Base de dados : IBECS
Pesquisa : B01.650.940.800.575.912.250.075.180 [Categoria DeCs]
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Fotocópia
Id: 181225
Autor: Barreto, Catarina; Salgueiro, Lígia.
Título: O contributo da fitoterapia na cicatrização de feridas / La contribución de la fitoterapia en la cicatri-zación de heridas / The contribution of phytotherapy in wound healing
Fonte: Rev. fitoter;18(1):53-69, dic. 2018. ilus, tab.
Idioma: pt.
Resumo: A pele é a primeira linha de defesa do corpo humano. Quando surge uma ferida há uma descontinuidade celular e anatómica de um tecido e por isso há maior suscetibilidade a infeções e outros tipos de agressões. A cicatrização da ferida é um processo fisiológico complexo e dinâmico, que se pode dividir em quatro fases: Homeostase; Inflamatória; Proliferativa; Remodelação. Os produtos de origem natural, particularmente, vários tipos de extratos vegetais e/ou compostos isolados têm demonstrado grande potencial no tratamento de feridas. Em alguns casos, o tratamento convencional pode não ser suficiente para a cicatrização completa das feridas, por exemplo, devido à resistência a antibióticos. A fitoterapia tem demonstrado um enorme potencial na cicatrização de feridas, quer como adjuvante, quer como alternativa à medicina convencional com eficácia demonstrada em ensaios in vitro e in vivo e em ensaios clínicos. Assim, este artigo tem como objetivo não só abordar o tema das feridas e fatores que condicionam a sua cicatrização, como também fazer uma revisão sobre os benefícios de alguns produtos naturais, como o mel de Leptospermum scoparium e extratos de diversas plantas, nomeadamente, Rosa rubiginosa, Centella asiatica, Aloe vera, Curcuma longa e Matricaria recutita

La piel es la primera línea de defensa del cuerpo humano. Cuando se produce una herida hay una discontinuidad celular y anatómica de un tejido y en consecuencia una mayor susceptibilidad a infecciones y otro tipo de agresiones. La cicatrización de la herida es un proceso fisiológico complejo y dinámico, que se puede dividir en cuatro fases: homeostasis, inflamatoria, proliferativa y de remodelación. Los productos de origen natural, particularmente, varios tipos de extractos vegetales y / o compuestos aislados, han demostrado un gran potencial en el tratamiento de las heridas. En algunos casos, el tratamiento convencional puede no ser suficiente para la cicatrización completa de las heridas, debido por ejemplo a la resistencia a los antibióticos. La fitoterapia ha demostrado un enorme potencial en la cicatrización de heridas, ya sea como adyuvante, o como alternativa a la medicina convencional, con eficacia demostrada en ensayos in vitro e in vivo y en estudios clínicos.Este artículo tiene como objetivo no sólo abordar el tema de las heridas y factores que condicionan su cicatrización, sino también hacer una revisión sobre los beneficios de algunos productos naturales, como la miel de Leptospermum scoparium y extractos de diversas plantas, en particular, Rosa rubiginosa, Centella asiatica, Aloe vera, Curcuma longa y Matricaria recutita

The skin is the first line of defense of the human body. When a wound is formed there is a disruption of the cel-lular and anatomic continuity of a tissue and therefore greater susceptibility to infections and other types of agressions. Wound healing is a complex and dynamic process, which can be divided into four phases: Homeostasis; Inflammatory; Proliferative; Remodeling. Natural products have shown good potential in wound treatment. Also, various types of plant extracts and/or plant isolates have demonstrated good efficacy. Sometimes, the convencional treatment is not enough for complete wound healing, for example due to antibiotic resistance. The phytotherapy has demonstrated enormous potencial in treat-ing wounds either as an adjuvante or as an alternative to conventional medicine with demonstrated efficacy in vitroand in vivo assays and in clinical trial. The purpose of this article is not only to address the issue of wounds and the factors that influence healing but also do a review about natural products as Leptospermum scoparium honey and extracts of many plants such as Rosa rubiginosa, Centella asiatica, Aloe vera, Curcuma longa and Matricaria recutita
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Fotocópia
Id: 142441
Autor: Duggina, Pragathi; Kalla, Chandra Mouli; Varikasuvu, Seshadri Reddy; Bukke, Suman; Tartte, Vijaya.
Título: Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action
Fonte: J. physiol. biochem;71(3):435-454, sept. 2015.
Idioma: en.
Resumo: This study was designed to investigate the protective effects of the centella triterpene saponins (EXT) on cyclophosphamide (CYP)-induced hepatotoxicity and immunosuppression in rats. The phytochemical profile of EXT was analyzed for centella saponins by using high-performance liquid chromatographic (HPLC). Therapeutic efficacy of EXT (250 mg/kg/day p.o) on hematological profile of blood, liver function markers, and cytokine profiles in CYP (10 mg/kg/day p.o)-treated rats. In addition, weights of immune organs (spleen and thymus) and histopathological changes in the liver, intestine, and spleen were also evaluated. The active principles in EXT were identified as madecassoside, asiaticoside, and asiatic acid by HPLC analysis. Upon administration of EXT, enhanced levels of glutamate pyruvate transaminase, alkaline phosphatase, and lipid peroxidation were found reduced while the levels of reduced glutathione and hematological parameters and relative weights of immune organs were restored to normal in CYP-treated rats. The hepatic mRNA level of TNF-α, which was increased during CYP administration, was significantly decreased by the EXT treatment. The decreased levels of mRNA expression of other cytokines like IFN-γ, IL-2, GM-CSF, after CYP treatment, were also found elevated upon administration of the EXT. Histopathological examination of the intestine, liver, and spleen indicated that the extract could attenuate the CYP-induced hepatic and immune organ damage. These results indicated that EXT modulated the immune and hepatic system function of rats against CYP-induced immunosuppression and hepatotoxicity by restoring the cytokine production, antioxidant system, and multiorgan injury. Thus, triterpene saponins may provide protective and/or therapeutic alternative against the immune-mediated liver diseases (AU)

