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Texto completo SciELO Cuba
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Id: lil-584481
Autor: Vanegas Acosta, Juan Carlos; Landínez Parra, Nancy Stella; Garzón-Alvarado, Diego Alexander.
Título: Mecanobiología de la interfase hueso-implante dental / Mechanobiology of bone-dental implant interphase
Fonte: Rev. cuba. estomatol;47(1):14-36, ene.-mar. 2010.
Idioma: es.
Resumo: La osteointegración es la conexión estructural y funcional entre el hueso y un implante. Cuando un implante se inserta en el hueso, se crea la denominada interfase hueso-implante, una zona de unión entre la superficie del biomaterial del implante y el hueso circundante. La cicatrización de esta interfase depende de las condiciones biológicas del hueso, las características de diseño del implante y la distribución de cargas entre hueso e implante. En este artículo se hace una revisión del proceso de cicatrización de la interfase hueso-implante para el caso de un implante dental. El objetivo es describir la secuencia de eventos biológicos iniciados con la lesión causada por la inserción del implante y que concluyen con la formación de nuevo hueso en la interfase. Esta descripción incluye una novedosa clasificación de los fenómenos mecánicos que intervienen durante el proceso de cicatrización de los tejidos lesionados. Esta descripción mecanobiológica de la interfase hueso-implante dental se utiliza para determinar las características más relevantes a tener en cuenta en la formulación de un modelo matemático de la osteointegración de implantes dentales(AU)

The osteointegration is the structural and functional connection between bone and implant. When an implant is inserted in bone, it creates the so-called bone-implant interphase, a joint zone between implant biomaterial surface and the surrounding bone. The healing of this interphase depends on bone biological conditions, characteristic of implant design and the distribution of loads between bone and implant. The aim of present article is to review of healing process of bone-implant interphase for a dental implant and also to describe the sequence of biological events beginning with lesion caused by implant insertion and leading to the formation of a new bone in the interphase. This description includes a novel classification of mechanical phenomena present in the healing process of tissues affected. This mechanobiological description of dental bone-implant interphase is used to determine the more significant features to be into account in formulation of a mathematical model of the osteointegration of dental implants(AU)
Descritores: Cicatrização
Projeto do Implante Dentário-Pivô/métodos
Interface Osso-Implante
-Fenômenos Mecânicos
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Texto completo SciELO Chile
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Id: biblio-1134557
Autor: Matos, Jefferson David Melo de; Nakano, Leonardo Jiro Nomura; Silva, Severino Alexandre Babosa da; Nascimento, Jaqueline Alves do; Aureliano, Geórgia Maria Granja; Andrade, Valdir Cabral; Bottino, Marco Antonio; Vasconcelos, John Eversong Lucena de; Lopes, Guilherme da Rocha Scalzer.
Título: Homogenous Bone Grafts as an Alternative in Oral Rehabilitation Treatments with Dental Implants / Los Injertos Óseos Homogéneos como una Alternativa en los Tratamientos de Rehabilitación Oral con Implantes Dentales
Fonte: Int. j. odontostomatol. (Print);14(4):678-684, dic. 2020. graf.
Idioma: en.
Resumo: ABSTRACT: The present study aims to describe, through a case report, the functioning of bone grafts, where they are obtained including bone banks and the different dental areas in which it is used. A 50-year.old female patient HMR, sought the postgraduate college of dentistry CECAPE for oral rehabilitation. The initial clinical examination revealed the absence of several dental elements in both the maxilla and mandi ble, bone resorption in the entire maxillary extension where there was an absence of elements in the anterior region and the presence of a torus in the palatal region. Initial tomographic examinations of the maxilla and mandible were performed, looking for the best conduct regarding the diagnosis and planning of the case. After the clinical and radiographic examinations was performed, and the diagnosis was reached, it was determined as a treatment for oral rehabilitation of the maxilla, bone grafting and an Implant-supported Removable Partial Prosthesis and for the mandible a Dento-muco-supported Removable Partial Prosthesis. Dental treatments and oral rehabilitation from the use of bone tissues and bone grafting have become commonly used. Procedures that would normally lead to failure started to increase the percentage of successes due to the use of these biomaterials. The use of bone grafts in dentistry has been shown to be a very effective and useful resource, considering its great applicability in bone reconstructions in different areas of dentistry.

