Database : LILACS
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Id: biblio-838416
Author: Soutelo, Jimena; Moldes, Sofía; Frisone, Cielo; Salvá, Laura; Agostinis, Cecilia; Faraj, Gabriel.
Title: The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma
Source: Arch. endocrinol. metab. (Online);61(1):98-102, Jan.-Feb. 2017. tab, graf.
Language: en.
Abstract: SUMMARY Paraneoplastic syndromes are a heterogeneous group of malignant diseases caused by events which involve endocrine, immune and metabolic aspects and whose symptoms vary according to the substance produced and the primary tumor. Hypercalcemia is a frequent complication in cancer patients. Prognosis of cancer patients with hypercalcemia is usually poor. A factor called parathyroid hormone related peptide, whose actions are similar to those of the parathyroid hormone, is thought to be the most common cause of malignancy associated hypercalcemia. Non-islet hypoglycemic cell tumor consists of a rare syndrome characterized by the presence of a solid tumor and severe fasting hypoglycemia determined by an insulin-independent pathway. We report a case of a 59-year-old-man with a renal tumor and a T-cell rich large B cell lymphoma who was hospitalized due to severe hypercalcemia and hypoglycemia. The laboratory examination reported hypercalcemia with inhibited PTH and hypoglycemia with inhibited insulin secretion, arriving to the conclusion of tumoral peptide production. He received denosumab and corticoid therapy. The patient died one month later despite initial improvement after medical treatment. While a single paraneoplastic manifestation may be expected in most tumors, the coexistence of two or more of them is rare, except in hepatocellular carcinomas, and it has not yet been described in renal tumors.
Responsable: BR1.1 - BIREME


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Id: biblio-838439
Author: Costa, Maria Manuel; Belo, Sandra; Capela-Costa, João; Costa, Jennifer; Carvalho, Davide.
Title: Malignant melanoma with synchronous thyroid metastases: case report and literature review
Source: Arch. endocrinol. metab. (Online);61(2):193-197, Mar.-Apr. 2017. graf.
Language: en.
Abstract: SUMMARY Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. A thoracoabdominal magnetic resonance imaging obtained for cancer staging revealed a > 50% tracheal obstruction caused by the goiter. The patient underwent simultaneous total thyroidectomy and melanoma excision. Histological analysis of the thyroid showed the presence of multiple metastatic foci from the melanoma. Due to the patient’s age, a decision was made to maintain her under surveillance and administer palliative treatment if necessary. Although metastases to the thyroid are rare, they should be considered in the differential diagnosis of thyroid lesions in patients with a known primary tumor. The thyroidectomy, performed in this patient’s case, allowed the diagnosis of the metastases and relief of compressive symptoms caused by the goiter.
Responsable: BR1.1 - BIREME


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Id: lil-719518
Author: Somocurcio, Jose; Alvarez, Gamero; Lara Campos, Gloria; Cahuana Aparco, Judith; Calongos Porras, Estefanny; Bermejo Cataño, Pedro; Tejada Llacsa, Paul.
Title: Oclusión arterial aguda asociada a hidatidosis diseminada / Acute arterial occlusion associated disseminated hydatidosis
Source: Rev. peru. med. exp. salud publica;31(2):375-379, abr.-jun. 2014. ilus.
Language: es.
Abstract: Hidatidosis o equinococosis son términos usados para denominar a la infestación zoonótica causada por los estadios adulto y larvario (metacéstode) del céstode del género Equinococcus (familia tenidae). El término hidatidosis debe ser aplicado a la infestación por el metacéstode mientras que el de equinococosis a los estadios larvario y adulto. En el Perú existe una alta prevalencia de esta infección siendo el hígado y pulmón los órganos más afectados. Existen factores tanto del agente infeccioso como del hospedero que contribuyen a esta infección, donde el componente inmunológico del hospedero es un punto importante tanto en la infección como en la diseminación. En el presente artículo se reporta un caso de oclusión arterial aguda asociada a hidatidosis diseminada en un paciente de 54 años de edad, natural y procedente de Huancavelica, de inicio súbito con un cuadro de obstrucción arterial aguda; que no mejoró luego de la cirugía con fallecimiento a las 48 horas de la presentación.

