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Id: lil-683039
Autor: Gutiérrez, William Arbey; Samudio Brigard, María Lucía; Fernández-Ávila, Daniel G; Díaz, María Claudia; Gutiérrez Dávila, Juan Martín.
Título: Artritis reumatoide en el anciano. Revisión narrativa / Rheumatoid arthritis in the elderly. A narrative review
Fonte: Rev. colomb. reumatol;20(2):91-101, abr.-jun. 2013. tab.
Idioma: es.
Resumo: Colombia está viviendo 2 fenómenos importantes, las transiciones demográfica y epidemiológica, los cuales se ven reflejados en un proceso acelerado de envejecimiento poblacional que, a su vez, aumenta la prevalencia de enfermedades crónicas, entre ellas la artritis reumatoide (AR). De acuerdo con la edad de aparición, la AR se clasifica en 2 subgrupos: la enfermedad reumatoide de aparición temprana y la AR de aparición tardía (en pacientes > 65 años). Anteriormente, se pensaba que la diferencia más importante entre los 2 subgrupos era que la AR de aparición tardía tenía un mejor pronóstico que la enfermedad reumatoide de aparición temprana. En la actualidad, se han descrito las diferencias que existen entre estas 2 formas de presentación de la AR. A través de este artículo se describirán las principales diferencias que existen en cuanto a la epidemiología, patogenia, manifestaciones clínicas, tratamiento, pronóstico y funcionalidad de los pacientes con AR de presentación temprana y tardía.

Colombia is experiencing two major phenomena, a demographic and an epidemiological transition, which is reflected in an accelerated process of population aging. This, in turn, increases the prevalence of chronic diseases, of which rheumatoid arthritis is one of them. According to the age of onset, it is classified into two subgroups: younger onset RA or YORA, and late onset RA or EORA (onset at 65 years or older). It was previously thought that the most important difference between the two subgroups was that EORA had a better prognosis than YORA. The differences between these two diseases has currently been described. This article presents the main differences as regards the epidemiology, pathogenesis, clinical manifestations, treatment, prognosis, and functioning of patients with RA of early and late presentation.
Descritores: Artrite Reumatoide
Idoso
-Membrana Sinovial
Doença Crônica
Incidência
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Revisão
Responsável: CO356.9


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Id: lil-683040
Autor: Saldarriaga Rivera, Lina María; Delgado Quiroz, Luis Alberto.
Título: Asociación de artritis reumatoide en paciente joven con anemia aplásica / Rheumatoid arthritis associated with aplastic anemia in a young patient
Fonte: Rev. colomb. reumatol;20(2):111-115, abr.-jun. 2013. tab.
Idioma: es.
Resumo: La artritis reumatoide es una enfermedad crónica, sistémica e inflamatoria, de etiología desconocida, que afecta, principalmente la membrana sinovial de las articulaciones. Se caracteriza por dolor crónico, y destrucción articular que conlleva un aumento de la mortalidad y un elevado riesgo de invalidez con altos costos para el enfermo y la sociedad. Describimos el caso de un paciente joven con anemia aplásica desde los 8 años, que inicia en 2009 cuadro de dolor y aumento de volumen articular en manos, muñecas y tobillos bilaterales, cumpliendo los criterios para artritis reumatoide.

Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory disease of unknown etiology that mainly affects the synovial membrane of the joints. It is characterized by chronic pain and joint destruction, which leads to premature mortality and risk of disability, with high costs to the patient and society. The case is presented of a young male patient with aplastic anemia since 8 years old who, in 2009, began with swelling and joint pain in the hands, wrists and ankles, fulfilling criteria for rheumatoid arthritis.
Descritores: Artrite Reumatoide
Anemia Aplástica
-Dor
Membrana Sinovial
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CO356.9


