Database : LILACS
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Id: lil-780314
Author: Calle-Velezmoro, Eduardo; Palti-Menéndez, León R; Agurto-Huerta, Andrés; Salazar-Fernández, Cinthia.
Title: Prevalencia de la mineralización de la cadena estilohioidea en radiografías panorámicas de pacientesmayores de 18 años / Prevalence of mineralization of the stylohyoid chain in panoramic radiographs of patients over 18 years
Source: Kiru;11(2):171-174, jul.-dic.2014. ilus, tab.
Language: es.
Abstract: Determinar la prevalencia de la mineralización de la cadena estilohioidea, en pacientes mayores de 18 años del Centro de Diagnóstico por Imágenes del 2012. Materiales y métodos. Se realizó un estudio descriptivo, trasversal y retrospectivo, donde se analizaron 1202 radiografías panorámicas digitales (404 masculino y 798 femenino). El proceso de mineralización de la cadena estilohioidea fue definida como la medida, de más de 30 mm desde el margen caudal de la placa timpánica a la punta de la cadena estilohioidea. Se utilizó la estadística descriptiva, donde los resultados se expresaron en porcentajes, se presentaron en tablas y gráficos. Resultados. Se halló que la prevalencia de mineralización de la cadena estilohioidea fue 82,9%. De los cuales, un 79,6% fue bilateral, con un predominio de mineralización tipo III 38,9%, se observó con mayor frecuencia en el sexo masculino 90,6% y en el rango de edad, mayores de 80 años con 94,3%. Conclusión. En nuestra población existe una alta prevalencia de mineralización de la cadena estilohioidea en comparación con estudios previamente realizados en diferentes partes del mundo, con una mayor prevalencia bilateral, de tipo III, presentándose en mayor porcentaje en pacientes de sexo masculino y en el rango de edad de mayores de 80 años...

Objective. To determine the prevalence of mineralization of the Stylohyoid Chain and the prevalence according to the side, type, sex and age group in patients older than 18 years treated at the ôCentro de Diagnóstico por Imágenesõ. Matherials and methods. 1 202 digital panoramic radiographs were analyzed to determine the beginning of a process of mineralization of the Stylohyoid Chain that should get more than 30 mm when it is measured from the caudal margin of the tympanic plate to the tip of the Stylohyoid Chain. Results. A prevalence of 82,9% having mineralization of the Stylohyoid Chain in which 79,6% was bilateral and there was a predominance of type III mineralization; also we obtained a prevalence of 90,6% in males and 94,3% in the age range over 80 years.Conclusion. In our population there is a high prevalence of the Stylohyoid Chain mineralization compared with previous studies in different parts of the world, as well as a higher prevalence bilateral type III, appearing at a higher rate in male patients and the age range of over 80 years...
Responsable: PE264.1 - Biblioteca


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Id: biblio-1069529
Author: Mont'Alverne Filho, José Ronaldo; Barreto, Carlos Eduardo Zerpa; Costa, Marco Aurélio Alvim; Staico, Rodolfo.
Title: Abordagem de lesões complexas / Severes injuries approach
Source: In: Sousa, Amanda GMR; Staico, Rodolfo; Sousa, J Eduardo MR. Stent Coronário. São Paulo, Atheneu, 2001. p.119-151, ilus.
Language: pt.
Responsable: BR79.1 - CIC - Centro de Informação Cardiovascular Mendonça de Barros
BR79.1


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Soares, Elza Cotrim
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Id: lil-639266
Author: Furtado, Alexandre Khodr; Santos, Allan de Oliveira; Zeitune, José Murilo Robilotta; Soares, Elza Cotrim.
Title: Osteodistrofia hepática / Hepatic osteodystrophy
Source: GED gastroenterol. endosc. dig;30(2):52-61, abr.-jun. 2011. ilus.
Language: pt.
Abstract: Osteodistrofia hepática é distúrbio de mineralização óssea associada à doença hepática crônica, sendo a osteoporose, e mais raramente a osteomalácia, sua forma de apresentação clínica. Apesar de pouco diagnosticada e com prevalência de grande variação na literatura, na maioria das vezes, apresenta-se de forma assintomática e, quando não identificada, aumenta consideravelmente o risco de fratura e sequelas permanentes. Seu diagnóstico, portanto, requer alta suspeição e faz-se, na prática clínica, por meio da avaliação da densitometria óssea. De fisiopatogenia multifatorial, envolve fatores genético, ambiental e do próprio estado clínico-nutricional do paciente. Uma atenção maior deve ser despendida a hepatopatas desnutridos, com cirrose hepática avançada, doença colestática crônica e transplantados pelo maior risco de desmineralização óssea. Nesta revisão, será discorrido sobre o metabolismo fisiológico da síntese óssea e a fisiopatologia do distúrbio de mineralização óssea, desde mecanismos fisiopatogênicos na doença hepática crônica, seu diagnóstico e revisão da terapêutica atual empregada.