Hydatidosis or echinococcosis are terms used to denote the zoonotic infestation caused by adult and larval stages (metacestode) of the cestode from the genus Echinococcus (family tenidae). The term hydatidosis should be applied to the infestation caused by the metacestode while echinococcosis for the larval and adult stages. In Peru there is a high prevalence of this infection, liver and lung being the most affected organs. There are factors from the host and from the infectious agent that contribute to this infection, with the immune component of the host as an important infection and dissemination point. A case of acute arterial occlusion associated with disseminated hydatidosis in a 54 years old patient, born and from Huancavelica, with sudden onset of an acute arterial obstruction is reported. The patient did not improve after surgery and died within 48 hours of presentation.
Responsable: PE14.1 - Biblioteca de la Sede Central


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Id: biblio-1122502
Author: Conto-Palomino, Nadin Melina; Cabrera-Bueno, María Luz; Vargas-Ponce, Kenneth Grenis; Rondón-Abuhadba, Evelina Andrea; Atamari-Anahui, Noé.
Title: Encefalitis asociada a COVID-19 en una niña de 13 años: reporte de caso / Encephalitis associated with COVID-19 in a 13-year-old girl: A case report
Source: Medwave;20(7), 31-08-2020.
Language: en; es.
Abstract: Existen limitados reportes de síntomas neurológicos en la población pediátrica con COVID-19. Reportamos el caso de una niña de 13 años con tres días de enfermedad caracterizada por cefalea, vómitos no explosivos, fiebre y trastorno del sensorio de inicio brusco asociado a dificultad para la bipedestación y hemiparesia en extremidades, sin evidencia de signos meníngeos. La tomografía cerebral reveló edema cerebral difuso y el estudio de líquido cefalorraquídeo era concordante con una infección viral. El diagnóstico de COVID-19 fue mediante pruebas serológicas. La paciente tuvo una evolución clínica desfavorable a pesar del tratamiento con hidroxicloroquina, azitromicina y corticoides, falleciendo al tercer día de hospitalización. La encefalitis en un paciente con COVID-19 es una asociación poco descrita en la población pediátrica. Esta infección debe ser considerado como diagnóstico diferencial en los pacientes que llegan a la emergencia con trastorno de sensorio o sintomatología neurológica en el contexto de la actual pandemia.

There are limited reports of neurological symptoms in the pediatric population with COVID-19. We report a 13-year-old girl with three days of illness characterized by headache, non-explosive vomiting, fever, and sudden-onset sensory disorder associated with difficulty in standing and hemiparesis in limbs without evidence of meningeal signs. Brain tomography revealed diffuse brain edema, and the cerebrospinal fluid study was consistent with a viral infection. COVID-19 was diagnosed based on serology. The patient had an untoward clinical course despite treatment with hydroxychloroquine, azithromycin, and corticosteroids, dying on the third day of hospitalization. Encephalitis in a patient with COVID-19 is not frequently reported in the pediatric population. It should be considered in the differential diagnosis in patients who arrives at the emergency with a sensory disorder or neurological symptomatology in the context of the COVID-19 pandemic.
Responsable: CL1.1 - Biblioteca Central


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Id: biblio-1118650
Author: De la Barra B, Sergio; Hernández C, Guillermo; Fernández G, Ernesto; Barría E, Ana María; De la Barra B, Pablo.
Title: Peritonitis bacteriana espontánea por Listeria monocytogenes en un paciente con cirrosis hepática: reporte de un caso / Spontaneous bacterial peritonitis due to Listeria monocytogenes in a patient with cirrhosis: case report
Source: Gastroenterol. latinoam;28(2):85-87, 2017.
Language: es.
Abstract: Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication in cirrhotic patients. Listeria monocytogenes is a rare cause of SBP, which should be suspected in individuals with impaired immunity such as advanced liver disease and inadequate response to standard antibiotic therapy. We report a case of a 72 year-old patient with liver cirrhosis secondary to alcohol consumption, asymptomatic carrier of Hepatitis B virus, diabetes Type II and coronary artery disease; who is admitted with a diagnosis of hepatic encephalopathy and suspicion of spontaneous bacterial peritonitis receiving empiric antibiotic treatment with ceftriaxona. Initially he showed clinical response but a few days later he got worse. Ascitic culture confirmed infection by Listeria monocytogenes. Antibiotic treatment was adjusted but patient continued deteriorating progressively, and finally died due to renal dysfunction.