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Id: biblio-990959
Autor: Arana, Paul; Salazar, Diana; Amaya, Sandra; Medina, Michelle; Moreno-Correa, Sandra; Moreno, Freddy; González, Herman; Contreras, Adolfo.
Título: Microorganismos periodontales en el líquido sinovial de pacientes con artritis reumatoide. Revisión sistemática de la literatura 2017 / Periodontal microorganisms in synovial fluid of patients with rheumatoid arthritis. Systematic review of the literature - 2017
Fonte: Rev. colomb. reumatol;25(4):271-286, oct.-dic. 2018. tab, graf.
Idioma: es.
Resumo: RESUMEN Introducción: La enfermedad periodontal (EP) y la artritis reumatoide (AR) son enfermedades inflamatorias crónicas multifactoriales que tienen en común algunos factores etiopatogénicos y la destrucción de los tejidos dentoalveolares y de las articulaciones sinoviales, de tal forma que se han identificado anticuerpos contra microorganismos periodontales en el fluido crevicular, líquido sinovial y en la membrana sinovial. Objetivo: Identificar, recuperar, analizar críticamente y sintetizar la literatura disponible acerca de la prevalencia de microorganismos periodontales en el líquido sinovial de pacientes con AR. Materiales y métodos: Se realizó búsqueda sistemática en Medline, ScienceDirect, SciELO y Google Scholar a través de los descriptores en salud Rheumatoid arthritis, periodontal microorganisms y synovial fluid. Se incluyeron artículos que describieron la presencia de microorganismos periodontales aislados en líquido sinovial de pacientes diagnosticados con AR. La búsqueda se cerró en febrero de 2017 y fue realizada con metodología PRISMA. Se emplearon las fichas de lectura crítica OSTEBA para valorar la validez externa y el nivel de evidencia de cada artículo en función del rigor metodológico. Resultados: Catorce publicaciones describieron la presencia de microorganismos periodontales en líquido sinovial de pacientes con EP y AR. Seis publicaciones realizaron detección de microorganismos periodontales en muestras de líquido sinovial, identificando en todas a P. gingivalis. Conclusiones: Los estudios incluidos evidenciaron la presencia de microrganismos periodontales en el líquido sinovial en sujetos con EP y AR, asociando la prevalencia de P. gingivalis con el aumento de los niveles de anticuerpos anti-CCP, lo que podría exacerbar los procesos inflamatorios y producir reacciones autoinmunes en AR.

ABSTRACT Introduction: Periodontal disease (PD) and rheumatoid arthritis (RA) are multifactorial chronic inflammatory diseases that share similar aetiopathogenic mechanisms that lead to the destruction of both dental-alveolar tissues and synovial joints, in such way that antibodies against periodontal pathogens have been identified in the crevicular fluid and in the synovial fluid and membranes. Objective: To identify, recover, critically analyze and synthesize the available literature on the prevalence of periodontal microorganisms in synovial fluid of patients with RA. Materials and methods: A systematic search was performed in MEDLINE, ScienceDirect, SciELO and Google Scholar using the medical subject headings "Rheumatoid arthritis", "periodontal microorganisms" and "synovial fluid". Articles were included that described the presence of isolated periodontal pathogens in synovial fluid of patients diagnosed with RA. The search was closed in February 2017 and was performed using PRISMA methodology. The OSTEBA critical reading sheets were used to assess the external validity and level of evidence of each article in terms of methodological rigor. Results: A total of 14 publications were included that described the presence of periodontal pathogens in synovial fluid of patients with PD and RA. Seven publications detected periodontal pathogens in synovial fluid, with P. gingivalis being positive in all of them. Conclusions: The included studies provided evidence of the presence of periodontal microorganisms in the synovial fluid in subjects with PD and RA, associating the prevalence of P. gingivalis with increased levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies, which could exacerbate inflammatory processes and produce autoimmune reactions in RA.
Descritores: Artrite Reumatoide
Líquido Sinovial
-Doenças Periodontais
Membrana Sinovial
Líquido do Sulco Gengival
Tipo de Publ: Revisão Sistemática
Responsável: CO356.9


