Database : LILACS
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Id: lil-797150
Author: Chassot, Janaíne Micheli; Ferreira, Luana Mota; Gomes, Felipe Pereira; Cruz, Letícia; Tasso, Leandro.
Title: Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions
Source: Braz. j. pharm. sci;51(4):803-810, Oct.-Dec. 2015. ilus, tab.
Language: en.
Abstract: A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasonedipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column(250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentrationrange of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relativestandard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from nanocapsules(98.03% to 100.35%). Specificity showed no interference from the components of nanocapsules or fromthe degradation products derived from acid, basic and photolytic conditions. In conclusion, the methodis suitable to be applied to assay BD in bulk drug and in nanocapsules, and it can be employed to studystability and degradation kinetics...

Um método simples de CLAE-FR/UV indicativo de estabilidade foi validado para a determinação dodipropionato de beclometasona (BD) em suspensões de nanocápsulas. As condições cromatográficasforam: coluna C18 fase reversa (250 mm x 4,60 mm, 5 µm, 110 Å), usando como fase móvel metanol eágua (85:15 v/v) a 1,0 mL/min, com detecção UV a 254 nm. A curva de calibração foi linear no intervalode 5,0-25,0 µg/mL com coeficiente de correlação >0,999. A precisão foi demonstrada por um desviopadrão relativo menor que 2,0%. A exatidão foi avaliada pelo teste de recuperação do BD a partir dasnanocápsulas (98,03% a 100,35%). O teste de especificidade não mostrou interferência dos componentesdas nanocápsulas e nem dos produtos de degradação derivados de condições ácidas, básicas e fotolíticas.Em conclusão, o método é adequado para ser aplicado na avaliação do BD puro e em nanocápsulas epode ser empregado para o estudo de estabilidade e degradação cinética...
Responsable: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-312488
Author: Siqueira, Amal Hachouch; Cardoso, Valbert Nascimento; Coelho, Luiz Gonzaga; Junqueira, Roberto Gonçalves; Simal, Carlos Jorge Rodrigues; Marinho, Frederico Passos; Correia, M. M; Soares, Marcela Penna; Chausson, Yvon.
Title: Measurement of gastric emptying of solid meal using scitigraphy with 99mTccoloidal sulfur and breath test with 14C-acid octanoic
Source: GED gastroenterol. endosc. dig;19(2):79-83, mar.-abr. 2000. tab, graf.
Language: en.
Abstract: The gastric emptying rate of solids was measures in 33 volunteers (19 female 14 male, mean age 38.2 (24-74) years) by scintigraphy and 14-C-octanoic acid breattest. Eleven participants were normal controls, 11 had functional dyspepsia, 5 patients were diabetic and 6 patients had pyloric stenosis due to peptic ulcer. Methods: The test meal consisted of an omelet labeled with 99mTc-sulfur colloid and 14C-octanoic acid for scitigraphy and breath tes, respectively. Radioscintigraphic scans were obtained every 15 min for a period of 150 min and breath samples were taken every 15 min for a period of 4 hours. Reults: the half gastric emptying time (t1/2) and lag phase (tlag) in diabetica and dyspeptic volunteers measured by scintigraphy and breath tes showed higher values than in controls. Two out 6 patients with pyloric stenosis showed gastric emptying rate delayed when compared with controls. There was a positive and significant (p<0.0001) correlation between the t1/2 determined by scintigraphy and breath test. Conclusions: 14C-octanoic acid breath test is a reliable and sensitive method that can be used as an alternative procedure to measure gastric emptying rat of solids
Responsable: BR9.1 - Biblioteca de Ciências da Saúde Profa. Susana Schimidt



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