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Pesquisa : B01.650.940.800.575.912.250.875.177.769 [Categoria DeCs]
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Id: 171250
Autor: Vázquez Gomis, Rosmari; Izquierdo Fos, Ignacio; Vázquez Gomis, Consuelo; Pastor Rosado, José.
Título: Dieta restrictiva en frutas como causa de escorbuto en niño de 7 años / Restricted diet in fruits causes scurvy in a child of 7 years old
Fonte: Endocrinol. diabetes nutr. (Ed. impr.);64(2):119-120, feb. 2017.
Idioma: es.
Resumo: No disponible
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Id: 160036
Autor: Akunna, Gabriel; Obikili, Emmanuel; Anyanwu, Emeka; Esom, Emmanuel.
Título: Protective and curative role of Citrus sinensis peel on cadmium-induced testicular and spermatic damage: a morphometric and immunohistochemical evaluation using monoclonal antibodies against Ki-67 and proliferating cell nuclear antigen
Fonte: Eur. j. anat;21(1):19-30, ene. 2017. ilus, tab.
Idioma: en.
Resumo: This study examined the protective and curative effects of aqueous zest extract of Citrus sinensis on Cadmium-induced testicular tumor in animal models. Twenty four male Wistar rats (10 to 12 weeks old) weighing 165-275 g were divided into group A (treated orally with 2.5 ml/kg body weight/daily of normal saline), Group B (treated intraperitoneally with a single dose of 5mg/kg of cadmium), group C (Treated intraperitoneally with 5 mg/kg of cadmium before 10 mg/kg aqueous zest extract of Citrus sinensis orally), group D (treated with 5mg/kg of cadmium before 40 mg/kg extract), group E (treated with 10 mg/kg extract before 5 mg/kg of cadmium) and group F (treated with 40 mg/kg extract before 5mg/kg of cadmium). The procedure lasted for 8 weeks. Group B rats showed a significant (p< 0.05) decrease in testis weight, testis volume, sperm count (p > 0.001), sperm motility (p > 0.001), abnormal sperm morphology (p<0.001) and a significant decrease in tubular diameter, length (p <0.05), cross sectional area, width, germinal epithelia height, numerical density (p <0.01), perimeter, number (p < 0.001) and a significant increase in tubular lumen of the seminiferous tubules. Rats that were treated with cadmium without pre-treatment or post-treatment with extract showed marked degeneration and atrophied seminiferous tubules with absence of late stage germ cells. There was also a reduction in proliferative cell nuclear antigen (PCNA) materials and Ki67 positive cells in these rats. Interestingly, all these parameters were however attenuated in the groups that were pre-treated and post-treated with the extract. Taken together therefore, it was concluded that aqueous zest extract of Citrus sinensis have protective and curative roles in the abatement of cadmium-induced testicular tumor and that these effects might be as a result of the antioxidant and free radical scavenging potentials of these neutraceuticals (AU)

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Texto completo SciELO Brasil
Id: 117668
Autor: Marinas, M. D. de las; Felix, R; Martorell, C; Cerda, J. C; Bartolome, B; Martorell, A.
Título: Cit s 3 as an Occupational Aeroallergen in an Orange Farmer
Fonte: J. investig. allergol. clin. immunol;23(7):510-512, nov.-dic. 2013. ilus.
Idioma: en.
Resumo: No disponible

