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Pesquisa : D01.339.387 [Categoria DeCs]
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Id: 184089
Autor: Kalm-Stephens, P; Nordvall, L; Janson, C; Neuman, Å; Malinovschi, A; Alving, K.
Título: Elevated exhaled nitric oxide in adolescents is associated with incident allergic symptoms: a prospective cohort study
Fonte: J. investig. allergol. clin. immunol;29(3):231-238, 2019. tab.
Idioma: en.
Resumo: Background: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation in the airways. Elevated FeNO may precede the development of allergic disease. The aim of the present study was to investigate the association between elevated FeNO and the development of allergic symptoms. Methods: A total of 959 adolescents from the general population and their parents completed a standardized questionnaire. Lung function and FeNO were assessed at baseline. Four years later, 921 of these individuals (96%) completed the same version of the baseline questionnaire. Results: Adolescents with self-reported incident allergic symptoms to cat (n=50) or dog (n=33) had higher baseline FeNO (P<.001) than those without allergic symptoms to cat and dog at both time points (n=776 and n=838, respectively). Adolescents with incident allergic symptoms to pollen did not have elevated baseline FeNO. The adjusted odds ratio (aOR [95%CI]) for incident allergic symptoms to cat was 4.2 (2.2-8.0) times higher if FeNO was >75th percentile (vs <75th percentile) at baseline. This was consistent after exclusion of individuals with reported asthma, wheeze, or rhinitis at baseline (8.6 [3.0-24.1]). Conclusion: Elevated FeNO in adolescents was associated with an increased risk of developing allergic symptoms to cat and dog allergens, but not to pollen allergens, after 4 years

Introducción: La fracción de óxido nítrico exhalado (FeNO) es un marcador de inflamación de tipo 2 en las vías respiratorias y un valor de FeNO elevado puede preceder al desarrollo de enfermedad alérgica. El objetivo del presente estudio fue investigar la asociación entre FeNO elevado y el desarrollo posterior de síntomas alérgicos. Métodos: Un total de 959 adolescentes, procedentes de población general, respondieron, junto con sus padres, a un cuestionario estandarizado, realizaron una prueba de función pulmonar y una medición de FeNO en una visita basal. Cuatro años después, 921 de estos sujetos (96%) completaron, la misma versión, en gran medida, del cuestionario de referencia. Resultados: Los adolescentes con síntomas alérgicos incidentes autoinformados por gato (n=50) o perro (n=33) tenían mayor FeNO inicial (p <0,001) que los sujetos sin síntomas alérgicos por estos alérgenos, en cualquier momento del estudio (n=776 y n=838, respectivamente). Por el contrario, los adolescentes con síntomas alérgicos incidentes por polen no presentaban un FeNO inicial elevado. La razón de riesgo ajustada [aOR (intervalo de confianza del 95%)] para síntomas alérgicos incidentes por gato fue 4,2 (2,2, 8,0) veces mayor si el FeNO fue mayor que percentil 75 de la muestra (vs. menor del percentil 75) al inicio del estudio. Este resultado se mantuvo también después de la exclusión de los sujetos con asma, sibilancias o rinitis notificados al inicio del estudio [aOR (IC 95%) 8,6 (3,0, 24,1)].Conclusiones: El FeNO elevado en adolescentes se relacionó con un mayor riesgo de desarrollar en los cuatro años siguientes síntomas alérgicos inducidos por gatos y perros, pero no por los alérgenos del polen
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Id: 184058
Autor: Sánchez-Jareño, M; Barranco, P; Padial Vilchez, MA; Valbuena, T; Lluch, M; Domínguez-Ortega, J; López-Carrasco, V; Quirce, S.
Título: Changes in fractional exhaled nitric oxide levels after bronchial challenge with Aspirin in patients with Aspirin-induced asthma
Fonte: J. investig. allergol. clin. immunol;29(2):137-139, 2019. tab.
Idioma: en.
