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Pesquisa : D01.625.050 [Categoria DeCs]
Referências encontradas : 21 [refinar]
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  1 / 21 IBECS  
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Texto completo SciELO Espanha
Id: 177706
Autor: Gil-Gómez, Antonio; Gómez-Sotelo, Ana-Isabel; Ranchal, Isidora; Rojas, Ángela; García-Valdecasas, Marta; Muñoz-Hernández, Rocío; Gallego-Durán, Rocío; Ampuero, Javier; Romero-Gómez, Manuel.
Título: Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
Fonte: Rev. esp. enferm. dig;110(7):427-433, jul. 2018. graf.
Idioma: en.
Resumo: Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or a sham operation (n = 4). Porto-caval shunted animals were randomized into two groups (n = 8) and either received 30 mg/kg/day of metformin for two weeks or were control animals. Plasma ammonia concentration, Gls gene expression and K-type glutaminase activity were measured in the small intestine, muscle and kidney. Furthermore, Caco2 were grown in different culture media containing glucose/glutamine as the main carbon source and exposed to different concentrations of the drug. The expression of genes implicated in glutamine metabolism were analyzed. Results: metformin was associated with a significant inhibition of glutaminase activity levels in the small intestine of porto-caval shunted rats (0.277 ± 0.07 IU/mg vs 0.142 ± 0.04 IU/mg) and a significant decrease in plasma ammonia (204.3 ± 24.4 µg/dl vs 129.6 ± 16.1 µg/dl). Glucose withdrawal induced the expression of the glutamine transporter SLC1A5 (2.54 ± 0.33 fold change; p < 0.05). Metformin use reduced MYC levels in Caco2 and consequently, SLC1A5 and GLS expression, with a greater effect in cells dependent on glutaminolytic metabolism. Conclusion: metformin regulates ammonia homeostasis by modulating glutamine metabolism in the enterocyte, exerting an indirect control of both the uptake and degradation of glutamine. This entails a reduction in the production of metabolites and energy through this pathway and indirectly causes a decrease in ammonia production that could be related to a decreased risk of HE development

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  2 / 21 IBECS  
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Id: 176258
Autor: Ojanguren, Iñigo; Cloutier, Yves; Chaboillez, Simone; Lemiere, Catherine.
Título: Chlorine Inhalation Challenge in Humans: Development of a New Closed-Circuit Methodology / Prueba de provocación bronquial con cloro en humanos: desarrollo de una nueva metodología con circuito-cerrado
Fonte: Arch. bronconeumol. (Ed. impr.);54(8):440-442, ago. 2018. graf.
Idioma: en.
Resumo: No disponible
Responsável: ES1.1
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  3 / 21 IBECS  
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Texto completo SciELO Espanha
Id: 125301
Autor: Pellicer Corbí, M; Herranz Muñoz, C; Baldominos Utrilla, G; Fernández-Pacheco García-Valdecasas, M.
Título: Déficit parcial de ornitin-carbamil-transferasa. A propósito de un caso / Partial deficiency of ornithine transcarbamylase. A case report
Fonte: Farm. hosp;38(1):75-76, ene.-feb. 2014. tab.
Idioma: es.
Resumo: No disponible

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  4 / 21 IBECS  
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Id: 121654
Autor: Cebo, Daniel; Aschenbach, Jörg R; Kolisek, Martin.
Título: RETRACTED ARTICLE: Ammonium transport proteins from Archaeoglobus fulgidus
Fonte: J. physiol. biochem;69(4):963-963, dic. 2013.
Idioma: en.
Responsável: ES1.1
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  5 / 21 IBECS  
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Id: 118208
Autor: Plasencia, Anna; Gich, Frederic; Fillol, Mireia; Borrego, Carles M.
Título: Phylogenetic characterization and quantification of ammonia-oxidizing archaea and bacteria from Lake Kivu in a long-term microcosm incubation
Fonte: Int. microbiol;16(3):177-189, sept. 2013. ilus.
Idioma: en.
Resumo: A microcosm cultivation-based method was set up to investigate the growth of ammonia-oxidizing archaea (AOA), isolated from a water sample acquired at a depth of 50 m from the northern basin of Lake Kivu. For this purpose, both CARD-FISH and qPCR targeting of archaeal 16S rRNA and amoA genes were used. Archaeal cell growth at the end of the 246-day microcosm experiment accounted for 35% of the SybrGold-stained cells, which corresponded to 6.61 x 10(6) cells/ml and 1.76 +/- 0.09 x 10(6) archaeal 16S rRNA gene copies/ml. Clone libraries and DGGE fingerprinting confirmed the dominance of AOA phylotypes in the archaeal community microcosm. The majority of the identified archaeal 16S rRNA gene sequences in the clone libraries were affiliated with Thaumarchaeota Marine Group 1 .1a. Subsequent cultivation of the AOA community on deep-well microtiter plates in medium containing different carbon sources to stimulate archaeal growth failed to show significant differences in archaeal abundance (ANOVA t14 = -1.058, P = 0.308 and ANOVA t14= 1.584, P = 0.135 for yeast extract and simple organic acids, respectively). The lack of growth stimulation by organic compounds is in concordance with the oligotrophic status of Lake Kivu. Finally, the addition of antibiotics to the growth medium resulted in archaeal cell counts that were significantly lower than those obtained from cultures in antibiotic-free medium (ANOVA t14 = 12.12, P < 0.001) (AU)

