Base de dados : LILACS
Pesquisa : A02.165 [Categoria DeCS]
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Id: biblio-837938
Autor: Cerci, Felipe Bochnia; Dellatorre, Gerson.
Título: Paramedian forehead flap combined with hinge flap for nasal tip reconstruction
Fonte: An. bras. dermatol;91(5,supl.1):140-143, Sept.-Oct. 2016. graf.
Idioma: en.
Resumo: Abstract The paramedian forehead flap is a great option for restoration of complex nasal defects. For full-thickness defects, it may be used alone or in combination with other methods. We present a patient with a basal cell carcinoma on the distal nose treated by Mohs micrographic surgery, and a resulting full-thickness defect repaired with paramedian forehead flap combined with a hinge flap. For optimal results with the paramedian forehead flap, adequate surgical planning, patient orientation and meticulous surgical technique are imperative.
Descritores: Neoplasias Cutâneas/cirurgia
Retalhos Cirúrgicos
Carcinoma Basocelular/cirurgia
Neoplasias Nasais/cirurgia
Cirurgia de Mohs/métodos
-Fatores de Tempo
Cartilagem/cirurgia
Nariz/cirurgia
Reprodutibilidade dos Testes
Resultado do Tratamento
Testa
Limites: Seres Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-975610
Autor: ElTaher, Mostafa; Othman, Yosry; Mohammed, Ibrahim; Ali, Khaled.
Título: Periosteal Graft Myringoplasty: Our Experience
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(4):374-377, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Introduction Different types of autologous graft materials are used for myringoplasty, with the temporalis fascia and cartilage being the most frequently used tissues. Periosteal tissue has been used for a long time in our department, and many advantages support its use in myringoplasty. To the best of our knowledge, this issue is scarcely discussed in the previously published literature. Objective To present our experience with periosteal graft myringoplasty, describing the technique and the anatomical and functional outcomes. Methods A prospective clinical study involving 88 patients (72 females and 16 males) with a mean age 26.9 years. The patients underwent myringoplasty using the mastoid cortex periosteum; they were all operated using the postauricular approach, and the graft was applied using the underlay technique. The patients performed pre- and postoperative pure tone audiometry for tested frequencies (0.5 kHz, 1 kHz, 2 kHz, and 4 kHz). All patients were followed-up for at least 12 months after the operation. Results The anatomical success rate among all patients was of 93%, which is comparable to the rate of success in procedures using other usual grafting materials. In addition, there was a highly significant postoperative improvement in pure tone audiometry results as compared with the preoperative ones (the main hearing gain was of ∼ 11 dB; p< 0.001). Conclusion The periosteal graft is easily harvested, easy to apply, with excellent anatomical and functional success.
Descritores: Periósteo/transplante
Miringoplastia
-Audiometria de Tons Puros
Transplante Autólogo
Membrana Timpânica/cirurgia
Cartilagem/transplante
Estudos Prospectivos
Fáscia/transplante
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Texto completo SciELO Brasil
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Id: lil-775567
Autor: Erkut, Adem; Tumkaya, Levent; Balik, Mehmet Sabri; Kalkan, Yildiray; Guvercin, Yilmaz; Yilmaz, Adnan; Yuce, Suleyman; Cure, Erkan; Sehitoglu, Ibrahim.
Título: The effect of prenatal exposure to 1800 MHz electromagnetic field on calcineurin and bone development in rats
Fonte: Acta cir. bras;31(2):74-83, Feb. 2016. tab, graf.
Idioma: en.
Resumo: PURPOSE: To investigated the effects of exposure to an 1800 MHz electromagnetic field (EMF) on bone development during the prenatal period in rats. METHODS: Pregnant rats in the experimental group were exposed to radiation for six, 12, and 24 hours daily for 20 days. No radiation was given to the pregnant rats in the control group. We distributed the newborn rats into four groups according to prenatal EMF exposure as follows: Group 1 was not exposed to EMF; groups 2, 3, and 4 were exposed to EMF for six, 12, and 24 hours a day, respectively. The rats were evaluated at the end of the 60th day following birth. RESULTS: Increasing the duration of EMF exposure during the prenatal period resulted in a significant reduction of resting cartilage levels and a significant increase in the number of apoptotic chondrocytes and myocytes. There was also a reduction in calcineurin activities in both bone and muscle tissues. We observed that the development of the femur, tibia, and ulna were negatively affected, especially with a daily EMF exposure of 24 hours. CONCLUSION: Bone and muscle tissue development was negatively affected due to prenatal exposure to 1800 MHz radiofrequency electromagnetic field.
Descritores: Efeitos Tardios da Exposição Pré-Natal/patologia
Desenvolvimento Ósseo/efeitos da radiação
Calcineurina/metabolismo
Campos Eletromagnéticos/efeitos adversos
-Fatores de Tempo
Gravidez
Cartilagem/patologia
Ratos Sprague-Dawley
Apoptose/efeitos da radiação
Condrócitos/metabolismo
Condrócitos/patologia
Modelos Animais
Músculo Quadríceps/metabolismo
Músculo Quadríceps/patologia
Cabeça do Fêmur/patologia
Limites: Seres Humanos
Animais
Masculino
Feminino
Recém-Nascido
Responsável: BR1.1 - BIREME


