Database : LILACS
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Leite, Celso Vieira de Souza
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Id: biblio-887570
Author: Schnor, Noa Pereira Prada; Verlengia, Rozangela; Novais, Patrícia Fátima Sousa; Crisp, Alex Harley; Leite, Celso Vieira de Souza; Rasera-Junior, Irineu; Oliveira, Maria Rita Marques de.
Title: Association of 5-HT2C (rs3813929) and UCP3 (rs1800849) gene polymorphisms with type 2 diabetes in obese women candidates for bariatric surgery
Source: Arch. endocrinol. metab. (Online);61(4):326-331, July-Aug. 2017. tab.
Language: en.
Abstract: ABSTRACT Objective Obesity can cause systemic arterial hypertension (SAH) and type 2 diabetes mellitus (DM2) factor that is also influenced by genetic variability. The present study aims to investigate the association between gene polymorphisms related with obesity on the prevalence of SAH and DM2 in the preoperative period and 1 year after Roux-en-Y gastric bypass surgery. Subjects and methods In total, 351 obese women in a Brazilian cohort completed the study. The clinical diagnosis of SAH and DM2 was monitored from medical records. Twelve gene polymorphisms (rs26802; rs572169; rs7799039; rs1137101; rs3813929; rs659366; rs660339; rs1800849; rs7498665; rs35874116; rs9701796; and rs9939609) were determined using real-time polymerase chain reaction and TaqMan assay. Results In the preoperative period, prevalence of SAH and DM2 was 57% and 22%, respectively. One year postoperatively, 86.8% subjects had remission of DM2 and 99.5% had control of SAH. Subjects with T allele from the serotonin receptor gene (5-HT2C, rs3813929) had five times greater chance of DM2, and the CC genotype from uncoupling protein 3 gene (UCP3, rs1800849) had three times greater chance in the preoperative period. Conclusion These findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to DM2 prevalence among the Brazilian obese women candidates for bariatric surgery.
Responsable: BR1.1 - BIREME


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Id: biblio-887575
Author: Melo, Thalita Lima; Froeder, Leila; Baia, Leandro da Cunha; Heilberg, Ita Pfeferman.
Title: Bone turnover after bariatric surgery
Source: Arch. endocrinol. metab. (Online);61(4):332-336, July-Aug. 2017. tab.
Language: en.
Project Fundação de Amparo à Pesquisa do Estado de São Paulo; . Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Abstract: ABSTRACT Objective The aim of the present study was to evaluate parameters of bone and mineral metabolism after bariatric surgery. Subjects and methods This sectional study included data from medical records from 61 bariatric surgery (BS) patients (minimum period of 6 months after the procedure) and from 30 class II and III obese patients as a control group (Cont), consisting of daily dietary intake of macronutrients, calcium and sodium, serum 25(OH)D and parathyroid hormone (PTH) and other biochemical serum and urinary parameters. Bone alkaline phosphatase (BAP), leptin, fibroblast growth factor-23 (FGF-23) and deoxypyridinoline (DPYD) were determined from available banked serum and urinary samples. Results Mean body mass index (BMI), median energy, carbohydrate, protein and sodium chloride consumption were significantly lower in the BS versus Cont, but calcium and lipids were not. No significant differences were found in ionized calcium, 25(OH)D, PTH and fibroblast growth factor 23 (FGF-23) between groups. Mean serum BAP was significantly higher for BS versus Cont and had a positive correlation with time after the surgical procedure. Mean serum leptin was significantly lower and median urinary DPYD higher in BS versus Cont. Conclusion The present study showed an increase in bone markers of both bone formation and resorption among bariatric patients up to more than 7 years after the surgical procedure, suggesting that an increased bone turnover persists even at a very long-term follow-up in such patients.
Responsable: BR1.1 - BIREME


