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Id: 180777
Autor: Cheng, L; Zhou, W-C.
Título: Sublingual immunotherapy of house dust mite respiratory allergy in China
Fonte: Allergol. immunopatol;47(1):85-89, ene.-feb. 2019. tab.
Idioma: en.
Resumo: Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed. Nevertheless, there are still several factors restricting its application in China, such as the uncertainty of its long-term effects and the prevention of new sensitizations onset, the risk of asthma attacks, the low public awareness of SLIT and poor compliance by patients. This is a narrative review of current evidence on SLIT coming from China

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Id: 174554
Autor: Bai, S; Hua, L; Wang, X; Liu, Q; Bao, Y.
Título: Association of a 4-Locus Gene Model Including IL13, IL4, FCER1B, and ADRB2 With the Asthma Predictive Index and Atopy in Chinese Han Children
Fonte: J. investig. allergol. clin. immunol;28(6):407-413, 2018. tab.
Idioma: en.
Resumo: Background: Asthma is a complex and heterogeneous disease. We found gene-gene interactions between IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic Chinese Han children. This 4-locus set constituted an optimal statistical interaction model. Objective: We examined associations between the 4-gene model (IL13, IL4, FCER1B, and ADRB2) and the Asthma Predictive Index (API) and atopy in Chinese Han children. Methods: Four single-nucleotide polymorphisms in the 4 genes were genotyped in 385 preschool children with wheezing symptoms using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The t test and x2 tests were used for the analysis. Results: Significant correlations were found between the 4-locus gene model and a stringent and loose API (both P<.0001). Additionally, a high-risk asthma genotype was a risk factor for a positive API (stringent API, OR=4.08; loose API, OR=2.36). We also found a statistically significant association between the 4-locus gene model and atopy (P<.01, OR=2.09). Conclusions: Our results indicated that the 4-locus gene model consisting of L13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 was associated with the API and atopy. These findings provide evidence that this gene model can be used to determine a high risk of developing asthma and atopy in Chinese Han children

Antecedentes: El asma es una enfermedad compleja y heterogénea. En este estudio, encontramos que las interacciones gen-gen entre IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713 y FCER1B rs569108, en niños asmáticos de nacionalidad china Han, constituyen un modelo estadístico óptimo de interacción. Objetivo: Este estudio examinó un modelo de las asociaciones de cuatro genes (IL13, IL4, FCER1B y ADRB2) con el Índice Predictivo de Asma (IPA) y la atopia en niños Han chinos. Métodos: Se genotiparon cuatro polimorfismos de un solo nucleótido (SNP) en los cuatro genes, en 385 niños en edad preescolar con síntomas de sibilancias, utilizando espectrometría de masas con desorción/ionización mediante láser asistida por Matriz (MALDI). Para el análisis estadístico de utilizaron el test t de Student y el c2. Resultados: Se encontraron correlaciones significativas entre el modelo génico de los cuatro locus y el valor de IPA estricto y laxo (ambos P <0,0001). Además, el genotipo de riesgo alto de asma fue un factor de riesgo para IPA positivo (IPA estricto: OR = 4,08, IPA laxo: OR = 2,36). También, encontramos una asociación estadísticamente significativa entre el modelo génico de los cuatro locus, con atopia (P <0,01, OR = 2,09). Conclusiones: Nuestros resultados indicaron que el modelo génico de cuatro locus compuesto por L13 rs20541, IL4 rs2243250, ADRB2 rs1042713 y FCER1B rs569108 estaba asociado con IPA y atopia. Estos hallazgos proporcionan la evidencia de la utilidad de este modelo génico para determinar el riesgo alto de desarrollar asma y atopia en niños chinos Han
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Id: 168461
Autor: Liu, JL; Ning, WX; Li, SX; Xu, YC; Wu, L; Wang, YS; Xu, XF; Jiang, Y; Sheng, YJ; Zhou, YL; Wang, JH; Tang, LF; Chen, ZM.
Título: The safety profile of subcutaneous allergen immunotherapy in children with asthma in Hangzhou, East China
Fonte: Allergol. immunopatol;45(6):541-548, nov.-dic. 2017. tab, graf.
Idioma: en.
Resumo: Background: The aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (SRs) to subcutaneous allergen immunotherapy (SCIT) in children and adolescents with asthma in Hangzhou, east China's Zhejiang province. Methods: From January 2011 to December 2016, this survey analysed the SCIT-related SRs involving 429 patients (265 children and 134 adolescents) affected by allergic asthma. Recorded data included demographics, diagnosis, patient statuses, pulmonary function testing results before and after each injection, allergen dosage, and details of SRs. Results: All patients finished the initial phase and six patients withdrew during the maintenance phase. There were 2.59% (328/12,655) SRs in all injections (3.28% in children and 1.47% in adolescents); 15.62% (67/429) patients experienced SRs (18.49% children and 10.98% adolescents). There were 54.57% SRs of grade 1; 42.37% SRs of grade 2; 3.05% SRs of grade 3; and no grades 4 or grade 5 SRs occurred in patients. Most reactions were mild, and were readily controlled by immediate emergency treatment. There was no need for hospitalisation. The occurrence of SRs was significantly higher in children than that in adolescents (p < 0.01). A higher ratio of SRs was found among patients with moderate asthma. Conclusion: This retrospective survey showed that properly-conducted SCIT was a safe treatment for children and adolescents with asthma in Hangzhou, East China. Children and patients with moderate asthma may be prone to develop SRs (AU)

