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Id: biblio-1132498
Autor: Dai, Shouqian; Liang, Ting; Fujii, Tadashi; He, Shuangjun; Zhang, Fan; Jiang, Huaye; Liu, Bo; Shi, Xiu; Luo, Zongping; Yang, Huilin.
Título: Increased elastic modulus of the synovial membrane in a rat ACLT model of osteoarthritis revealed by atomic force microscopy
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;53(11):e10058, 2020. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Basic Research Program of Jiangsu Province; . Natural Science Foundation of the Jiangsu Higher Education Institutions of China; . Jiangsu Planned Projects for Postdoctoral Research Funds.
Resumo: This study aimed to explore changes in nanoscale elastic modulus of the synovium using atomic force microscopy (AFM) in addition to investigate changes in synovial histomorphology and secretory function in osteoarthritis (OA) in a rat anterior cruciate ligament transection (ACLT) model. Sprague-Dawley rats were randomly assigned to sham control and ACLT OA groups. All right knee joints were harvested at 4, 8, or 12 weeks (W) after surgery for histological assessment of cartilage damage and synovitis in both the anterior and posterior capsules. AFM imaging and nanoscale biomechanical testing were conducted to measure the elastic modulus of the synovial collagen fibrils. Immunohistochemistry was used to visualize the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-3 (MMP-3) in the synovium. The OA groups exhibited progressive development of disease in the cartilage and synovium. Histopathological scores of the synovium in the OA groups increased gradually. Significant differences were observed between all OA groups except for the posterior 4W group. The synovial fibril arrangement in all OA groups was significantly disordered. The synovial fibrils in all ACLT OA groups at each time point were stiffer than those in the sham controls. OA rats displayed a significantly higher expression of IL-1β and MMP3 in the anterior capsule. In summary, synovial stiffening was closely associated with joint degeneration and might be a factor contributing to synovitis and increased production of proinflammatory mediators. Our data provided insights into the role of synovitis, particularly stiffening of the synovium, in OA pathogenesis.
Descritores: Osteoartrite
Cartilagem Articular
-Membrana Sinovial
Ligamento Cruzado Anterior
Ratos Sprague-Dawley
Microscopia de Força Atômica
Módulo de Elasticidade
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1340618 LILACS-Express
Autor: Trueba, Ricardo.
Título: Presentación del caso / Case presentation
Fonte: Rev. Asoc. Argent. Ortop. Traumatol;85(3):190-191, ago. 2020.
Idioma: es.
Descritores: Dor
Membrana Sinovial
Articulação do Cotovelo
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: biblio-1132558
Autor: Resende, G G; Machado, C R L; Rocha, M A; Macedo, R B V; Bueno Filho, J S S; Kakehasi, A M; Andrade, M V.
Título: IL-22 increases the production of sFRP3 by FLS in inflammatory joint diseases
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;53(9):e9880, 2020. tab, graf.
Idioma: en.
Projeto: FAPEMIG.
Resumo: Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) are inflammatory diseases with different bone remodeling patterns. Fibroblast-like synoviocytes (FLS) are cells involved in the transition from an acute and reparable phase to a chronic and persistent stage in these diseases. The distinction of joint phenotypes involves inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-17, and IL-22 directly or through key signaling pathways such as Wnt. To evaluate the role of FLS as the source of Wnt antagonists (sFRP3/FRZB and Dkk1) in the synovia, levels of TNF- α, IL-17, IL-22, Dkk1, and sFRP3 were measured by ELISA directly in the synovial fluid of patients with RA, PsA, or AS. Dkk1 and sFRP3 were also measured in the FLS culture supernatants after different inflammatory stimulus. sFRP3 and Dkk1 are constitutively expressed by FLS. IL-22 and sFRP3 were positively correlated (r=0.76; P<0.01) in synovial fluid. The stimulation of FLS with IL-22, but not TNF-alpha and IL-17, increased the production of sFRP3. No stimulus altered the basal expression of Dkk1. These results showed, for the first time, the ability of IL-22 to increase the expression of sFRP3/FRZB by human FLS in both in vitro and ex vivo models. This finding linked IL-22 to local inhibition of Wnt signaling and possibly to blockade of osteogenesis. Furthermore, FLS presented as a source of this inhibitor in synovial fluid, assigning to this cell a bone injury mechanism.
Descritores: Interleucinas/metabolismo
Sinoviócitos
-Membrana Sinovial
Células Cultivadas
Fator de Necrose Tumoral alfa
Fibroblastos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1291386
Autor: Jorge, Carolina Souza; Martins, Letícia Neves; Ricardo, Bernardo Ferreira de Paula; Tavares Júnior, Wilson Campos; Lanna, Cristina Costa Duarte; Santos, Fabiana Miranda Moura dos.
Título: Lipoma Arborescente: uma causa de sinovite crônica? / Lipoma Arborescens: a cause of chronic synovitis?
Fonte: Rev. méd. Minas Gerais;31:31409, 2021.
Idioma: pt.
Resumo: O lipoma arborescente é uma causa incomum de lesão intra-articular que se apresenta como aumento de volume articular indolor, lentamente progressivo, que persiste por muitos anos e é acompanhado por derrames articulares intermitentes. O envolvimento de sítios extra-articulares é incomum, mas pode ocorrer em bainhas tendíneas e bursas. A ressonância magnética é o melhor exame para o diagnóstico, embora a biópsia sinovial possa ser necessária em alguns casos. Relatamos três casos com o objetivo de destacar o espectro clínico da doença, as características da imagem e a resposta ao tratamento imunossupressor.

