Base de dados : IBECS
Pesquisa : D01.339.387 [Categoria DeCs]
Referências encontradas : 255 [refinar]
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Id: 179926
Autor: Neto, Manoel Miranda; Toscano, Luciana Tavares; Lima, Fabiano Ferreira de; Da Silva, Taís Feitosa; Da Silva, Cássia Surama Oliveira; Silva, Alexandre Sérgio.
Título: Effect of l-arginine intake on exercise-induced hypotension / Efecto de la ingestión de L-arginina en la hipotensión inducida por el ejercicio
Fonte: Nutr. hosp;35(5):1195-1200, sept.-oct. 2018. graf, tab.
Idioma: en.
Resumo: Objective: to verify if one single dose of L-arginine improves post-exercise hypotension (PEH) in hypertensive. Methods: double-blind, placebo, randomized with 20 hypertensive (51.47 ± 1.24 years). Two sessions of aerobic exercise were performed proceeded for the ingestion of one dose of 7 g of L-arginine (EX-LARG) or placebo (EX-PLA), plus one session only with L-arginine ingestion (L-ARG). Blood pressure (BP) was measured at rest, and each ten minutes for a period of 60 minutes recovery after exercise. Blood samples were taken before and after exercise for analysis of plasma concentration of nitrite and malondial de hyde (MDA). One-way ANOVA tests were used to compare the baseline conditions and two-way ANOVA, to evaluate possible differences in pressure responses between procedures. Results: both sessions EX-LARG and EX-PLA showed similar peak reduction for the mean systolic blood pressure (-6.58 ± 0.95 mmHg and -8.38 ± 1.29 mmHg respectively, p = 0.28). On the other hand, for the diastolic component, only L-ARG was able to promote PEH (-1.85 ± 0.44 mmHg), significantly better than EX-PLA (+2.13 ± 0.62 mmHg; p < 0.01). L-ARG alone did not result in significant changes in BP. Nitrite and MDA behaved similarly between procedures. Conclusion: a single dose of L-arginine before exercise improves diastolic PEH

Objetivo: verificar si una sola dosis de L-arginina mejora la hipotensión post-ejercicio (HPE) en hipertensos. Métodos: estudio doble ciego, placebo, aleatorizado con 20 hipertensos (51,47 ± 1,24 anos). Se realizaron dos sesiones de ejercicio aeróbico para la ingestión de una dosis de 7 g de L-arginina (EX-LARG) o placebo (EX-PLA), mas una sesión solo con ingestión de L-arginina (L-ARG). La presión arterial (PA) se midió en reposo y cada diez minutos durante un periodo de recuperación de 60 minutos después del ejercicio. Se tomaron muestras de sangre antes y después del ejercicio para el análisis de la concentración plasmática de nitrito y malondialdehido (MDA). Se usaron pruebas de ANOVA de una via para comparar las condiciones iniciales y ANOVA de dos vías para evaluar las posibles diferencias en las respuestas de presión entre procedimientos. Resultados: ambas sesiones, EX-LARG y EX-PLA, mostraron una reducción máxima similar de la presión arterial sistólica media (-6,58 ± 0,95 mmHg y -8,38 ± 1,29 mmHg, respectivamente, p = 0,28). Por otro lado, con respecto al componente diastólico, solo L-ARG fue capaz de promover HPE (-1,85 ± 0,44 mmHg), significativamente mejor que EX-PLA (+2,13 ± 0,62 mmHg, p < 0,01). L-ARG solo no dio como resultado un cambio significativo en la PA. El nitrito y la MDA se comportaron de manera similar entre los procedimientos. Conclusión: una dosis unica de L-arginina antes del ejercicio mejora la HPE diastolic
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Texto completo SciELO Espanha
Id: 179753
Autor: Fumero Lessmann, Patricia; Jiménez Vólquez, Lídia Carolina; Meza Caballero, María Eva.
Título: Óxido Nítrico como biomarcador en asma ocupacional inducida por isocianatos en talleres de pintura automotriz / Nitric-Oxide as Biomarker in Isocyanate-Induced Occupational Asthma at the Vehicle Paint and Body Repair Industry
Fonte: Med. segur. trab;64(250):89-103, ene.-mar. 2018. tab, graf.
Idioma: es.
