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Pesquisa : A01.923.047.025.600 [Categoria DeCS]
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Id: biblio-886195
Autor: Duzgun, Ozgul; Sarici, Inanc Samil; Gokcay, Serkan; Ates, Kivilcim Eren; Yılmaz, Mehmet Bertan.
Título: Effects of nivolumab in peritoneal carcinamatosis of malign melanoma in mouse model
Fonte: Acta cir. bras;32(12):1006-1012, Dec. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the efficacy of nivolumab and comparison with dacarbazine (DTIC) on peritoneal carcinomatosis of malignant melanoma in mouse model. Methods: Mouse skin melanoma cells was injected under the capsule of the peritoneal surface in the left side of the abdomen. On postoperative day ten, mouses randomised into three groups. Group 1: Control, Group 2: HIPEC (Hyperthermic intraperitoneal chemotherapy) with DTIC and Group 3: HIPEC with Nivolumab. After the sacrification on postoperative day fifteen, peritoneum evaluated macroscopically and histopathologically by using peritoneal regression grading score (PRGS). Results: In the 15th day exploration, all animals developed extensive intraperitoneal tumor growth in Group 1. In Group 2 and Group 3 median tumor size was 0.7±0.3cm and 0.3±0.2cm respectively (p: 0.023). Peritoneal carcinomatosis index (PCI) were significantly lower in Group 3 than other groups (p: 0.019). The lowest total tumor nodules in group 3 was 4 ± 2. The PGRS score was found significantly lower in Group 3 than other groups (p: 0.03). Lymphocytic response rate was found higher in the Group 3. Conclusions: It has been found that nivolumab significantly better than DTIC on peritoneal metastases of malign melanoma in mouse models. Nivolumab treatment gives promising results with pathological evidence in the treatment of metastatic disease of malignant melanoma.
Descritores: Neoplasias Peritoneais/tratamento farmacológico
Peritônio/patologia
Melanoma/tratamento farmacológico
Anticorpos Monoclonais/farmacologia
Antineoplásicos/farmacologia
-Neoplasias Peritoneais/cirurgia
Neoplasias Peritoneais/patologia
Neoplasias Peritoneais/secundário
Peritônio/efeitos dos fármacos
Distribuição Aleatória
Análise de Regressão
Dacarbazina/uso terapêutico
Modelos Animais de Doenças
Avaliação Pré-Clínica de Medicamentos
Gradação de Tumores
Nivolumabe
Hipertermia Induzida
Melanoma/secundário
Anticorpos Monoclonais/uso terapêutico
Antineoplásicos/uso terapêutico
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Medeiros, Francisco das Chagas
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Id: biblio-1001089
Autor: Pereira, Francisco Edson Ximenes Gomes; Medeiros, Francisco das Chagas; Rocha, Hermano Alexandre Lima; Silva, Karine Saraiva da.
Título: Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and fertility in peritoneal endometriosis in rats
Fonte: Acta cir. bras;34(4):e201900405, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the effects of the nutraceuticals omega-6/3 and omega-9/6 on endometriosis-associated infertility and pain. Methods: Controlled experimental study, with each group composed of eight female rats. Fertility groups: sham-operated control (0.9% saline solution); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); and meloxicam (0.8 mg/kg/day). Pain groups: sham-operated control (0.9% saline); control with endometriosis (0.9% saline); omega-6/3 (1.2 g/kg/day); omega-9/6 (1.2 g/kg/day); medroxyprogesterone acetate (5 mg/kg/every 3 days); and meloxicam (0.8 mg/kg/day). Peritoneal endometriosis was surgically induced. Pain was evaluated with the writhing test. Fertility was evaluated by counting the number of embryos in the left hemi-uterus. Results: The mean number of writhings was as follows: sham-operated, 11.1 ± 2.9; control with endometriosis, 49.3 ± 4.4; omega-6/3, 31.5 ± 2.7; omega-9/6, 34.1 ± 4.5; medroxyprogesterone acetate, 2.1 ± 0.8; meloxicam, 1 ± 0.3. There was a significant difference between both controls and all drugs used for treatment. Regarding fertility, the mean values were as follows: sham-operated, 6.8 ± 0.6; control with endometriosis, 4.2 ± 0.7; omega-6/3, 4.7 ± 1; omega-9/6, 3.8 ± 0.9; and meloxicam, 1.8 ± 0.9. Conclusions: The omega-6/3 and omega-9/6 nutraceuticals decreased pain compared to the controls. There was no improvement in fertility in any of the tested groups.
