Database : LILACS
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Id: lil-728038
Author: Goicochea-Lugo, Sergio; Zavala-Flores, Ernesto; Salazar-Granara, Alberto.
Title: Mecanismos de interacción entre el extracto etanólico de Jatropha curcas L. y metoclopramida en el sistema gastrointestinal / The mechanisms of interaction between the ethanol extract of Jatrohpa curcas L. and metoclopramide on gastrointestinal system
Source: Horiz. méd. (Impresa);14(2):27-33, jul. 2014. tab, ilus.
Language: es.
Abstract: Objetivo: Determinar los mecanismos de interacción entre el extracto etanólico de Jatrohpa curcas L. y la metoclopramida sobre el sistema gastrointestinal. Material y Métodos: Se usó 30 ratones albinos machos, en5 grupos; los que recibieron por vía oral: Grupo 1: Jatropha curcas L. 800 mg/Kg, y 0, 5mg/Kg de metoclopramida. Grupo 2: 0.5 mg/mL de metoclopramida. Grupo 3: 1.5 mg/Kg de Atropina. Grupo 4: 800 mg/kg de Jatropha curcas L. Grupo 5: no recibió medicamento. A todos, se les administró por vía oral: carbón activado al 5% 0,1 mL/10g, como marcador intestinal. Se empleó el Método Arboset al, para evaluar la motilidad intestinal. La validación estadística del recorrido intestinal se realizó aplicando las pruebas de Kolmogorov Smirnov, ANOVA de 1 cola, Tukey y Newman-Keuls. Resultados: Se observó un el porcentaje de recorrido del carbón de 36.46% del grupo 1 frente a 65,45%, 3,66% y 58,87% de los grupos 2, 3 y 4, respectivamente; y de 58,87% del grupo 4 frente a 20,94% del grupo 5. Conclusiones: Se evidenció el antagonismo entre el extracto etanólico de la semilla de Jatropha curcas L. con la metoclopramida, el cual se explicaría por la interacción entre el sistema colinérgico, adrenérgico, GABAérgico y de neuropéptidos sobre la glándula suprarrenal, sistema nervioso central y gastrointestinal.