Resumo: Introducción: El asma ocupacional (AO) es la enfermedad respiratoria de origen laboral más prevalente en los países desarrollados. Ocurre principalmente por exposición inhalatoria a agentes como el isocianato, contenido en las pinturas utilizadas en el sector automotriz. Su diagnóstico depende de varios factores y está en estudio la utilidad de la fracción espirada de óxido nítrico (FeNO) como marcador de inflamación respiratoria, siendo un método sencillo, rápido y no invasivo. Este trabajo resume la evidencia científica sobre la utilidad de FeNO en la evaluación del asma inducida por isocianato. Material y Métodos: Se realizó una revisión sistemática de la literatura científica publicada en 6 bases de datos, utilizando ecuaciones de búsqueda en términos MeSH. Se procedió a un cribado de las referencias y se seleccionaron los artículos basándonos en los objetivos del estudio y en los de mayor evidencia científica según SIGN. Resultados: Se recuperaron 45 referencias y se incluyeron 8 en la revisión; 7 de ellos fueron de diseño transversal. Hubo asociación estadísticamente significativa entre hiperreactividad bronquial (HRB) y FeNO en trabajadores expuestos a isocianato en todos los artículos, con excepción de uno. Conclusiones: A pesar de las limitaciones en los estudios revisados en cuanto al tipo de diseño, tamaño de la muestra y objetivos, se demuestra que existe evidencia científica que apoya la utilidad del FeNO en la evaluación del asma ocupacional por isocianatos

Introduction: Occupational asthma (AO) is the most predominant work-related respiratory illness in developing countries. It shows up mainly due to the inhalation of agents like isocyanate, a compound used during automobile painting application and widely used in the vehicle body repair industry. Its diagnosis is multifactorial. The nitric oxide fraction concentration in exhaled breath (FeNO) as a marker of respiratory inflammation is a simple, fast and non-invasive method. This paper summarizes the scientific evidence on the usefulness of FeNO in the assessment of isocyanate induced asthma. Material and Methods: A systematic review of the published scientific literature was carried out in 6 databases, using search equations in terms of MeSH. The references were filtered and the articles were selected based on the objectives of the study and on the highest scientific evidence according to SIGN. Results: 45 references were retrieved and 8 were included in the review; 7 of them were of transversal design. With the exception of one of them, there was a statistically significant association between bronchial hyperresponsiveness (BHP) and FeNO in isocyanate exposed workers in all articles. Conclusions: Despite the limitations of the reviewed studies regarding design type, sample size and objectives, it is showed that there is scientific evidence supporting the validity of FeNO in the assessment of occupational asthma by isocyanates
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Id: 178917
Autor: Reza Izadi, Mohammad; Ghardashi Afousi, Alireza; Asvadi Fard, Maryam; Babaee Bigi, Mohammad Ali.
Título: High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals
Fonte: J. physiol. biochem;74(1):47-55, feb. 2018. graf, tab.
Idioma: en.
Resumo: Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15). The exercise training was conducted for three 35-min sessions a week (1.5-min interval at 85û90% of heart rate reserve [HRR] and 2 min active phase at 50û55% of HRR). Assessment of plasma apelin, nitrite/nitrate (NOx), and endothelin-1 (ET-1) was performed before and after the intervention. At the end of the study, apelin, and NOx plasma levels increased significantly in the high-intensity interval training (HIIT) group (P = 0.021, P = 0.003, respectively). Conversely, ET-1 plasma levels significantly decreased in the training group after the intervention (P = 0.015). Moreover, there was a positive correlation between the change of plasma apelin and change of plasma NOx (r = 0. 771, P = 0.0008). In addition, there was a negative correlation between the change of plasma ET-1, change of plasma apelin (r = - 0.595, P = 0.019), and variation of NOx (r = - 0.572, P = 0.025). This study indicates that, by increasing of apelin and NOx plasma levels, HIIT may be effective in reducing blood pressure

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Id: 178913
Autor: Ito, Tatsuo; Kubo, Masayuki; Nagaoka, Kenjiro; Funakubo, Narumi; Setiawan, Heri; Takemoto, Kei; Eguchi. Eri; Fujikura, Yoshihisa; Ogino, Keiki.
Título: Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and l-arginine metabolism in mice
Fonte: J. physiol. biochem;74(1):9-16, feb. 2018. graf, ilus, tab.
Idioma: en.
