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Id: 178071
Autor: Mostaza Prieto, José María.
Título: Sobre el descubrimiento de los fármacos hipolipemiantes / About the discovery of hypolipidemic drugs
Fonte: Med. clín (Ed. impr.);130(18):698-703, mayo 2008. ilus, graf.
Idioma: es.
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Id: 171374
Autor: Oshima, Fumiyo; Iwasa, Kazunori; Nishinaka, Hirofumi; Suzuki, Takanobu; Umehara, Saika; Fukui, Itaru; Shimizu, Eiji.
Título: Factor structure and reliability of the japanese version of the young schema questionnaire short form
Fonte: Int. j. psychol. psychol. ther. (Ed. impr.);18(1):99-109, ene. 2018. tab.
Idioma: en.
Resumo: The Young Schema Questionnaire-Short Form (YSQ-SF) is one of the most widely used measures of individual early maladaptive schemas in schema therapy, and this study examined the factor structure and reliability of its Japanese version (YSQ-SF-J). We created a subsample to ensure the samples' mutual independence (N= 248, mean age= 19.75; 121 females). Then, Japanese participants (N= 800) completed the Japanese-translated YSQ-SF. Participants were divided into 2 samples: Sample 1 (n= 700, mean age= 23.05; 350 females); and Sample 2 (n= 100, mean age= 20.27; 50 females) for test-retest reliability. Exploratory and confirmatory factor analyses revealed that the YSQ-SF-J's item-factor structure was identical to the English version. Moreover, the scale showed good internal consistency and test-retest reliability. Results revealed the scale's adequate psychometric properties. Thus, this study provided the first examples of empirical support for the YSQ-SF-J (AU)

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Id: 170556
Autor: Uhara, H; Kiyohara, Y; Tsuda, A; Takata, M; Yamazaki, N.
Título: Characteristics of adverse drug reactions in a vemurafenib early post-marketing phase vigilance study in Japan
Fonte: Clin. transl. oncol. (Print);20(2):169-175, feb. 2018. tab.
Idioma: en.
Resumo: Background. Post-approval research or monitoring is important to determine real-world safety of new products; however, evidence is scant for vemurafenib in Japanese patients. In Japan, a unique system is officially obligated to investigate post-approval safety. Here we report the first adverse drug reaction (ADR) data from vemurafenib-treated Japanese patients with metastatic melanoma. Data were collected in an early post-marketing phase vigilance (EPPV) study. Methods. ADRs were events for which a causal relationship with vemurafenib could not be ruled out or was unknown. ADR data were collected for patients treated with vemurafenib (960 mg bid) between 26 February and 25 August 2015. Results. Among 95 patients, 46 patients had 118 ADRs (24 serious ADRs in 13 patients). The most common serious ADRs were hypersensitivity (n = 1; 3 events), arthralgia (n = 2; 2 events), pyrexia (n = 2; 2 events) and drug eruption (n = 2; 2 events). Seven patients had serious skin disorders or hypersensitivity, six of whom had prior anti-programmed cell death-1 (PD-1) antibodies 5û35 days before starting vemurafenib. ADR reports of serious skin disorders appeared to be collected more rapidly than previously reported. Cutaneous squamous cell carcinoma developed in only one patient. Conclusions. EPPV in Japanese vemurafenib-treated patients identified no new safety signals. The most serious skin and hypersensitivity ADRs occurred in patients with prior anti-PD-1 exposure. Cutaneous squamous cell carcinoma appeared to be rare in Japanese patients. Further research is needed to clarify whether prior treatment with anti-PD-1 agents or racial differences affect the characteristic profile of cutaneous ADRs in Japanese patients (AU)