Objective: Determinate the mechanisms of interaction between the ethanol extract of Jatrohpacurcas L. and metoclopramide on gastrointestinal system. Material and Methods: 30 male albino mice were used, forming 5 groups and received oral medications as follows: Group 1: Jatropha curcas L. 800 mg / kg, and 0.5 mg/Kg of metoclopramide. Group 2: 0.5 mg/mL of metoclopramide. Group 3: 1.5 mg/Kg of atropine. Group 4: 800 mg/Kg of Jatropha curcas L. Group 5 received no medication. All groups receivedoral activated charcoal 0.1 mL/10g as intestinal marker. The Arbos et al method was used to evaluate intestinal motility. The statistical validation of the intestine dynamics was performed using the Kolmogorov Smirnov, 1-tailed ANOVA, Tukey and Newman-Keuls. Results: the percentage of charcoal runs in the 1rst group was 36.46% compared to 65.45%, 3.66 % and 58.87% for the 2nd, 3th and 4th groups, respectively. In the 4th group was 58,87% compared to 20.94% in the 5th group. Conclusions: the antagonism between the ethanol extract of the seeds of J.curcas L. with metoclopramide, which is probably would explain by the interaction between the cholinergic system, adrenergic system, GABAergic system and neuropeptides on the adrenal gland, central nervous system and gastrointestinal system.
Responsable: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-1005363
Author: Sanango, Ximena; González, Geovanny; Sinchi, Silvana; Morocho, Ismael; Sacoto, Adrián.
Title: PREVALENCIA DE REACCIONES ADVERSAS NEUROPSIQUIÁTRICAS A LOS MEDICAMENTOSEN PACIENTES HOSPITALIZADOS EN LOS SERVICIOSDE CLÍNICA, CIRUGÍA, PEDIATRÍA Y GINECOLOGÍA-OBSTETRICIA DEL HOSPITAL VICENTE CORRAL MOSCOSO 2014 / PREVALENCE OF ADVERSE NEUROPSIQUIATRIC REACTIONS TO DRUGS, IN HOSPITALIZED PATIENTS IN THE SERVICES OF CLINIC, SURGERY, PEDIATRICS AND GYNECOLOGY-OBSTETRICS OF HOSPITAL VICENTE CORRAL
Source: Rev. Fac. Cienc. Méd. Univ. Cuenca;32(2):40-51, Septiembre 2014. tab.
Language: es.
Abstract: La prevalencia de reacciones adversas a los medicamentos (RAM) de tipo neuropsiquiátricas se encuentra alrededor del 11,4% del total de las reacciones adversas registradas según la mayoría de estudios. En nuestro medio carecemos de datos.Objetivo: Determinar la prevalencia de RAM de tipo neuropsiquiátricas en pacientes internados en los servicios de pediatría, clínica, cirugía y ginecología-obstetricia del Hospital Vicente Corral Moscoso (HVCM) de la ciudad de Cuenca.Método y materiales: Se realizó un estudio descriptivo a partir del mes de enero de 2014, hasta completar la muestra. La muestra fue de 336 casos y por conglomerados. La información se obtuvo mediante notificación espontánea, con una encuesta basada en la tarjeta amarilla modificada por los autores.Resultados: Se obtuvo una prevalencia de 39,6% casos con posibles RAM de tipo neurop-siquiátricas; el sexo femenino es el más afectado, en una razón de 3 a 1; la edad de mayor afectación está entre los 20 a 29 años; el ser-vicio de atención en donde se encontró una mayor frecuencia fue el de Ginecología-Obstetricia con un 19,96% de los casos; el tipo más frecuente fue la cefalea con un 21,4%; el diag-nóstico asociado con mayor frecuencia fue la neumonía adquirida en la comunidad con un 59,09%; el fármaco que con mayor frecuencia se asoció a RAM fue la Metoclopramida con un 53,84% (la RAM que con mayor frecuencia se asoció con Metoclopramida fue el mareo con 26%). Conclusión: La presencia de RAM tipo neurop-siquiátricas en el Hospital Vicente Corral Mos-coso presenta una prevalencia alta.

The prevalence of adverse drug reactions (ADRs) of neuropsychiatric type reactions is around 11.4% of all adverse reactions reported by most studies. In our lack of data.Objective: To determine the prevalence of neuropsychiatric RAM type inpatient pediatric services, clinic, surgery and obstetrics and gy-necology of Vicente Corral Moscoso Hospital (HVCM) of the city of Cuenca.Method and Materials: A descriptive study was conducted from January 2014 to complete the sample. The sample was 336 and conglomera-tes. The information was obtained by sponta-neous reporting, with a survey based on yellow card modified by the authors.Results: A prevalence of 39.6% of cases with possible neuropsychiatric RAM type was ob-tained; female gender is most affected, in a ratio of 3-1; most affected age is between 20 to 29 years; the service where a higher fre-quency was found Obstetrics-Gynecology with 19.96% of the cases; type headache was more frequent with 21.4%; diagnosis was more frequently associated with pneumonia acqui-red in the community with a 59.09%; the drug most often associated with metoclopramide RAM was a 53.84%% (the RAM that is most of-ten associated with metoclopramide was dizzi-ness 26%).Conclusion: The presence of neuropsychiatric RAM type Vicente Corral Moscoso in the hospi-tal has a high prevalence.
Responsable: EC3.1 - Biblioteca


