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Pesquisa : C11.187.183.200 [Categoria DeCs]
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Id: 177868
Autor: Gómez-Henao, CM; Herrera-Morales, CI; Ramírez-Giraldo, R; Cardona-Villa, R.
Título: Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia
Fonte: Allergol. immunopatol;46(4):370-377, jul.-ago. 2018. tab, graf.
Idioma: en.
Resumo: Vernal keratoconjunctivitis is one of the most serious ocular allergies that have the potential to induce large ocular morbidity and significant visual changes affecting the quality of life of these individuals. Methodology: This study was conducted in two phases. The first phase consisted of the clinical characterization of 32 patients from the Clinical Allergology center of the I.P.S. Universitaria from July 2014 to February 2015. A retrospective analysis of medical records was performed. In the second phase, the evaluation of quality of life was conducted using the questionnaire KIDSCREEN 27, which was validated in our population and evaluated as recommended by the creators of this instrument. Results: A total of 24 patients (75%) were men, mean age of 12.1 (SD 2.6) years. 100% of the patients had clinical evaluation and were monitored by Allergology and Ophthalmology, 12 patients (37.5%) were found in mild level, 5 patients (15.6%) were moderate and 14 patients (43.8%) were severe level. The most common symptoms were pruritus (75%), photophobia (50%), lacrimation (37.5%), and secretions (28.1%). 5.6% had a family history of atopy and 84.4% had an allergic comorbidity. Aeroallergen skin tests were found positive in 25 patients (78.1%). All patients had initiated ocular treatment by the time the survey of quality of life was conducted; but, they still had low quality of life scores in the 5 domains assessed. When the scores were evaluated by gender, the only statistically significant difference was found in the domain of family life and free time, which was lower for women. Conclusion: The vernal keratoconjunctivitis is a disease more prevalent in men. It apparently has an important atopic base in our environment, which due to its severe ocular involvement causes a marked decrease in the quality of life of the children who present it

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Id: 174449
Autor: Ojeda, P; Sastre, J; Olaguibel, JM; Chivato, T.
Título: Alergólogica 2015: A National Survey on Allergic Diseases in the Adult Spanish Population
Fonte: J. investig. allergol. clin. immunol;28(3):151-164, 2018. tab, graf.
Idioma: en.
Resumo: Background: The frequency of allergic diseases is increasing worldwide, particularly in industrialized countries. From a clinical, management, and public heath perspective, it is important to determine the reasons for consulting an allergist, the distribution by frequency of allergic diseases, and how health care is provided. Objective: Alergológica 2015 was carried out to obtain information on clinical practice in allergy departments in Spain, and compare it with the previous study editions. Methods: The data cover the year 2014 and the first quarter of 2015. The target sample was 6000 patients seen at public and private centers throughout Spain. A total of 500 allergists were invited to participate. Data were collected on an electronic case report form. Data were compared with the Alergológica surveys for 1992 and 2005 to identify differences. Results: The final study population comprised 2914 patients (mean age 33.6 [18.9] years, 58% women, 17% children), of whom 6.1% were foreign-born. The frequency distribution was as follows: rhinitis, 62%; asthma, 23.4%; drug allergy, 17.7%; urticaria/angioedema, 11.5%; food allergy, 10.4%; contact dermatitis, 4%; atopic dermatitis, 3%; insect venom allergy, 2%. A statistically significant increase was observed between data from 2005 and from 2015 with respect to the prevalence for allergic rhinitis, food allergy and drug hypersensitivity. An increase in the prevalence of a personal history of asthma, rhinitis, conjunctivitis, and eczema/atopic dermatitis were also observed. Besides, the number of relevant allergens in the same patient also increased. Most patients were referred from primary care, although a considerable percentage were referred by ENT specialists and dermatologists. Conclusions: Increasing trends were observed for allergic rhinitis, drug allergy, and food allergy, and a decreasing trend was observed for asthma. Findings for other diseases remained practically unchanged. Allergic patients are increasingly complex and present with a myriad of atopic manifestations