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Id: biblio-950066
Author: Magno, Fernanda Cristina Carvalho Mattos; Sousa, Priscila Alves Medeiros de; Rodrigues, Marcelo Paiva; Pereira, Lícia Lopes Pio; Oliveira, José Egídio Paulo de; Rosado, Eliane Lopes; Carneiro, João Régis Ivar.
Title: Long term maintenance of glucose and lipid concentrations after Roux-en-Y gastric bypass
Source: Arch. endocrinol. metab. (Online);62(3):346-351, May-June 2018. tab, graf.
Language: en.
Abstract: Abstract Objective: Roux-en-Y gastric bypass (RYGB) reduces body weight and the comorbidities associated with obesity. The aim of this study was to evaluate whether glucose and lipid profiles were maintained during a 5-year follow-up period after RYGB. Subjects and methods: Anthropometric and laboratory data from 323 patients who had undergone this operation were analyzed. Differences in laboratory variables between the baseline and 12, 24, 36, 48 and 60 months postoperatively (PO) were assessed using a one-way ANOVA test to compare the three groups. Delta significance using one-way ANOVA was performed to assess anthropometric variable in the postoperative period (p < 0.05). Results: 77 patients (24%) were included in Group 1 (G1), 101 (32%) in Group 2 (G2), and 141 (44%) in Group 3 (G3). The majority of patients, 71.7% in G1, 82.8% in G2, and 70% in G3, showed high triglycerides (TG) before surgery. A decrease in weight loss was observed in all groups followed by an increase in body weight in G2 and G3 at 36, 48 and 60 months. Laboratory results for G1, G2 and G3 showed no significant differences between groups at baseline and during the post-operative period. Conclusion: Our results suggest that weight regain after RYGB has no significant impact on the long-term evolution of the lipid profile and glycemia.
Responsable: BR1.1 - BIREME


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Id: lil-715237
Author: Salazar-Maya, Ángela María; Hoyos-Duque, Teresa Nury; Bojanini-Acevedo, Lucas.
Title: Perception of quality of life of a group of individuals subjected to bariatric surgery / Percepción de calidad de vida de un grupo de personas operadas de cirugía bariátrica / Percepção de qualidade de vida de um grupo de pessoas operadas de cirurgia bariátrica
Source: Invest. educ. enferm;32(1):22-32, Jan.-Apr. 2014. tab.
Language: en.
Abstract: Objective. The study sought to identify the state of health and quality of life of post-bariatric surgery patients. Methodology. This was a cross-sectional study conducted in 2012 with the participation of 338 individuals attending the private practice of a bariatric surgeon from Medellín (Colombia). With prior signed informed consent, the survey was filled out by each patient. The information gathered was sociodemographic in nature along with the World Health Organization's Quality of Life Brief Questionnaire (WHOQoL-Bref). Results. It was found that 82.2% were women and mean age was 41±12 years. Gastric bypass was practiced on 79.6% of the cases. Mean weight before surgery was 106.3±17.5 Kg and after surgery it was 73.2±13.4 Kg. Nine of every 10 participants classified their quality of life and state of health between extremely well and quite well. Quality of life was better in men, in those younger than 40 years of age, in those from socio-economic levels 4 to 6, and in those with educational level above the secondary (high school). Conclusion. As a consequence of the important and rapid weight loss occurring during the first months after surgery, most of the participants perceived having a good quality of life and were satisfied with their health status. For nursing, it is a challenge to implement educational programs and projects, bearing in mind the sociocultural diversity of the individuals and communities, through interdisciplinary and inter-sector work, which contributes to the well-being of obese individuals subjected to bariatric surgery and their families.

Objetivo. Identificar el estado de salud y calidad de vida (CV) de los pacientes posoperados de cirugía bariátrica. Metodología. Estudio cross-sectional realizado en 2012 en el que participaron 338 personas que asistieron a la consulta particular de un cirujano bariátrico de Medellín (Colombia). Previo consentimiento informado firmado, se aplicó una encuesta que fue diligenciada por cada paciente. La información recolectada fue de tipo sociodemográfica y el cuestionario abreviado de calidad de vida de la Organización Mundial de la Salud (WHOQoL-Bref). Resultados. El 82.2% pertenecía al sexo femenino, la edad media fue 41±12 años. Les practicaron Bypass gástrico al 79.6% de los casos. El peso medio antes de la cirugía fue de 106.3±17.5 Kg y después de ella de 73.2±13.4 Kg. 9 de cada 10 participantes calificaron entre extremadamente bien y bastante bien su calidad de vida y el estado de salud. Aquella fue mejor en los hombres, en los menores de 40 años, en quienes pertenecían a estratos socioeconómicos 4 a 6 y en los que tenían estudios superiores a los secundarios. Conclusión. Como consecuencia de la rápida pérdida de peso ocurrida durante los primeros meses tras la cirugía, la mayor parte de los participantes percibe tener una buena calidad de vida y está satisfecha con su estado de salud. Para la enfermería es un reto implementar programas y proyectos educativos, teniendo en cuenta la diversidad sociocultural de las personas y las comunidades, a partir de un trabajo interdisciplinar e intersectorial, que contribuya al bienestar de las personas obesas sometidas a cirugía bariátrica, así como al de su familia.