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Id: biblio-906550
Author: Vasconcellos, Marcos Carvalho de; Duarte, Marco Antônio; Machado, Márcia Gomes Penido.
Title: Vômitos: abordagem diagnóstica e terapêutica / Vomiting: a diagnostic and therapeutic approach
Source: Rev. méd. Minas Gerais;24(supl.10):5-11, 2014.
Language: pt.
Responsable: BR21.1 - Biblioteca J Baeta Vianna- Campus Saúde UFMG


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Id: biblio-884793
Author: Schell, María Constanza; Parodi, Benjamin.
Title: Intoxicación aguda por metoclopramida / Acute metoclopramide poisoning
Source: Rev. Asoc. Med. Bahía Blanca;23(1):18-20, enero-marzo 2013.
Language: es.
Abstract: Se presenta el caso de un paciente de 18 años de edad, sexo masculino, peso de 65 Kg, buen estado general, que ingresa al servicio de cirugía con un cuadro de dolor en fosa ilíaca derecha de 48 horas de evolución, punto de Mac Burney positivo, cronología de Murphy. En el interrogatorio el paciente refiere haber ingerido gotas de metoclopramida. Se le realizan estudios de laboratorio (HCT: 37%; Leucocitos 14.700/mm3) y una Ecografía abdominal (sin alteraciones). Se le practica una apendicetomía sin complicaciones. Posteriormente, se le indica nada por boca, metoclopramida 10 mg/8h, ranitidina 50 mg/6hs, metronidazol 500 mg/8hs. gentamicina 325 mg/d, diclofenac 150 mg/d). Cursando 24 horas de postoperatorio, presenta un cuadro de contractura muscular generalizada, opistótonos, trismus, disglosia, lúcido y orientado temporoespacialmente. En la interconsulta con el Servicio de Neurología se interpreta como un cuadro de tétanos que se descarta por hipoclacemia. El paciente ingresa a terapia intensiva con una reacción adversa a la metoclopramida, medicando con difenhidramina 10mg/4 hs, revirtiendo los signos neurológicos en el transcurso de 4 horas.

A healthy 18 year old male patient, 65 kg or weigh, is admitted at the Surgery Department with a 48 hour evolution pain in the right iliac fossa, positive McBurney's point, Murphy chronology. Upon questioning, the patient says to have taken metoclopramide drops. Laboratory tests (HCT: 37%; Leucocytes 14,700/mm3) and an abdominal scan that did not reveal alterations are carried out . An appendectomy is performed with no complications. Then, no oral intakes are prescribed, 10 mg/8h of metoclopramide, 50 mg/6h of ranitidine, 500 mg/8h of metronidazole, 325 mg/d of gentamycin, 150 mg/d of diclofenac. 24 hours after surgery, the patient presents generalized muscle contraction, opistothons, trismus, diglosia; he is lucid and oriented in time and space. Upon referral to the Neurology Department, the diagnosis was a tetanus infection, later discarded due to hypokalemia. The patient is admitted at the UTI with an adverse reaction to metoclopramide, and receives 10 mg/4h difenhidramine, thus reverting neurological signs within 4 hours.
Responsable: AR393.1 - Centro de Información y Documentación Dr H. Urquiola


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Amato, Angelica Amorim
Wanderley, Miriam da Silva
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Id: biblio-843915
Author: Zingler, Emilie; Amato, Angélica Amorim; Zanatta, Alysson; Vogt, Maria de Fátima Brito; Wanderley, Miriam da Silva; Mariani Neto, Coríntio; Zaconeta, Alberto Moreno.
Title: Lactation Induction in a Commissioned Mother by Surrogacy: Effects on Prolactin Levels, Milk Secretion and Mother Satisfaction / Indução da lactação em mãe por útero de substituição: efeitos na concentração de prolactina, produção láctea e satisfação materna
Source: Rev. bras. ginecol. obstet;39(2):86-89, Feb. 2017. tab, graf.
Language: en.
Abstract: Abstract Case report of a 39-year-old intended mother of a surrogate pregnancy who underwent induction of lactation by sequential exposure to galactagogue drugs (metoclopramide and domperidone), nipple mechanical stimulation with an electric pump, and suction by the newborn. The study aimed to analyze the effect of each step of the protocol on serum prolactin levels, milk secretion and mother satisfaction, in the set of surrogacy. Serum prolactin levels and milk production had no significant changes. Nevertheless, themother was able to breastfeed for four weeks, and expressed great satisfaction with the experience. As a conclusion, within the context of a surrogate pregnancy, breastfeeding seems to bring emotional benefits not necessarily related to an increase in milk production.