RESUMEN: El presente estudio tiene como objetivo describir a través de un informe de caso, el funcionamiento de los injertos óseos, donde se obtienen, incluidos los bancos de huesos y las diferentes áreas dentales en las que se emplea. Una paciente HMR, de 50 años de edad, asistió el centro universitario de posgrado CECAPE para rehabilitación oral. El examen clínico inicial reveló la ausencia de varios dientes tanto en el maxilar como en la mandíbula, la resorción ósea en toda la extensión maxilar donde había ausencia de dientes en la región anterior y la presencia de un torus en la región palatina. Se realizaron exámenes tomográficos iniciales del maxilar y mandíbula, buscando la mejor conducta con respecto al diagnóstico y la planificación del caso. Después de los exámenes clínicos y radiográficos realizados y el diagnóstico listo, se determinó como un tratamiento para la rehabilitación oral del maxilar, el injerto óseo y una prótesis removible implantosoportada y para la mandíbula una prótesis parcial removible dento-muco-soportada. Los tratamientos dentales y la rehabilitación oral a partir del uso de tejidos óseos y el injerto óseo se han utilizado comúnmente. Los procedimientos que normalmente conducirían al fracaso comenzaron a aumentar el porcentaje de éxitos debido al uso de estos biomateriales. Se ha demostrado que el uso de injertos óseos en odontología es un recurso muy eficaz y útil, considerando su gran aplicabilidad en las reconstrucciones óseas en diferentes áreas de la odontología.
Descritores: Transplante Ósseo/métodos
Implantação Dentária Endo-Óssea/métodos
Interface Osso-Implante/anatomia & histologia
-Tomografia Computadorizada por Raios X
Técnicas de Laboratório Clínico
Mandíbula/diagnóstico por imagem
Reabilitação Bucal
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-886250
Autor: Linden, Maria Salete Sandini; Bittencourt, Marcos Eugênio de; Carli, João Paulo De; Miyagaki, Daniela Cristina; Santos, Pâmela Letícia dos; Paranhos, Luiz Renato; Groppo, Francisco Carlos; Ramacciato, Juliana Cama.
Título: The effects of subcutaneous injection of nicotine on osseointegration of machined and anodized implants in rabbits
Fonte: Acta cir. bras;33(1):31-39, Jan. 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the influence of subcutaneous injection nicotine in osseointegration process on different implant surfaces. Methods: Twenty-two male rabbits were distributed into two groups according to the subcutaneous injections: (1) nicotine 3 mg/day/kg and (2) 0.9 % NaCI 3 mL/day/kg, three times a day; subgroups were then designated-machined and anodized implants were placed in the right and left tibia bones, respectively. The animals were submitted euthanasia after periods of eight weeks to determine nicotine and cotinine levels, alkaline phosphatase and biomechanical analysis. Results: The plasmatic levels of nicotine and cotinine were 0.5 ± 0.28 ng/mL and 9.5 ± 6.51 ng/mL, respectively. The alkaline phosphatase analyses in blood levels in control group were observed 40.8 ± 11.88 UI/L and 40.75 ± 12.46 UI/L, for the surfaces machined and anodized, respectively. In the test group was observed levels 37.9 ± 4.84 UI/L, for both implant surfaces. No significant differences were observed between control and test groups and between the implant surfaces regarding alkaline phosphatase blood levels. For biomechanics, no significant differences were observed in control group between the machined (25±8.46 Ncm) or anodized (31.2 ± 6.76 Ncm) implants. However, the treatment with nicotine induced higher torque than control in both machined (38.3 ± 13.52 Ncm) and anodized (35.5 ± 14.17 Ncm) implants, with p = 0.0024 and p = 0.0121, respectively. Conclusion: Subcutaneous injection of nicotine following implant insertion didn't have effect on osseointegration, independently from the implant surface.
Descritores: Implantes Dentários
Osseointegração/efeitos dos fármacos
Interface Osso-Implante
Nicotina/efeitos adversos
-Propriedades de Superfície/efeitos dos fármacos
Fatores de Tempo
Fenômenos Biomecânicos
Fumar/efeitos adversos
Distribuição Aleatória
Torque
Cotinina/sangue
Fosfatase Alcalina/sangue
Injeções Subcutâneas
Nicotina/administração & dosagem
Nicotina/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-893658
Autor: Oki, Yoshifumi; Doi, Kazuya; Makihara, Yusuke; Kobatake, Reiko; Kubo, Takayasu; Tsuga, Kazuhiro.