Resumo: No disponible
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Texto completo SciELO Espanha
Id: 179926
Autor: Neto, Manoel Miranda; Toscano, Luciana Tavares; Lima, Fabiano Ferreira de; Da Silva, Taís Feitosa; Da Silva, Cássia Surama Oliveira; Silva, Alexandre Sérgio.
Título: Effect of l-arginine intake on exercise-induced hypotension / Efecto de la ingestión de L-arginina en la hipotensión inducida por el ejercicio
Fonte: Nutr. hosp;35(5):1195-1200, sept.-oct. 2018. graf, tab.
Idioma: en.
Resumo: Objective: to verify if one single dose of L-arginine improves post-exercise hypotension (PEH) in hypertensive. Methods: double-blind, placebo, randomized with 20 hypertensive (51.47 ± 1.24 years). Two sessions of aerobic exercise were performed proceeded for the ingestion of one dose of 7 g of L-arginine (EX-LARG) or placebo (EX-PLA), plus one session only with L-arginine ingestion (L-ARG). Blood pressure (BP) was measured at rest, and each ten minutes for a period of 60 minutes recovery after exercise. Blood samples were taken before and after exercise for analysis of plasma concentration of nitrite and malondial de hyde (MDA). One-way ANOVA tests were used to compare the baseline conditions and two-way ANOVA, to evaluate possible differences in pressure responses between procedures. Results: both sessions EX-LARG and EX-PLA showed similar peak reduction for the mean systolic blood pressure (-6.58 ± 0.95 mmHg and -8.38 ± 1.29 mmHg respectively, p = 0.28). On the other hand, for the diastolic component, only L-ARG was able to promote PEH (-1.85 ± 0.44 mmHg), significantly better than EX-PLA (+2.13 ± 0.62 mmHg; p < 0.01). L-ARG alone did not result in significant changes in BP. Nitrite and MDA behaved similarly between procedures. Conclusion: a single dose of L-arginine before exercise improves diastolic PEH

Objetivo: verificar si una sola dosis de L-arginina mejora la hipotensión post-ejercicio (HPE) en hipertensos. Métodos: estudio doble ciego, placebo, aleatorizado con 20 hipertensos (51,47 ± 1,24 anos). Se realizaron dos sesiones de ejercicio aeróbico para la ingestión de una dosis de 7 g de L-arginina (EX-LARG) o placebo (EX-PLA), mas una sesión solo con ingestión de L-arginina (L-ARG). La presión arterial (PA) se midió en reposo y cada diez minutos durante un periodo de recuperación de 60 minutos después del ejercicio. Se tomaron muestras de sangre antes y después del ejercicio para el análisis de la concentración plasmática de nitrito y malondialdehido (MDA). Se usaron pruebas de ANOVA de una via para comparar las condiciones iniciales y ANOVA de dos vías para evaluar las posibles diferencias en las respuestas de presión entre procedimientos. Resultados: ambas sesiones, EX-LARG y EX-PLA, mostraron una reducción máxima similar de la presión arterial sistólica media (-6,58 ± 0,95 mmHg y -8,38 ± 1,29 mmHg, respectivamente, p = 0,28). Por otro lado, con respecto al componente diastólico, solo L-ARG fue capaz de promover HPE (-1,85 ± 0,44 mmHg), significativamente mejor que EX-PLA (+2,13 ± 0,62 mmHg, p < 0,01). L-ARG solo no dio como resultado un cambio significativo en la PA. El nitrito y la MDA se comportaron de manera similar entre los procedimientos. Conclusión: una dosis unica de L-arginina antes del ejercicio mejora la HPE diastolic
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Texto completo SciELO Espanha
Id: 179753
Autor: Fumero Lessmann, Patricia; Jiménez Vólquez, Lídia Carolina; Meza Caballero, María Eva.
Título: Óxido Nítrico como biomarcador en asma ocupacional inducida por isocianatos en talleres de pintura automotriz / Nitric-Oxide as Biomarker in Isocyanate-Induced Occupational Asthma at the Vehicle Paint and Body Repair Industry
Fonte: Med. segur. trab;64(250):89-103, ene.-mar. 2018. tab, graf.
