R samples. Greater bone volume and frequency of bone chips are observed in OD samples. CONCLUSION: The utilization of OD as a design for improved fixation of hardware was supported by increased levels of stability, both primary and secondary. Histological data with OD provided notably different results from those of the regular drilling method

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Id: 188338
Author: Álvarez Carrión, L; Gutiérrez Rojas, I; Ardura, JA; Alonso, V.
Title: Células osteogénicas afectadas por los factores solublestumorales contribuyen a la formación del nichopre-metastásico óseo / Osteogenic cells affected by soluble tumor factorscontribute to bone pre-metastatic niche formation
Source: Rev. osteoporos. metab. miner. (Internet);11(2):64-71, abr.-jun. 2019. ilus, tab, graf.
Language: es.
Abstract: Objetivo: Analizar el efecto de los secretomas de tumores sólidos organotrópicos hacia el hueso en células de linaje osteogénico, de tipo osteoblástico y osteocítico, en la expresión de genes relacionados con el metabolismo óseo. Material y método: Caracterizamos los cambios en expresión génica por PCR cuantitativa a tiempo real del eje OPG/RANKL, así como de otros genes relacionados con la diferenciación osteoblástica como son Runx2 y osteocalcina, inducidos por los medios condicionados de células tumorales prostáticas, mama y melanoma en pre‐osteoblastosMC3T3‐E1 y osteocitos MLO‐Y4 murinos o en osteoblastos humanos, según correspondiese por especie. Resultados: La estimulación de las células osteocíticas con medios condicionados de células de melanoma o adenocarcinoma prostático indujo un incremento en la expresión génica de OPG y también de RANKL, viéndose incrementado la ratio OPG/RANKL. Únicamente el secretoma de las células de adenocarcinoma prostático alteró la expresión de Runx2en osteocitos. Los medios condicionados de células de cáncer de mama modificaron únicamente la expresión de RANKLen células osteoblásticas, viéndose disminuido la ratioOPG/RANKL. Conclusión: Los factores solubles tumorales tienen como diana celular a las células osteocíticas, favoreciendo la inducción de un nicho pre‐metastásico óseo por modificación de la ratio OPG/RANKL en el entorno óseo, y, con ello, la progresión de tumores organotrópicos óseos como son el melanoma y adenocarcinomas prostático

Objective: To analyze the effect of the secrets of solid organotropic tumors towards bone in osteogenic, osteoblastic and osteocytic lineage cells, in the expression of genes related to bone metabolism. Material and method: We characterize the changes in gene expression by quantitative real‐time PCR of the OPG/RANKL axis, as well as other genes related to osteoblastic differentiation such as Runx2 and osteocalcin, induced by the conditioned means of prostate tumor cells, breast and melanoma in pre MC3T3‐E1 osteoblasts and murine MLO‐Y4 osteocytes or in human osteoblasts, as appropriate by species. Results: Stimulation of osteocitic cells with conditioned means of melanoma or prostate adenocarcinoma cells inducedan increase in OPG and RANKL gene expression, with the OPG/RANKL ratio being increased. Only the secretome of prostate adenocarcinoma cells altered the expression of Runx2 in osteocytes. Conditioned media of breast cancer cellsonly modified the expression of RANKL in osteoblast cells, with a decrease in OPG/RANKL ratio. Conclusion: Soluble tumor factors have osteocitic cells as their cellular target, favoring the induction of a pre‐metastatic bone niche by modifying the OPG/RANKL ratio in the bone environment, and, thus, the progression of bone organo‐tropic tumors such as melanoma and prostatic adenocarcinomas
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Id: 186921
Author: Naranjo Morales, Beatriz.
Title: Eficacia del método Ponseti en el tratamiento del pie equinovaro / Ponseti method efficacy in treatment of clubfoot
Source: Rev. int. cienc. podol. (Internet);13(2):99-113, 2019. tab, mapas, graf.
Language: es.
Abstract: Contexto: El pie equinovaro es una deformidad musculoesquelética congénita caracterizada por la presencia de cavo, varo, adducto y equino. Afecta a 1-7 de cada 1000 nacimientos. Un pie zambo no tratado puede generar dolor y discapacidad durante la vida de la persona. El método Ponseti se ha convertido en la principal modalidad de tratamiento para el manejo del pie zambo produciendo buenos resultados a largo plazo. El objetivo de este manuscrito fue evaluar la eficacia del método Ponseti y la evolución de los pacientes en función de las tasas de recurrencia, tenotomías y cirugías asociadas. También se determinó si la edad de los niños influía en el éxito del tratamiento. Métodos: Se realizó una estrategia de búsqueda a través de Pubmed hasta abril de 2018. Los términos de búsqueda incluyeron pie zambo, método Ponseti y pie equinovaro. Se incluyeron metaanálisis, revisiones sistemáticas, ensayos clínicos y series de casos. También se examinaron las referencias bibliográficas de los artículos seleccionados. Resultados: Veintisiete artículos fueron incluidos en esta revisión. La literatura actual muestra una tasa de éxito del 78-92% utilizando el método Ponseti. Conclusión: El método Ponseti ofrece resultados alentadores en términos funcionales y estéticos, así como disminución del grado de corrección quirúrgica cuando los resultados no sean los esperados. Se necesita más investigación para generar evidencia de mayor calidad con mayores tamaños muestrales y unificación a la hora de medir la severidad de la deformidad. Otra limitación encontrada fue la ausencia de la definición de fracaso de tratamiento y sus correspondientes motivos