Título: Effects of continual intermittent administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model
Fonte: J. appl. oral sci;25(5):498-505, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Projeto: Scientific Research.
Resumo: Abstract Objective: This study aimed to evaluate the effects of continual intermittent administration of parathyroid hormone (PTH) on implant stability in the presence of osteoporosis, using rabbit models. Material and Methods: Fifteen female New Zealand white rabbits underwent ovariectomy and were administered glucocorticoids to induce osteoporosis, following which they were divided into three groups. The first group received intermittent subcutaneous PTH for 4 weeks until implant placement (PTH1), while the second and third groups received PTH (PTH2) and saline (control), respectively, for 4 weeks before and after implant placement. After intermittent administration of PTH or saline, titanium implants were inserted into the left femoral epiphyses of all animals, and the implant stability quotient (ISQ) was measured immediately after placement to assess the primary stability and at 2 and 4 weeks after implant placement to assess osseointegration. At 4 weeks after implant placement, histological and histomorphometric evaluations were conducted and the bone area around the implant socket was measured as a ratio of the total bone area to the total tissue area. Results: Regarding primary stability, the ISQ values for the PTH1 and PTH2 groups were significantly higher than those for the control group (p<0.05). Concerning osseointegration, the ISQ values at 2 and 4 weeks were significantly higher for the PTH2 group than for the PTH1 and control (p<0.05) groups. Histological assessments showed a thicker and more trabecular bone around the implant sockets in the PTH2 specimens than in the PTH1 and control specimens. The bone area around the implant socket was significantly greater in the PTH2 group than in the PTH1 and control groups (p<0.05). Conclusions: Our results suggest that continual intermittent PTH administration before and after dental implant placement is effective for the achievement of favorable stability and osseointegration in the presence of osteoporosis.
Descritores: Osteoporose/fisiopatologia
Hormônio Paratireóideo/administração & dosagem
Implantes Dentários
Osseointegração/efeitos dos fármacos
Conservadores da Densidade Óssea/administração & dosagem
-Osteoporose/patologia
Valores de Referência
Fatores de Tempo
Ovariectomia
Reprodutibilidade dos Testes
Osseointegração/fisiologia
Resultado do Tratamento
Remodelação Óssea/efeitos dos fármacos
Implantação Dentária Endo-Óssea/métodos
Modelos Animais de Doenças
Fêmur/efeitos dos fármacos
Fêmur/patologia
Interface Osso-Implante/fisiopatologia
Análise de Frequência de Ressonância
Glucocorticoides
Injeções Subcutâneas
Limites: Animais
Feminino
Coelhos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Borges, Alexandre Luiz Souto
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Id: biblio-970620
Autor: Tribst, João Paulo Mendes; Dal Piva, Amanda Maria de Oliveira; Borges, Alexandre Luiz Souto; Bottino, Marco Antonio.
Título: Effect of implant number and height on the biomechanics of full arch prosthesis
Fonte: Braz. j. oral sci;17:e18222, 2018. ilus.
Idioma: en.
Resumo: Aim: The goal of this study was to clarify the stress distribution in a full arch prosthesis according to the implant number and height in order to guide the clinical choice during planning. Methods: A computational analysis was performed to analyze the stress distribution in implants and bone tissue according to implant number (3, 4 or 5) and height (5, 8, 11 mm). A model of a jaw with polyurethane properties to simulate bone tissue was created through the Rhinoceros software (version 5.0 SR8, McNeel North America, Seattle, WA, USA). The titanium bar was fixed to the implant through a retention screw. The final geometry was exported in STEP format to ANSYS (ANSYS 15.0, ANSYS Inc., Houston, USA) and all materials were considered homogeneous, isotropic and linearly elastic. To assess distribution of stress forces, an axial load (200 N) was applied on the cantilever. Results in Von-Mises stress and strain criteria's were obtained for implants and bone, respectively. Qualitative and quantitative evaluations were performed. Results: The implant number and height influenced the prosthesis biomechanics, with more von-Mises stress and bone strain concentration for combination of 3 implants with 5 mm. Conclusion: It was concluded that higer length and more quantity of implant supporting a full arch prosthesis promoted less stress concentration during the simulated load. Decreasing the number of implants in rehabilitation is more harmful than decreasing their length for the stress and strain distribution
Descritores: Prostodontia
Resistência à Tração
Análise de Elementos Finitos
Interface Osso-Implante
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Texto completo SciELO Brasil
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Id: biblio-959170
Autor: Santos, Ricardo Barreto Monteiro dos; Prazeres, Cleber Maciel de Morais; Fittipaldi, Ricardo Mertens; Monteiro Neto, João; Nogueira, Tiago Cerqueira Lima; Santos, Saulo Monteiro dos.