Descritores: Dor/tratamento farmacológico
Ácidos Graxos Ômega-3/administração & dosagem
Acetato de Medroxiprogesterona/administração & dosagem
Endometriose/tratamento farmacológico
Fertilidade/efeitos dos fármacos
Meloxicam/administração & dosagem
-Peritônio/patologia
Modelos Animais de Doenças
Endometriose/patologia
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-886203
Autor: Rodrigues, Adilson Costa; Santos, Luana Carla Dos; Otsuki, Denise Aya; Saad, Karen Ruggeri; Saad, Paulo Fernandes; Montero, Edna Frasson de Souza; Utiyama, Edivaldo Massazo.
Título: Animal model of continuous peritoneal lavage with vacuum peritoneostomy
Fonte: Acta cir. bras;32(6):467-474, June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To establish and evaluate the feasibility of continuous peritoneal lavage with vacuum peritoneostomy in an animal model. Methods: Eight pigs aged 3-4 months, females, were anesthetized and submitted to laparotomy and installation of a continuous peritoneal lavage with vacuum peritoneostomy. The sta-bility of the system, the physiological effects of washing with NaCl 0.9% and the sys-tem clearance were evaluated. Results: Stability of vacuum peritoneostomy was observed, with no catheter leaks or obstructions and the clearance proved adequate, however, the mean volume of fluids aspirated by the peritoneostomy at the end of the experiment was higher than the volume infused by the catheters (p=0.02). Besides that, the animals presented a progressive increase in heart rate (p=0.04) and serum potassium (p=0.02). Conclusion: The continuous peritoneal lavage technique with vacuum peritoneostomy is feasible and presents adequate clearance.
Descritores: Peritônio/cirurgia
Lavagem Peritoneal/métodos
-Suínos
Estudos de Viabilidade
Modelos Animais
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-886257
Autor: Goret, Ceren Canbey; Goret, Nuri Emrah; Kiraz, Asli; Ozkan, Omer Faruk; Karaayvaz, Muammer.
Título: The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats
Fonte: Acta cir. bras;33(2):134-143, Feb. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.
Descritores: Doenças Peritoneais/prevenção & controle
Peritônio/cirurgia
Flavonoides/uso terapêutico
Aderências Teciduais/prevenção & controle
-Doenças Peritoneais/etiologia
Peritônio/patologia
Complicações Pós-Operatórias
Flavonoides/efeitos adversos
Imuno-Histoquímica
Extratos Vegetais
Aderências Teciduais/etiologia
Aderências Teciduais/patologia
Espécies Reativas de Oxigênio/metabolismo
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Radicais Livres/análise
Inflamação/induzido quimicamente
Inflamação/patologia
Laparotomia
Linfonodos/efeitos dos fármacos
Linfonodos/patologia
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-886194
Autor: Seitenfus, Rafael; Ferreira, Paulo Roberto Walter; Santos, Gabriel Oliveira dos; Alves, Rafael José Vargas; Kalil, Antonio Nocchi; Barros, Eduardo Dipp de; Glehen, Olivier; Casagrande, Thaís Andrade Costa; Bonin, Eduardo Aimoré; Silva Junior, Edison Martins da.
Título: A prototype single-port device for pressurized intraperitoneal aerosol chemotherapy. Technical feasibility and local drug distribution
Fonte: Acta cir. bras;32(12):1056-1063, Dec. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). Methods: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure. Four domestic pigs were used in the study, one control animal that received multidirectional microjets of 9 mL/sec for 30 min and three animals that received multidirectional aerosolization (pig 02: 9 mL/sec for 30 min; pigs 03 and 04: 3 mL/sec for 15 min). Aerosolized silver nitrate solution was applied for anatomopathological evaluation of intraperitoneal drug distribution. Results: Injection time was able to maintain the pneumoperitoneum pressure below 20 mmHg. The rate of moderate silver nitrate staining was 45.4% for pig 01, 36.3% for pig 02, 36.3% for pig 03, and 72.7% for pig 04. Conclusions: Intra-abdominal drug distribution had a broad pattern, especially in animals exposed to the drug for 30 min. Our sample of only four animals was not large enough to demonstrate an association between aerosolization and a higher silver nitrate concentration in the stained abdominal regions.