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Id: lil-743152
Autor: Calvo, Rafael; Figueroa, David; Vaisman, Alex; De La Fuente, Paulina.
Título: Tratamiento de lesiones del cartílago patelar a través del sistema transferencia osteocondral autólogo / Treatment of patellar cartilage injuries with osteochondral autologous transfer system
Fonte: Artrosc. (B. Aires);20(4):114-117, dic. 2013.
Idioma: es.
Resumo: Las lesiones osteocondrales en la rodilla representan un problema frecuente en la práctica médica. Estas llevan a la degeneración del cartílago hialino con la consecuente artrosis, causa importante de dolor y discapacidad. En los últimos años se han desarrollado múltiples técnicas para tratar estas lesiones. El sistema de transferencia osteocondral autólogo (OATS) ha sido descrito para el tratamiento de estos defectos focales en los cóndilos femorales; sin embargo, su aplicación real en la patela es todavía un tema de controversia. Una correcta selección de los pacientes en conjunto con una técnica quirúrgica adecuada son fundamentales para el resultado exitoso de esta cirugía. Nuestro objetivo es describir la técnica quirúrgica y los aspectos involucrados en el sistema de transferencia osteocondral autólogo para lesiones condrales focales de la patela.

Osteochondral injuries in the knee are a common problem in medical practice. These lead to the degeneration of the hyaline cartilage and the consequent osteoarthritis, a major cause of pain and disability. In recent years several techniques have been developed to treat these injuries. The osteochondral autologous transfer system (OATS) has been described for the treatment of these defects on the femoral condyles, however its actual implementation in the patella is not yet clear. Patient selection and adequate surgical technique are fundamental to a successful surgery. Our objective is to describe the surgical technique and aspects involved in the osteochondral autograft transfer system for isolated chondral injuries of the patella.
Descritores: Articulação do Joelho/cirurgia
Artroscopia/métodos
Cartilagem Articular/cirurgia
Cartilagem Articular/lesões
Cartilagem/transplante
Osteocondrite/cirurgia
Patela/cirurgia
Patela/lesões
Transplante Autólogo/métodos
Limites: Seres Humanos
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: lil-530437
Autor: Fu, Freddie H.
Título: 50 anos de pesquisa em cartilagem na Universidade de Pittsburgh / Fifty years of cartilage research at Pittsburgh University
Fonte: RBM rev. bras. med;66(supl.2):57-58, abr. 2009.
Idioma: pt.
Descritores: Cartilagem/citologia
Cartilagem/metabolismo
Condrócitos/metabolismo
-Pesquisa Biomédica/métodos
Pesquisa Biomédica/tendências
Limites: Seres Humanos
Tipo de Publ: Artigo Histórico
Responsável: BR12.1 - Biblioteca Setorial da Ciências da Saúde