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Czeczko, Nicolau Gregori
Malafaia, Osvaldo
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Id: biblio-827664
Autor: Morais, Sebastião Vieira de; Czeczko, Nicolau Gregori; Malafaia, Osvaldo; Ribas Filho, Jurandir Marcondes; Garcia, João Batista Santos; Miguel, Marcelo Tizzot; Zini, Cassio; Massignan, Angeline Garcez.
Título: Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee
Fonte: Acta cir. bras;31(11):765-773, Nov. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane. METHODS: Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control group. The second was submitted to experimental osteoarthritis of the right knee induced by monosodium iodoacetate and corresponded to the osteoarthritis group. All animals were subjected to comparative tests of forced ambulation and joint movements, inability to articulate and tactile allodynia on day 1 post-experiment by forced ambulation (Roto-rod test), joint assessment of disability (weight bearing test) and assessment of tactile allodynia (Von Frey test). After inflammatory induction they were divided into four sub-groups corresponding to the scheduled death in 7, 14, 21 and 28 days when they were submitted to radiographic examination of the knee, arthrotomy and collection of the synovial membrane. RESULTS: The osteoarthritis group showed significant differences compared to control group on days 7 and 14 in Roto-rod, in weight bearing and Von Frey tests in all days, and in radiological evaluation. Microscopic examination of the synovial membrane showed abnormalities of inflammatory character at all stages. CONCLUSION: The osteoarthritis induced by intra-articular monosodium iodoacetate in rats knee is a good model to be used in related research, because it provides mensurable changes on joint movements, tactile allodynia, progressive radiological degeneration and microscopic inflammation of the synovial membrane, that represent markers for osteoarthritis evaluation
Descritores: Membrana Sinovial/patologia
Cartilagem Articular/patologia
Osteoartrite do Joelho/induzido quimicamente
Ácido Iodoacético/efeitos adversos
Articulação do Joelho/fisiopatologia
-Membrana Sinovial/diagnóstico por imagem
Ratos Wistar
Osteoartrite do Joelho/fisiopatologia
Osteoartrite do Joelho/patologia
Ácido Iodoacético/administração & dosagem
Modelos Animais de Doenças
Hiperalgesia/fisiopatologia
Hiperalgesia/induzido quimicamente
Hiperalgesia/patologia
Injeções Intra-Arteriais
Articulação do Joelho/fisiologia
Movimento
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-674970
Autor: Ferro, Diego; Previgliano, Juan Pablo.
Título: Hemangioma sinovial: presentación de un caso y revisión bibliográfica / Synovial hemangioma: case report and bibliographic revision
Fonte: Artrosc. (B. Aires);19(3):157-160, sept. 2012.
Idioma: es.
Resumo: El hemangioma sinovial es un tumor benigno vascular de partes blandas mayormente visto en niños y adolescentes. La patogenia de esta lesión es incierta y se encuentra en debate. Presentamos el caso de un paciente de sexo masculino de 41 años de edad, futbolista y tenista amateur, que concurre a nuestro centro con antecedente de dolor de rodilla izquierda de 3 años de evolución. Al examen físico la rodilla era estable, las maniobras de Pívot y Lachman fueron negativas, tampoco presentaba semiología meniscal ni efusión. Se constató un déficit de extensión de 15º, con una flexión completa. Las radiografías de la rodilla afectada no presentaban lesiones óseas y en la resonancia magnética no se visualizaban alteraciones. Luego de realizar tratamiento kinesiológico sin resultados satisfactorios se realizo cirugía artroscópica. Constatándose en la región anterior a la inserción tibial del ligamento cruzado anterior la presencia de una masa de aspecto quístico, similar a la observada en los casos de Ciclops Síndrome. El informe de anatomía patológica informo hemangioma arteriovenoso. En aquellos casos donde se trata de hemangiomas focalizados o pediculados y de tamaño apropiado, la resección artroscópica es la alternativa de tratamiento, y en los hemangiomas puramente sinoviales la embolización selectiva del vaso principal es una alternativa a la cirugía.
Descritores: Articulação do Joelho/patologia
Artroscopia/métodos
Hemangioma/diagnóstico
Hemangioma/patologia
Membrana Sinovial
-Neoplasias Vasculares/diagnóstico
Neoplasias Vasculares/patologia
Limites: Criança
Adolescente
Adulto
Tipo de Publ: Relatos de Casos
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: biblio-894990
Autor: Vieira, Lizyana; Lovison, Keli; Kunz, Regina Inês; Antunes, Juliana Sobral; Bertolini, Gladson Ricardo Flor; Brancalhão, Rose Meire Costa; Ribeiro, Lucinéia de Fátima Chasko.
Título: Resistance exercise recovers the structure of cartilage and synovial membrane of the ankle joint of rats after sciatic compression
Fonte: Motriz (Online);23(3):e101707, 2017. tab, ilus.
Idioma: en.
Resumo: Aim: to determine the effects of sciatic compression and treatment with resistance exercise on the morphology of the ankle joint of Wistar rats. Methods: 32 male rats, aged 10 ± 1 week, weighing 376±22 grams were divided into the following four groups (n=8/group): CG (control), LG (lesion), EG (exercise) and LEG (lesion and exercise). Three days after sciatic compression, the animals in the EG and LEG were submitted to resistance exercise by climbing stairs (five days/week) for three weeks and a load of 100 grams was added. The exercise was carried out in two sets of ten consecutive ascents of the steps. The ankle joint tissues were analyzed for their morphometry and morphology using light microscopy. Results: Regarding the number of chondrocytes, the LG and EG had more cells in the anterior articular cartilage in the tibia (62 and 43%) and in the talus (57 and 45%) when compared to the CG. In the LEG there was a 25% and 26% reduction of chondrocytes in the anterior cartilage in the tibia and talus when compared to the LG. Changes were observed in the tibia and talus in the LG, with the presence of flocculation, invagination of the subchondral bone, discontinuity of tidemark and pannus covering the subchondral bone in the talus, as well as changes in the synovial membrane. These alterations were minimized in the articular cartilage and synovial membrane in the LEG. Conclusions exercise restores the tissue morphology of ankle joint in Wistar rats after sciatic compression.(AU)
Descritores: Membrana Sinovial
Cartilagem Articular
Treinamento de Resistência
Articulação do Tornozelo
-Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