Resumo: Obesity is a risk factor for vascular endothelial cell dysfunction characterized by low-grade, chronic inflammation. Increased levels of arginase I and concomitant decreases in l-arginine bioavailability are known to play a role in the pathogenesis of vascular endothelial cell dysfunction. In the present study, we focused on changes in the systemic expression of arginase I as well as l-arginine metabolism in the pre-disease state of early obesity prior to the onset of atherosclerosis. C57BL/6 mice were fed a control diet (CD; 10% fat) or high-fat diet (HFD; 60% fat) for 8 weeks. The mRNA expression of arginase I in the liver, adipose tissue, aorta, and muscle; protein expression of arginase I in the liver and plasma; and systemic levels of l-arginine bioavailability and NO2 − were assessed. HFD-fed mice showed early obesity without severe disease symptoms. Arginase I mRNA and protein expression levels in the liver were significantly higher in HFD-fed obese mice than in CD-fed mice. Arginase I levels were slightly increased, whereas l-arginine levels were significantly reduced, and these changes were followed by reductions in NO2 − levels. Furthermore, hepatic arginase I levels positively correlated with plasma arginase I levels and negatively correlated with l-arginine bioavailability in plasma. These results suggested that increases in the expression of hepatic arginase I and reductions in plasma l-arginine and NO2 − levels might lead to vascular endothelial dysfunction in the pre-disease state of early obesity

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Id: 178899
Autor: Thirupathi, Anand; De Souza, Claudio Teodoro.
Título: Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
Fonte: J. physiol. biochem;73(4):487-494, nov. 2017. tab, graf.
Idioma: en.
Resumo: Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition

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Id: 177417
Autor: Moreno-Galarraga, L; Urriza Yeregui, L; Urriza Ripa, I; Fernández-Montero, A; Peñafiel freire, D; Viguria Sánchez, N.
Título: Evolución de la función pulmonar en niños con asma grave en tratamiento con omalizumab / Lung function evolution in children with severe asthma treated with omalizumab
Fonte: Acta pediatr. esp;76(9/10):105-108, sept.-oct. 2018. tab, graf.
Idioma: es.
Resumo: Introducción: Omalizumab es un anticuerpo monoclonal frente a la inmunoglobulina E utilizado en el tratamiento del asma alérgica grave. El objetivo de este estudio fue describir el efecto de omalizumab sobre los valores de la función pulmonar y la fracción exhalada de óxido nítrico (FeNO) en pacientes pediátricos. Material y métodos: Análisis estadístico de la función pulmonar y de la FeNO en los 13 niños tratados con omalizumab en el servicio de pediatría de un hospital terciario entre los años 2010 y 2016. Resultados: Se observa una mejoría estadísticamente significativa a los 3 meses de tratamiento que se mantiene estable en el tiempo, tanto en valores de función pulmonar (pretratamiento: capacidad vital forzada [FVC] 84,1% y volumen espiratorio forzado en el primer segundo [FEV1] 72%; postratamiento: FVC 101% [p= 0,02] y FEV1 92% (p= 0,01) como en la FeNO (pretratamiento: 82 ppb; postratamiento: 36 ppb). Conclusiones: En nuestros pacientes pediátricos con asma grave, omalizumab es capaz de mejorar y mantener estable en el tiempo la función pulmonar y disminuir el valor de la FeNO

Introduction: Omalizumab is a monoclonal antibody against immunoglobulin E used in the treatment of severe allergic asthma. The aim of this study was to describe, in pediatric patients, the effects of omalizumab in pulmonary function values and in the nitric oxide concentration levels in exhaled breath (FeNO). Material and methods: We performed a statistical analysis of lung function and FeNO evolution in 13 children treated with omalizumab in a pediatric service, between year 2010 and 2016. Results: A statistically significant improvement was observed after 3 months of treatment, which remained stable over time, in lung function values (pre-treatment: forced vital capacity [FVC] 84.1% and forced expiratory volume in the first second [FEV1] 72%; after treatment: FVC 101% [p= 0.02] and FEV1 92% [p= 0.01]). A significant improvement was also detected in the FeNO levels (pre-treatment: 82 ppb; after treatment: 36 ppb). Conclusions: In our pediatric patients with severe asthma, omalizumab was able to improve and maintain stable in time both pulmonary function and FeNO values
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Id: 176246
Autor: Alcázar-Navarrete, Bernardino; Castellano Miñán, Francisca; Santiago Díaz, Pablo; Ruiz Rodríguez, Oliveiro; Romero Palacios, Pedro J.
Título: Óxido nítrico alveolar y bronquial en la enfermedad pulmonar obstructiva crónica y el solapamiento de asma y EPOC (ACO) / Alveolar and Bronchial Nitric Oxide in Chronic Obstructive Pulmonary Disease and Asthma-COPD Overlap
Fonte: Arch. bronconeumol. (Ed. impr.);54(8):414-419, ago. 2018. graf, ilus.