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Id: biblio-1013716
Autor: Karmali, Samir; Guerreiro, Rui; Costa, Daniel Sá da; Fonseca, Jorge; Gonçalves, Ricardo.
Título: Mosaicplasty Technique in the Treatment of Isolated Knee Femoral Condyle Osteochondral Lesions - a Retrospective Study / Técnica de mosaicoplastia no tratamento de lesões osteocondrais isoladas do côndilo femoral do joelho - estudo retrospectivo
Fonte: Rev. bras. ortop;54(3):316-321, May-June 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective Focal osteochondral lesions of the knee are found in two thirds of patients undergoing arthroscopy; their treatment, when isolated and especially in young individuals, remains a debating topic. The present study analyzes the results obtained by the application of the mosaicplasty technique on the treatment of isolated knee femoral condyle osteochondral lesions. Methods Retrospective study of patients submitted tomosaicplasty and to subjective analyseswith pre- and postsurgery International KneeDocumentation Committee (IKDC) scores. Results A total of 13 cases with an average age of 34 years old, with male patients (n = 4; 31%) with an average age of 23 years old (range: 17-31 years old), and female patients (n = 9; 69%) with an average age of 39 years old (range: 16-56 years old); medial versus lateral femoral (n = 11; 85% versus n = 2; 15%); the average size of the lesion was 1.8 cm2 (range: 0.6-4 cm2); average follow-up time: 5.045 ± 3.47 years (range: 1.15-11.01 years). The average preoperative IKDC score was of 31.63 points (± 20.24), the average postoperative IKDC score was of 74.18 points (± 20.26). The difference between the post- and preoperative IKDC scores was of 42.55 (± 21.05) points, being theminimal score increase of 8.1 points andthemaximumscore increaseof82.8 points.Astatistically significant difference (p < 0.001) was found between the IKDC scores before and after the surgery. A statistically significant relation (p = 0.038) was found between the IKDC score increase (the difference between the postoperative and the preoperative scores) and the dimension of the lesion. Conclusions Mosaicplasty with osteochondral autograft transfer, when adequately used, can produce excellent results with great durability and functional impact, low morbidity rates and costs. Expansion of the indication criteria shows promising midterm and long-term results.

Resumo Objetivo Lesões osteocondrais focais do joelho são encontradas em dois terços dos pacientes submetidos a artroscopia; seu tratamento, quando isoladas e, principalmente, em indivíduos jovens, ainda é debatido. O presente estudo analisa os resultados obtidos com a aplicação da técnica de mosaicoplastia no tratamento de lesões osteocondrais isoladas do côndilo femoral do joelho. Métodos Estudo retrospectivo de pacientes submetidos à mosaicoplastia e análise subjetiva com pontuações do International Knee Documentation Committee (IKDC, na sigla em inglês) antes e após a cirurgia. Resultados Um total de 13 casos, com média de idade de 34 anos; pacientes do sexo masculino (n = 4; 31%) apresentaram média de idade de 23 anos (17-31 anos), e pacientes do sexo feminino (n = 9; 69%) apresentaram média de 39 anos; (16-56 anos); femoral medial ou lateral (n = 11, 85% versus n = 2, 15%, respectivamente); o tamanho médio da lesão foi de 1,8 cm2 (0,6-4 cm); o tempo médio de acompanhamento foi de 5,045 ± 3,47 anos (1,15-11,01 anos). A pontuação IKDC média préoperatória foi 31,63 pontos ( ± 20,24), e a pós-operatória foi 74,18 pontos ( ± 20,26). A diferença entre as pontuações IKDC obtidas depois e antes da cirurgia foi de 42,55 ( ± 21,05) pontos, com o aumento mínimo de 8,1 pontos e o aumento máximo de 82,8 pontos. Uma diferença estatística significativa (p < 0,001) foi encontrada entre a pontuação IKDC antes e após a cirurgia. Uma relação estatisticamente significativa (p = 0,038) foi observada entre o aumento da pontuação IKDC (a diferença entre a pontuação pré- e pós-operatória) e as dimensões da lesão. Conclusões A mosaicoplastia com transferência de autoenxerto osteocondral, quando adequadamente usada, pode produzir resultados excelentes com grande durabilidade e impacto funcional, baixas taxas de morbidade e baixos custos. A expansão dos critérios de indicação mostra resultados promissores no médio e longo prazo.
Descritores: Osteocondrite/cirurgia
Osteocondrite/diagnóstico
Artroscopia
Cartilagem
Cartilagem Articular
Articulação do Joelho
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR26.1 - Biblioteca Central