Antecedentes: La frecuencia de las enfermedades alérgicas está aumentando globalmente, particularmente en los países industrializados. Desde una perspectiva clínica, de gestión y de salud pública, es importante determinar los motivos de consulta al alergólogo, la distribución de la frecuencia de las enfermedades alérgicas y cómo se presta la atención sanitaria. Objetivo: Alergológica 2015 se realizó para obtener información de la práctica clínica en los servicios de alergia españoles y comparar sus resultados con los de las ediciones previas del estudio. Métodos: Los datos cubren el año 2014 y el primer trimestre de 2015. La muestra diana fue de 6.000 pacientes atendidos en los centros públicos y privados de toda España. Se invitó a participar a un total de 500 alergólogos. Los datos se recogieron en un formulario electrónico. Se compararon los datos con lo de los estudios de los años 1992 y 2005 para identificar diferencias. Resultados: La población final del estudio comprendió 2.914 pacientes (edad media 33,6 [18,9] años), 58% de mujeres, 17% niños) de los cuáles el 6,1% fueron extranjeros. La distribución por frecuencia fue: rinitis en el 62% de los sujetos; asma 23,4%; alergia a fármacos 17,7%; urticaria/angioedema 11,5%; alergia alimentaria 10,4%; dermatitis de contacto 4%; dermatitis atópica 3%; alergia al veneno de insectos 2%. Comparativamente con los resultados obtenidos en Alergológica 2005 se observó un aumento estadísticamente significativo con respecto a la prevalencia de rinitis alérgica, alergia a los alimentos e hipersensibilidad a los medicamentos. También se observó un aumento en la prevalencia de antecedentes personales de asma, rinitis, conjuntivitis y eccema / dermatitis atópica. Además, el número de alérgenos relevantes en el mismo paciente también aumentó La mayoría de los pacientes fueron remitidos desde atención primaria, si bien un porcentaje considerable lo hizo por el especialista ORL y dermatología. Conclusiones: Se observaron tendencias al alza para rinitis alérgica, alergia a fármacos y alergia a los alimentos y una tendencia a la baja para el asma. Los hallazgos para otras enfermedades alérgicas quedaron prácticamente iguales. Los pacientes alérgicos son cada vez más complejos y presentan una diversidad de manifestaciones atópicas
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Id: 172172
Autor: Yan, A; Luo, G; Zhou, Z; Hang, W; Qin, D.
Título: Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis
Fonte: Allergol. immunopatol;46(2):144-118, mar.-abr. 2018. tab, graf.
Idioma: en.
Resumo: Background: Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC. Methods: Eighty AC children (seasonal and perennial AC) and twenty controls were enrolled in this study. Serum and tears of different time points (during and out of the pollen season) were collected and used for enzyme-linked immunosorbent assay (ELISA) of OPN and T-help cell related cytokines, respectively. The relationship between serum and tears OPN and Th1/2/17Treg related cytokines as well as disease severity were analysed. Results: Our results showed that expression of tear OPN protein by perennial AC patients increased significantly compared with controls or seasonal AC patients out of the pollen season. Tear OPN expression was positively related to local Th2/17 cytokines and negatively related to IL-10 and TGF-Beta expression. The tear OPN expression was also significantly related to disease severity. Conclusion: Tear OPN reflects the local clinical status of ocular allergy and might play an important pathophysiological role in local Th2/17/Treg inflammation in children with AC (AU)

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Id: 170238
Autor: Prieto, L.
Título: Tablet-based sublingual immunotherapy for respiratory allergy
Fonte: Allergol. immunopatol;45(supl.1):30-35, dic. 2017. tab, graf.
Idioma: en.
Resumo: Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Sublingual immunotherapy (SLIT) tablets are now available for grass- or ragweed-induced rhinoconjunctivitis and will be available in Spain for house dust mite (HDM)-induced rhinoconjunctivitis and asthma in the next months. In this review, new developments in the field of tablet-based SLIT for respiratory allergy are summarized, with special emphasis on HDM-induced allergic rhinitis and asthma. SLIT tablets are the best-documented immunotherapy products on the market and represent a more patient-friendly concept because they can be self-administrated at home (AU)

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Texto completo SciELO Espanha
Id: 169782
Autor: Abascal Azanza, C; Abárzuza Cortaire, R; Plaza Ramos, P.
Título: Síndrome de Horner: presentación oftalmológica inusual de linfoma de Hodgkin / Horner's Syndrome: an unusual ophthalmological presentationof Hodgkin lymphoma
Fonte: An. sist. sanit. Navar;40(3):461-466, sept.-dic. 2017. tab, ilus.
Idioma: es.
Resumo: El Síndrome de Horner (SH) es un síndrome neurológico que se caracteriza por la triada miosis pupilar incompleta, ptosis palpebral y anhidrosis facial debido a la lesión de la vía oculosimpática, compuesta por tres neuronas, desde el hipotálamo hasta el ojo. Identificar su causa representa un reto diagnóstico ya que, a pesar de su aparente levedad clínica, el SH puede ser la primera o única manifestación de un trastorno grave o incluso potencialmente mortal. Presentamos el caso de un paciente varón de 19 años con una historia de molestias oculares inespecíficas de dos meses de evolución. Acudió a la consulta de urgencias de Oftalmología en la que fue diagnosticado de un SH como primera manifestación clínica de linfoma de Hodgkin (AU)