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Id: 166996
Autor: Chen, JB; Zhang, J; Hu, HZ; Xue, M; Jin, YJ.
Título: Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population
Fonte: Allergol. immunopatol;45(5):432-438, sept.-oct. 2017. tab, ilus.
Idioma: en.
Resumo: Objective: To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children. Methods: 572 adolescent asthma patients and 590 age-matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of TGFB1, rs2378383 of TLE4, rs2523924 of MUC22, and rs907092 of IKZF3. Allele frequencies of the patients and the control group were compared by the Chi-square test. The Student t test was used to analyse the relationship between genotypes and clinical feature of the patients. Results: Patients were found to have significantly different frequencies of allele A of rs2241715, allele G of rs2378383 and allele A of rs2523924 as compared with the controls (40.4% vs. 45.9%, p = 0.01 for rs2241715; 17.2% vs. 13.4%, p=0.01 for rs2378383; 15.3% vs. 11.9%, p = 0.02 for rs2523924). For patients with severe asthma, those with genotype AA/AG of rs2241715 had remarkably higher FEV1% as compared with those with genotype GG (59.1 ± 4.3% vs. 55.4 ± 3.7%, p < 0.001). Moreover, those with genotype GG/GA of rs2378383 had remarkably lower FEV1% as compared with those with genotype AA (54.6 seg ± 2.9% vs. 58.6 ± 4.1%, p < 0.001). Conclusions: Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population. Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children (AU)

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Id: 165298
Autor: Liu, Hao; Dai, Xia.
Título: Correlation between physical activity and self-efficacy in Chinese university students / Correlación entre la actividad física y la autoeficacia en estudiantes universitarios chinos
Fonte: Rev. psicol. deport;26(supl.4):110-114, 2017. tab.
Idioma: en.
Resumo: Physical inactivity is becoming increasingly prevalent in Chinese university students. This study aims to assess the leisure-time physical activity level of the Chinese university students and to examine the correlation between the physical activity level and the self-efficacy to overcome barriers to physical activity. Five hundred and thirty Chinese university students participated in the study voluntarily. The International Physical Activity Questionnaire (IPAQ, Chinese Short version) and the Self-Efficacy to Overcome Barriers to Physical Activity Scale (SOBPAS) are adopted. The results suggested: (1) the level of leisure-time physical activity in Chinese University students is relatively low; (2) self-efficacy to overcome barriers to physical activity is significantly correlated with the physical activity, it can be used as a predictor of university students' leisure time physical activity (AU)