Título: Bankart lesion repair: biomechanical and anatomical analysis of Mason-Allen and simple sutures in a swine model / Reparo da lesão de Bankart: análise biomecânica e anatômica das suturas tipo Mason-Allen e simples em modelo suíno
Fonte: Rev. bras. ortop;53(4):454-459, July-Aug. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To evaluate the labral height and pullout resistance after the repair of Bankart lesions in the glenohumeral joint of swine models, using double-loaded anchors with two suture configurations: simple and Mason-Allen. Methods: Ten swine shoulders were used, in which Bankart lesions were created. For each specimen, the lesion was sutured randomly with Mason-Allen sutures or simple sutures. The labral height was measured before the lesion was created and after the labral repair. The specimens were submitted to a tensile test for biomechanical evaluation. Results: In specimens submitted to simple suture (n = 5), the mean labral height observed before the lesion was 3.86 mm, and after suturing, 3.33 mm. In specimens submitted to Mason-Allen suture (n = 5), it was observed that the mean labral height before the lesion was 3.92 mm, and after suturing, 3.48 mm. When comparing the labral height after simple suture and Mason-Allen suture, no significant difference was observed. The pullout force at the end of the tensile test on specimens with single suture was 130 N, and in specimens with Mason-Allen suture, 128.6 N. No statistically significant differences were observed between the shoulders treated with single suture and Mason-Allen suture; p = 0.885. Conclusions: Repair of Bankart lesions with Mason-Allen suture provides increased labrum height; however, it does not increase the pullout strength.

RESUMO Objetivo: Avaliar a altura labral e a resistência ao arrancamento do reparo da lesão de Bankart em articulação glenoumeral de suínos, com âncoras duplamente carregadas com duas configurações de sutura: simples e tipo Mason-Allen. Métodos: Foram usados dez ombros suínos, nos quais foram criadas as lesões de Bankart. Para cada espécime foi feita a sutura da lesão com suturas tipo Mason-Allen e simples de forma aleatória. A altura labral foi mensurada previamente à confecção da lesão e após o reparo labral. Os espécimes foram submetidos ao ensaio de tração para avaliação biomecânica. Resultados: Nos espécimes submetidos a sutura simples (n = 5), observou-se altura média previamente à confecção da lesão de 3,86 mm e após a sutura, de 3,33 mm. Nos espécimes submetidos a sutura Mason-Allen (n = 5), observou-se que a altura média previamente à confecção da lesão era de 3,92 mm e após a sutura, de 3,48 mm. Ao comparar a altura labral após a sutura simples e Mason-Allen, não foram observadas diferenças significantes. A força de arrancamento no fim do ensaio de tração nos espécimes com sutura simples foi de 130 N e nos espécimes com sutura Mason-Allen, 128,6 N. Não houve diferença estatisticamente significante entre os ombros com suturas simples e Mason-Allen, p = 0,885. Conclusões: O reparo das lesões de Bankart com sutura Mason-Allen proporciona aumento da altura do labrum, mas não eleva a força de resistência ao arrancamento.
Descritores: Luxação do Ombro
Cápsula Articular
Interface Osso-Implante
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-905392
Autor: Vaz Ayub, Karen.
Título: Avaliação clínica e radiográfica de implantes curtos: estudo retrospectivo no período de 7 anos / Clinical and radiographic evaluation of short implants: retrospective study for a period of 7 years.
Fonte: Bauru; s.n; 2017. 84 p. ilus, graf, tab.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Odontologia de Bauru para obtenção do grau de Doutor.