Horner's Syndrome (HS) is a neurological síndrome characterised by the triad incomplete pupillary miosis, palpebral ptosis and facial anhidrosis, due to a lesión of the oculosympathetic pathway, formed of three neurons from the hipothalamus to the eye. Identifying its cause is a diagnostic challenge since in spite of its apparent lack of clinical importance, HS can be the first or only manifestation of a serious, or even potentially mortal disorder. We present the case of a 19-year-old male patient with a history of nonspecific ocular pains of two months evolution. He attended the emergency ophthalmological clinic where he was diagnosed with an HS as the first clinical manifestation of Hodgkin lymphoma (AU)
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Id: 166999
Autor: Di Coste, A; Occasi, F; De Castro, G; Zicari, AM; Galandrini, R; Giuffrida, A; Indinnimeo, L; Duse, M.
Título: Predictivity of clinical efficacy of sublingual immunotherapy (SLIT) based on sensitisation pattern to molecular allergens in children with allergic rhinoconjunctivitis
Fonte: Allergol. immunopatol;45(5):452-456, sept.-oct. 2017. tab, graf.
Idioma: en.
Resumo: Background: The diagnostic and therapeutic approach to grass pollen allergy is now possible by detecting specific IgE (sIgE) to its allergenic components. Aim: To evaluate the correlation between the sensitisation to different molecular Phleum pratense (Phl p) allergens and clinical efficacy of SLIT. Methods: The pilot study included 36 patients affected by allergic rhinoconjunctivitis, all treated with SLIT actively. We performed serum analysis of sIgE to Phl p 1, 2, 4, 5, 6, 7, 11 and 12. The Average Rhinoconjunctivitis Total Symptom Score (ARTSS) and the Average Combined Score (ACS) were evaluated before and after one year of immunotherapy. Results: Three different groups of sensitisation were defined based on the range of IgE reactivity to Phleum pratense allergens at baseline: group I (sIgE reactive to 1-3 allergens); group II (sIgE reactive to 4-5 allergens); and group III (sIgE reactive to 6-8 allergens). At T0 ACS was 1.79 ± 0.18 in group I; 1.81 ± 0.23 in group II; and 1.95 ± 0.34 in group III. At T1 ACS was 0.85 ± 0.55 in group I; 1.01 ± 0.31 in group II; and 1.44 ± 0.39 in group III. At T1 there was a significant improvement of ARTSS and ACS for group I (p = 0.001). Conclusions: Sublingual immunotherapy with a grass pollen is efficacious irrespective of the patients' baseline sensitisation to either single or multiple grass pollen molecular allergens. We found that patients with few sensitisations have a greater improvement in combined symptom and medication score. SLIT improves the clinical course of allergic patients although new sensitisations may appear (AU)

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Id: 153644
Autor: Palao-Ocharan, P; Domínguez-Ortega, J; Barranco, P; Diaz-Almiron, M; Quirce, S.
Título: Does the profile of sensitization to grass pollen allergens have clinical relevance?
Fonte: J. investig. allergol. clin. immunol;26(3):188-189, 2016.
Idioma: en.
Resumo: No disponible

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Id: 152602
Autor: Torres, JA; Sastre, J; Vivanco, F; Sanz Maroto, A; Heras, M de las; Pastor-Vargas, C.
Título: Clinical characteristics of patients sensitized to Siberian Hamster
Fonte: J. investig. allergol. clin. immunol;26(2):113-115, 2016. tab.
Idioma: en.
Resumo: No disponible

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Id: 152509
Autor: Gómez, S; Chivato, T; Mateos, JM; La Vin, Jr; Laguna, R.
Título: Rinoconjuntivitis alérgica / Allergic rhinitis and conjunctivitis
Fonte: Med. aeroesp. ambient;3(2):59-65, dic. 2000. tab.
Idioma: es.
Resumo: La rinoconjutivitis alérgica ya sea estacional o perenne es una enfermedad frecuente, producida por una gran variedad de agentes etiológicos. Su prevalencia ha aumentado en los últimos años especialmente en los países occidentales. A menudo es una enfermedad tratada de forma insuficiente, la sintomatología clínica es molesta, la capacidad para la concentración mental y para realizar actividades cotidianas se ve afectada, disminuyendo la calidad de vida de los pacientes que la padecen. El tratamiento más utilizado consiste en la administración de antihistamínicos anti-HI orales y corticoides intranasales. Hoy en día existen dos antihistamínicos anti-Hl disponibles de forma tópica, por vía intranasal y ocular. Son la levocabastina y la azelastina, especialmente indicados cuando la capacidad de atención, concentración y rendimiento no puede estar disminuida, también están indicados en el embarazo, por la práctica inexistencia de efectos indeseables Y en aquellas ocasiones en las que no se quieren utilizar corticoides por vía tópica nasal. En este artículo se repasa la etiología, fisiopatología, clínica, diagnóstico y tratamiento de la rinoconjuntivitis alérgica (AU)

Seasonal or perennial allergic rhinitis is an extremely common disease, due to a lot of etiologic agents. Its prevalence has increased in the Occidental countries during the last years. Frequently is undertreated, clinical symptoms are annoying, mental attention and daily capacity are reduced. The most frequently therapies used are oral HI-blockers and intranasal corticosteroids. Nowadays exist two H1 blockers for topic use: levocabastine and azelastine, these drugs are recommended when mental attention and production capacity cannot be decreased, also during pregnancy are recommended due to the few secundary effects. In this article etiology, physiophatology, clinic diagnostic and treatment of rhinitis and conjunctivitis are reviewed (AU)
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Id: 146798
Autor: Martínez Gimeno, A.
Título: Alergia y problemas otorrinolaringológicos pediátricos / No disponible
Fonte: An. pediatr. (2003. Ed. impr.);1(supl.1):29-34, jun. 2003. tab.
Idioma: es.
Resumo: No disponible

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