La peritonitis bacteriana espontánea (PBE) es una complicación frecuente y grave en los pacientes cirróticos. Listeria monocytogenes es una causa poco frecuente de PBE, que debe sospecharse en individuos con inmunidad alterada como es la enfermedad hepática avanzada y con respuesta inadecuada a terapia antibiótica habitual. Presentamos el caso de un paciente de 72 años con antecedentes de cirrosis hepática secundaria a consumo de alcohol, portador asintomático del virus de la Hepatitis B (VHB), diabético tipo II y cardiópata coronario. Se hospitaliza por encefalopatía hepática secundaria a PBE, recibe tratamiento antibiótico empírico con ceftriaxona con respuesta clínica inicial y deterioro posterior. Cultivo de líquido ascítico confirma infección por Listeria monocytogenes. Pese a ajuste de tratamiento antibiótico, continúa empeorando y finalmente fallece por disfunción renal.
Responsable: CL61.1 - Biblioteca Central Campus Sur


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Id: biblio-983804
Author: Danilowicz, Karina; Abbati, Santiago Gonzalez; Sosa, Soledad; Witis, Florencia Lustig; Sevlever, Gustavo.
Title: Suprasellar chordoid glioma: a report of two cases
Source: Arch. endocrinol. metab. (Online);62(6):648-654, Dec. 2018. graf.
Language: en.
Abstract: SUMMARY Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. She was in amenorrhea. A brain magnetic resonance imaging (MRI) demonstrated a 35 mm-diameter sellar and suprasellar mass. An emergency ventricular peritoneal valve was placed due to obstructive hydrocephalus. Transcraneal surgery was performed. The patient developed central hypothyroidism, adrenal insufficiency and transient diabetes insipidus; she never recovered spontaneous menstrual cycles. Histopathologic study showed cells in cords, inside a mucinous stroma, positive for glial fibrillary acidic protein (GFAP). Due to residual tumor gamma knife radiosurgery was performed. Three years after surgery, the patient is lucid, with hypopituitarism under replacement. 2) A 46 year-old woman complained about a three year-history of amenorrhea, galactorrhea and headache. An MRI showed a solid-cystic sellar mass 40 mm-diameter that extended to the suprasellar cistern. She had hypogonatropic hypogonadism and mild hyperprolactinemia. The tumor mass was removed via nasal endoscopic approach. Histopathological study reported cellular proliferation of glial lineage positive for GFAP. The patient evolved with central hypothyroidism and diabetes insipidus. She was re-operated for fistula and again under the diagnosis of extradural abscess. She evolved with cardiorespiratory descompensation and death, suspected to be due to a thromboembolism. In conclusion, the first case confirms that best treatment for CG is surgery considering radiotherapy as an adjuvant therapy. The other case, on the contrary, illustrates the potentially fatal evolution due to surgical complications.
Responsable: BR1.1 - BIREME


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Id: biblio-1057212
Author: Antunes, Pedro de Souza Lucarelli; Tersariol, Heloísa Gabriel; Veiga, Mainã Marques Belém; Menezes, Maria Conceição Santos de; Bernardi, Fabíola Del Carlo; Forte, Wilma Carvalho Neves.
Title: Neuroendocrine tumor in a child with common variable immunodeficiency / Tumor neuroendócrino em criança com imunodeficiência comum variável
Source: Rev. Paul. Pediatr. (Ed. Port., Online);38:e2018146, 2020. graf.
Language: en.
Abstract: ABSTRACT Objective: To report a case of a child with primary immunodeficiency who at eight years developed digestive symptoms, culminating with the diagnosis of a neuroendocrine tumor at ten years of age. Case description: One-year-old boy began to present recurrent pneumonias in different pulmonary lobes. At four years of age, an immunological investigation showed a decrease in IgG and IgA serum levels. After the exclusion of other causes of hypogammaglobinemia, he was diagnosed with a Common Variable Immunodeficiency and started to receive monthly replacement of human immunoglobulin. The patient evolved well, but at 8 years of age began with epigastrium pain and, at 10 years, chronic persistent diarrhea and weight loss. After investigation, a neuroendocrine tumor was diagnosed, which had a rapid progressive evolution to death. Comments: Medical literature has highlighted the presence of gastric tumors in adults with Common Variable Immunodeficiency, emphasizing the importance of early diagnosis and the investigation of digestive neoplasms. Up to now there is no description of neuroendocrine tumor in pediatric patients with Common Variable Immunodeficiency. We believe that the hypothesis of digestive neoplasm is important in children with Common Variable Immunodeficiency and with clinical manifestations similar to the case described here in the attempt to improve the prognosis for pediatric patients.