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Id: 152073
Autor: Kobayashi, H; Naito, M; Masuya, M; Maruyama, M; Urata, K; Takahashi, Y; Tomaru, A; Fujiwara, K; Ohnishi, M; Takagi, T; Kobayashi, T; D,Alessandro-Gabazza, C; Urawa, M; Gabazza, EC; Taguchi, O; Takei, Y.
Título: Circulating fibrocytes correlate with the asthma control test score
Fonte: Allergol. immunopatol;44(3):191-196, mayo-jun. 2016. tab, graf.
Idioma: en.
Resumo: Background: Bronchial asthma is characterised by airway inflammation and remodelling with a decline of lung function. Fibrocytes are bone marrow-derived mesenchymal progenitor cells that play important roles in the pathogenesis of airway remodelling. Several clinical parameters are currently being used in routine clinical practice to assess outcome of therapy in asthma including frequency of rescue with short-acting β2-agonist and the asthma control test. In this study, we hypothesised that asthma control test is associated with circulating levels of fibrocytes in bronchial asthma. Methods: There were 20 patients with asthma and seven healthy controls. The number of CD45+Collagen I+circulating fibrocytes was assessed in the peripheral blood by flow cytometry. Results: The number of circulating fibrocytes was significantly increased in asthma patients with moderate and severe disease compared to controls, and it was inversely correlated with % forced expiratory volume in one second and % forced vital capacity (%FVC). The frequency of inhalation of short-acting β2 agonist and the asthma control test score was significantly and inversely correlated with the number of circulating fibrocytes. Conclusion: The results of this study showed that the number of circulating fibrocytes is inversely correlated with clinical asthma control parameters, further supporting the relevance of measuring circulating fibrocytes as a marker of clinical control in bronchial asthma (AU)

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Id: 151807
Autor: García Ortega, Alberto; Briones Gómez, Andrés; Fabregat, Sandra; Martínez Tomás, Raquel; Martínez García, Miguel Ángel; Cases, Enrique.
Título: Utilidad de la ecografía en el diagnóstico de lesiones torácicas periféricas realizadas en una unidad de técnicas de neumología / Benefit of Chest Ultrasonography in the Diagnosis of Peripheral Thoracic Lesions in an Interventional Pulmonology Unit
Fonte: Arch. bronconeumol. (Ed. impr.);52(5):244-249, mayo 2016. ilus, tab.
Idioma: es.
Resumo: Introducción y objetivos: La ecografía como guía en la punción percutánea de lesiones torácicas periféricas (LTP) ofrece ventajas frente a otras técnicas de imagen. La mayoría de los estudios con esta técnica han sido comunicados por radiólogos intervencionistas. El objetivo de este estudio ha sido analizar la rentabilidad diagnóstica de la punción percutánea guiada por ecografía en una unidad de técnicas de neumología. Metodología: Estudio retrospectivo de 58 pacientes con LTP puncionadas con visualización ecográfica en tiempo real, entre el 1 de marzo de 2011 y el 1 de septiembre de 2014. Los resultados fueron divididos en 3 categorías diagnósticas: maligna, benigna y no diagnóstica (ND); esta última incluye los resultados de benignidad no específica (SD) y los de muestra insuficiente para diagnóstico (MID). Resultados: Se obtuvo: resultado maligno en 34 (58,6%) de los procedimientos, resultado benigno en 13 (22,4%) y ND en 11 (19%) (SD en 5 [8,6%] y MID en 6 [10,3%]). En 5 de los casos ND el resultado final fue de malignidad y en 4 de ellos se tratada de una MID. La sensibilidad diagnóstica obtenida fue del 75,6%, el valor predictivo negativo del 54,2%, y la especificidad y el valor predictivo positivo del 100%, con una rentabilidad diagnóstica del 81%. Cuando se excluyeron los casos con MID los valores fueron del 87,2%, 72,3%, 100% y 100%, respectivamente, con una rentabilidad diagnóstica del 90,4%. No hubo complicaciones graves con la técnica. Conclusiones: La punción percutánea bajo guía ecográfica en LTP realizada por neumólogos intervencionistas es una técnica segura y con una alta rentabilidad diagnóstica (AU)