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  6 / 21 IBECS  
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Texto completo SciELO Espanha
Id: 114512
Autor: Escobar, Laura; Mejía, Natalia; Gil, Helena; Santos, Fernando.
Título: La acidosis tubular renal distal: una enfermedad hereditaria en la que no se pueden eliminar los hidrogeniones / Distal renal tubular acidosis: a hereditary disease with an inadequate urinary H+ excretion
Fonte: Nefrología (Madrid);33(3):289-296, abr.-jun. 2013. ilus.
Idioma: es.
Resumo: La acidosis tubular renal distal (ATRD) o ATR tipo I se caracteriza por una disminución en la excreción urinaria de los hidrogeniones H+ y del amonio. En los niños afectados por ATRD hay retraso en el crecimiento, vómito, estreñimiento, falta de apetito, polidipsia y poliuria, nefrocalcinosis, debilidad y hasta parálisis muscular por la hipopotasemia. En este trabajo se resumen los avances en el estudio genético de la ATRD en las poblaciones hasta ahora estudiadas. La ATRD es heterogénea, por lo que también se analizan los transportadores y canales iónicos que se han identificado hasta ahora en las células intercaladas alfa del túbulo colector, y que podrían explicar los casos de ATRD que no se asocian con los genes hasta ahora estudiados. La ATRD puede ser autosómica dominante o autosómica recesiva. La ATRD autosómica recesiva se manifiesta en los primeros meses de vida, cursa con nefrocalcinosis y sordera temprana o tardía. La ATRD autosómica dominante es menos severa y aparece en la adolescencia o en la etapa adulta, y puede o no presentar nefrocalcinosis. En las células intercaladas alfa de los túbulos colectores se lleva a cabo la excreción urinaria de la carga ácida: los ácidos titulables (fosfatos) y el amonio. La ATRD autosómica recesiva se asocia con mutaciones en los genes ATP6V1B1, ATP6V0A4 y SLC4A1, los cuales codifican las subunidades a4 y B1 de la V-ATPasa y el intercambiador de bicarbonato/cloruro AE1, respectivamente. En contraste, la ATRD autosómica dominante se relaciona con mutaciones solo en AE1 (AU)

Distal renal tubular acidosis (dRTA) or RTA type I is characterised by reduced H+ hydrogen ions and ammonium urinary excretion. In children affected by dRTA there is stunted growth, vomiting, constipation, loss of appetite, polydipsia and polyuria, nephrocalcinosis, weakness and muscle paralysis due to hypokalaemia. This work summarises progress made in dRTA genetic studies in populations studied so far. DRTA is heterogeneous and as such, transporters and ion channels are analysed which have been identified in alpha-intercalated cells of the collecting duct, which could explain cases of dRTA not associated with the hitherto studied genes. DRTA can be autosomal dominant or autosomal recessive. Autosomal recessive dRTA appears in the first months of life and progresses with nephrocalcinosis and early or late hearing loss. Autosomal dominant dRTA is less severe and appears during adolescence or adulthood and may or may not develop nephrocalcinosis. In alpha-intercalated cells of the collecting duct, the acid load is deposited into the urine as titratable acids (phosphates) and ammonium. Autosomal recessive dRTA is associated with mutations in genes ATP6V1B1, ATP6V0A4 and SLC4A1, which encode subunits a4 and B1 of V-ATPase and the AE1 bicarbonate/chloride exchanger respectively. By contrast, autosomal dominant dRTA is only related to mutations in AE1 (AU)
Responsável: ES1.1
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  7 / 21 IBECS  
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Id: 110488
Autor: Ortega, Luis M; Arora, Swati.
Título: Metabolic acidosis and progression of chronic kidney disease: incidence, pathogenesis, and therapeutic options
Fonte: Nefrología (Madrid);32(6):724-730, nov.-dic. 2012. tab.
Idioma: en.
Resumo: In the chronic kidney disease population metabolic acidosis is prevalent presenting already in the early stages of renal dysfunction. The pathogenesis associates the lack of bicarbonate production with the accumulation of organic/inorganic acids and the development of tubulointerstitial damage through ammonium retention and complement deposition. The empiric use of oral sodium bicarbonate represents an interesting therapeutic option that has been documented in a few clinical trials in human subjects. The availability of oral sodium, in its diverse forms, represents an inexpensive and simple way of treating an entity that could hasten the progression of kidney disease, as well as protein catabolism, bone disease and mortality (AU)