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Id: biblio-878743
Autor: Heluany, Cíntia Scucuglia.
Título: Papel da exposição à Hidroquinona na artrite reumatoide experimental induzida pelo colágeno / Role of Hydroquinone exposure on experimental collagen-induced arthritis.
Fonte: São Paulo; s.n; 2017. 154 p. ilus, graf, tab.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Ciências Farmacêuticas para obtenção do grau de Doutor.
Resumo: Artrite reumatoide (AR) é uma doença autoimune, que causa inflamação crônica nas membranas sinoviais de diversas articulações. O modelo experimenal de artrite induzida pelo colágeno (AIC) é empregado para investigar os mecanismos da AR e para identificar potenciais agentes terapêuticos. Embora a etiologia da AR ainda seja desconhecida, há evidências que a AR se desenvolve em indivíduos predispostos geneticamente, após exposição a fatores ambientais, como o tabagismo, que se destaca como maior fator de risco para indução da AR e para o agravamento em pacientes com AR já estabelecida. Porém, o mecanismo efetivo da ação dos diversos componentes do cigarros ainda precisa ser elucidado. A Hidroquinona (HQ) é um composto fenólico, encontrada em concentração elevada no cigarro, com maior ativade pró-oxidativa, além de ser produto da biotransformação do benzeno, também encontrado no cigarro. Neste caso, a HQ é responsável pela imunotoxicidade e mielotoxicidade do benzeno. Devido a alta exposição de fumantes à HQ e a associação do tabagismo com a AR, investigamos se a exposição à HQ teria participação no desenvolvimento da AIC em ratos Wistar. Para tanto, animais foram expostos à HQ em diferentes protocolos experimentais, a saber: A - por 35 dias consecutivos, durante fase de indução e desenvolvimento da artrite; B - por 14 dias consecutivos, até a segunda injeção de colágeno, na fase de sensibilização e indução da AIC; C - por 7 dias consecutivos, do 29º ao 35º dia, na fase posterior ao desenvolvimento da AIC. Os resultados obtidos mostraram que a HQ agravou a AR nos 3 grupos experimentais, aumentando os parâmetros clínicos, o número de células no líquido sinovial, a inflamação nas sinóvias, caracterizada por maior influxo de neutrófilos, proliferação de sinoviócitos (histologia por HE e imunohistoquímica), aumento nos níveis de IL-6 e IL-1ß (ELISA) no líquido sinovial e rearranjo do colágeno na sinóvia (microscopia por segundo harmônico). No entanto, os efeitos mais acentuados foram observados em animais dos grupos A e C, que também tiveram perda de peso significativa. Ademais, exposição à HQ, nos 3 grupos experimentais, causou expressão aumentada do receptor aril hidrocarboneto (AhR), um receptor ativado por xenobióticos durante a AR, e aumento nos níveis do fator de transcrição ROR e de IL-17 na sinóvia. Como AhR/ROR/IL-17 em linfócitos e neutrófilos é uma via importante na gênese da AR, ensaios in vitro foram realizados para elucidar o papel da HQ nesta via. A incubação com HQ in vitro de esplenócitos de animais naive elevou a expressão de AhR e de secreção de IL-17 (por citometria de fluxo), as quais foram bloqueadas pelo antagonista de AhR (α-naftoflavona). Em conjunto, os resultados obtidos nos permitem concluir que a HQ, como um importante componente do cigarro agrava a CIA em ratos, e a ativação via AhR/IL-17 é um possível mecanismo da patogênese da artrite