RESUMO Objetivo: Relatar um caso de criança portadora de imunodeficiência primária que, aos oito anos, desenvolveu sintomas digestivos, culminando com o diagnóstico de tumor neuroendócrino aos dez anos de idade. Descrição do caso: Menino, com um ano de idade, começou a apresentar pneumonias de repetição em diferentes lobos pulmonares. Aos quatro anos, a investigação imunológica mostrou diminuição dos níveis séricos de IgG e IgA. Após exclusão de outras causas de hipogamaglobulinemia, teve diagnóstico de imunodeficiência comum variável, passando a receber reposição mensal de imunoglobulina humana. Evoluiu bem, porém, aos oito anos, começou com epigastralgia e, aos dez anos, diarreia crônica persistente e perda de peso. O quadro culminou com o diagnóstico de tumor neuroendócrino intestinal, de rápida progressão, com óbito do paciente. Comentários: A literatura tem chamado a atenção para tumores gástricos em adultos com imunodeficiência comum variável, alertando para a importância do diagnóstico precoce e da pesquisa de neoplasias digestivas. Até o momento, não há descrição de tumor neuroendócrino em pacientes pediátricos portadores de imunodeficiência comum variável. Acredita-se ser importante a hipótese de neoplasia digestiva diante de crianças com imunodeficiência comum variável e com manifestações clínicas semelhantes ao caso descrito, na tentativa de melhorar o prognóstico para pacientes pediátricos.
Responsable: BR1.1 - BIREME


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Id: biblio-899274
Author: Pena, Hilda Fátima de Jesus; Evangelista, Camila Mariellen; Casagrande, Renata Assis; Biezus, Giovana; Wisser, Claudia Salete; Ferian, Paulo Eduardo; Moura, Anderson Barbosa de; Rolim, Veronica Machado; Driemeier, David; Oliveira, Solange; Alves, Bruna Farias; Gennari, Solange Maria; Traverso, Sandra Davi.
Title: Fatal toxoplasmosis in an immunosuppressed domestic cat from Brazil caused by Toxoplasma gondii clonal type I / Toxoplasmose fatal em um gato doméstico imunossuprimido do Brasil causada por Toxoplama gondii clonal tipo I
Source: Rev. bras. parasitol. vet;26(2):177-184, Apr.-June 2017. tab, graf.
Language: en.
Project CAPES/PROEX.
Abstract: Abstract The objective of the study was to report on a fatal case of feline toxoplasmosis with coinfection with the feline leukemia virus (FeLV). A domestic cat (Felis silvestris catus) presented intense dyspnea and died three days later. In the necropsy, the lungs were firm, without collapse and with many white areas; moderate lymphadenomegaly and splenomegaly were also observed. The histopathological examination showed severe necrotic interstitial bronchopneumonia and mild necrotic hepatitis, associated with intralesional cysts and tachyzoites of Toxoplasma gondii that were positive by anti-T. gondii immunohistochemical (IHC) evaluation. The bone marrow showed chronic myeloid leukemia and the neoplastic cells were positive by anti-FeLV IHC evaluation. DNA extracted from lungs was positive for T. gondii by PCR targeting REP-529. T. gondii was characterized by PCR-RFLP and by the microsatellites technique. ToxoDB-PCR-RFLP #10, i.e. the archetypal type I, was identified. Microsatellite analysis showed that the strain was a variant of type I with two atypical alleles. This was the first time that a T. gondii clonal type I genotype was correlated with a case of acute toxoplasmosis in a host in Brazil.

Resumo O objetivo deste estudo foi relatar um caso de toxoplasmose felina fatal com coinfecção com o vírus da leucemia felina (FeLV). Um gato doméstico (Felis silvestris catus) apresentou intensa dispneia e morreu três dias depois. Na necropsia, observaram-se pulmões firmes, não colabados e com múltiplas áreas brancas, além de linfoadenomegalia e esplenomegalia moderadas. No exame histopatológico, evidenciaram-se broncopneumonia intersticial necrótica acentuada e hepatite necrótica discreta associada a cistos e taquizoítas de T. gondii intralesionais positivos na imuno-histoquímica (IHC) anti-T. gondii. Evidenciou-se ainda, na medula óssea, leucemia mieloide crônica com IHC anti-FeLV positiva nas células neoplásicas. O DNA extraído dos pulmões foi positivo para T. gondii por meio da PCR-REP-529. T. gondii foi caracterizado por PCR-RFLP e pela técnica de microssatélites. Foi identificado o genótipo ToxoDB-PCR-RFLP #10, i.e., o arquétipo tipo I. A análise por microssatélites mostrou que a cepa era uma variante do tipo I, com dois alelos atípicos. Esta é a primeira vez que T. gondii clonal tipo I foi relacionado com um caso agudo de toxoplasmosis em um hospedeiro no Brasil.
Responsable: BR1.1 - BIREME