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Texto completo SciELO Espanha
Id: 055594
Autor: Francés, Francesc; Corella, Dolores; Carrasco, Paula; Sáiz, Carmen; Guillén, Marisa.
Título: Modulación de la expresión fenotípica del paciente con cistinuria: influencia de la intervención terapéutica y de la dieta / Modulation of the phenotypic expression in the patient with cystinuria: influence of therapeutic intervention and diet
Fonte: Arch. esp. urol. (Ed. impr.);60(2):109-118, mar. 2007. tab.
Idioma: Es.
Resumo: OBJETIVOS: El fenotipo final del paciente con cistinuria depende, por una parte, de la ausencia o defecto molecular más o menos grave en el transporte de cistina y aminoácidos dibásicos; y por otra parte también de factores ambientales. El objetivo del presente estudio es conocer el efecto de la modulación de diversos factores ambientales (pH urinario, ingesta de líquido, tratamiento farmacológico y en especial la dieta) sobre el fenotipo final del paciente con cistinuria. METODOS: Se estudiaron 45 sujetos diagnosticados como pacientes con cistinuria (25 hombres y 20 mujeres), 42 individuos pertenecientes al árbol genealógico de estos pacientes con cistinuria (15 hombres y 27 mujeres) y 90 controles. Se obtuvieron datos antropométricos, clínicos (antecedentes personales y familiares de infecciones urinarias, cólicos, expulsión de cálculos y problemas renales), bioquímicos (análisis microscópico de orina y cuantificación de aminoácidos en orina) y estilo de vida (dieta y tratamiento recibido). El estudio estadístico incluyó, además de pruebas de comparación de frecuencias y de medias, regresión logística y análisis multivariante. RESULTADOS: De los 45 pacientes con cistinuria, sólo el 20% presentaban cristales de cistina en orina; el resto de manifestaciones fenotípicas de la enfermedad, se encontraron con la misma prevalencia que en el grupo de familiares y el grupo control. El 50% de los pacientes no estaban siguiendo ninguna pauta terapéutica, y de estos, solo en el 50% era efectivo. En pacientes con cistinuria, la presencia de cristales de cistina se asoció a una dieta rica en carnes y baja en productos lácteos (p<0,05). El consumo de carnes también tendía a asociarse a mayor riesgo de presentar infecciones urinarias, mientras que la expulsión de piedras mostró una tendencia negativa con una dieta rica en fitatos. El consumo elevado de naranjas y mandarinas fue la variable de la dieta que más se asoció con las concentraciones de aminoácidos en orina, fundamentalmente con menores niveles de lisina y arginina (p<0,05). CONCLUSIONES: Diversos componentes de la dieta, además del tratamiento estándar, modulan las manifestaciones fenotípicas de la enfermedad (AU)

OBJECTIVES: The final phenotype of patients with cystinuria depends on the absence or molecular defect, more or less acute, of the transport of cystine and dibasic aminoacids, and, also on environmental factors. The objective of this work is to study the effect of the modulation of some environmental factors (urinary pH, intake of liquids, pharmacological treatment and, specially, diet) on the final phenotype of the patient with cystinuria. METHODS: We study 45 patients with cystinuria (25 men and 20 women), 42 relatives (15 men and 27 women) and 90 unrelated controls. Anthropometric, clinical (personal and familiar history of urinary infections, colics and calculi expulsion), biochemical (microscopy analysis of urine and urinary aminoacids cuantification) and life style (diet and medical treatment) variables were obtained. Statistical analysis was performed using tests to compare means and frequencies and, also, logistic regression and multivariate analysis. RESULTS: Of the 45 patients with cystinuria, only 20% showed cystine cristalls in urine, the rest of the phenotypical manifestations of cystinuria were found with the same prevalence as in relatives and in the control group. 50% of the patients did not undergo any therapeutic intervention; of these, only 50% were effective. In patients with cystinuria, the presence of cystine cristalls was associated with a diet rich in meats and poor in milk products (p < 0.05). Meat consumption also tend to associate with a higher risk of urinary infections, meanwhile the stone expulsion showed a negative tendance with a diet rich in phytate. The elevate consumption of oranges and mandarins was the variable of the diet which was more associated with urinary aminoacids concentrations, specially with lower levels of lysine and arginine (p < 0.05). CONCLUSIONS: Some components of the diet, in addition to standard treatment, modulate the phenotypical manifestations of cystinuria (AU)
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