La inactividad física es cada vez más frecuente en los estudiantes universitarios chinos. Este estudio tiene como objetivo evaluar el nivel de actividad física de los estudiantes universitarios chinos y examinar la correlación entre el nivel de actividad física y la autoeficacia para superar las barreras a la actividad física. Quinientos treinta estudiantes universitarios chinos participaron voluntariamente en el estudio. Se aprueban el Cuestionario Internacional de Actividad Física (IPAQ, Versión Corta Chino) y la Autoeficacia para Superar Barreras a la Escala de Actividad Física (SOBPAS). Los resultados sugieren: 1) que el nivel de actividad física en los estudiantes universitarios chinos es relativamente bajo; (2) la autoeficacia para superar las barreras a la actividad física está significativamente correlacionada con la actividad física, puede ser utilizado como predictor de la actividad física de los estudiantes universitarios de tiempo libre (AU)
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Id: 162723
Autor: Lin, Yanhui; Chen, Zhiheng; Guo, Xu; Deng, Yulin.
Título: Valor de los parámetros de EZSCAN para el cribado de diabetes en la población china / Value of EZSCAN parameters for diabetes screening in Chinese
Fonte: Med. clín (Ed. impr.);148(10):444-448, mayo 2017. tab, graf.
Idioma: es.
Resumo: Objetivo: Estudiar los parámetros de EZSCAN como herramienta de cribado de la diabetes en la población china. Métodos: En el estudio participaron 6.270 sujetos. A todos ellos se les realizó la prueba EZSCAN, la prueba de fasting plasma glucose (FPG, «glucosa plasmática en ayunas»), el test de tolerancia oral de la glucosa y HbA1c. Resultados: 1. Se dividió a los sujetos en 4 grupos: el grupo normal, el grupo de riesgo bajo, formado por sujetos con anomalías metabólicas del azúcar, el grupo de riesgo medio y el grupo de alto riesgo. La diferencia en cuanto a incidencia de diabetes entre los 4 grupos fue estadísticamente significativa. Con el incremento de la puntuación EZSCAN, la prevalencia de diabetes se incrementó significativamente. Pero no se produjo diferencia estadísticamente significativa entre el grupo de bajo riesgo y el de riesgo medio. 2. Tras ajustar otras variables, se produjo una relación significativamente positiva entre la puntuación de riesgo EZSCAN y el riesgo de diabetes, mientras que no se produjo una diferencia estadísticamente significativa entre el grupo de bajo riesgo y el de riesgo medio. 3. El punto de corte de EZSCAN para la diabetes fue del 44,5%, con una sensibilidad del 73,2%, que fue superior a FPG y HbA1c. Conclusión:A medida que aumenta la puntuación de riesgo de diabetes EZSCAN, se incrementa el riesgo de la enfermedad. EZSCAN puede utilizarse como herramienta de cribado de la diabetes. Con un valor de punto de corte para el cribado de la diabetes del 44,5%, la sensibilidad es superior a la de los métodos tradicionales FPG y HbA1c (AU)