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Texto completo SciELO Chile
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Id: lil-676829
Autor: Raín H, Marcelo; Faba C, Gabriel.
Título: Manejo del dorso nasal: experiencia del Departamento de Otorrinolaringología del Hospital Clínico de la Pontificia Universidad Católica de Chile / Management of the nasal dorsum: Hospital Clínico de la Pontificia Universidad Católica de Chile, ENT Department experience
Fonte: Rev. otorrinolaringol. cir. cabeza cuello;72(3):221-228, dic. 2012. ilus.
Idioma: es.
Resumo: Introducción: Un dorso recto es uno de los principales objetivos para los pacientes que se realizan una rinoseptoplastía. Sin embargo, una resección dorsal excesiva puede traer consecuencias estéticas y funcionales. Objetivos: Describir la experiencia del Departamento de Otorrinolaringología del Hospital Clínico de la Pontificia Universidad Católica de Chile en el manejo del dorso nasal. Material y método: Estudio retrospectivo descriptivo. Se revisaron los protocolos quirúrgicos de los pacientes sometidos a una rinoseptoplastía entre enero de 2010 y junio de 2011. Resultados: Se recopiló un total de 153 pacientes, 67% mujeres. La edad promedio fue de 27,5 años. El abordaje fue abierto en el 78%%. Más del 95%% requirió resección dorsal osteocartilaginosa y osteotomías. El injerto espaciador fue el injerto dorsal más frecuente (51%%). En 101 mujeres y 47 hombres se realizó trabajo de punta nasal (p <0,05). Discusión: En nuestra experiencia el abordaje abierto nos permite obtener una visión más clara de la anatomía. La septoplastía, importante en el manejo de la obstrucción nasal, nos permite además obtener injertos de buena calidad. En pacientes de riesgo de colapso valvular, es importante una resección dorsal conservadora y considerar los injertos espaciadores.

Introduction: A right dorsum is one of the main objectives for patients who undergoes to rhinoseptoplasty. However, excessive dorsal resection can bring aesthetic and functional consequences. Aim: To describe the experience in the management of the nasal dorsum by the Hospital Clínico de la Pontificia Universidad Católica de Chile, ENT Department. Material and method: Retrospective study. All patient's surgical protocols of rhinoseptoplasty between January 2010 and June 2011 were reviewed. Results: 153 patients were collected, 67%% of them were women. The average age was 27.5 years. The open approach was performed in 78%%. Over 95%% of patients required dorsal osteocartilaginous resection and osteotomies. The spreader graft was the most commonly used dorsal graft (51%%). In 101 women and 47 men, nasal tip work were performed (p <0.05). Discussion: In our experience the open approach allows us to obtain a clear vision of the nasal anatomy. Septoplasty is important in the management of the nasal obstruction, and it permits to obtain good quality grafts. In patients at risk of valvular collapse is important a conservative dorsal resection and spreader grafts.
Descritores: Rinoplastia/estatística & dados numéricos
Septo Nasal/cirurgia
-Osteotomia
Cartilagem/transplante
Nariz/cirurgia
Epidemiologia Descritiva
Estudos Retrospectivos
Procedimentos Cirúrgicos Nasais/estatística & dados numéricos
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: CL30.1 - Biblioteca