Resumo: Áreas edêntulas com severa reabsorção óssea têm sido reabilitadas com próteses fixas instaladas sobre implantes curtos, evitando que os pacientes sejam submetidos a cirurgias de reconstrução óssea. Este estudo retrospectivo descreve o comportamento de implantes curtos avaliados em um período de 7 anos. A amostra foi composta por 70 pacientes, de ambos os gêneros, que receberam 136 implantes, de 6 ou 8mm de comprimento (Straumann® bone level e tissue level standard plus) sobre os quais foram instaladas próteses unitárias e múltiplas, cimentadas e parafusadas. Foram realizadas avaliações clínicas e radiográficas mensurando a estabilidade do implante por frequência de ressonância, perda óssea marginal por meio de radiografias panorâmicas, índices de placa e de sangramento marginal, taxas de sobrevivência do implante e da prótese. Dois implantes instalados na mandíbula foram perdidos, resultando em uma taxa de sobrevivência de 98,3%. A taxa de sobrevivência das próteses foi de 100%; a média de perda óssea foi de - 0,28mm; a estabilidade média dos implantes foi de 76,515 ISQ; as médias dos índices de placa e de sangramento foram de 32,83% e 33,21%, respectivamente. A estabilidade do implante foi maior na mandíbula que na maxila (p = 0,006). Os resultados obtidos nesta pesquisa, possibilitam afirmar que os implantes curtos podem ser utilizados com segurança dentro de suas indicações específicas.(AU)

Edentulous areas with severe bone resorption have been rehabilitated with fixed prostheses installed on short implants, avoiding surgeries of bone reconstruction. This retrospective study describes the behavior of short implants evaluated during 7 years. The sample consisted of 70 patients, of both genders, who received 136 implants, 6 or 8mm in length (Straumann® bone level and tissue level standard plus) on which single and multiple, cemented and screwed prostheses were installed. Clinical and radiographic evaluations were performed by measuring implant stability by resonance frequency, marginal bone loss by panoramic radiographs, plaque and marginal bleeding rates, the implant and prostheses survival rates. Two implants installed in mandible were lost, resulting in a survival rate of 98,3%. The prostheses survival rate was 100%; mean bone loss was -0,28mm; mean implants stability was 76,52 ISQ; mean plaque and bleeding indexes were 32,83% and 33,21%, respectively. The implant stability was higher in the mandible than in the maxilla (p = 0.006). The results obtained in this research make it possible to state that short implants can be used safely within their specific indications.(AU)
Descritores: Interface Osso-Implante/diagnóstico por imagem
Implante Dentário Subperiósteo/métodos
Implantes Dentários
-Perda do Osso Alveolar
Análise de Variância
Radiografia Panorâmica
Reprodutibilidade dos Testes
Estudos Retrospectivos
Resultado do Tratamento
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta
BR28.1, Ay96a


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Id: biblio-881977
Autor: Miranda, Aline Baía.
Título: Avaliação histológica e histomorfométrica da energia superficial e molhabilidade em implantes de titânio grau IV e grau V: estudo experimental em coelhos / Histologic and histomorphometric evaluation of surface energy and wettability in dental implants of titanium grade IV and V: experimental study in rabbits.
Fonte: Bauru; s.n; 2016. 173 p. tab, ilus.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Odontologia de Bauru para obtenção do grau de Doutor.
Resumo: O presente estudo teve como objetivo avaliar a resposta biológica ao redor de implantes de titânio grau IV (titânio comercialmente puro) e grau V (Ti6Al4V), com diferentes tipos de tratamentos de superfície através da análise do contato ossoimplante (bone implant contact - BIC) e da área de neoformação óssea com e sem fluorocromo (bone area BA e BAfluo) das 3 primeiras roscas em contato ósseo de cada implante. Para isso, utilizou-se um total de 90 implantes Cone Morse de titânio grau IV (Drive 45 implantes) e titânio grau V (Facility 45 implantes), com dimensões de 3.5x8mm e 2.9x7mm, respectivamente. Estes dois tipos de implantes foram avaliados em três tratamentos de superfícies diferentes: a) superfície com jateamento com partículas abrasivas seguido de tratamento ácido - NeoPoros (NP) - em embalagem seca (Grupo Controle); b) superfície jateada seguido de tratamento ácido e energia de superfície, armazenado em líquido (ESm); c) superfície jateada seguido de tratamento ácido com energia de superfície e embalado a seco (ESs); totalizando 6 grupos, distribuídos em 15 coelhos New Zealand, em cada um