Objective: To study the parameters of EZSCAN as a screening tool for diabetes in Chinese. Methods: A total of 6,270 subjects participated in the study. All subjects underwent tests of EZSCAN, fasting plasma glucose (FPG), oral glucose tolerance test and HbA1c. Results: 1. All subjects were divided into 4 groups: the normal group, sugar metabolic abnormalities as low-risk group, middle-risk group and high-risk group. The difference of diabetes incidence among the 4 groups was statistically significant. With the increase of EZSCAN score, the prevalence of diabetes increased significantly. But there is no statistically difference between the low-risk group and the middle-risk group. 2. After adjustment for other variables, there is significantly positive relationship among EZSCAN risk score and the risk of diabetes. Meanwhile there is no statistically difference between the low-risk group and the middle-risk group. 3. The cut-off point of EZSCAN for diabetes was 44.5% with the sensitivity was 73.2% which was higher than of FPG and HbA1c. Conclusion: As EZSCAN-diabetes risk score increases, the risk of diabetes increases. EZSCAN can be used as a tool for screening for diabetes. At the best screening diabetes cut-off point value 44.5%, the sensitivity is higher than traditional method of FPG and HbA1c (AU)
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Id: 161240
Autor: Duan, Shi Jun; Huang, Ning; Zhang, Bi He; Shi, Jia Yu; He, Sha; Ma, Jian; Yu, Qiong Qiong; Shi, Bing; Jia, Zhong Lin.
Título: New insights from GWAS for the cleft palate among han Chinese population
Fonte: Med. oral patol. oral cir. bucal (Internet);22(2):e219-e227, mar. 2017. graf, tab, ilus.
Idioma: en.
Resumo: Background: Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, whether these loci associated with nonsyndromic cleft palate only (NSCPO) remains unknown. Material and Methods: In this study, we replicated 38 SNPs (Single nucleotide polymorphisms) which has the most significant p values in published GWASs, genotyping by using SNPscan among 144 NSCPO trios from Western Han Chinese. We performed the transmission disequilibrium test (TDT) on individual SNPs and gene-gene (GxG) interaction analyses on the family data; Parent-of-Origin effects were assessed by separately considering transmissions from heterozygous fathers versus heterozygous mothers to affected offspring. Results: Allelic TDT results showed that T allele at rs742071 (PAX7) (p=0.025, ORtransmission=3.00, 95%CI: 1.09- 8.25) and G allele at rs2485893 (10kb 3' of SYT14) were associated with NSCPO (p=0.0036, ORtransmission= 0.60, 95%CI: 0.42-0.85). Genotypic TDT based on 3 pseudo controls further confirmed that rs742071 (p-value=0.03, ORtransmission=3.00, 95%CI: 1.09-8.25) and rs2485893 were associated with NSCPO under additive model (p-value= 0.02, ORtransmission= 0.66, 95%CI: 0.47-0.92). Genotypic TDT for epistatic interactions showed that rs4844913 (37kb 3' of DIEXF) interacted with rs11119388 (SYT14) (p-value=1.80E-08) and rs6072081 (53kb 3' of MAFB) interacted with rs6102085 (33kb 3' of MAFB) (p-value=3.60E-04) for NSCPO, suggesting they may act in the same pathway in the etiology of NSCPO. Conclusions: In this study, we found that rs742071 and rs2485893 were associated NSCPO from Han Chinese population; also, interactions of rs4844913:rs11119388 and rs6072081:rs6102085 for NSCPO were identified, genegene interactions have been proposed as a potential source of the remaining heritability, these findings provided new insights of the previous GWAS (AU)

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Id: 161158
Autor: Zhan, Xiao-Dong; Li, Chao-Pin; Yang, Bang-He; Zhu, Yu-Xia; Tian, Ye; Shen, Jing; Zhao, Jin-Hong.
Título: Investigation on the zoonotic trematode species and their natural infection status in Huainan areas of China / Investigación sobre las especies de trematodos zoonóticos y su estado natural de infección en las zonas de Huainan en China
Fonte: Nutr. hosp;34(1):175-179, ene.-feb. 2017. tab.
Idioma: en.
Resumo: Background: To investigate the species of zoonotic trematodes and the endemic infection status in the domestic animals in Huainan areas, north Anhui province of China, we intent to provide evidences for prevention of the parasitic zoonoses. Methods: The livestock and poultry (definitive hosts) were purchased from the farmers living in the water areas, including South Luohe, Yaohe, Jiaogang and Gaotang Lakes, and dissected the viscera of these collected hosts to obtain the parasitic samples. Then the specimens were microscopically identified, with reference to the descriptions in previous literatures for counting the zoonotic species found in these areas. Results: A total of 41 species were detected in the domestic samples, in which 23 were zoonotic trematodes, and 18 were internal trematodes of animals. Of the 41 species, 38 were novel records in Huainan areas, and 12 were newly detected in Anhui province, including Metorchis anatinus, Echinostoma hortense, E. cinetorchis, E. angustitestis, E. lindoensis, E. nordiana, E. ilocanum, Metagonimus yokogawai, Prosthogonimus gracilis, P. skrjabini, P. anatinus and Trichobilharzia sp. which generally occurred in definitive hosts of chicken, ducks, geese, dogs, cattle, buffaloes, sheep, goats and pigs, respectively. Conclusion: A large quantity of livestock and poultry are fed by the local farmers living along the river banks in Huainan area, suggesting that the population in that area are at higher risks of natural focus of zoonotic infections, since these animals are favorable definitive hosts to the zoonotic trematodes (AU)