Descritores: Neoplasias Peritoneais/tratamento farmacológico
Sistemas de Liberação de Medicamentos/métodos
Aerossóis/administração & dosagem
-Neoplasias Peritoneais/patologia
Neoplasias Peritoneais/secundário
Peritônio/efeitos dos fármacos
Pressão
Fatores de Tempo
Insuflação
Estudos de Viabilidade
Sistemas de Liberação de Medicamentos/instrumentação
Aerossóis/farmacocinética
Cavidade Abdominal
Sus scrofa
Modelos Animais de Doenças
Injeções Intraperitoneais
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-886261
Autor: Biondo-Simões, Maria de Lourdes Pessole; Oda, Marian Hanae; Pasqual, Suzane; Robes, Rogério Ribeiro.
Título: Comparative study of polyglactin 910 and simple catgut in the formation of intraperitoneal adhesions
Fonte: Acta cir. bras;33(2):102-109, Feb. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To compare polyglactin 910 and simple catgut sutures for the incidence of intraperitoneal adhesions. Methods: Twenty female Wistar rats were placed into two groups. Group 1 received ischemic sutures and Group 2 received polyglactin 910. Five sutures inductive of adhesions in each rat were made. After 14 days, the rats were euthanized with an assessment of the presence of adhesions, the number of sutures involved and classification according to the Granat et al. scale described by Ozel et al17. Results: In total, 19 of the 20 rats presented adhesions, with nine from Group 1 and ten from Group 2. There was a smaller number of affected sutures in Group 1, while in Group 2 the majority of the sutures formed adhesions (p=0.0197). According to the Granat et al. scale, Group 1 predominately developed fine, filamentous adhesions or thickening in a restricted area. Group 2 mainly presented extensive, thick adhesions with the involvement of the viscera (p=0.0055). Conclusion: Polyglactin 910 sutures formed more adhesions that were more extensive and thicker than the simple catgut sutures.
Descritores: Doenças Peritoneais/etiologia
Peritônio/cirurgia
Poliglactina 910/efeitos adversos
Técnicas de Sutura/efeitos adversos
Categute/efeitos adversos
Isquemia/etiologia
-Doenças Peritoneais/prevenção & controle
Peritônio/irrigação sanguínea
Poliglactina 910/farmacocinética
Complicações Pós-Operatórias/etiologia
Aderências Teciduais/etiologia
Aderências Teciduais/prevenção & controle
Categute/tendências
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Feminino
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-1078060
Autor: Barros Neto, Alexandre Luiz de Almeida.
Título: Dor em ginecologia: dores pélvicas não ligadas à menstruação / Pain in gynecology: pelvic pain not related to menstruation
Fonte: In: São Paulo(Estado). Secretaria da Saúde. DTN. Grupo da Saúde da Mulher. Subprograma de saúde da mulher: assistência ginecológicai. São Paulo, s.n, s.d. p.31-38. (Saúde da Mulher, v.4).
Idioma: pt.
Descritores: Dor Pélvica
Infecções Urinárias
Peritônio/patologia
Vísceras
Responsável: BR91.2 - Centro de Documentação
BR91.2; WA309, S239a, 1986, v.4


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Id: lil-785020
Autor: Arslan, Ersoy; Irkorucu, Oktay; Sozutek, Alper; Cetinkunar, Suleyman; Reyhan, Enver; Yaman, Abit; Doran, Figen.
Título: The potential efficacy of Survanta (r) and Seprafilm (r) on preventing intra-abdominal adhesions in rats
Fonte: Acta cir. bras;31(6):389-395tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions. METHODS: Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group (BG), Seprafilm(r) group (SG), and combined group (COG). All rats underwent cecal abrasion via midline laparotomy. Before abdominal closure, isotonic saline, beractant, Seprafilm, and combined agents were intraperitoneally administered. Adhesions were classified macroscopically with Canbaz Scoring System on postoperative day 10. Ceacum was resected for histopathological assessment. RESULTS: Macroscopic adhesion scores were significantly lower in BG, SG, and COG than CG (p<0.05); (45%, 15%, 25%, and 15%; respectively). Histopathological assessment revealed a reduced inflammation and fibrosis score in the study groups than CG (p<0.05). In BG, adhesion development, inflammation and fibrosis scores were lower than SG; however, it was not statistically significant. CONCLUSIONS: Intra-abdominal application of beractant is significantly effective for the prevention of adhesion formation with no adverse effect by covering the whole peritoneal mesothelium with excellent gliding properties in a rat model. The combination of both agents is also effective in reducing adhesion formation, however, not superior to single beractant application.