Hay una prevalencia importante de la acidosis metabólica en los pacientes que padecen enfermedad renal crónica, presentándose en niveles tempranos de pérdida de filtrado glomerular. La patogénesis se basa en la falta de síntesis de bicarbonato sérico con la acumulación de ácidos de naturaleza orgánica e inorgánica, ocasionando daño tubulointersticial a través de la retención de amoniaco y el depósito de complemento, aunque esta última hipótesis se ha cuestionado en el pasado. El uso empírico de bicarbonato oral representa una opción terapéutica interesante que ha sido utilizada en estudios clínicos recientes. La disponibilidad de bicarbonato de sodio oral en sus diversas formas representa una opción barata y simple de utilizar para decelerar la progresión de la enfermedad renal, sin mencionar las mejoras en el catabolismo proteico, la osteodistrofia renal y la mortalidad (AU)
Responsável: ES1.1
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  8 / 21 IBECS  
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Texto completo SciELO Espanha
Id: 71052
Autor: García Martínez, R; Córdoba Cardona, J.
Título: Actualización en el tratamiento de la encefalopatía hepática / Update on the management of hepatic encephalopathy
Fonte: Rev. esp. enferm. dig;100(10):637-644, oct. 2008. ilus, tab.
Idioma: Es.
Resumo: No disponible
Responsável: ES15.1 - Biblioteca Nacional de Ciencias de la Salud
ES15.1 - BNCS


  9 / 21 IBECS  
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Id: 054096
Autor: Pérez-Fidalgo, J. A; Chirivella González, I; Günthner, S; Cervera Miguel, J. I; March Villalba, J. A; Cervantes Ruipérez, A.
Título: La encefalopatía hiperamonémica, una posible complicación por derivación urinaria tras cistectomía radical. Revisión de la literatura a proposito de un caso / Hyperammonaemic encephalopathy, possible complication after urinary diversion in radical cystectomy. Review of the literature with regard to a clinical case
Fonte: Actas urol. esp;31(4):394-399, abr. 2007. ilus, tab.
Idioma: Es; Fr.
Resumo: Introducción: La cistectomía radical es una intervención con una elevada morbilidad. Las derivaciones postcistectomía pueden ocasionar complicaciones metabólicas como la encefalopatía hiperamonémica. Caso Clínico: Presentamos el caso de una paciente cistectomizada por un carcinoma vesical con posterior ureterosigmoidostomía. Tras la intervención acudió en 4 ocasiones con síntomas neurológicos y confusión. Todo el estudio analítico y pruebas de imagen fueron normales. Los niveles de amonio en sangre estaban elevados. Tras tratamiento de soporte y hemodiálisis la clínica desapareció. Posteriormente fue sometida a una nueva derivación quirúrgica (conducto ileal). Discusión: El empleo de técnicas de derivación continentes tras la cistectomía se aconseja ante la importante afectación de la calidad de vida que produce el conducto ileal. Sin embargo, estas técnicas tienen complicaciones, como la encefalopatía hiperamonémica de causa no hepática. La elevada absorción de amonio por el epitelio intestinal de la neovejiga induce una encefalopatía. Es esencial su diagnóstico temprano con el fin de iniciar un tratamiento eficaz

Introduction: Radical cystectomy is an intervention with an important morbidity. Urinary diversion is a possible cause of metabolic complications like hyperammonaemic encephalopathy. Case report: We present the case of a patient treated with a radical cystectomy and modified ureterosigmoidostomy after diagnosis of bladder cancer. After surgery the patient presented in 4 ocasions recurrent episodic confusion. Laboratory and image tests were normal. Levels of seric ammonium was increased. After supportive treatment and hemodyalisis symptoms disappeared. Later patient was reoperated and a reconstruction to ileal conduit was made. Discussion: Continent urinary diversions are advised due to important negative impact on quality of life produced by ileal conduit. However these diversions have several complications, like encephalopathy secondary to non-hepatic hyperammonaemia. Increased absortion of ammonium by intestinal tissue of the new-ladder induces encephalopathy. Early diagnosis of this complication is essencial in order to administer an effective treatment
Responsável: ES1.1
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  10 / 21 IBECS  
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Id: 043568
Autor: Bordel, M. Teresa; Miranda, Alberto.
Título: Nevo comedoniano unilateral: eficacia tras el tratamiento con lactato amónico al 12 por ciento / Unilateral nevus comedonicus: efficacy after treatment with 12% ammonium lactate
Fonte: Actas dermo-sifiliogr. (Ed. impr.);97(2):150-150, mar. 2006.
Idioma: Es.
Responsável: ES1.1
ES1.1 - BNCS



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