Idioma: es.
Resumo: Introducción: El asma ocupacional (AO) es la enfermedad respiratoria de origen laboral más prevalente en los países desarrollados. Ocurre principalmente por exposición inhalatoria a agentes como el isocianato, contenido en las pinturas utilizadas en el sector automotriz. Su diagnóstico depende de varios factores y está en estudio la utilidad de la fracción espirada de óxido nítrico (FeNO) como marcador de inflamación respiratoria, siendo un método sencillo, rápido y no invasivo. Este trabajo resume la evidencia científica sobre la utilidad de FeNO en la evaluación del asma inducida por isocianato. Material y Métodos: Se realizó una revisión sistemática de la literatura científica publicada en 6 bases de datos, utilizando ecuaciones de búsqueda en términos MeSH. Se procedió a un cribado de las referencias y se seleccionaron los artículos basándonos en los objetivos del estudio y en los de mayor evidencia científica según SIGN. Resultados: Se recuperaron 45 referencias y se incluyeron 8 en la revisión; 7 de ellos fueron de diseño transversal. Hubo asociación estadísticamente significativa entre hiperreactividad bronquial (HRB) y FeNO en trabajadores expuestos a isocianato en todos los artículos, con excepción de uno. Conclusiones: A pesar de las limitaciones en los estudios revisados en cuanto al tipo de diseño, tamaño de la muestra y objetivos, se demuestra que existe evidencia científica que apoya la utilidad del FeNO en la evaluación del asma ocupacional por isocianatos

Introduction: Occupational asthma (AO) is the most predominant work-related respiratory illness in developing countries. It shows up mainly due to the inhalation of agents like isocyanate, a compound used during automobile painting application and widely used in the vehicle body repair industry. Its diagnosis is multifactorial. The nitric oxide fraction concentration in exhaled breath (FeNO) as a marker of respiratory inflammation is a simple, fast and non-invasive method. This paper summarizes the scientific evidence on the usefulness of FeNO in the assessment of isocyanate induced asthma. Material and Methods: A systematic review of the published scientific literature was carried out in 6 databases, using search equations in terms of MeSH. The references were filtered and the articles were selected based on the objectives of the study and on the highest scientific evidence according to SIGN. Results: 45 references were retrieved and 8 were included in the review; 7 of them were of transversal design. With the exception of one of them, there was a statistically significant association between bronchial hyperresponsiveness (BHP) and FeNO in isocyanate exposed workers in all articles. Conclusions: Despite the limitations of the reviewed studies regarding design type, sample size and objectives, it is showed that there is scientific evidence supporting the validity of FeNO in the assessment of occupational asthma by isocyanates
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Id: 178917
Autor: Reza Izadi, Mohammad; Ghardashi Afousi, Alireza; Asvadi Fard, Maryam; Babaee Bigi, Mohammad Ali.
Título: High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals
Fonte: J. physiol. biochem;74(1):47-55, feb. 2018. graf, tab.
Idioma: en.
Resumo: Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15). The exercise training was conducted for three 35-min sessions a week (1.5-min interval at 85û90% of heart rate reserve [HRR] and 2 min active phase at 50û55% of HRR). Assessment of plasma apelin, nitrite/nitrate (NOx), and endothelin-1 (ET-1) was performed before and after the intervention. At the end of the study, apelin, and NOx plasma levels increased significantly in the high-intensity interval training (HIIT) group (P = 0.021, P = 0.003, respectively). Conversely, ET-1 plasma levels significantly decreased in the training group after the intervention (P = 0.015). Moreover, there was a positive correlation between the change of plasma apelin and change of plasma NOx (r = 0. 771, P = 0.0008). In addition, there was a negative correlation between the change of plasma ET-1, change of plasma apelin (r = - 0.595, P = 0.019), and variation of NOx (r = - 0.572, P = 0.025). This study indicates that, by increasing of apelin and NOx plasma levels, HIIT may be effective in reducing blood pressure

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Id: 178913
Autor: Ito, Tatsuo; Kubo, Masayuki; Nagaoka, Kenjiro; Funakubo, Narumi; Setiawan, Heri; Takemoto, Kei; Eguchi. Eri; Fujikura, Yoshihisa; Ogino, Keiki.