Objetivo. Identificar o estado de saúde e qualidade de vida (CV) dos pacientes pós-operados de cirurgia bariátrica. Metodologia. Estudo cross-sectional realizado em 2012 no que participaram 338 pessoas que assistiram à consulta particular de um cirurgião bariátrico de Medellín (Colômbia. Prévio consentimento informado assinado se aplicou uma enquete que foi diligenciada por cada paciente. A informação coletada foi de tipo sócio-demográfica e o questionário abreviado de qualidade de vida da Organização Mundial da Saúde (WHOQoL-Bref). Resultados. 82.2% foram mulheres, a idade média foi 41±12 anos. Praticaram-lhes Bypass gástrico ao 79.6% dos casos. O peso médio antes da cirurgia foi de 106.3±17.5 Kg e depois dela de 73.2±13.4 Kg. 9 de cada 10 participantes qualificaram entre extremamente bem e bastante bem seu CV e o estado de saúde. A qualidade de vida foi melhor nos homens, nos menores de 40 anos, nos que pertenciam a estratos socioeconômicos 4 a 6 e nos que tinham estudos superiores aos secundários. Conclusão. Como consequência à importante e rápida perda de importância ocorrida durante os primeiros meses depois da cirurgia, a maior parte dos participantes percebem ter uma boa qualidade de vida e estão satisfeitos com o estado de saúde. Para a enfermagem é um repto implementar programas e projetos educativos, tendo em conta a diversidade sociocultural das pessoas e as comunidades, através de um trabalho interdisciplinar e intersetorial, que contribua a bem-estar das pessoas obesas, suas famílias que são submetidas a cirurgia bariátrica.
Responsable: CO332 - Facultad de Medicina


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Id: biblio-833538
Author: Tinoco, Renam C; Tinoco, Augusto Claudio; Sueth, Daniela M; Farfan, Stephany R; Conti, Luana C. A; Gottardi, Lorena F.
Title: Trombose venosa profunda e tromboembolismo pulmonar nos pacientes submetidos à gastroplastia laparoscópica / Venous thrombosis and venous thromboembolism in bariatric laparoscopic surgery
Source: GED gastroenterol. endosc. dig;36(1):7-10, jan.-mar. 2017. ilus, tab.
Language: pt.
Abstract: Racional: a obesidade é fenômeno mundial, que aumenta a morbimortalidade e qualidade de vida dos indivíduos afetados. Considerada fator de risco isolado para o desenvolvimento de múltiplas complicações no pós-operatório, tais como trombose venosa profunda (TVP) e tromboembolismo pulmonar (TEP). Objetivo: analisar a prevenção de TVP e TEP em 3.199 pacientes submetidos à gastroplastia redutora em Y de Roux (LRYGB) e gastrectomia vertical (GV) laparoscópica no Hospital São José do Avaí, Itaperuna, RJ entre agosto de 1999 e janeiro de 2015. Método: a prevenção de trombose venosa profunda foi realizada através de compressores pneumáticos de membros inferiores (CPIMI) no intraoperatório, associado à deambulação precoce. A profilaxia medicamentosa não foi realizada de rotina, apenas em casos selecionados. Resultados: 0,37% (doze pacientes) evoluíram com TVP dos quais 0,18% (seis pacientes) evoluíram para TEP, com mortalidade de 0,03% (1 paciente), sendo esse por complicações em uma segunda abordagem cirúrgica. Todos os casos foram diagnosticados através dos dados clínicos aliados ao ecodoppler de membros inferiores e à angiotomografia de tórax. Os pacientes foram tratados conservadoramente com infusão de heparina não fracionada na dose padrão. Conclusão: a compressão pneumática intermitente no intraoperatório e deambulação precoce foram benéficas na prevenção do TEP/TVP no pós-operatório como único método profilático. Em casos selecionados é recomendado o uso de heparina profilática.