Resumo Relato de caso de mãe por útero de substituição, de 39 anos de idade, submetida a indução da lactação por exposição sequencial a drogas galactogogas (metoclopramida e domperidona), estimulação mamilar mecânica com bomba elétrica, e sucção pelo recém-nascido. O estudo teve como objetivo analisar os efeitos de cada etapa do protocolo na concentração sérica de prolactina, no volume de secreção láctea e na satisfação materna. A concentração sérica de prolactina e a produção láctea não apresentaram mudanças significativas. Entretanto, a mãe foi capaz de amamentar a criança por quatro semanas, e manifestou grande satisfação com a experiência. Como conclusão, no contexto de maternidade por útero de substituição, o aleitamento materno parece promover benefícios emocionais, não necessariamente relacionados ao aumento do volume de leite.
Responsable: BR1.1 - BIREME


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Id: lil-772926
Author: Sánchez, Julián.
Title: Efectos extrapiramidales por metoclopramida en embarazo y recién nacido / Extrapyramidal effects for metoclopramide in pregnancy and newborn
Source: Rev. salud bosque;5(1):63-66, 2015. tab.
Language: es.
Abstract: Las náuseas y la emesis son complicaciones posoperatorias que pueden derivar en bronco aspiración, una situación clínica potencialmente fatal. Para su prevención, se usan medicamentos como la metoclopramida. Se presenta un reporte de caso de extrapiramidalismo por metoclopramida en el recién nacido y la madre. Es una reacción secundaria a un medicamento, clasificada como un evento serio y definitivo, de tipo A. Se requiere considerar el balance entre riesgo y beneficio de este medicamento en este tipo de condiciones, como también considerar otras medidas que eviten estos casos. El reporte de reacciones adversas a medicamentos es una actividad que contribuye al uso seguro de los medicamentos.

Postoperative nauseas and vomiting are complications that can lead to bronchoaspiration, a potentially fatal clinical event. Medications such as metoclopramide are used to prevent them. A case report of extrapyramidal signs in a newborn and mother metoclopramide is presented. It has been classified as a serious drug reaction, type A. The risk-benefit balance of this drug in such conditions should be considered as well as other measures to prevent such events. The reporting of adverse drug reactions is an activity that contributes to the safe use of medicines.
Responsable: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.


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Id: lil-767600
Author: Silva, Silvana Marques e; Jerônimo, Márcio Sousa; Silva-Pereira, Ildinete da; Tavares, Aldo Henrique; Bocca, Anamélia Lorenzetti; Sousa, João Batista de.
Title: Effects of metoclopramide on the expression of metalloproteinases and interleukins in left colonic anastomoses. An experimental study
Source: Acta cir. bras;30(11):762-769, Nov. 2015. tab, graf.
Language: en.
Abstract: PURPOSE : To evaluate the effects of metoclopramide on metalloproteinases (MMP) and interleukins (IL) gene expression in colonic anastomoses in rats. METHODS : Eighty rats were divided into two groups for euthanasia on the 3rd or 7th postoperative day (POD), then into two subgroups for sepsis induction or not, and then into subgroups to receive either metoclopramide or saline solution. Left colonic anastomosis were performed and then analyzed. RESULTS : On the 3rd POD, metoclopramide was associated with increased expression of MMP-1a, MMP-13, and TNF-α. On the 7th POD, the transcripts of all MMPs, TNF-α, IL-1β, IFN-γ, and IL-10 of the treated animals became negatively modulated. In the presence of sepsis, metoclopramide did not change MMPs and decreased IL-6, IL-1β, IFN-γ and IL-10 gene expression on the 3rd POD. On the 7th POD, increased expression of all MMPs, IFN-γ and IL-10 and negative modulated TNF-α and IL-6 gene expression. CONCLUSION : Administration of metoclopramide increased metalloproteinases and interleukins gene expression on the 3rd postoperative day and negatively modulated them on the 7th POD. In the presence of abdominal sepsis, metoclopramide did not change MMPs and decreased ILs gene expression on the 3rd POD. On the 7th POD, the drug increased expression of all MMPs.
Responsable: BR1.1 - BIREME