Descritores: Produtos Biológicos/farmacologia
Doenças do Ceco/prevenção & controle
Ceco/efeitos dos fármacos
Ácido Hialurônico/farmacologia
-Peritônio/efeitos dos fármacos
Peritônio/patologia
Cuidados Pós-Operatórios/instrumentação
Fibrose
Distribuição Aleatória
Ceco/cirurgia
Ceco/patologia
Aderências Teciduais/patologia
Aderências Teciduais/prevenção & controle
Ratos Wistar
Modelos Animais
Quimioterapia Combinada/métodos
Inflamação/patologia
Inflamação/prevenção & controle
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Id: lil-781325
Autor: Saad-Hossne, Rogério; Barretto, Adriana Beatriz; Siqueira, Juliana Menezes; Denadai, Rafael.
Título: Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits
Fonte: Acta cir. bras;31(4):227-234, Apr. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: PURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. Methods: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. Results: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. Conclusion: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits.
Descritores: Doenças Peritoneais/tratamento farmacológico
Injeções Intralesionais
Aspirina/administração & dosagem
Inibidores de Ciclo-Oxigenase/administração & dosagem
Endometriose/tratamento farmacológico
-Doenças Peritoneais/patologia
Peritônio/efeitos dos fármacos
Peritônio/patologia
Fatores de Tempo
Reprodutibilidade dos Testes
Resultado do Tratamento
Apoptose
Modelos Animais de Doenças
Endometriose/patologia
Endométrio/efeitos dos fármacos
Endométrio/patologia
Anti-Inflamatórios/administração & dosagem
Limites: Animais
Feminino
Coelhos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-530678
Autor: Vicente, Priscila Cadima; Caramori, Jacqueline Costa Teixeira; Franco, Sonia Regina Verde da Silva; Vicente, Eduardo José Danza; Pereira, José Jonas; Santos, Sueli Maria dos Reis.
Título: Efeito da glicose na histomorfologia do peritônio durante a diálise peritoneal / Glucose effects on the histomorfology of the peritoneum during peritonealdialysis
Fonte: HU rev;34(1):27-31, jan.-mar. 2008. ilus.
Idioma: pt.
Resumo: As alterações peritoneais em pacientes submetidos à diálise peritoneal por longos períodos começam com as modificações mesoteliais e, mais tarde, envolvem alterações submesoteliais, fibrose e vasculopatias. Entre outros fatores, essas alterações podem ser decorrentes da alta concentração de glicose da solução de diálise. Desta forma, o objetivo do presente estudo foi estudar as alterações histomorfológicas na membrana peritoneal de ratos submetidos à diálise peritoneal, com solução de glicose a temperatura ambiente. Foram utilizados 20 ratos Wistar divididos em dois grupos: grupo controle (GC) com oito animais que não receberam nenhuma injeção intraperitoneal, e grupo solução concentrada (GSC) com 12 animais que receberam 10ml de fluido de diálise com 4,25% de glicose uma vez por dia durante 30 dias. Nos animais do GSC, o peritônio visceral do baço e o parietal da parede abdominal apresentaram alterações epiteliais com transformação cúbica das células mesoteliais e espessamento na camada submesotelial, respectivamente. Esses resultados sugerem que a solução de diálise com 4,25% de glicose em temperatura ambiente realizada uma vez por dia durante 30 dias pode alterar a histomorfologia do peritônio.

Alterations in the peritoneum of patients submitted to peritoneal dialysis during long periods begins with modifications of the mesothelium, and latter unfolds to alterations of the submesothelium, of the vascular system and fibrosis. One of the possible explications to these alterations is the high concentration of glucose in the dialysis solution. Therefore, the aim of this study was to study the histomorphological alterations of the peritoneal membrane in rats submitted to peritoneal dialysis, with the glucose solution at the local temperature. 20 Wistar rats were used, divided into two groups: control group (CG) with eight animals that didn't receive intraperitoneal injection and the concentrated solution group (CSG) with12 animals that received 10ml of the dialysis fluid with 4.25% of glucose, once a day, for 30 days. The visceral peritoneum of the spleen and the parietal peritoneum of the abdominal wall of the animals of CSG showed alterations of the epithelial layer with cubic transformation of the mesothelium cells and the thickness of the submesothelium layer, respectively. The dialysis solution of glucose at the concentration of 4.25%, at local temperature, applied once a day, during 30 days, altered the histomorphology of the peritoneum.
Descritores: Glucose/efeitos adversos
-Peritônio
Diálise Peritoneal
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central



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