Introduction and objectives: The use of ultrasound in peripheral thoracic lesions offers advantages over other radiological guiding methods. This diagnostic procedure has been applied in most studies published by radiologists. Our aim was to determine the diagnostic efficacy of percutaneous ultrasound-guided punctures and biopsies of peripheral thoracic lesions performed by pulmonologists. Methodology: A retrospective analysis of 58 patients who underwent real-time ultrasound-guided transthoracic punctures and biopsy of peripheral thoracic lesions between March 2011 and September 2014 in the pulmonology department of our hospital. Cases were classified into the following diagnostic categories: malignant, benign and non-diagnostic (non-specific benign without evidence of malignancy and insufficient specimen). Results: A conclusive diagnosis was obtained in 47 procedures (81%), of which 13 (22.4%) were specific benign lesions and 34 (58.6%) cancers. In the remaining 11 (19%) patients, a non-diagnostic result was obtained [non-specific benign in 5 cases (8.6%) and insufficient specimen in 6 (10.3%)]. Sensitivity was 75.6%, negative predictive value was 54.2%, specificity and positive predictive value were 100%, and diagnostic accuracy was 81%. Excluding procedures with insufficient specimens, the results were 87.2%, 72.3%, 100%, 100% and 90.4% respectively. There were no serious complications. Conclusions: Percutaneous ultrasound-guided puncture and biopsy in the diagnosis of peripheral thoracic lesions performed by pulmonologists is a safe procedure with high diagnostic accuracy. We achieved similar results to those previously obtained by radiologists (AU)
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Id: 151273
Autor: Álvarez Pérez, Jacqueline; Serra Majem, Lluís.
Título: La soja en la prevención de la enfermedad cardiovascular / Soy in the prevention of cardiovascular disease
Fonte: Rev. esp. nutr. comunitaria;18(supl.2):11-18, 2012. graf.
Idioma: es.
Resumo: Los alimentos de soja o aislados de proteína de soja contienen dos componentes bioactivos principales, las isoflavonas (ISF) asociadas con la proteína de soja y los péptidos generados a partir de las dos principales proteínas de la soja, B-conglicina y la glicina. Algunos componentes de la dieta con soja controlan las funciones de adhesión del endotelio vascular, mediante la regulación de los mecanismos claves de control de las moléculas de adhesión endoteliales, la función de la integrina en los monocitos, citoquinas y quimoquinas en el control del tráfico y migración de los monocitos. También podrían regular la oxLDL en la generación y regulación de la expresión de los recogedores de radicales libres. La dieta con soja y otras dietas con efectos antiinflamatorios pueden bloquear el proceso inflamatorio asociado con la aterogénesis, reduciendo así el riesgo de ECV. Se requieren de más estudios que aclaren tanto a nivel experimental como clínico los mecanismos de acción de las ISF en la protección cardiovascular (AU)

Soy food or soybean protein isolates contain two major bioactive components, isoflavones (ISF) associated with soy protein, and peptides generated from two major soybean protein, B-conglycinin and glycine. Some components of the diet with soybean control the functions of vascular endotelial adhesion, by regulating the control key mechanisms of endothelial adhesion molecules, integrin function in monocytes, cytokines and chemokines in the traffic control and migration of monocytes. OxLDL may also regulate the generation and regulation of expression of catchers of free radicals. The diet with soy and other anti-inflammatory diets can block the inflammatory process associated with atherogenesis, thus reducing the risk of CVD. Further studies are required to clarify both experimental and clinical mechanism of action of the ISF cardiovascular protection (AU)
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Id: 148059
Autor: Shimizu, T; Nakagawa, Y; Takahashi, N; Hashimoto, S.
Título: Thymidylate synthase gene amplification predicts pemetrexed resistance in patients with advanced non-small cell lung cancer
Fonte: Clin. transl. oncol. (Print);18(1):107-112, ene. 2016. tab, ilus, graf.
Idioma: en.
Resumo: Background. Thymidylate synthase (TYMS) expression in lung cancer tissue affects the therapeutic efficacy of pemetrexed (PMT). TYMS protein expression is primarily assessed using immunohistochemistry (IHC), but this method is not suitable for accurate quantitative analysis. It is not known whether the analysis of TYMS gene copy number using fluorescence in situ hybridization (FISH) is a useful method for assessment of TYMS expression. Patients and methods. The participants were patients with chemo-naïve advanced NSCLC treated with PMT plus carboplatin (CBDCA) in prospective clinical phase II study. TYMS expression was evaluated in 40 patients by gene copy number and protein expression using FISH and IHC. Therapeutic efficacy was evaluated by investigating the response rate (RR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Results. TYMS gene amplification was detected in 8 patients (32 %) among 25 patients who could be evaluated for TYMS gene copy number. There were no patients with complete or partial response in the TYMS amplified group. RR and DCR were lower in the TYMS amplified group compared with the TYMS unamplified group (0 versus 35.3 %, p = 0.0539, 62.5 versus 94.1 %, p = 0.0443). PFS and OS were reduced in the TYMS amplified group. The analysis of TYMS gene copy number had higher sensitivity and specificity compared with TYMS protein expression (76.2 versus 50.0 %, 75.0 versus 66.7 %). Conclusion. The analysis of TYMS gene copy number is more suitable than TYMS protein expression for assessment of TYMS expression. TYMS gene amplification predicts outcome of patients receiving PMT with advanced NSCLC (AU)