Idioma: es.
Resumo: Introducción: La medición del óxido nítrico en el aire exhalado diferencia fenotipos de pacientes con EPOC del solapamiento de asma y EPOC (ACO). Hasta el momento no se ha estudiado si existen diferencias entre los componentes alveolar y bronquial del FENO en este grupo de pacientes. Métodos: Estudio observacional transversal realizado en consultas externas de Neumología, incluyendo a pacientes con diagnóstico de EPOC a los que se les realizó una determinación del óxido nítrico en aire exhalado - FENO - diferenciando en esta medida el componente alveolar -CANO- y el de vía aérea central -JawNO-, y realizando las mediciones a distintos flujos. Se compararon los valores de CANO y JawNO entre los pacientes con eosinofilia (definidos como aquellos pacientes con ≥ 300 eosinófilos/ μL en sangre periférica, o bien ≥ 2% eosinófilos o ≥ 3% eosinófilos) y se realizó un análisis de regresión lineal para estudiar las variables clínicas y biológicas que se asociaban a estas mediciones. Resultados: Participaron en el estudio 73 pacientes con EPOC. Los criterios de eosinofilia utilizados se asociaban a incrementos de los valores de CANO y de JawNO (en este último caso solo los criterios ≥ 300 eosinófilos y ≥ 3% eosinófilos). CANO se asoció al recuento de eosinófilos y PCR, y JawNO se asoció a tabaquismo y recuento de eosinófilos. Conclusiones: Los pacientes diagnosticados de EPOC y que tienen características de ACO muestran mayor inflamación a nivel bronquial y de vía aérea pequeña. CANO y JawNO se relacionan con variables clínicas y biológicas

Introduction: Exhaled nitric oxide (FENO) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. Methods: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO) from bronchial (JawNO) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements. Results: 73 COPD patients were included in the study. Eosinophil counts were associated with increased values of CANO and JawNO (for the latter only the association with ≥ 300 or ≥ 3% eosinophils was significant). CANO was also associated with CRP, and JawNO with smoking. Conclusions: Patients with COPD and ACO characteristics show increased inflammation in the large and small airways. CANO and JawNO are associated with clinical and biological variables
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Id: 174465
Autor: Alvarez Puebla, MJ; Aroabarren Aleman, E; Corcuera Garcia, A; Ibañez Bereiz, B; Iraola Iribar, A; Olaguibel Rivera, JM.
Título: Blood Eosinophils, Fraction of Exhaled Nitric Oxide, and Serum Eosinophil Cationic Protein as Surrogate Markers for Sputum Eosinophils in Asthma: Influence of Treatment With Inhaled Corticosteroids
Fonte: J. investig. allergol. clin. immunol;28(3):210-212, 2018. tab.
Idioma: en.
Resumo: No disponible
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Texto completo SciELO Espanha
Id: 174141
Autor: Moreira, SR; Nóbrega, OT; Santana, HAP; Sales, MM; Farinatti, PTV; Simões, HG.
Título: Impact of ACE I/D gene polymorphism on blood pressure, heart rate variability and nitric oxide responses to the aerobic exercise in hypertensive elderly / Impacto del polimorfismo I/D del gen de la Enzima Conversora de la Angiotensina en la presión sanguínea, variacion de la frecuencia cardíaca y óxido nítrico en respuesta a ejercicios aeróbicos en mayores hipertensos / Impacto do polimorfismo I/D do gene da ECA nas respostas de pressão arterial, variabilidade da frequência cardíaca e óxido nítrico ao exercício aeróbio em idosas hipertensas
Fonte: Rev. andal. med. deporte;11(2):57-62, abr.-jun. 2018. tab, graf.
Idioma: es.