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Id: biblio-1007307
Autor: Sandoval, David; Tellez, Jelua; Rivera, Guillermo; Moreno, Sandra; Moreno, Freddy.
Título: Técnica de diafanización para describir el desarrollo embrionario del sistema óseo. Revisión de la literatura / Diaphanization technique for the description of the embryonic development of the skeletal system. Systematic literature review
Fonte: Univ. med;57(4):488-501, oct. - dic. 2016. ilus, tab.
Idioma: es.
Resumo: Introduction: The anatomic diaphanization technique consists in the transparency of soft tissues of vertebrate organisms (clearing), in order to dye the mineralized tissue and visualize bone and cartilage (staining). Objective: To review the reports available on specialized literature that describes the embryonic development of mammal ́s skeletal system through the diaphonization technique and simple staining or double staining processes. Materials and methods: A literature review was made on PubMed, Academic Google and SciELO, based on PRISMA, through the association of the term double staining with the health descriptors of the Medical Subject Headings (MeSH) alizarin red, alician blue, bone and cartilage , and the combination of the Boolean operators + and &. Results: There were included 22 articles that described the diaphanization technique and the simple staining or double staining technique used in the observation, registration and analysis of the embryonic development of mammal ́s skeletal system. Conclusion: The diaphanization technique and simple staining or double staining technique is an anatomic study technique­versatile and of low cost­of the embryonic development of mammal ́s skeletal system, which may be used in toxicology studies, discarding the possibility of developmental anomalies during the cartilage or bone formation (chondrogenesis and osteogenesis, respectively) associated to the exposure to a possible teratogenic agent.
Descritores: Anatomia Comparada
-Desenvolvimento Ósseo
Cartilagem
Estruturas Embrionárias
Limites: Seres Humanos
Responsável: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.


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Id: lil-784746
Autor: Arruda, Mauricio Ferraz de; Cassettari, Lucas Langoni; Neves, Lais Mara Siqueira das; Oliveira, Olga Maria Mascarenhas de Faria; Marcolino, Alexandre Márcio.
Título: Iontoforese de ácido ascórbico para ganho condral em ratos com artrite / Ascorbic acid iontophoresis for chondral gain in rats with arthritis
Fonte: Acta ortop. bras;22(4):202-205, Jul-Aug/2014. ilus, tab.
Idioma: en; pt.
Resumo: Verificar a celularidade e espessura da cartilagem articulardo fêmur em ratos com artrite após terapia por iontoforese.Métodos: Para avaliar estes objetivos, uma análise histológicafoi realizada em hematoxilina e eosina, onde a celularidade e asespessuras da cartilagem foram observadas e avaliadas qualitativae quantitativamente por contagem manual por área de700.09 μm². Resultados: O grupo tratado com IAA obteve normalidadede celularidade (40,1 células/µm²) e manutenção da cartilagemnão calcificada (75,5 μm), sugerindo espessura normal. Ogrupo não tratado C+, por outro lado, apresentou menor médiado número de condrócitos (13.0 µm²), (P <0,05), e em relação àespessura da cartilagem mostrou maior média de cartilagem calcificadacom espessura (104,8 μm) e menor média de cartilagemnão calcificada (53,3 µm) Conclusão: A terapia da iontoforese comL-ácido ascórbico através da corrente elétrica continua contribuiupara um ganho quantitativo de condrócitos e melhorou a distribui-ção de espessuras da cartilagem calcificadas e não calcificadas.Nível de Evidência III, Estudo de Caso Controle...