Título: Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and l-arginine metabolism in mice
Fonte: J. physiol. biochem;74(1):9-16, feb. 2018. graf, ilus, tab.
Idioma: en.
Resumo: Obesity is a risk factor for vascular endothelial cell dysfunction characterized by low-grade, chronic inflammation. Increased levels of arginase I and concomitant decreases in l-arginine bioavailability are known to play a role in the pathogenesis of vascular endothelial cell dysfunction. In the present study, we focused on changes in the systemic expression of arginase I as well as l-arginine metabolism in the pre-disease state of early obesity prior to the onset of atherosclerosis. C57BL/6 mice were fed a control diet (CD; 10% fat) or high-fat diet (HFD; 60% fat) for 8 weeks. The mRNA expression of arginase I in the liver, adipose tissue, aorta, and muscle; protein expression of arginase I in the liver and plasma; and systemic levels of l-arginine bioavailability and NO2 − were assessed. HFD-fed mice showed early obesity without severe disease symptoms. Arginase I mRNA and protein expression levels in the liver were significantly higher in HFD-fed obese mice than in CD-fed mice. Arginase I levels were slightly increased, whereas l-arginine levels were significantly reduced, and these changes were followed by reductions in NO2 − levels. Furthermore, hepatic arginase I levels positively correlated with plasma arginase I levels and negatively correlated with l-arginine bioavailability in plasma. These results suggested that increases in the expression of hepatic arginase I and reductions in plasma l-arginine and NO2 − levels might lead to vascular endothelial dysfunction in the pre-disease state of early obesity

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Id: 178899
Autor: Thirupathi, Anand; De Souza, Claudio Teodoro.
Título: Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
Fonte: J. physiol. biochem;73(4):487-494, nov. 2017. tab, graf.
Idioma: en.
Resumo: Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition

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Id: 177417
Autor: Moreno-Galarraga, L; Urriza Yeregui, L; Urriza Ripa, I; Fernández-Montero, A; Peñafiel freire, D; Viguria Sánchez, N.
Título: Evolución de la función pulmonar en niños con asma grave en tratamiento con omalizumab / Lung function evolution in children with severe asthma treated with omalizumab
Fonte: Acta pediatr. esp;76(9/10):105-108, sept.-oct. 2018. tab, graf.
Idioma: es.
Resumo: Introducción: Omalizumab es un anticuerpo monoclonal frente a la inmunoglobulina E utilizado en el tratamiento del asma alérgica grave. El objetivo de este estudio fue describir el efecto de omalizumab sobre los valores de la función pulmonar y la fracción exhalada de óxido nítrico (FeNO) en pacientes pediátricos. Material y métodos: Análisis estadístico de la función pulmonar y de la FeNO en los 13 niños tratados con omalizumab en el servicio de pediatría de un hospital terciario entre los años 2010 y 2016. Resultados: Se observa una mejoría estadísticamente significativa a los 3 meses de tratamiento que se mantiene estable en el tiempo, tanto en valores de función pulmonar (pretratamiento: capacidad vital forzada [FVC] 84,1% y volumen espiratorio forzado en el primer segundo [FEV1] 72%; postratamiento: FVC 101% [p= 0,02] y FEV1 92% (p= 0,01) como en la FeNO (pretratamiento: 82 ppb; postratamiento: 36 ppb). Conclusiones: En nuestros pacientes pediátricos con asma grave, omalizumab es capaz de mejorar y mantener estable en el tiempo la función pulmonar y disminuir el valor de la FeNO

Introduction: Omalizumab is a monoclonal antibody against immunoglobulin E used in the treatment of severe allergic asthma. The aim of this study was to describe, in pediatric patients, the effects of omalizumab in pulmonary function values and in the nitric oxide concentration levels in exhaled breath (FeNO). Material and methods: We performed a statistical analysis of lung function and FeNO evolution in 13 children treated with omalizumab in a pediatric service, between year 2010 and 2016. Results: A statistically significant improvement was observed after 3 months of treatment, which remained stable over time, in lung function values (pre-treatment: forced vital capacity [FVC] 84.1% and forced expiratory volume in the first second [FEV1] 72%; after treatment: FVC 101% [p= 0.02] and FEV1 92% [p= 0.01]). A significant improvement was also detected in the FeNO levels (pre-treatment: 82 ppb; after treatment: 36 ppb). Conclusions: In our pediatric patients with severe asthma, omalizumab was able to improve and maintain stable in time both pulmonary function and FeNO values
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Id: 176246
Autor: Alcázar-Navarrete, Bernardino; Castellano Miñán, Francisca; Santiago Díaz, Pablo; Ruiz Rodríguez, Oliveiro; Romero Palacios, Pedro J.