Background: Clubfoot is a congenital musculoskeletal deformity characterized by heel varus, indfoot equinus, mid-foot cavus and forefoot adduction. It is the most common defect that affects between 1 and 7 births in every 1000. Left untreated, clubfoot may lead to pain and disability throughout the person ́s life. Ponseti method has become the main treatment modality for the management of clubfoot producing good long-term results. The aim of this manuscript was to determine the efficacy of the Ponseti method for the treatment of CTEV and to evaluate the evolution of patients based on the recurrence rate, tenotomies rates and surgeries. Also determine if the age of children influences the success of the treatment. Methods: A search strategy completed examined Pubmed from inception to April 2018. Search terms included clubfoot, Ponseti method and equinovarus. Meta-analysis, systematic reviews, randomized control trials and case series were included. The reference lists of the selected articles were also examined. Results: Twenty-seven articles were included in this review. The current literature shows a success of the Ponseti method of 78-92%. Conclusion: Ponseti treatment for clubfoot has encouraging results in terms of attaining a functionally and cosmetically foot and lessening the extent of surgical correction in cases in which it does not reach the expected results. Further research is needed to generate higher quality evidence with larger sample sizes hich evaluate the severity of the deformity with the same measures. Another lack was the absence of a definition of treatment failure with the reasons
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Id: 184223
Author: Andrade Delgado, Laura; Gordillo Dominguez, Luis Felipe; Ortiz-Monasterio Todd, Iván; Contreras Mérida, Sara; Gevara Valmaña, Osvaldo.
Title: Abordaje quirúrgico temprano de la trigonocefalia / Early quirurgic management of trigonocephaly
Source: Cir. plást. ibero-latinoam;45(2):159-168, abr.-jun. 2019. ilus.
Language: es.
Abstract: Introducción y objetivo. La trigonocefalia, originada por la sinostosis prematura de la sutura metópica, en sus formas más graves presenta mayor restricción del crecimiento lateral de los huesos frontales y temporales, afectando a los rebordes supraorbitarios, limitando el crecimiento y condicionando un hipoteleorbitisimo aparente. Los principales problemas de las técnicas quirúrgicas empleadas para su tratamiento son: falta de corrección del defecto, vaciamiento temporal, daño de suturas no afectadas al hacer transposiciones que producen defectos de crecimiento (sinostosis secundarias), sobrecorrección del hipoteleorbitisimo y defectos óseos. El objetivo de este trabajo es presentar nuestra experiencia en una serie de casos tratados de forma temprana con modificaciones propias a las técnicas abiertas propuestas por Dhellemmes en Francia. Material y método. Entre 2010 y 2018 operamos 7 pacientes con trigonocefalia no sindrómica severa, con una media de 7 meses de edad. Todos fueron estudiados con tomografía computerizada de cráneo con reconstrucción ósea en tres dimensiones (TCC-3D) preoperatoria, postoperatoria inmediata y al año de evolución, electroencefalograma, valoración del neurodesarrollo y por Pediatría y Oftalmología. Resecamos la sutura metópica estenosada y efectuamos craneotomías frontales en forma de alas de escarabajo respetando la sutura coronal. Remodelamos la barra frontoorbitaria con injerto óseo para corregir la angulación y la fijamos con un injerto de hueso. Finalmente practicamos osteotomías radiadas en parietal para modificar la restricción del crecimiento de la bóveda. Resultados. Los resultados funcionales y estéticos fueron excelentes, sin defectos de osificación ni vacío de la fosa temporal, ni morbimortalidad, con cicatriz oculta por el cabello. El desarrollo neurocognitivo de los niños tuvo una mejoría notable de la irritabilidad y de la actividad e interacción con los padres. Conclusiones. En trigonocefalia, la cirugía temprana logra la corrección total del defecto en un solo tiempo quirúrgico, obteniendo una remodelación ósea y un crecimiento armónico del cráneo al respetar el crecimiento del sistema suturario. Las modificaciones a la técnica que proponemos evitan el defecto de vaciamiento temporal y permiten no utilizar material de osteosíntesis