Lipoma arborescens is an uncommon cause of intra-articular masses that presents as slowly progressive painless swelling of the joint, which persists for many years and is accompanied by intermittent effusions. Extra-articular site(s) involvement is unusual, but can occur in tendon sheaths and bursas. Magnetic resonance imaging is the best diagnostic exam, although synovial biopsy may be necessary. We report three cases in order to highlight the clinical spectrum and imaging features of the disease, so that early diagnosis and appropriate treatment can be given.
Descritores: Sinovite
Traumatismos do Joelho
Lipoma
-Artrite
Membrana Sinovial
Imageamento por Ressonância Magnética
Adipócitos
Sinovectomia
Articulações
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1561.1 - Biblioteca Virtual AMMG


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Id: lil-412946
Autor: Soroa, Victoria; Galatro, Gustavo; Giannone, Carlos; Mejail, Adrian; Nuova, Pablo; Espeche Velazquez, Maria V; Moretti, Noemi; Dafuncchio, Carla; Nicolini, Jorge; Caviglia, Horacio.
Título: Radiosinovectomias o radiosinoviortesis en hemofilia / Radiosynovectomies or radiosynoviorthesis in hemophilia
Fonte: Rev. Asoc. Argent. Ortop. Traumatol;70(1):68-81, mar. 2005. ilus, tab.
Idioma: es.
Descritores: Membrana Sinovial
Sinovite
Coloides/uso terapêutico
Hemartrose
Hemofilia A
Limites: Adulto
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: biblio-1159964
Autor: Gamboa, Miguel A; Arriola, Americo F; Monserrat, Alberto J.
Título: Serosas peritoneal y articulares. Histofisiopatología y posibilidades terapéuticas / Peritoneal and articular serous membranes. Histophysiopathology and therapeutic possibilities
Fonte: Arch. argent. pediatr;69(9):362-364, 1971 Nov.
Idioma: es.
Descritores: Doenças Peritoneais
Peritônio
Artrite
Membrana Serosa
Membrana Sinovial
Limites: Humanos
Responsável: AR94.1 - Centro de Información Pediatrica