Introducción: para investigar las especies de trematodos zoonóticos y el estado de infección endémica en los animales domésticos en áreas de Huainan, al norte de la provincia de Anhui, China, tenemos la intención de proporcionar evidencias para la prevención de enfermedades zoonóticas. Métodos: el ganado y las aves (hospedadores definitivos) fueron adquiridos a los campesinos que viven en las zonas con agua, incluyendo el sur de Luohe, Yaohe, Jiaogang y Gaotang Lagos, y se diseccionaron las vísceras de estos anfitriones recogidos para obtener las muestras parasitarias. Las muestras fueron identificadas microscópicamente, con referencia a las descripciones de la literatura revisada para contar las especies zoonóticas que se encuentran en estas áreas. Resultados: se detectaron un total de 41 especies en las muestras nacionales, de las que 23 eran trematodos zoonóticos y 18 eran trematodos internos de los animales. Estas especies representaron 22 géneros en 12 familias de 4 órdenes. De las 41 especies, 38 fueron registros nuevos en las áreas de Huainan y 12 fueron detectadas recientemente en la provincia de Anhui, incluyendo Metorchis anatinus, Echinostoma hortense, E. cinetorchis, E. angustitestis, E. lindoensis, E. nordiana, Euparyphium ilocanum, Metagonimus yokogawai, Prosthogonimus gracilis, P. skrjabini, P. anatinus y Trichobilharzia sp., generalmente producidos en huéspedes definitivos de pollo, patos, gansos, perros, vacas, búfalos, ovejas, cabras y cerdos, respectivamente. Conclusión: los agricultores locales que viven a lo largo de las orillas del río se alimentan de gran cantidad de ganado y aves de corral de la zona de Huainan, lo que sugiere que la población en esa área tiene mayor riesgo ante el foco natural de las infecciones zoonóticas, ya que estos animales son huéspedes definitivos favorables a los trematodos zoonóticos (AU)
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Id: 160282
Autor: Xu, Menglin; Leung, Shing-On.
Título: Bifactor structure for the categorical Chinese Rosenberg Self-Esteem Scale
Fonte: Span. j. psychol;19(1):e67.1-e67.11, 2016. tab, graf.
Idioma: en.
Resumo: Recently, the bifactor model was suggested for the latent structure of the Rosenberg Self-Esteem Scale (RSES). The present paper investigates (i) the differences among bifactor, bifactor negative and other models; (ii) the effects of treating data as both categorical vs continuous; (iii) whether a problematic item in the Chinese RSES should be removed; and (iv) whether the final scoring would be affected. With a sample of 1.734 grade 4-6 school pupils in Hong Kong, we used BIC differences in addition to the usual model fit indices, and found that there was strong evidence for using the bifactor model (RMSEA = .052, 90% CI [.043, .062], CFI = .992, TLI = .984 for 9-item RSES categorical). Little difference is found between treating data as categorical or continuous for fit indices, but the factor loading patterns are better in categorical case. Keeping a problematic item has little effect on fit indices, but would lead to unexpected negative loading. The ranking of loadings within positive and negative items across different conditions are the same, which has important effects on scoring. Loadings in the method effects in the bifactor models are all positive (p < .001), which is different from previous research. All models show similar results on scoring, and support the usual simple sum score in most practice (AU)

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Id: 159776
Autor: Wang, Yang; Liu, Jiannan; Yin, Xuelai; Hu, Jingzhou; Kalfarentzos, Evagelos; Zhang, Chenping; Xu, Liqun.
Título: Venous thromboembolism after oral and maxillofacial oncologic surgery: Report and analysis of 14 cases in Chinese population
Fonte: Med. oral patol. oral cir. bucal (Internet);22(1):e115-e121, ene. 2017. ilus, tab.
Idioma: en.
Resumo: Background: Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) is a leading cause of death in cancer patients. The aim of this study was to explore the potential risk factor of VTE in oral and maxillofacial oncological surgery. Material and Methods: The data of patients who received operation in our institution were gathered in this retrospective study. A diagnosis of VTE was screened and confirmed by computer tomography angiography (CTA) of pulmonary artery or ultrasonography examination of lower extremity. Medical history and all perioperative details were analyzed. Results: 14 patients were diagnosed as VTE, including 6 cases of PE, 7 cases of DVT, 1case of DVT and PE. The mean age of these patients was 62.07 years. Reconstruction was performed in 12 patients of these cases, most of which were diagnosed as malignance. Mean length of surgery was 8.74 hours, and lower extremity deep venous cannula (DVC) was performed in all these patients. Conclusions: We analyzed several characters of oral and maxillofacial surgery and suggested pay attention to lower extremity DVC which had a high correlation with DVT according to our data (AU)

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