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Simöes, Manuel de Jesus
Baracat, Edmund Chada
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Id: lil-759286
Author: Araujo, Ariadne Stavare Leal; Simões, Manuel de Jesus; Verna, Carina; Simões, Ricardo Santos; Soares Júnior, José Maria; Baracat, Edmund Chada; Gomes, Regina Célia Teixeira.
Title: Influence of hyperprolactinemia on collagen fibers in the lacrimal gland of female mice
Source: Clinics;70(9):632-637, Sept. 2015. tab, ilus.
Language: en.
Abstract: OBJECTIVE:To quantify the collagen fibers in the lacrimal gland of female mice with hyperprolactinemia.METHODS:Forty adult female mice were randomly divided into two groups with 20 animals each: nonpregnant control (CTR1, control group, 0.2 mL of saline solution) and nonpregnant experimental (HPRL1, experimental group, 200 µg/day metoclopramide). Treatments lasted for 50 consecutive days. On day 50, 10 females from each group (control and experimental) were euthanized in the proestrus phase; then, the blood was collected and the lacrimal glands were removed. Thereafter, the remaining females were placed with the mates and continued to receive treatment with saline solution or metoclopramide. On the 6th post-coital day, 10 pregnant females from the control group (CTR2) and 10 pregnant females from the experimental group (HPRL2) were euthanized, after which blood was collected and the lacrimal glands removed. The lacrimal glands were processed for morphological analyses and collagen quantification, and prolactin and sex steroid levels were measured in the blood samples. Data were statistically analyzed using an unpaired Student t test (p<0.05).RESULTS:Morphological analysis revealed greater structural tissue disorganization of the lacrimal glands in the metoclopramide-treated groups. The total collagen content was significantly higher in the HPRL1 group than in the CTR1 group (p<0.05), whereas the difference between the CTR2 and HPRL2 groups was not significant.CONCLUSION:Our data suggest an impairment in the functioning of the lacrimal gland as a consequence of increased prolactin levels and decreased serum levels of estrogen and progesterone.
Responsable: BR1.1 - BIREME


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Id: lil-736223
Author: Pons, Emilia da Silva; Guimarães, Luciano Santos Pinto; Knauth, Daniela Riva; Pizzol, Tatiane da Silva Dal.
Title: Analysis of agreement between Visual Analogue Scales (VAS) and numerical questions to assess perception of teratogenic risks in treatment with drugs and radiotherapy in women / Análise de concordância entre as escalas visual analógica (VAS) e questões numéricas para avaliar a percepção de riscos teratogênicos em tratamento com medicamentos e radioterapia em mulheres
Source: Rev. bras. saúde matern. infant;14(4):393-399, Oct-Dec/2014. tab, graf.
Language: en.
Abstract: To evaluate the agreement between Visual Analogue Scales (VAS) and numerical questions as a way of assessing the perception of teratogenic risk of treatment with drugs and radiotherapy. Methods: the sample comprised 144 pregnant and 143 non-pregnant women consecutively recruited at public health centers in Porto Alegre, in the State of Rio Grande do Sul, from February to August 2011. The perception of risk for congenital malformations in the general population and the perceptions of teratogenic risk for exposure to acetaminophen, meto-clopramide, misoprostol and radiotherapy were measured using VAS and numerical questions. The agreement between the results of the two techniques was tested using a Bland-Altman plot. Results: the medians for the perceptions measured using VAS were higher than those obtained using numerical questions for all variables. The perception of risk for acetaminophen showed the lower bias of the two techniques (bias=13.17; p<0.001) and exposure to radiotherapy, the higher (bias=25.02; p<0.001). Conclusion: there was no agreement between the measurements obtained using the two techniques for any of the risk perceptions under study. Risk perceptions were higher using VAS, for all kinds of exposure. Studies should be conducted to assess whether there is overestimation in other situations and social contexts owing to the use of VAS...