To examine the cellularity and thickness of the articularcartilage of the femur in rats with arthritis after treatment withiontophoresis. Methods: To evaluate these objectives, a histologicalanalysis was performed on hematoxylin and eosin, wherecellularity and cartilage thickness were observed and evaluatedqualitatively and quantitatively by manual counting by 700.09 μm²area. Results: The group treated with IAA had normal cellularity(40.1 cells/μm2) and maintenance of non-calcified cartilage(75.5 μm), suggesting normal thickness. The non-treated groupC+, on the other hand, had a lower mean number of chondrocytes(13.0 μm2) (P <0.05) and, when the cartilage thickness was compared,it showed higher average thickness of calcified cartilage(104.8 μm) and lower mean of non-calcified cartilage (53.3 μm)Conclusion: The use of iontophoresis with L-ascorbic acid bythe continuous electric current contributed to a quantitative gainof chondrocytes and improved the thickness distribution of calcifiedand non-calcified cartilage. Level of Evidence III, CaseControl Study...
Descritores: Artrite
Cartilagem
Iontoforese
Osteoartrite
Ácido Ascórbico
Limites: Ratos
Responsável: BR734.1 - Biblioteca Central Cesar Lattes - BCCL


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Texto completo SciELO Chile
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Id: lil-708739
Autor: Ortega-Martínez, Marta; de-la-Garza-González, Carlos; Ancer-Rodríguez, Jesús; Jaramillo-Rangel, Gilberto.
Título: Nestin-positive stem cells participate in chondrocyte renewal in healthy adult lung cartilage / Células troncales nestin-positivas participan en la renovación de condrocitos en el cartílago pulmonar del adulto sano
Fonte: Int. j. morphol;32(1):151-153, Mar. 2014. ilus.
Idioma: en.
Resumo: It is considered that healthy adult cartilage has little or no capacity for renewal, and that chondrocytes maintain a stable resting phenotype and resist proliferation and differentiation throughout life. Recently we found that cell turnover in lung cartilage is possible and that nestin-positive cells may have a role in it. In this paper, we report additional findings about chondrocyte renewal in lung cartilage. Lung specimens from CD1 mice at the age of 2, 6, 12, 18 or 24 months were fixed in 10% neutral-buffered formalin and paraffin-embedded. Nestin expression was examined by an immunohistochemical peroxidase-based method. We found nestin-positive cells inside of cartilage islets and cells in division very close from them. Our findings indicate that there exist nestin-positive mesenchymal stem cells in the adult that are able to differentiate into lung chondrocytes, perhaps to maintain homeostasis or repair damaged tissue. These findings may improve our knowledge about the cartilage biology and could provide new cell candidates for cartilage tissue engineering.

Se considera que el cartílago adulto sano tiene poca o ninguna capacidad para renovarse, y que sus condrocitos permanecen en un estado de reposo estable, careciendo de las propiedades de proliferación y diferenciación. Recientemente encontramos que el recambio celular en el cartílago pulmonar es posible y que células troncales positivas para nestin pudieran tener algún papel en el mismo. En este artículo, reportamos nuevos hallazgos acerca de la renovación de condrocitos en el cartílago pulmonar. Pulmones de ratones CD1 de 2, 6, 12, 18 o 24 meses de edad se fijaron en formalina amortiguada al 10% y se incluyeron en parafina. Se analizó la expresión de nestin utilizando un método inmunohistoquímico basado en un sistema de detección con peroxidasa. Encontramos células positivas para nestin en el interior de los islotes de cartílago y células en división muy cercanas a ellas. Estos hallazgos indican que existen células madre mesenquimales positivas para nestin en el adulto con capacidad para diferenciarse en condrocitos pulmonares, probablemente para mantener la homeostasis tisular o reparar daños en el tejido. Asimismo, estos hallazgos pueden aumentar nuestra comprensión acerca de las propiedades biológicas del cartílago y podrían proporcionar nuevos candidatos para la ingeniería celular en la terapia regenerativa en enfermedades de las articulaciones.
Descritores: Células-Tronco/fisiologia
Cartilagem/citologia
Condrócitos/fisiologia
Nestina/metabolismo
Pulmão/citologia
-Imuno-Histoquímica
Responsável: CL1.1 - Biblioteca Central



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