Hepatic osteodystrophy is a disorder of bone mineralization associated to liver disease, clinically manifested by osteoporosis and more rarely osteomalacia. Although seldomly diagnosed and varying greatly in literature, most of the time, it presents asymptomatically and, when it is not recognized, it enhances considerably the risk of fracture and permanent sequelae. Indeed it requires a high grade of suspicion and it is confirmed by means of bone densitometry evaluation in clinical practice. Presenting with a multifactorial physiopathology, it involves factors, such as genetical, environmental, and patient clinical-nutritional status. A greater attention must be spent on patients with liver disease, especially those malnourished, with advanced cirrhosis, chronic cholestatic disease, and transplanted, because of a higher risk of bone demineralization. In this data, it will be reviewed the bone synthesis metabolism and the physiopathology of bone mineralization disorder ? since fisiopatogenic mechanisms in chronic liver disease, diagnosis and recent therapeutic review employed.
Responsable: BR9.1 - Biblioteca de Ciências da Saúde Profa. Susana Schimidt


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Id: lil-787550
Author: YILDIRIMTURK, Senem; BATU, Sule; ALATLI, Canan; OLGAC, Vakur; FIRAT, Deniz; SIRIN, Yigit.
Title: The effects of supplemental melatonin administration on the healing of bone defects in streptozotocin-induced diabetic rats
Source: J. appl. oral sci;24(3):239-249tab, graf.
Language: en.
Project Istanbul University; . Coordinatorship of Teaching Staff Training Programme.
Abstract: ABSTRACT Diabetes mellitus (DM) causes an increased production of free radicals that can impair bone healing. Melatonin is a hormone secreted mainly by the pineal gland, which participates in the neutralization process of free radicals. Objective The aim of this study was to investigate histologic and biochemical effects of supplemental melatonin administration on bone healing and antioxidant defense mechanism in diabetic rats. Material and Methods Eighty-six Sprague-Dawley male rats were used in this study. Diabetes mellitus was induced by intraperitoneal (i.p.) administration of 65 mg/kg streptozotocin (STZ). Surgical bone defects were prepared in the tibia of each animal. Diabetic animals and those in control groups were treated either with daily melatonin (250 μg/animal/day/i.p.) diluted in ethanol, only ethanol, or sterile saline solution. Rats were humanely killed at the 10th and 30th postoperative days. Plasma levels of Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), and Superoxide Dismutase (SOD) were measured. The number of osteoblasts, blood vessels and the area of new mineralized tissue formation were calculated in histologic sections. Results At the 10th day, DM+MEL (rats receiving both STZ and melatonin) group had significantly higher number of osteoblasts and blood vessels as well as larger new mineralized tissue surfaces (p<0.05 for each) when compared with DM group. At the 30th day, DM group treated with melatonin had significantly lower levels of AOPP and MDA than those of DM group (p<0.05). Conclusion Melatonin administration in STZ induced diabetic rats reduced oxidative stress related biomarkers and showed beneficial effects on bone healing at short term.
Responsable: BR1.1 - BIREME