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Fotocópia
Id: 73800
Autor: Bustamante Delgado, Sandro E; Torres Castro, Rodrigo; Morales Segura, Miguel A.
Título: Fitofármacos en el tratamiento de la insuficiencia venosa crónica / Phytopharmaceuticals in the treatment of chronic venous insufficiency
Fonte: Rev. fitoter;9(1):35-51, 2009.
Idioma: es.
Resumo: La insuficiencia venosa crónica (IVC) es uno de los desórdenes vascularesmás comunes. Los principales factores de riesgo son el efectogravitacional sobre la circulación venosa, la edad avanzada, una historiafamiliar de enfermedades venosas, la obesidad y el embarazo.También inciden las condiciones de trabajo y el estilo de vida que favorezcanel ortostatismo.Las preparados mas utilizados para el tratamiento de la IVC derivan deAesculus hippocastanum, Ruscus aculeatus, Pinus pinaster y Hamamelisvirginiana, entre otras, y contienen compuestos bioactivos talescomo saponósidos, proantocianidinas y flavonoides. El uso de fitofármacosen el tratamiento de la IVC se asocia al alivio tanto del dolorcomo de la pesadez de piernas, cansancio, calambres y parestesia,síntomas que constituyen el síndrome prevaricoso. Aunque existe unaamplia evidencia de su efecacia y seguridad a corto plazo, se consideranecesaria la realización de más estudios clínicos(AU)

Chronic venous insufficiency (CVI) is one of the most commonvascular disorders. The main risk factors are the gravitationaleffect on the venous circulation, elderly, a familyhistory of venous disease, obesity and pregnancy. Also, theworking conditions and lifestyles favouring orthostatismcan have a role in CVI.The preparations most commonly used for the treatment ofIVC come from Aesculus hippocastanum, Ruscus aculeatus,Pinus pinaster and Hamamelis virginiana, among others,and contain bioactive compounds such as saponins,proanthocyanidins and flavonoids. The use of phytopharmaceuticalsin the treatment of IVC is associated with reliefof pain and heaviness in the legs, fatigue, cramps andparaesthesia, symptoms that constitute the pre-varicosesyndrome. Although there is evidence of its safety and efficacyat short term use, it is considered necessary to carryout further clinical studies(AU)
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Fotocópia
Id: 042712
Autor: Salas Campos, Luis; Fernández Mansilla, Marta; Martínez de la Chica, Ana M.
Título: Quimioterápicos tópicos en el tratamiento de las quemaduras / Topical chemotherapy for the treatment of burns
Fonte: Rev. Rol enferm;28(5):387-390, mayo 2005. ilus, tab.
Idioma: Es.
Resumo: Una quemadura es una lesión que provoca alteraciones en la piel que varían desde el eritema local hasta la destrucción total de la misma. Independien-temente de su magnitud es suficiente la lesión del estrato córneo para que la piel pierda su capacidad como barrera protectora. Por esta razón, un aspecto muy importante del tratamiento de las quemaduras pasa por conseguir la rápida reepitelización de los tejidos destruidos y evitar la infección. La Blastoestimulina® es un producto farmacéutico que asocia una sustancia reepitelizante, la Centella asiática, con un agente antibiótico, la neomicina. El extracto de Centella asiática se ha demostrado eficaz en la inducción, mantenimiento y regularización de la lesión, en tanto que la neomicina es un antibiótico que cubre perfectamente el espectro bacteriano frente a microorganismos grampositivos y negativos. Ofrece excelentes resultados en el tratamiento de las quemaduras ya que favorece la cicatrización de la herida, reduce la inflamación y previene su contaminación

A burn is a tissue lesion which provokes different alterations that vary from topical erythema to total destruction of the structures affected. A burn always produces an alteration in the skin, a lesion in the corneal strata is sufficient to cause the skin to lose its capacity to act as a barrier. The objective the treatment for a burn has i to produce epithelization as soon as possible in order to prevent infection and to reduce functional and esthetic aftereffects. Infection is the main cause of death due to burns due to the growth of endogenous flora or due to external contamination. The use of topical chemotherapy is fundamental to prevent infections when there are deep and superficial burns or extensive intermediary burns. Centella asiatica extract has proven to be efficient in helping, maintaining and regularizing cicatrisation of skin affected by burns. Its usage combined with an antibiotic agent such as neomycin covers the bacterial spectrum for grampositive or -negative microorganisms, guaranteeing an anti-infectious efficiency for this extract
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