Background and objective. The premature synostosis of the metopic suture in the most severe forms occurs with a restriction of the lateral growth of frontal and temporal bones, affecting the supraorbital rims, which limits its growth and leads to hypoteleorbitism. The triangular shape of the forehead is accentuated by the compensatory growth of the other structures of the skull. The main problem of the handling techniques are: temporal emptying, lack of defect correction, damage of unaffected sutures while making transpositions that will later produce defects in growth and cranial molding. Our aim is to show our surgical experience operated with the variations of the open technique that was conceived by Dhellemmes in France. Methods. Between 2010 and 2018 we operated 7 patients with trigonocephaly; patients' average age was 7 months. They were studied with presurgical and post operatory CBT-3D, electroencephalograms, neurodevelopmental assessment and by Pediatry and Ophthalmology. Stenosed metopic suture was resected and frontal craniotomies shaped like beetle wings were performed out without drying the coronal suture, securing them to the fronto-orbital bar with a discreet progress of the side edges. The medial osteotomy of the orbital toolbar was used to reshape it and correct its angulation fixing it with a bone graft and radiated parietal osteotomy to modify the restriction of frontoparietal growth. Results. Functional and aesthetic results were excellent, without ossification defects or vacuum the temporal fossa, morbidity or mortality, with the scar hidden by hair. Children's neuropsychological development had a noticeable improvement in irritability, activity and interaction with their rents. Conclusions. In trigonocephaly, early surgery achieves total defect correction in a single procedure and a bone remodeling and harmonic skull growth by respecting the sutures system. Our modifications to the technique avoid the temporary emptying defect and don't use osteosynthesis material
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Id: 184207
Author: Castro Villegas, María del Carmen; Collantes-Estévez, Eduardo.
Title: Bases fisiopatológicas de la neoformación en las espondiloartritis / Physiopathological foundations of neoformation in spondyloarthritis
Source: Reumatol. clin., Supl. (Barc.);15(supl.1):2-6, abr. 2019. ilus.
Language: es.
Abstract: Una de las características patogénicas de las espondiloartritis (EspA) es la neoformación ósea. Distintos estudios han puesto de manifiesto que el origen de este proceso está en las entesis, donde algunos factores desen cadenantes, como el estrés biomecánico, en un individuo genéticamente predispuesto producirían una compleja cascada de señales que favorecería la vasodilatación local y la activación de células inmunocompetentes residentes. Estas, a su vez, provocarían una respuesta inflamatoria caracterizada por la secreción de factor de necrosis tumoral alfa e interleucina 17 (IL-17), entre otros, y reclutamiento de otras células inmunocompetentes. Además, se ha demostrado que la IL-17 y la IL-22 favorecen la proliferación de células madre mesenquimatosas del periostio perientesítico, lo que lleva a la formación de hueso nuevo en la entesis. En las EspA, la formación de hueso nuevo es principalmente ortotópica (en continuidad con el hueso existente) y se origina a partir de la entesis y del periostio. Al parecer, la mayoría de la neoformación ósea se produce mediante osificación endocondral. En la osificación endocondral, las células progenitoras mesenquimatosas se diferencian en condrocitos, que construyen un «molde» de cartílago, en el cual las células progresivamente maduran y evolucionan hacia condrocitos hipertróficos. Esta matriz es invadida por vasos y precursores osteoblásticos que reemplazan progresivamente el modelo por hueso maduro