Rational: obesity is a global phenomenon, which increases the morbidity of an individual's quality of life and increases the mortality risk in people who are affected by this disorder. This is a considered independent risk factor that can cause the development of multiple complications after surgery, such as deep vein thrombosis (DVT) and pulmonary embolism (PE). Purpose: the purpose of this study is to analyze the prevention of DVT and PE in 3199 patients that were undergoing gastric bypass (LRYGB) and sleeve Gastrectomy (GV) in the Laparoscopic Hospital in São José do Avai, Itaperuna, RJ, between August 1999 and January 2015. Method: the prevention of deep vein thrombosis was performed using Intermittent pneumatic compression (IPC) intra-operatively, and was associated with the early ambulation of the patients. Drug prophylaxis is not routinely performed, except in selected cases. Results: out of all the patients, 0.37% (Twelve patients) developed DVT of which six patients evolved TEP with mortality in 1 patient. All the cases were diagnosed by clinical data combined with a Doppler ultra-sound of the lower limbs and the chest CT angiography. The patients were treated conservatively with the infusion of unfractionated heparin in the standard dose. Conclusion: the intermittent pneumatic compression done intra-operatively and the early ambulation were beneficial in the prevention of PE / DVT postoperatively and were the only prophylactic methods used. In selected cases, it is recommended that one use prophylactic heparin.
Responsable: BR9.1 - Biblioteca de Ciências da Saúde Profa. Susana Schimidt


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Id: biblio-1100678
Author: Villarreal Juris, Andrea Patricia; Torres Castillo, Antonio Rolando; Albán Tigre, Jorge Luis; Albán Tigre, Juan Pablo; Villarreal Juris, Ramiro Gunther; Uzcátegui Arregui, Ricardo José.
Title: Implementación del programa de cirugía bariátrica en el Hospital de Especialidades de las Fuerzas Armadas Nro. 1: resultados iniciales / Bariatric surgery program implementation at the Hospital de Especialidades de las Fuerzas Armadas N° 1: initial results
Source: Rev. Fac. Cienc. Méd. Univ. Cuenca;38(1):43-51, 2020. ilus, tab.
Language: es.
Abstract: Introducción: la obesidad afecta al 22.1% de la población ecuatoriana y su prevalencia continúa en aumento. La cirugía bariátrica constituye una opción efectiva para su tratamiento, pero alcanza apenas al 1% de la población afectada. Objetivo: describir la experiencia en la implementación del programa de cirugía bariátrica en el Hospital de Especialidades de las Fuerzas Armadas N°1. Metodología: estudio descriptivo, retrospectivo, desde febrero del 2016 hasta febrero del 2019; se reportó características demográficas, seguimiento prequirúrgico, evolución del peso antes y después del procedimiento a corto, mediano y largo plazo. Resultados: se incluyeron 39 individuos, 74.4% mujeres y 25.6% hombres. La edad media fue 45.9 años (DS ±9.9 años); el índice de masa corporal medio en la primera valoración fue 41.04 kg/m2 (DS ±5.1), al primer mes se logró un porcentaje de reducción del exceso de peso del 21.7 % (DS ±14.7), al tercer mes del 42.8 % (DS ±18.27) y al año del 66.3 % (DS ±12.6), sin embargo, 13 pacientes abandonaron el seguimiento. Conclusión: a pesar de la dificultad técnica y operativa para implementar un programa de cirugía bariátrica, queda demostrado su beneficio.

Introduction: the obesity affects about 22.1% of the Ecuadorian population and its prevalence continues to increase. Bariatric surgery is an effective option for its treatment, but it reaches only 1% of the affected population. Objective: to describe the experience in the implementation of bariatric surgery program at the Hospital de Especialidades de las Fuerzas N° 1. Methodology: It is a descriptive and retrospective study, it was conducted from February 2016 to February 2019; demographic characteristics, presurgical follow-up, weight evolution before and after the procedure was measured at short, medium and long term. Results: A total of 39 individuals were included, 74.4% women and 25.6% men. The average age was 45.9 years (SD ± 9.9 years); the mean body mass index at the first evaluation was 41.04 kg / m2 (DS ± 5.1), at the first month a percentage reduction of excess weight of 21.7% (DS ± 14.7) was achieved, at the third month 42.8% ( SD ± 18.27) and one year after 66.3% (DS ± 12.6), however, 13 patients abandoned follow-up. Conclusion: despite the technical and operational difficulties in implementing a bariatric surgery program, its benefit has been demonstrated.
Responsable: EC3.1 - Biblioteca