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Id: biblio-1117850
Author: Elias, Julia Garcia Leal; Lopes, Maurício Marson Lopes; Mori, Fernanda Betanho; Monferdini, Luana; Ciscon, Maria Ligia; Barbosa, Guilherme Viana.
Title: Trombo Atrial Gigante em Paciente com Estenose Mitral. Relato de Caso / Giant Atrial Thrombus in a Patient with Mitral Stenosis: A Case Report
Source: ABC., imagem cardiovasc;33(3):[abc71], 2020.
Language: pt.
Responsable: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-1118521
Author: Silveira, Edilene Aparecida Araújo da; Magalhães, Ana Carolina Guimarães de; Alves, Michely Izabel; Silva, Vivianny Christine Marques; Oliveira, Patrícia Peres de.
Title: Experiencing cardiorespiratory arrest and death by relatives: a descriptive study / Vivenciando a parada cardiorrespiratória e óbito por familiares: estudo descritivo / Vivenciando la parada cardiorrespiratoria y muerte por familiares: estudio descriptivo
Source: Online braz. j. nurs. (Online);16(3):344-354, 2017. ilus.
Language: en; es; pt.
Abstract: AIM: understand the experience of relatives of people who suffered cardiac arrest and died. METHOD: this is a descriptive, qualitative study that used, respectively, symbolic interactionism and interpretive interactionism as a theoretical and methodological reference. Data were collected through a semi-structured interview at the household of 11 relatives, from November 2015 to June 2016. RESULTS: the analysis of the narratives evidenced several feelings such as anger, anxiety and hope. Two epiphanies were identified. The first epiphany, discovering that the relative died, had as categories: experiencing the moment of the CRA and receiving the news. In the second epiphany, coexisting with the immediate changes, the following categories were evidenced: remembering and feeling the pain of loss and changes after the death of the relative. CONCLUSION: the interactionist perspective made it possible to better understand the experience of relatives in waiting for the attendance of cardiorespiratory arrest and the subsequent reception of the news of death of their loved one.

OBJETIVO: compreender a vivência de familiares de pessoas que sofreram parada cardiorrespiratória e foram a óbito. MÉTODO: estudo descritivo, qualitativo, que utilizou como referencial teórico e metodológico, respectivamente, interacionismo simbólico e interacionismo interpretativo. Os dados foram coletados por intermédio de entrevista semiestruturada no domicílio de 11 familiares, no período de novembro de 2015 a junho de 2016. RESULTADOS: a análise das narrativas evidenciou diversos sentimentos como raiva, ansiedade e esperança. Foram identificadas duas epifanias. A primeira epifania, descobrindo que o familiar morreu, teve como categorias: vivenciando o momento da PCR e recebendo a notícia. Na segunda epifania, convivendo com as mudanças imediatas, evidenciou-se as categorias: relembrando e sentindo a dor da perda e mudanças após o falecimento do familiar. CONCLUSÃO: a perspectiva interacionista permitiu melhor compreender a experiência de familiares ao aguardar o atendimento de parada cardiorrespiratória e a posterior recepção da notícia de morte de seu ente querido.

OBJETIVO: comprender la experiencia de familiares de personas que sufrieron parada cardiorrespiratoria y murieron. MÉTODO: estudio descriptivo, cualitativo, que utilizó como referencial teórico y metodológico, respectivamente, interaccionismo simbólico e interaccionismo interpretativo. Los datos fueron colectados por intermedio de entrevista semiestructurada en domicilio de 11 familiares, en el período de noviembre de 2015 a junio de 2016. RESULTADOS: el análisis de las narrativas evidenció diversos sentimientos como rabia, ansiedad y esperanza. Fueron identificadas dos epifanías. La primera epifanía, descubriendo que el familiar murió, tuvo como categorías: viviendo el momento de la PCR y recibiendo la noticia. En la segunda epifanía, conviviendo con los cambios inmediatos, eran evidente las categorías: recordando y sintiendo el dolor de la perdida y cambios después del fallecimiento del familiar. CONCLUSIÓN: la perspectiva interaccionista permitió comprender mejor la experiencia de familiares al aguardar el atendimiento de la parada cardiorrespiratoria y la posterior recepción de la noticia de la muerte de su ser querido.
Responsable: BR1342.1 - Biblioteca da Escola de Enfermagem BENF



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