Resumo: Objective. To analyze the impact of I/D polymorphism of the angiotensin-converting enzyme gene on the responses of 24 h blood pressure, heart rate variability and nitric oxide after moderate aerobic exercise session. Method. Twenty seven hypertensive elderly were genotyped for the I/D polymorphism of the angiotensin-converting enzyme gene (D/D: n=9; I/D: n=9; I/I: n=9) and performed a bout of aerobic exercise at 90% of anaerobic threshold. Measurements of mean blood pressure, heart rate variability and nitric oxide were performed before and during 24h post-aerobic exercise session. Results. The D/D genotype showed impaired mean arterial pressure responses (elevation) in the nocturnal sleep (10:30pm to 06:30am) post-aerobic exercise when compared to rest (D/D= -4.2±8.1mmHg; p>0.05, I/D=-9.2±9.1mmHg; p<0.05 and I/I=-7.0±6.9mmHg; p<0.05). Besides, in day time of 06:30am to 10:30am (next day) higher values of mean arterial pressure responses occur between D/D=4.7±4.6mmHg vs. I/D=−2.0±13.0mmHg; p<0.05. The carriers of the D allele, in addition to not release nitric oxide significantly post-aerobic exercise session (p>0.05), showed reduced elevation of nitric oxide between genotypes immediately after aerobic exercise (D/D=12.8±135.3μM and I/D=-8.7±69.0μM vs. I/I=132.9±188.7μM; p<0.05). Reduced elevation of heart rate variability post-aerobic exercise session occurred when compared to rest (D/D=1h: -0.08±0.09s; p<0.05 and 24h: -0.08±0.11s; p<0.05). Conclusion. Elderly hypertensive individuals carrying the D/D genotype of the angiotensin converting enzyme gene showed impaired responses of blood pressure post-aerobic exercise, especially during sleep, and reduced heart rate variability during the 24h post-aerobic exercise. Besides, to angiotensin converting enzyme genotypes with the presence of D allele (D/D and I/D) was impaired release of nitric oxide post-aerobic exercise session

Objetivo. Analizar el impacto del polimorfismo I/D del gen de la enzima conversora de la angiotensina en la presión sanguínea, variación de la frecuencia cardíaca y óxido nítrico durante 24h en espuesta a una batería moderada de ejercicios aeróbicos. Método. Veintisiete ancianas hipertensas fueron genotipadas para el polimorfismo I/D del gen de la enzima conversora de la angiotensina (D/D: n=9; I/D: n=9; I/I: n=9) y realizaron una batería de ejercicios aeróbicos al 90% del umbral anaeróbico. Se realizaron medidas de la presión arterial media, variabilidad de la frecuencia cardíaca y óxido nítrico, antes y durante las 24h siguientes después de una sesión de ejercicios aeróbicos. Resultados. El genotipo D/D presentó una respuesta inadecuada de la presión arterial media (aumento) durante el sueño nocturno después del ejercicio (22:30-06:30) en comparación con el reposo (D/D=-4.2±8.1mmHg; p>0.05, I/D=-9.2±9.1mmHg; p<0.05 and I/I=-7.0±6.9mmHg; p<0.05). Por otro lado, durante el día, de 06:30 hasta las 10:30 de la mañana (del día siguinete) se registraron valores elevados del aumento de la presión arterial media en el genotipo D/D=4.7±4.6mmHg vs. I/D=-2.0±13.0mmHg; p<0.05. Las portadoras del alelo D, más allá de no mostrar significación en los niveles de óxido nítrico después de la sesión de ejercicio, mostraron una reducción del incremento de óxido nítrico entre los genotipos después del ejercicio aeróbico (D/D=12.8±135.3μM y I/D=-8.7±69.0μM vs. I/I=132.9±188.7μM; p<0.05)...

Objetivo. Analisar o impacto do polimorfismo I/D do gene da enzima conversora da angiotensina na pressão sanguínea, variabilidade da frequência cardíaca e óxido nítrico durante 24h, em resposta a uma bateria moderada de exercícios aeróbicos. Método. Vinte e sete idosas hipertensas foram genotipadas para o polimorfismo I/D do gene da enzima conversora da angiotensina (D/D: n=9; I/D: n=9; I/I: n=9) e realizaram uma sessão de exercício aeróbio à 90% do limiar anaeróbio. Medidas de pressão arterial média, variabilidade da frequência cardíaca e óxido nítrico foram coletadas antes e durante as 24h seguintes, após a sessão de exercício aeróbio. Resultados. O genótipo D/D mostrou uma resposta inadequada da pressão arterial média (elevação) durante o sono após o exercício (22:30-06:30) em comparação ao repouso (D/D=-4.2±8.1mmHg; p>0.05, I/D=-9.2±9.1mmHg; p<0.05 e I/I=-7.0±6.9mmHg; p<0.05). Além disso, durante o dia, de 06:30-10:30da manhã (do dia seguinte), maiores valores de pressão arterial média ocorreram entre D/D=4.7±4.6mmHg vs. I/D=-2.0±13.0mmHg; p<0.05. O grupo carreador do alelo D, além de não revelar significância no óxido nítrico após a sessão de exercício, mostrou uma redução da elevação do óxido nítrico entre os genótipos logo após o exercício aeróbio (D/D=12.8±135.3μM e I/D=-8.7±69.0μM vs. I/I=132.9±188.7μM; p<0.05). Ocorreu uma redução do R-Ri após os exercícios quando comparada com os valores do repouso (D/D=1h: -0.08±0.09s; p<0.05 e 24h: -0.08±0.11s; p<0.05). Conclusão. Indivíduos idosos e hipertensos carreadores do genótipo D/D para o gene da enzima conversora da angiotensina mostraram resposta inadequada de pressão arterial pós-exercício aeróbio, especialmente durante o sono, e reduzida variabilidade da frequência cardíaca durante as 24h seguintes pós-exercício. Além disso, o genótipo da enzima conversora da angiotensina com a presença do alelo D (D/D e I/D) teve sua liberação de óxido nítrico prejudicada nos momentos após a sessão de exercício aeróbio
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Id: 173568
Autor: Yang, SY; Kim, YH; Byun, MK; Kim, HJ; Ahn, CM; Kim, SH; Lee, HS; Park, HJ.