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Id: biblio-1117413
Author: Navarini, Daniel; Albuquerque, Antônio Benincá; Rovani, André Luca Boeira; Silva, Victor Vasconcelos da; Ranzolin, Bernardo Antoniolli; Reffatti, Diego; Perin, Ramir Luan; Madalosso, Carlos Augusto Scussel.
Title: Mesenteric desmoid tumor after Roux-en-Y gastric bypass: a case report
Source: Clin. biomed. res;40(1):54-57, 2020.
Language: en.
Abstract: We report the case of a 37-year-old woman investigated for left flank pain 1 year after bariatric surgery (Roux-en-Y gastric bypass). Abdominal computed tomography (CT) revealed a solid intra-abdominal lesion measuring 9.3 × 9.4 × 10.4 cm, compressing adjacent structures with no signs of invasion. Ileocolectomy with partial mesenteric resection was performed. A histopathological and immunohistochemical analysis confirmed the diagnosis of mesenteric desmoid tumor.(AU)
Responsable: BR18.1 - Biblioteca FAMED/HCPA


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Id: lil-740627
Author: Carrera, Cecilia; De Luca, Silvina; Andraca, Florencia; Muscillo, Laura; Andrés, Santiago; Eyheremendy, Eduardo.
Title: Hernia de Petersen. Complicación del bypass gástrico: hallazgos tomográficos / Petersen's hernia. Complication of gastric bypass: CT findings
Source: Rev. argent. radiol;76(3):241-244, set. 2012. ilus.
Language: es.
Abstract: El bypass gástrico en Y de Roux (BGYR) es una de las técnicas de elección en pacientes con obesidad mórbida y en la actualidad es el procedimiento de cirugía bariátrica más utilizado. Consiste en una técnica mixta, es decir, tiene un carácter principalmente restrictivo y genera un cierto grado de malabsorción. Puede realizarse por cirugía convencional o laparoscópica, siendo esta última la de elección. La anastomosis retrocólica crea un espacio en el mesenterio, posibilitando la formación de un tipo de hernia transmesentérica denominada“hernia de Petersen”. El objetivo de este trabajo es describir y analizar los hallazgos tomográficos de la hernia de Petersen en pacientes con antecedente de bypass gástrico. Se analizaron las historias clínicas de 92 pacientes con antecedente de BGYR (realizados todos en nuestra institución) .Tres pacientes presentaron un cuadro de obstrucción intestinal y se les realizó tomografía computada multislice (TCMS) de abdomen. En función de los hallazgos tomográficos consistentes con hernia interna, los pacientes fueron intervenidos quirúrgicamente y se confirmó la presencia de hernia de Petersen. El conocimiento de la técnica quirúrgica, los cambios anatómicos y las posibles complicaciones es de gran utilidad para diagnosticar la causa de dolor abdominal en pacientes sometidos a bypass gástrico. La TCMS brinda información sobre las estructuras extraluminales y su alta resolución espacial permite examinar tanto los cambios anatómicos como las probables complicaciones secundarias al bypass gástrico...
Responsable: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Bassi, Deomir Germano
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Id: lil-742116
Author: Mariano, Maria Luiza Lobato; Paula, Maria Angela Boccara de; Bassi, Deomir Germano; Paula, Pedro Roberto de.
Title: Bariatric surgery: impact on sexuality of the obese person / Cirurgia bariátrica: repercussões na sexualidade da pessoa obesa
Source: Rev. Col. Bras. Cir;41(6):412-420, Nov-Dec/2014. tab.
Language: en.
Abstract: Objective: To assess the impact of surgical treatment in the sexuality of the obese. Methods: We conducted a qualitative / quantitative research with 30 patients who had undergone Fobi-Capella Roux-Y gastric bypass for at least one year. We collected data through individual interviews using a questionnaire with 10 mixed questions and one open, between May and June 2011. The objective data were quantified in absolute numbers and percentages, and the subjective ones were analyzed using the Discourse of the Collective Subject (DCS) and discussed in view of reference published on the subject. Results: 30 patients were enrolled, with a mean age 44 ± 12 years, 24 (80%) were female and six (20%) were male, 23 (77%) were married, 23 (96%) were hypertensive and eight (33%) were diagnosed with Diabetes Mellitus. After the operation, 11 (37%) individuals reported no change in the number sexual intercourses, but 19 (63%) reported that this number was altered, 16 (53%) informed increased frequency, one (3%) reported a decrease in frequency, one (3%) did not practice sexual intercourse anymore and one (3%) did not report the frequency. The central ideas (CI) raised originated four DCSs: Experience of female sexuality; No experience of female sexuality; Experience of male sexuality; and improvements of comorbidities and psychological factor. Conclusion: there are positive repercussions of physical and emotional orders of the surgical treatment of obesity, favoring the quality of life, including sexuality. .