foram instalados 6 implantes, sendo 3 em cada tíbia. Após 15 dias de osseointegração, os coelhos passaram por eutanásia e as tíbias seccionadas, fixadas e incluídas para a avaliação histológica e histomorfométrica. Mensurações no analisador de imagens ImageJ foram realizadas e a análise dos dados estatísticos, de todos os grupos foram avaliados através da análise de variância a dois critérios e do teste de Tukey para comparações múltiplas grupo a grupo, adotando o nível de significância de 5% (p<0,05). Os resultados mostraram que não houve diferença estatisticamente significante entre os dois tipos de titânio, porém houve diferença estatisticamente significante entre os tipos de superfície em relação ao BIC, BA e BAfluo; também, não houve interação entre titânio e superfície. Na análise do contato osso-implante (BIC) a superfície ESm teve melhor desempenho em relação ao NP, que por sua vez foi semelhante ao ESs. Quanto à área óssea (BA), a superfície NP teve menor desempenho em relação à ESs, este obteve semelhante desempenho a ESm. Quanto a área ósseo neoformada com presença de fluorocromo (BAfluo), NP teve menor desempenho em relação ao ESs, o qual obteve semelhante comportamento a ESm. Com isso, concluiu-se que implantes de titânio de gau IV e grau V obtiveram respostas biológicas equivalentes, enquanto que a energia de superfície com a molhabilidade podem ser consideradas como vantagem, uma vez que otimizam o processo de osseointegração.(AU)

This study aimed to evaluate the biological response around grade IV (commercially pure titanium) and grade V (Ti6Al4V) titanium implants with different types of surface treatments by analyzing bone-implant contact (BIC) and the bone formation area with and without fluorochrome (BA and BAfluo) of the 3 first threads on bone contact of each implant. To this end, this study used 90 Morse Taper grade IV (Drive - 45 implants) and grade V (Facility - 45 implants) titanium implants, measuring 3.5x8mm and 2.9x7mm, respectively. Both types of implants were evaluated in three different surface treatments: a) blasted/acid-etched implant surface - NeoPoros (NP) - dry pack (control group); b) blasted/acid-etched implant surface and surface energy, stored in liquid (ESm); c) blasted/acid-etched implant surface with surface energy and dry packed (ESs); totalizing 6 groups, distributed in 15 New Zealand rabbits. Six implants were placed in each rabbit, 3 in each tibia. After 15 days of osseointegration, the rabbits were euthanized and the tibias sectioned, fixed and embedded for histologic and histomorphometric evaluation. Measurements were carried out using the image analysis program ImageJ and the assessment of statistical data concerning all groups was done through the two-way analysis of variance and the Tukey test for multiple comparisons group to group, adopting the significance level of 5% ( p <0.05). The results showed no statistically significant difference between the types of titanium used. However, there were statistically significant differences between the types of surface in relation to the BIC, BA and BAfluo. In addition, there was no interaction between titanium and the surface. Concerning the analysis of bone-implant contact (BIC), the ESm surface had better performance compared to the NP, which, in turn, was similar to the ESs. As for bone area (BA), the NP surface had lower performance in relation to the ESs surface, as the latter had a similar performance to the ESm surface. Concerning the newly formed bone area with presence of fluorochrome (BAfluo), the NP had lower performance if compared to the ESs, which behaved similarly to that of the ESm surface. Thus, this study concluded that grade IV and grade V titanium implants showed equivalent biological responses, while the surface energy, together with its wettability, can be considered an advantage, enhancing the osseointegration process.(AU)
Descritores: Regeneração Óssea/fisiologia
Interface Osso-Implante/fisiologia
Titânio/química
Titânio/uso terapêutico
-Implantação Dentária Endo-Óssea/métodos
Reprodutibilidade dos Testes
Propriedades de Superfície
Tíbia/fisiologia
Tíbia/cirurgia
Resultado do Tratamento
Limites: Humanos
Masculino
Coelhos
Tipo de Publ: Estudo de Avaliação
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: lil-796872
Autor: Schiper, Luis; Faintuch, Bluma Linkowski; Badaró, Roberto José da Silva; Oliveira, Erica Aparecida de; Chavez, Victor E. Arana; Chinen, Elisangela; Faintuch, Joel.
Título: Functional investigation of bone implant viability using radiotracers in a new model of osteonecrosis
Fonte: Clinics;71(10):617-625, Oct. 2016. graf.
Idioma: en.