One of the pathogenic characteristics of spondyloarthritis (SpA) is bone neoformation. Several studies have revealed that this process originates in the enthesis, in which triggering factors such as biomechanical stress in genetically predisposed individuals may produce a complex cascade of signals favouring local vasodilation and activation of resident immune cells. These in turn induce an inflammatory response characterised by secretion of TNF-alfa and IL-17 (among other substances) and recruitment of other immune cells. In addition, it has been demonstrated that IL-17 and IL-22 favour the proliferation of mesenchymal stem cells of the peri-enthesic periosteum, leading to the formation of new bone in the enthesis. In SpA, new bone formation is mainly orthotopic (in continuity with existing bone) and arises from the enthesis and periosteum. Most bone neoformation seems to occur through endochondral ossification. In this process, mesenchymal progenitor cells differentiate towards chondrocytes, which construct a cartilaginous "mould" in which the cells progressively mature and develop towards hypertrophic chondrocytes. This matrix is invaded by vessels and osteoblastic precursors that progressively replace the model with mature bone
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Id: 183728
Author: Sánchez-Labrador Martínez de Morentin, Luis; Pérez González, Fabián; Martín-Ares, María; Madrigal Martínez-Pereda, Cristina; López-Quiles Martínez, Juan; Martínez-González, José María.
Title: Utilización de dentina autógena como material de injerto en Cirugía Bucal / Autogenous dentine as graft material in Oral Surgery
Source: Cient. dent. (Ed. impr.);16(2):155-160, mayo-ago. 2019. tab.
Language: es.
Abstract: Las extracciones dentarias producen una pérdida ósea en sentido horizontal y vertical, que conllevan alteraciones funcionales para los pacientes, y dificultan la colocación de implantes dentales para los profesionales. Para minimizar esta pérdida ósea, se utilizan diferentes materiales de injerto, entre los cuales destaca el injerto autógeno, por cumplir las características de osteogénesis, osteoconducción y osteoinducción. En el año 2010 se describe por primera vez la utilización de dentina como material de injerto autógeno, demostrando que este material puede ser una alternativa terapéutica al resto de materiales de injerto, al permitir la osteoconducción y la osteoinducción, y mostrar la formación de hueso nuevo en un 46-87% del área con injerto de dentina autógena, 3 meses después de su utilización. La última revisión sistemática publicada en el año 2018, concluyó que los implantes colocados en áreas regeneradas en zonas en las que se empleó dentina como material de injerto, presentaron tasas de supervivencia del 97,7% después de 1 año de seguimiento, sugiriendo este nuevo material como una alternativa con resultados prometedores, aunque son necesarios más estudios al respecto