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Id: lil-779903
Author: RAHMAN, Mohammad Zeshaan; SHIGEISHI, Hideo; SASAKI, Kazuki; OTA, Akira; OHTA, Kouji; TAKECHI, Masaaki.
Title: Combined effects of melatonin and FGF-2 on mouse preosteoblast behavior within interconnected porous hydroxyapatite ceramics - in vitro analysis
Source: J. appl. oral sci;24(2):153-161, Mar.-Apr. 2016. graf.
Language: en.
Project Ministry of Education, Culture, Sports, Science and Technology.
Abstract: ABSTRACT Objective Biocompatible materials such as interconnected porous hydroxyapatite ceramics (IP-CHA) loaded with osteogenic cells and bioactive agents are part of an evolving concept for overcoming craniofacial defects by use of artificial bone tissue regeneration. Amongst the bioactive agents, melatonin (MEL) and basic fibroblast growth factor (FGF-2) have been independently reported to induce osteoblastic activity. The present in vitro study was undertaken to examine the relationship between these two bioactive agents and their combinatory effects on osteoblastic activity and mineralization in vitro. Material and Methods Mouse preosteoblast cells (MC3T3-E1) were seeded and cultured within cylindrical type of IP-CHA block (ø 4x7 mm) by vacuum-assisted method. The IP-CHA/MC3T3 composites were subjected to FGF-2 and/or MEL. The proliferation assay, alkaline phosphatase enzyme activity (ALP), mRNA expressions of late bone markers, namely Osteocalcin (OCN) and Osteopontin (OPN), and Alizarin Red staining were examined over a period of 7 days. Results FGF-2 mainly enhanced the proliferation of MC3T3-E1 cells within the IP-CHA constructs. MEL mainly induced the mRNA expression of late bone markers (OCN and OPN) and showed increased ALP activity of MC3T3 cells cultured within IP-CHA construct. Moreover, the combination of FGF-2 and MEL showed increased osteogenic activity within the IP-CHA construct in terms of cell proliferation, upregulated expressions of OCN and OPN, increased ALP activity and mineralization with Alizarin Red. The synergy of the proliferative potential of FGF-2 and the differentiation potential of MEL showed increased osteogenic activity in MC3T3-E1 cells cultured within IP-CHA constructs. Conclusion These findings indicate that the combination of FGF-2 and MEL may be utilized with biocompatible materials to attain augmented osteogenic activity and mineralization.
Responsable: BR1.1 - BIREME


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Id: biblio-1008381
Author: Xu, Guojing; Li, Dongwei; Jiao, Binquan; Li, Dou; Yin, Yajie; Lun, Limei; Zhao, Ziqiang; Li, Shan.
Title: Biomineralization of a calcifying ureolytic bacterium Microbacterium sp. GM-1
Source: Electron. j. biotechnol;25:21-27, ene. 2017. ilus, graf, tab.
Language: en.
Project Natural Science Foundation of China; . Chongqing Science & Technology Commission.
Abstract: Background: Biomineralization is a significant process performed by living organisms in which minerals are produced through the hardening of biological tissues. Herein, we focus on calcium carbonate precipitation, as part of biomineralization, to be used in applications for environmental protection, material technology, and other fields. A strain GM-1, Microbacterium sp. GM-1, isolated from active sludge, was investigated for its ability to produce urease and induce calcium carbonate precipitation in a metabolic process. Results: It was discovered that Microbacterium sp. GM-1 resisted high concentrations of urea up to 60 g/L. In order to optimize the calcification process of Microbacterium sp. GM-1, the concentrations of Ni2+ and urea, pH value, and culture time were analyzed through orthogonal tests. The favored calcite precipitation culture conditions were as follows: the concentration of Ni2+ and urea were 50 µM and 60 g/L, respectively, pH of 10, and culture time of 96 h. Using X-ray diffraction analysis, the calcium carbonate polymorphs produced by Microbacterium sp. GM-1 were proven to be mainly calcite. Conclusions: The results of this research provide evidence that Microbacterium sp. GM-1 can biologically induce calcification and suggest that strain GM-1 may play a potential role in the synthesis of new biominerals and in bioremediation or biorecovery.
Responsable: CL1.1 - Biblioteca Central