Título: Repeated measurement of fractional exhaled nitric oxide is not essential for asthma screening
Fonte: J. investig. allergol. clin. immunol;28(2):98-105, 2018. tab, graf.
Idioma: en.
Resumo: Background: Older guidelines recommend that fractional exhaled nitric oxide (FeNO) should be checked more than twice during the same session to confirm an asthma diagnosis. Recent studies show the excellent reproducibility of FeNO measurements. Objective: We aimed to determine whether repeated FeNO measurements during the same session are necessary for asthma screening. Methods: We retrospectively reviewed the electronic medical records of adult outpatients who visited the respiratory medicine department for diagnosis of asthma and assessed FeNO measurements obtained from June 2016 to July 2017. Results: Of the 132 patients enrolled, 79 (59.8%) were diagnosed with asthma. Repeated FeNO measurements taken during the same session showed high reproducibility (intraclass correlation coefficient >0.9; P<.001) and a strong correlation (Pearson coefficient >0.9; P<.001), although reproducibility and correlation were slightly weaker in patients with low FeNO values. The value of repeated measurement was not significant; however, the second FeNO measurement was significantly higher than the first measurement in patients with the worst and best lung function. The predictive power of the first measurement of FeNO (sensitivity, 80.5%; specificity, 85.1%) was not inferior to the second (sensitivity, 76.6%; specificity 85.1%). The same was true of the geometric mean of the two. Conclusion: Repeated FeNO measurement during the same session is not essential for asthma screening in cases where the first acceptable FeNO measurement is performed using the proper method

Introducción: Aunque las guías más antiguas recomiendan que el óxido nítrico exhalado (FeNO) se determine más de dos veces en la misma sesión para el diagnóstico de asma, algunos estudios recientes han demostrado la excelente reproducibilidad de las mediciones de FeNO. Objetivo: Nuestro objetivo fue determinar si las mediciones repetidas de FeNO durante la misma sesión son necesarias para el cribado del asma. Métodos: Revisamos retrospectivamente los registros médicos electrónicos de pacientes adultos ambulatorios que visitaron el departamento de neumología para confirmar un diagnóstico de asma durante los meses de junio de 2016 a julio de 2017, y se evaluaron las mediciones de FeNO obtenidas. Resultados: De un total de 132 pacientes estudiados, 79 pacientes (59,8%) fueron diagnosticados con asma. Las mediciones repetidas de FeNO tomadas durante la misma sesión mostraron una alta reproducibilidad (coeficiente de correlación intraclase> 0,9; p <0,001) y una fuerte correlación (coeficiente de Pearson> 0,9; p <0,001); sin embargo, la reproducibilidad y la correlación fueron ligeramente más débiles en sujetos con valores bajos de FeNO. El valor de la medición repetida no fue significativamente diferente entre sí en general; sin embargo, la segunda medición de FeNO fue significativamente más alta que la primera medición en sujetos con valores de la función pulmonar más bajos y más altos. El poder predictivo de FeNO para el diagnóstico de asma medido la primera vez (sensibilidad, 80,5%; especificidad, 85,1%) no fue inferior al medido la segunda vez (sensibilidad, 76,6%; especificidad 85,1%) o la media geométrica uniforme de los dos. Conclusión: La medición repetida de FeNO durante la misma sesión no es esencial para el cribado del asma en los casos en que la primera medición de FeNO es aceptable y se realiza con el método adecuado
Responsável: ES1.1
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