Avaliar a concordância entre Escalas Visuais Analógicas (EVA) e perguntas numéricas para aferir a percepção de risco teratogênico de medicamentos e radioterapia. Métodos: a amostra foi constituída por 144 gestantes e 143 não gestantes recrutadas consecutivamente em centros públicos de saúde de Porto Alegre, RS, entre fevereiro e agosto de 2011. A percepção de risco de malformações congênitas na população geral e as percepções de risco teratogênico das exposições a paracetamol, metoclo-pramida, misoprostol e radioterapia na gestação foram aferidas por EVA e perguntas numéricas. A concordância entre as duas técnicas foi avaliada pela análise gráfica de Bland-Altman Resultados: as medianas das percepções de risco teratogênico medidas por EVA foram superiores às obtidas através da pergunta numérica, para todas as variáveis. A percepção de risco ao paracetamol apresentou o menor viés entre as duas técnicas de aferição (viés=13,17; p<0,001) e a exposição à radioterapia, o maior (viés=25,02;p<0,001). Conclusões: não houve concordância entre as duas técnicas, para nenhuma das percepções de risco estudadas. As percepções de risco foram maiores para EVA, para todas as exposições. Sugerimos a realização de estudos que avaliem se também ocorre superestimação em outras situações e contextos sociais, em função do uso de EVA...
Responsable: BR663.1 - Biblioteca da Saúde da Mulher e da Criança


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Id: lil-722166
Author: Silva, S.M.; Jerônimo, M.S.; Silva-Pereira, I.; Bocca, A.L.; Sousa, J.B..
Title: Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study
Source: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(10):911-916, 10/2014. tab, graf.
Language: en.
Abstract: Anastomotic dehiscence is the most severe complication of colorectal surgery. Metalloproteinases (MMPs) and interleukins (ILs) can be used to analyze the healing process of anastomosis. To evaluate the effects of bromopride on MMP and cytokine gene expression in left colonic anastomoses in rats with or without induced abdominal sepsis, 80 rats were divided into two groups for euthanasia on the third or seventh postoperative day (POD). They were then divided into subgroups of 20 rats for sepsis induction or not, and then into subgroups of 10 rats for administration of bromopride or saline. Left colonic anastomosis was performed and abdominal sepsis was induced by cecal ligation and puncture. A colonic segment containing the anastomosis was removed for analysis of gene expression of MMP-1α, MMP-8, MMP-13, IL-β, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). On the third POD, bromopride was associated with increased MMP-1α, MMP-13, IL-6, IFN-γ, and IL-10 gene expression. On the seventh POD, all MMP transcripts became negatively modulated and all IL transcripts became positively modulated. In the presence of sepsis, bromopride administration increased MMP-8 and IFN-γ gene expression and decreased MMP-1, TNF-α, IL-6, and IL-10 gene expression on the third POD. On the seventh POD, we observed increased expression of MMP-13 and all cytokines, except for TNF-α. In conclusion, bromopride interferes with MMP and IL gene expression during anastomotic healing. Further studies are needed to correlate these changes with the healing process.
Responsable: BR1.1 - BIREME



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