Objetivo: Conhecer as repercussões do tratamento cirúrgico na vivência da sexualidade da pessoa obesa. Métodos: Pesquisa quali/quantitativa realizada com 30 pacientes submetidos à gastroplastia em Y de Roux, à Fobi e Capella, há pelo menos um ano. Dados obtidos por meio de entrevista individual utilizando instrumento com 10 questões mistas e uma aberta, no período de maio e junho de 2011. Os dados objetivos foram quantificados em números absolutos e percentuais e, os subjetivos foram submetidos à análise por meio do Discurso do Sujeito Coletivo (DSC) e discutidos à luz do referencial publicado sobre a temática. Resultados: foram incluídos 30 pacientes com média de idade 44±12 anos, sendo 24 (80%) do sexo feminino e seis (20%) do masculino, 23 (77%) casados, 23 (96%) hipertensos e oito (33%) com diagnóstico de Diabetes Mellitus. Após a operação, 11 (37%) não relataram alteração no número de relações sexuais, porém 19 (63%) informaram que este número sofreu alteração, sendo que 16 (53%) afirmaram ter aumentado a frequência das relações sexuais, um (3%) relatou a diminuição da frequência, um (3%) não pratica mais o ato sexual e um (3%) não declarou a frequência. As ideias centrais (IC) levantadas originaram quatro DSC: Vivência da sexualidade feminina; Não vivência da sexualidade feminina; Vivência da sexualidade masculina; e Melhorias das comorbidades e fator psicológico. Conclusão: existem repercussões, de ordem física e emocional, positivas do tratamento cirúrgico da obesidade favorecendo a qualidade de vida, inclusive na sexualidade. .
Responsable: BR1.1 - BIREME


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Id: lil-767849
Author: Oliveira, Cleiton da Silva; Beserra, Bruna Teles Soares; Cunha, Raphael Salles Granato; Brito, Ana Gabriela Estevam; Miranda, Rafaella Cristina Dimbarre de; Zeni, Lúcia Andréia Zanette Ramos; Nunes, Everson Araújo; Trindade, Erasmo Benicio Santos de Moraes.
Title: Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles / Impacto da derivação gástrica em Y-de-Roux no perfil inflamatório e lipídico
Source: Rev. Col. Bras. Cir;42(5):305-310, Sept.-Oct. 2015. tab, graf.
Language: pt.
Abstract: Objective: To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass. Methods : We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol. Results : participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050). Conclusion : Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.

Objetivo: avaliar o comportamento das proteínas de fase aguda e o perfil lipídico em pacientes submetidos à derivação gástrica em Y-de-Roux. Métodos: estudo prospectivo, constituído por três momentos: M1 - pré-cirúrgico (24 horas antes do procedimento cirúrgico); M2 - 30 dias pós-cirúrgico; e M3 - 180 dias pós-cirúrgico. Foram realizadas aferição antropométrica de peso, altura e IMC, como também determinação das concentrações das proteínas de fase aguda (proteína c reativa (PCR), albumina e alfa-1-glicoproteína-ácida) e de colesterol total, LDL-c, HDL-c e triacilglicerol. Resultados: participaram desse estudo 25 indivíduos, com média de idade de 39,28±8,07, sendo 72% do sexo feminino. Em todos os momentos do estudo observou-se diferença estatística significativa quanto à redução de peso e IMC. Verificou-se diminuição com diferença nas concentrações da PCR entre os momentos M1 e M3 (p=0,041); M2 e M3 (p=0,018). As concentrações da a1-GA reduziram e foram diferentes entre os momentos M1 e M2 (p=0,023); M1 e M3 (p=0,028). Os valores de albumina aumentaram, mas não diferiram entre os momentos. O colesterol total e o triacilglicerol diminuíram com diferença entre todos os momentos. As concentrações de LDL-c diminuíram e diferiram entre os momentos M1 e M2 (p=0,001); M1 e M3 (p=0,001). Os valores de HDL-c aumentaram, entretanto apenas diferiram entre os momentos M1 e M2 (p=0,050). Conclusão: a derivação gástrica em Y-de-Roux promoveu diminuição nas concentrações plasmáticas da PCR e alfa-1-glicoproteína ácida, melhorando o perfil inflamatório e lipídico.
Responsable: BR1.1 - BIREME



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