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Texto completo SciELO Chile
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Id: biblio-950828
Autor: Xu, Yuan-kun; Ke, Yan; Wang, Bin; Lin, Jian-hao.
Título: The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis
Fonte: Biol. Res;48:1-8, 2015. ilus, graf, tab.
Idioma: en.
Projeto: Beijing Municipal Science and Technology Commission; . The National Natural Science Fund.
Resumo: BACKGROUND: Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented. RESULTS: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 (CCR2) in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001) and the expression of MMP-13 also increased (P < 0.05). MCP-1 stimulation also induced (or enhanced) the apoptosis of OA chondrocytes (P < 0.05). Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13) in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA) model. CONCLUSIONS: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis.
Descritores: Quimiocina CCL2/metabolismo
Condrócitos/metabolismo
Osteoartrite do Joelho/fisiopatologia
Receptores CCR2/metabolismo
-Membrana Sinovial/citologia
Técnicas In Vitro
Ensaio de Imunoadsorção Enzimática
Ratos Sprague-Dawley
Apoptose/fisiologia
Progressão da Doença
Quimiocina CCL2/genética
Metaloproteinase 3 da Matriz/metabolismo
Condrócitos/enzimologia
Ácido Iodoacético
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Metaloproteinase 13 da Matriz/metabolismo
Receptores CCR2/antagonistas & inibidores
Receptores CCR2/genética
Fibroblastos/metabolismo
Proteínas Matrilinas/metabolismo
Camundongos Endogâmicos C57BL
Limites: Humanos
Animais
Masculino
Feminino
Adolescente
Pessoa de Meia-Idade
Idoso
Camundongos
Ratos
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-683039
Autor: Gutiérrez, William Arbey; Samudio Brigard, María Lucía; Fernández-Ávila, Daniel G; Díaz, María Claudia; Gutiérrez Dávila, Juan Martín.
Título: Artritis reumatoide en el anciano. Revisión narrativa / Rheumatoid arthritis in the elderly. A narrative review
Fonte: Rev. colomb. reumatol;20(2):91-101, abr.-jun. 2013. tab.
Idioma: es.
Resumo: Colombia está viviendo 2 fenómenos importantes, las transiciones demográfica y epidemiológica, los cuales se ven reflejados en un proceso acelerado de envejecimiento poblacional que, a su vez, aumenta la prevalencia de enfermedades crónicas, entre ellas la artritis reumatoide (AR). De acuerdo con la edad de aparición, la AR se clasifica en 2 subgrupos: la enfermedad reumatoide de aparición temprana y la AR de aparición tardía (en pacientes > 65 años). Anteriormente, se pensaba que la diferencia más importante entre los 2 subgrupos era que la AR de aparición tardía tenía un mejor pronóstico que la enfermedad reumatoide de aparición temprana. En la actualidad, se han descrito las diferencias que existen entre estas 2 formas de presentación de la AR. A través de este artículo se describirán las principales diferencias que existen en cuanto a la epidemiología, patogenia, manifestaciones clínicas, tratamiento, pronóstico y funcionalidad de los pacientes con AR de presentación temprana y tardía.

Colombia is experiencing two major phenomena, a demographic and an epidemiological transition, which is reflected in an accelerated process of population aging. This, in turn, increases the prevalence of chronic diseases, of which rheumatoid arthritis is one of them. According to the age of onset, it is classified into two subgroups: younger onset RA or YORA, and late onset RA or EORA (onset at 65 years or older). It was previously thought that the most important difference between the two subgroups was that EORA had a better prognosis than YORA. The differences between these two diseases has currently been described. This article presents the main differences as regards the epidemiology, pathogenesis, clinical manifestations, treatment, prognosis, and functioning of patients with RA of early and late presentation.
Descritores: Artrite Reumatoide
Idoso
-Membrana Sinovial
Doença Crônica
Incidência
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Revisão
Responsável: CO356.9


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Id: lil-683040
Autor: Saldarriaga Rivera, Lina María; Delgado Quiroz, Luis Alberto.
Título: Asociación de artritis reumatoide en paciente joven con anemia aplásica / Rheumatoid arthritis associated with aplastic anemia in a young patient
Fonte: Rev. colomb. reumatol;20(2):111-115, abr.-jun. 2013. tab.
Idioma: es.
Resumo: La artritis reumatoide es una enfermedad crónica, sistémica e inflamatoria, de etiología desconocida, que afecta, principalmente la membrana sinovial de las articulaciones. Se caracteriza por dolor crónico, y destrucción articular que conlleva un aumento de la mortalidad y un elevado riesgo de invalidez con altos costos para el enfermo y la sociedad. Describimos el caso de un paciente joven con anemia aplásica desde los 8 años, que inicia en 2009 cuadro de dolor y aumento de volumen articular en manos, muñecas y tobillos bilaterales, cumpliendo los criterios para artritis reumatoide.

Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory disease of unknown etiology that mainly affects the synovial membrane of the joints. It is characterized by chronic pain and joint destruction, which leads to premature mortality and risk of disability, with high costs to the patient and society. The case is presented of a young male patient with aplastic anemia since 8 years old who, in 2009, began with swelling and joint pain in the hands, wrists and ankles, fulfilling criteria for rheumatoid arthritis.
Descritores: Artrite Reumatoide
Anemia Aplástica
-Dor
Membrana Sinovial
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CO356.9


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Id: biblio-990959
Autor: Arana, Paul; Salazar, Diana; Amaya, Sandra; Medina, Michelle; Moreno-Correa, Sandra; Moreno, Freddy; González, Herman; Contreras, Adolfo.
Título: Microorganismos periodontales en el líquido sinovial de pacientes con artritis reumatoide. Revisión sistemática de la literatura 2017 / Periodontal microorganisms in synovial fluid of patients with rheumatoid arthritis. Systematic review of the literature - 2017
Fonte: Rev. colomb. reumatol;25(4):271-286, oct.-dic. 2018. tab, graf.
Idioma: es.
Resumo: RESUMEN Introducción: La enfermedad periodontal (EP) y la artritis reumatoide (AR) son enfermedades inflamatorias crónicas multifactoriales que tienen en común algunos factores etiopatogénicos y la destrucción de los tejidos dentoalveolares y de las articulaciones sinoviales, de tal forma que se han identificado anticuerpos contra microorganismos periodontales en el fluido crevicular, líquido sinovial y en la membrana sinovial. Objetivo: Identificar, recuperar, analizar críticamente y sintetizar la literatura disponible acerca de la prevalencia de microorganismos periodontales en el líquido sinovial de pacientes con AR. Materiales y métodos: Se realizó búsqueda sistemática en Medline, ScienceDirect, SciELO y Google Scholar a través de los descriptores en salud Rheumatoid arthritis, periodontal microorganisms y synovial fluid. Se incluyeron artículos que describieron la presencia de microorganismos periodontales aislados en líquido sinovial de pacientes diagnosticados con AR. La búsqueda se cerró en febrero de 2017 y fue realizada con metodología PRISMA. Se emplearon las fichas de lectura crítica OSTEBA para valorar la validez externa y el nivel de evidencia de cada artículo en función del rigor metodológico. Resultados: Catorce publicaciones describieron la presencia de microorganismos periodontales en líquido sinovial de pacientes con EP y AR. Seis publicaciones realizaron detección de microorganismos periodontales en muestras de líquido sinovial, identificando en todas a P. gingivalis. Conclusiones: Los estudios incluidos evidenciaron la presencia de microrganismos periodontales en el líquido sinovial en sujetos con EP y AR, asociando la prevalencia de P. gingivalis con el aumento de los niveles de anticuerpos anti-CCP, lo que podría exacerbar los procesos inflamatorios y producir reacciones autoinmunes en AR.

ABSTRACT Introduction: Periodontal disease (PD) and rheumatoid arthritis (RA) are multifactorial chronic inflammatory diseases that share similar aetiopathogenic mechanisms that lead to the destruction of both dental-alveolar tissues and synovial joints, in such way that antibodies against periodontal pathogens have been identified in the crevicular fluid and in the synovial fluid and membranes. Objective: To identify, recover, critically analyze and synthesize the available literature on the prevalence of periodontal microorganisms in synovial fluid of patients with RA. Materials and methods: A systematic search was performed in MEDLINE, ScienceDirect, SciELO and Google Scholar using the medical subject headings "Rheumatoid arthritis", "periodontal microorganisms" and "synovial fluid". Articles were included that described the presence of isolated periodontal pathogens in synovial fluid of patients diagnosed with RA. The search was closed in February 2017 and was performed using PRISMA methodology. The OSTEBA critical reading sheets were used to assess the external validity and level of evidence of each article in terms of methodological rigor. Results: A total of 14 publications were included that described the presence of periodontal pathogens in synovial fluid of patients with PD and RA. Seven publications detected periodontal pathogens in synovial fluid, with P. gingivalis being positive in all of them. Conclusions: The included studies provided evidence of the presence of periodontal microorganisms in the synovial fluid in subjects with PD and RA, associating the prevalence of P. gingivalis with increased levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies, which could exacerbate inflammatory processes and produce autoimmune reactions in RA.
Descritores: Artrite Reumatoide
Líquido Sinovial
-Doenças Periodontais
Membrana Sinovial
Líquido do Sulco Gengival
Tipo de Publ: Revisão Sistemática
Responsável: CO356.9



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