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Id: lil-628232
Author: Granela Cortiñas, Kesia; Pérez Gesen, Cecilia; Carvajal Martínez, Francisco; Navarro Despaigne, Daysi; Domínguez Alonso, Emma; DÝaz Horta, Oscar; Monteagudo Peña, Gilda.
Title: Mineralización ósea en niños y adolescentes con hipotiroidismo congénito / Bone mineralization in children and adolescents presenting with a congenital hypothyroidisM
Source: Rev. cuba. endocrinol;22(2):118-132, Mayo.-ago. 2011.
Language: es.
Abstract: Introducción: en el hipotiroidismo congénito la mineralización ósea puede afectarse por la enfermedad o por los efectos del tratamiento con hormonas tiroideas.Objetivo: determinar en pacientes con hipotiroidismo congénito la mineralización ósea. Métodos: se realizó estudio descriptivo transversal pareado, en niños cubanos con hipotiroidismo congénito (n=67) y un grupo control (n=67). Se analizó la mineralización ósea por densitometría, y se tuvo en cuenta la edad, el sexo, la maduración ósea y sexual, el diagnóstico hormonal y el tratamiento. Se aplicaron intervalos de confianza (95 por ciento), análisis de varianza y correlación con significación. Resultados: la densidad, el contenido mineral óseo y el z-score en niños cubanos con hipotiroidismo congénito, y el grupo control no fue diferente significativamente (p=0,466; 0,155; 0,416 respectivamente). Estimaciones de asociación de mineralización ósea por edad mostró diferencia significativa en la densidad mineral ósea y contenido mineral óseo (p=0,000) para ambos grupos, y el z-score solo para los enfermos. La mineralización ósea fue significativa en la dosis promedio con levotiroxina en la segunda y tercera fase ósea, y en el tiempo de tratamiento. En el hipotiroidismo congénito permanente hubo correlación con el diagnóstico hormonal y el tiempo de tratamiento (p=0,000). Conclusiones: la mineralización ósea es homogénea en ambos grupos. La densidad y el contenido mineral óseo en niños cubanos con hipotiroidismo congénito y el grupo control se asocian con la edad, y son independientes del sexo. El z-score en pacientes con hipotiroidismo congénito sufre variación con la edad, y es independiente al sexo en ambos grupos. La densidad y el contenido mineral óseo varían en niños con hipotiroidismo congénito(AU)

Introduction: in the case of the congenital hypothyroidism the bone mineralization may be affected by disease or by the effects of the thyroid hormones treatment. Objective: to determine the bone mineralization in patients presenting with congenital hypothyroidism. Methods: a cross-sectional, matched and descriptive study was conducted in Cuban children with congenital hypothyroidism (n= 67) and a control group (n= 67). The bone mineralization was analyzed by densitometry taking into account age, sex, bone and sexual maturation, hormonal diagnosis and treatment. The 95 percent CI were applied, variance analysis and correlation with significance. Results: density, bone mineral content and z-score in Cuban children with congenital hypothyroidism and the control group there was significantly different (p= 0,466; 0,155; 0,416), respectively. The estimations of bone mineralization association according to age showed a significant difference in bone mineralization density and the bone mineral content (p= 0,000) for both groups, and the z-score only for the sick persons. The bone mineralization was marked in mean dose with levothyroxine during the second and third bone phase and the treatment time. In the case of permanent congenital hypothyroidism there was a correlation with hormonal diagnosis and the treatment time (p= 0,000). Conclusions: the bone mineralization is homogeneous in both groups. Density and bone mineral content in Cuban children with congenital hypothyroidism and the control group are associated with age independently of sex in both groups. Density and bone mineral content are different in the children with congenital hypothyroidism(AU)
Responsable: CU1.1 - Biblioteca Médica Nacional


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Soares, Elza Cotrim
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Id: lil-602452
Author: Furtado, Alexandre Khodr; Santos, Allan de Oliveira; Zeitune, José Murilo Rubilotta; Soares, Elza Cotrim.
Title: Osteodistrofia hepática / Hepatic osteodystrophy
Source: GED gastroenterol. endosc. dig;29(4):126-135, out.-dez. 2010. ilus, tab, graf.
Language: pt.
Abstract: Osteodistrofia hepática é distúrbio de mineralização óssea associada à doença hepática crônica, sendo a osteoporose, e mais raramente, a osteomalácia, sua forma de apresentação clínica. Apesar de pouco diagnosticada e prevalência com grande variação na literatura, na maioria das vezes, apresenta-se de forma assintomática e, quando não identificada, aumenta consideravelmente o risco de fratura e sequelas permanentes. Seu diagnóstico, portanto, requer alta suspeição e faz-se, na prática clínica, por meio da avaliação da densitometria óssea. De fisiopatogenia multifatorial, envolve fatores genético, ambiental e do próprio estado clínico-nutricional do paciente. Uma atenção maior deve ser despendida a hepatopatas desnutridos, com cirrose hepática avançada, doença colestática crônica e transplantados pelo maior risco de desmineralização óssea. Nesta revisão, será discorrido sobre o metabolismo fisiológico da síntese óssea e a fisiopatologia do distúrbio de mineralização óssea, desde mecanismos fisiopatogênicos na doença hepática crônica, seu diagnóstico e revisão da terapêutica atual empregada.