Resumo: OBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a subcutaneous abdominal pocket was devised. To maintain animal mobility and longevity, the femur was harvested from syngeneic donors. Two technetium-99m-labeled tracers targeting angiogenesis and bone matrix were selected. METHODS: Medronic acid and a homodimer peptide conjugated with RGDfK were radiolabeled with technetium-99m, and biodistribution was evaluated in Swiss mice. The grafted and control femurs were evaluated after 15, 30 and 60 days, including computed tomography (CT) and histological analysis. RESULTS: Radiolabeling achieved high (>95%) radiochemical purity. The biodistribution confirmed good blood clearance 1 hour after administration. For 99mTc-hydrazinonicotinic acid (HYNIC)-E-[c(RGDfK)2, remarkable renal excretion was observed compared to 99mTc-methylene diphosphonate (MDP), but the latter, as expected, revealed higher bone uptake. The results obtained in the control femur were equal at all time points. In the implanted femur, 99mTc-HYNIC-E-[c(RGDfK)2 uptake was highest after 15 days, consistent with early angiogenesis. Regarding 99mTc-MDP in the implant, similar uptake was documented at all time points, consistent with sustained bone viability; however, the uptake was lower than that detected in the control femur, as confirmed by histology. CONCLUSIONS: 1) Graft viability was successfully diagnosed using radiotracers in severely ischemic bone at all time points. 2) Analogously, indirect information about angiogenesis could be gathered using 999mTc-HYNIC-E-[c(RGDfK)2. 3) These techniques appear promising and warrant further studies to determine their potential clinical applications.
Descritores: Interface Osso-Implante/fisiologia
Compostos de Organotecnécio
Osteonecrose/fisiopatologia
Peptídeos Cíclicos
Compostos Radiofarmacêuticos
-Transplante Ósseo
Difosfonatos
Modelos Animais de Doenças
Fêmur/patologia
Fêmur/fisiopatologia
Marcação por Isótopo/métodos
Neovascularização Fisiológica/fisiologia
Osteonecrose/patologia
Reprodutibilidade dos Testes
Fatores de Tempo
Sobrevivência de Tecidos/fisiologia
Tomografia Computadorizada por Raios X
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-777359
Autor: Pimentel, Suzana Peres; Casarin, Renato Correa; Ribeiro, Fernanda Vieira; Cirano, Fabiano Ribeiro; Rovaris, Karla; Haiter Neto, Francisco; Casati, Marcio Zaffalon.
Título: Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats
Fonte: J. appl. oral sci;24(1):45-51, Jan.-Feb. 2016. graf.
Idioma: en.
Resumo: ABSTRACT The use of natural substances and micronutritional approaches has been suggested as a therapeutic alternative to benefit the bone healing associated with no side effects. Nevertheless, the influence of micronutritional interventions with therapeutic proprieties on the bone repair has yet to be intensely evaluated, and no evidence is available exploring the impact of micronutrient supplementation on the peri-implant bone healing. Objective This study investigated the effect of micronutrients supplementation on the bone repair around implants. Material and Methods One screw-shaped titanium implant was inserted in each tibia of each rat, which were assigned to: daily administration, for 30 d, of the placebo solution (Placebo group-n:18) or micronutrients supplementation (Micronutrients group-n:18), based on calcium, magnesium, zinc, and vitamin D3 intake. After, the animals were sacrificed. One of the implants was removed by applying a counter-torque force to evaluate the force to rupture the bone-implant interface. The other implant was evaluated by microcomputed tomography (CT) examination to determine the bone-to-implant contact (BIC) and the bone volume (BV/TV). Results No statistically significant differences were observed between the groups for both counter-torque values and microCT parameters (p>0.05). Conclusion Within the limits of this study, micronutrients supplementation did not provide additional benefits to the bone healing around dental implants.
Descritores: Regeneração Óssea/efeitos dos fármacos
Implantação Dentária Endo-Óssea/métodos
Suplementos Nutricionais
Micronutrientes/farmacologia
-Parafusos Ósseos
Interface Osso-Implante
Cálcio/farmacologia
Colecalciferol/farmacologia
Consolidação da Fratura/efeitos dos fármacos
Magnésio/farmacologia
Efeito Placebo
Ratos Wistar
Tíbia/efeitos dos fármacos
Titânio
Torque
Resultado do Tratamento
Microtomografia por Raio-X
Zinco/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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