Título: Óxido nítrico alveolar y bronquial en la enfermedad pulmonar obstructiva crónica y el solapamiento de asma y EPOC (ACO) / Alveolar and Bronchial Nitric Oxide in Chronic Obstructive Pulmonary Disease and Asthma-COPD Overlap
Fonte: Arch. bronconeumol. (Ed. impr.);54(8):414-419, ago. 2018. graf, ilus.
Idioma: es.
Resumo: Introducción: La medición del óxido nítrico en el aire exhalado diferencia fenotipos de pacientes con EPOC del solapamiento de asma y EPOC (ACO). Hasta el momento no se ha estudiado si existen diferencias entre los componentes alveolar y bronquial del FENO en este grupo de pacientes. Métodos: Estudio observacional transversal realizado en consultas externas de Neumología, incluyendo a pacientes con diagnóstico de EPOC a los que se les realizó una determinación del óxido nítrico en aire exhalado - FENO - diferenciando en esta medida el componente alveolar -CANO- y el de vía aérea central -JawNO-, y realizando las mediciones a distintos flujos. Se compararon los valores de CANO y JawNO entre los pacientes con eosinofilia (definidos como aquellos pacientes con ≥ 300 eosinófilos/ μL en sangre periférica, o bien ≥ 2% eosinófilos o ≥ 3% eosinófilos) y se realizó un análisis de regresión lineal para estudiar las variables clínicas y biológicas que se asociaban a estas mediciones. Resultados: Participaron en el estudio 73 pacientes con EPOC. Los criterios de eosinofilia utilizados se asociaban a incrementos de los valores de CANO y de JawNO (en este último caso solo los criterios ≥ 300 eosinófilos y ≥ 3% eosinófilos). CANO se asoció al recuento de eosinófilos y PCR, y JawNO se asoció a tabaquismo y recuento de eosinófilos. Conclusiones: Los pacientes diagnosticados de EPOC y que tienen características de ACO muestran mayor inflamación a nivel bronquial y de vía aérea pequeña. CANO y JawNO se relacionan con variables clínicas y biológicas

Introduction: Exhaled nitric oxide (FENO) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. Methods: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO) from bronchial (JawNO) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements. Results: 73 COPD patients were included in the study. Eosinophil counts were associated with increased values of CANO and JawNO (for the latter only the association with ≥ 300 or ≥ 3% eosinophils was significant). CANO was also associated with CRP, and JawNO with smoking. Conclusions: Patients with COPD and ACO characteristics show increased inflammation in the large and small airways. CANO and JawNO are associated with clinical and biological variables
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Id: 174465
Autor: Alvarez Puebla, MJ; Aroabarren Aleman, E; Corcuera Garcia, A; Ibañez Bereiz, B; Iraola Iribar, A; Olaguibel Rivera, JM.
Título: Blood eosinophils, fraction of exhaled nitric oxide, and serum eosinophil cationic protein as surrogate markers for sputum eosinophils in asthma: influence of treatment with inhaled corticosteroids
Fonte: J. investig. allergol. clin. immunol;28(3):210-212, 2018. tab.
Idioma: en.
Resumo: No disponible
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