Subsequent to tooth extraction, a reduction of the length and width of alveolar ridge can be observed. It causes functional alterations to patiens, and problems to proper insertion of dental implants. In order to prevent this bone atrophy, different graft materials can be used, being considered autogenous graft the best because allows osteogenesis, osteoconduction and osteoinduction. In 2010 it was first published the use of autogenous dentine as a graft material, showing it could be an ideal graft material, as a material with excellent osteoconduction and osteoinduction. Besides, this graft material is slowly absorbed and replaced by new bone, in 46-87% of the áreas grafted with dentine, 3 months after regeneration. Last systematic review published in 2018 concluded dental implants inserted in regenerated areas with autogenous dentine had survival rates of 97,7% for over a year follow-up, so this new material is considered an alternative with good results, but there are necessary more studies with long term follow-up
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Id: 178994
Author: Gan, Xueqi; Zhang, Ling; Liu, Beilei; Zhu, Zhuoli; He, Yuting; Chen, Junsheng; Zhu, Junfei; Yu, Haiyang.
Title: CypD-mPTP axis regulates mitochondrial functions contributing to osteogenic dysfunction of MC3T3-E1 cells in inflammation
Source: J. physiol. biochem;74(3):395-402, ago. 2018. graf, ilus.
Language: en.
Abstract: Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is usually tipped in favor of bone destruction. Evidence suggests that the inflammatory destruction of bone is mainly attributed to oxidative stress and is closely related to mitochondrial dysfunction. The mechanisms underlying osteogenic dysfunction in inflammation still need further investigation. Reactive oxygen species (ROS) is associated with mitochondrial dysfunction and cellular damage. Here, we reported an unexplored role of cyclophilin D (CypD), the major modulator of mitochondrial permeability transition pore (mPTP), and the CypD-mPTP axis in inflammation-induced mitochondrial dysfunction and bone damage. And the protective effects of knocking down CypD by siRNA interference or the addition of cyclosporin A (CsA), an inhibitor of CypD, were evidenced by rescued mitochondrial function and osteogenic function of osteoblast under tumor necrosis factor-alfa (TNF-alfa) treatment. These findings provide new insights into the role of CypD-mPTP-dependent mitochondrial pathway in the inflammatory bone injury. The protective effect of CsA or other moleculars affecting the mPTP formation may hold promise as a potential novel therapeutic strategy for inflammation-induced bone damage via mitochondrial pathways

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Id: 178912
Author: Eaton, Michael S; Weinstein, Nicholas; Newby, Jordan B; Plattes, Maggie M; Foster, Hanna E; Arthur, Jon W; Ward, Taylor D; Shively, Stephen R; Shor, Ryann; Nathan, Justin; Davis, Hannah M; Plotkin, Lilian I; Wauson, Eric M; Dewar, Brian J; Broege, Aaron; Lowery, Jonathan W.
Title: Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption
Source: J. physiol. biochem;74(1):3-8, feb. 2018. graf.
Language: en.
Abstract: The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear. Here, we independently corroborate the increased thickness of cortical bone in femurs of 20-week-old male Tas1R3 mutant mice and confirm that Tas1R3 is expressed in the bone environment. Tas1R3 is expressed in undifferentiated bone marrow stromal cells (BMSCs) in vitro and its expression is maintained during BMP2-induced osteogenic differentiation. However, levels of the bone formation marker procollagen type I N-terminal propeptide (PINP) are unchanged in the serum of 20-week-old Tas1R3 mutant mice as compared to controls. In contrast, levels of the bone resorption marker collagen type I C-telopeptide are reduced greater than 60% in Tas1R3 mutant mice. Consistent with this, Tas1R3 and its putative signaling partner Tas1R2 are expressed in primary osteoclasts and their expression levels positively correlate with differentiation status. Collectively, these findings suggest that high bone mass in Tas1R3 mutant mice is due to uncoupled bone remodeling with reduced osteoclast function and provide rationale for future experiments examining the cell-type-dependent role for TAS1R family members in nutrient sensing in postnatal bone remodeling

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Id: 175883
Author: González-Galván, María del Carmen; Mosqueda-Taylor, Adalberto; Bologna-Molina, Ronell; Setien-Olarra, Amaia; Marichalar-Mendia, Xabier; Aguirre-Urizar, José-Manuel.
Title: Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
Source: Med. oral patol. oral cir. bucal (Internet);23(3):e315-e319, mayo 2018. tab, ilus.
Language: en.
Abstract: Background: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANK-L / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives: To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and Methods: Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANK-L and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results: There are significant differences in the expression of RANK in OM samples as compared to DF (p= 0.022) and among the OMSs and OMLs (p= 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions: Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas

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