Hepatic osteodystrophy is a disorder of bone mineralization associated to liver disease, clinically manifested by osteoporosis and more rarely osteomalacia. Although seldomly diagnosed and varying greatly in literature, most of the time, it presents asymptomatically and, when it is not recognized, it enhances considerably the risk of fracture and permanent sequelae. Indeed it requires a high grade of suspicion and it is confirmed by means of bone densitometry evaluation in clinical practice. Presenting with a multifactorial physiopathology, it involves factors, such as genetical, environmental, and patient clinical-nutritional status. A greater attention must be spent on patients with liver disease, especially those malnourished, with advanced cirrhosis, chronic cholestatic disease, and transplanted, because of a higher risk of bone demineralization. In this data, it will be reviewed the bone synthesis metabolism and the physiopathology of bone mineralization disorder - since fisiopatogenic mechanisms in chronic liver disease, diagnosis and recent therapeutic review employed.
Responsable: BR9.1 - Biblioteca de Ciências da Saúde Profa. Susana Schimidt


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Id: biblio-964330
Author: Oliveira, Roberto Sotto-Maior Fortes de; Peters, Vera Maria; Vitral, Robert Willer Farinazzo.
Title: Determinação do ponto de descalcificação para o preparo histológico de tecidos mineralizados / Determination of the descaling point for the histological preparation of mineralized tissues
Source: Rev. interdisciplin. estud. exp. anim. hum. (impr.);1(2):84-84, Junho 2009. [].
Language: pt.
Responsable: BR1.1 - BIREME


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Id: biblio-914781
Author: Negri, A. L.
Title: El eje hueso-riñón en el control del fósforo sérico y la mineralización ósea / Bone-Kidney axis in the control of serum phosphorus and bone mineralization
Source: Rev. argent. endocrinol. metab;44(2):86-93, abr.-jun. 2007.
Language: es.
Abstract: El eje hueso-riñón ha sido pensado como un mecanismo por el cual el esqueleto se comunica con el riñón para coordinar la mineralización de la matriz extracelular ósea con el manejo renal del fosfato. Osteoblastos /osteocitos están bien preparados para coordinar las homeostasis sistémica de fósforo y la mineralización ósea, ya que ellos expresan todos los componentes implicados en un posible eje hueso-riñón, incluyendo al PHEX, FGF-23, MEPE, y DMP1. Los efectos autocrinos de proteínas de la familia SIBLING como MEPE y DMP1 sobre los osteoblastos podrían regular la producción de proteínas de matriz extracelular que intervienen en la mineralización. El riñón provee uno de los efectores de este eje que regula el balance de fosfato a través de la expresión apical de los cotransportadores sodio/fosfato NaPi-IIa y NaPi-IIc en el túbulo proximal. Central en este eje es el FGF-23, producido por los osteoblastos que tiene acciones fosfatúricas sobre el riñón. Cuando se descubrió que el FGF23, la primera fosfatonina era de origen osteoblástico/osteocitico, quedó establecido el eje hueso-riñón. Probar definitivamente la existencia de este eje hueso-riñón y definir exactamente su rol fisiológico requerirá de investigaciones adicionales

The bone-kidney axis has been thought as a mechanism for the skeleton to communicate with the kidney to coordinate the mineralization of extracelular matrix with the renal handling of phosphate. Osteoblasts / osteocytes are well suited for coordinating systemic phosphate homeostasis and mineralization, since they express all of the implicated components of a possible bone-kidney axis, including PHEX, FGF-23, MEPE, and DMP1. In addition, autocrine effects of SIBLING proteins as MEPE and DMP1 on osteoblasts could regulate the production of ECM proteins that regulate mineralization. The kidney provides one of the effectors of the axis that regulates phosphate balance through the apical expression of NaPi-IIa and NaPi-IIc in proximal tubules. Central in this axis is FGF-23, produced by osteoblasts that has phosphaturic actions on the kidney. When FGF23, the first phosphatonin, was discovered to be of osteoblastic/osteocyte origin, the bone kidney axis was established. Proving the existence of this bone-kidney axis and defining its physiological role will require additional investigations
Responsable: AR635.1 - FCVyS - Servicio de Información y Documentación



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