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Id: 138613
Autor: Tsuzuki, Manabu.
Título: Examination about the effects of future career choice on time perspective in Japanese high school students
Fonte: Span. j. psychol;18(1):e17.1-e17.6, 2015.
Idioma: en.
Resumo: This study investigated types of career choice in high school students and examined the effects of career paths on time perspective development. The participants were 4,756 third grade students from nine public high schools in Tokyo. The high school questionnaire survey was conducted throughout autumn of 2008, 2009, and 2010. One year later, 962 graduates participated in the follow-up questionnaire survey by post. Distinguishing gender difference among career paths was found. Girls tend to choose significantly shorter learning careers (p < .01), for example junior college or vocational school in comparison to boys. Career indecision, i.e. students who could not set a concrete future career in high school, had significantly more negative time perspective than other groups (p < .05), which was caused by a deficiency of their basic cognitive ability. Longitudinal data showed different patterns of fluctuation in time perspective between «school to school transition» and «school to work transition». It is suggested that the «school to work transition» tends to be more critical for adolescents and has negative effects on time perspective. These results suggest that the goal content in careers may promote or inhibit the formation of time perspectives during the graduation transition (AU)

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Texto completo SciELO Espanha
Id: 134733
Autor: Andreeva, Anna.
Título: Childbirth in aristocratic households of Heian Japan
Fonte: Dynamis (Granada);34(2):357-376, 2014.
Idioma: en.
Resumo: This paper focuses on childbirth in Japan's aristocratic households during the Heian period (794-1185). Drawing on various sources, including court diaries, visual sources, literary records, and Japan's first medical collection, with its assortment of gynaecological and obstetric prescriptions, as well as Buddhist and other ritual texts, this short excursion into the cultural history of childbirth offers an insight into how childbirth was experienced and managed in Heian Japan. In particular, it addresses the variety of ideas, knowledge systems and professionals involved in framing and supporting the process of childbirth in elite households. In so doing, it casts light on the complex background of early Japanese medicine and healthcare for women (AU)

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Id: 133262
Autor: Kurosawa, M; Yukawa, T; Hozawa, S; Mochizuki, H.
Título: Recent advance in investigation of gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease
Fonte: Allergol. immunopatol;43(1):92-100, ene.-feb. 2015.
Idioma: en.
Resumo: Aspirin-exacerbated respiratory disease (AERD) is a complex clinical syndrome characterised by severe asthmatic attack upon treatment with aspirin and/or non-steroidal anti-inflammatory drugs (NSAIDs). Genetic predisposition has been considered as a crucial determinant and candidate genes have concentrated especially on cysteinyl leukotrienes (LTs)- related genes as the inhibitory action of aspirin and NSAIDs on cyclooxygenase activity may cause overproduction of cysteinyl LTs. However, conflicting results have been reported, in parallel with replication studies in different ethnic groups. Thus, future areas of investigations need to focus on comprehensive approaches towards the discovery of other genetic biomarkers. Unfortunately, few papers have been reported about gene polymorphisms in Japanese patients with AERD. Here, we described on our recent genetic investigations on B2ADR, IL-13, IL-17A, CYP2C19, TBXA2R, CRTH2 and HSP70. This review indicates potential genetic biomarkers contributing to the early diagnosis of AERD, which may include CYP2C19 and HSP70 gene polymorphisms, and future validation studies in independent population are required to provide reassurance about our findings (AU)

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