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in the joint synovial membranes. The experimental model of collagen-induced arthritis (CIA) is used to investigate the involved mechanisms in RA and to identify novel therapeutic agents. The genesis of RA is multifactorial, involving interplay of genetic and environmental factors and smoking is the trigger factor in the development or RA and worsens the pre-existing RA but the mechanisms undlerlying are yet to be elucidated. Hydroquinone (HQ) is a phenolic compound, found in high concentrations in cigarette, where HQ is the major oxidative component. Moreover, HQ is benzene metabolite, which is also found in cigarette smoke, being responsible for the myelotoxicity and immunotoxicity detected during benzene exposure. Due to this association, we aimed to investigate the role of HQ exposure on CIA development in Wistar rats and the involved mechanisms. Animals were exposed to HQ according to different protocols: A - during 35 consecutive days, during the sensitization and devolpment phases of the disease; B - during 14 consecutive days, until the second injection of collagen, during the sensitization phase; C - during 7 consecutive days, from day 29 to 35, after the development phase of CIA. The results showed that HQ worsened the RA in the 3 experimental protocols, HQ elevated the clinical parameters of CIA development, increased inflammation in the synovial membrane, characterized by increased influx of neutrophis, synoviocytes proliferation (visualized by Immunohistochemistry and Histology analysis), augmented the levels of IL-6 and IL-1ß in the synovial fluid (ELISA assay) and led to intense collagen deposition on the synovia. The most pronounced effects where observed in animals from groups A and C, which also had weight body loss. In addition, in the 3 protocols, HQ exposure also increased the expression of AhR receptor, a receptor activated by xenobiotics during RA, and increased the expression of ROR and levels of IL-17 secretion in the synovial membranes. As AhR/ROR/IL-17 in lymphocytes and neutrophils is an important pathway involved in the genesis of RA, in vitro studies have been performed to elucidate the role of HQ exposure in this pathway. The HQ in vitro treatment augmented the expression of AhR and secretion of IL-17 by splenocytes (FACS assay) and the administration of an AhR antagonist (α-naphtoflavone) blocked these effects. Taken together, the results obtained here allow us to conclude that HQ, as an important cigarette component, aggravates CIA in rats, and the activation of AhR/IL-17 pathway is a possible mechanism involved in the RA pathogenesis
Descritores: Artrite Experimental/classificação
Hidroquinonas/farmacocinética
Membrana Sinovial
-beta-Naftoflavona
Poluentes Ambientais
Produtos do Tabaco/análise
Limites: Animais
Masculino
Tipo de Publ: Técnicas In Vitro
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; T615.9, H484p. 30100022381-F


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Cohen, Moisés
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Id: lil-787427
Autor: Cohen, Carina; Leal, Mariana Ferreira; Belangero, Paulo Santoro; Figueiredo, Eduardo Antônio; Smith, Marília Cardoso; Andreoli, Carlos Vicente; de Castro Pochini, Alberto; Cohen, Moises; Ejnisman, Benno; Faloppa, Flávio.
Título: The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study
Fonte: Clinics;71(6):325-331tab, graf.
Idioma: en.
Resumo: OBJECTIVES: We evaluated mRNA expression levels of genes that encode TGF-β1; the TGF-β1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. METHODS: We obtained glenohumeral joint synovium/capsule specimens from 9 patients with idiopathic adhesive capsulitis who had not shown improvement in symptoms after 5 months of physiotherapy. Adhesive capsulitis was confirmed in all patients by magnetic resonance imaging. We also obtained specimens from 8 control patients who had underwent surgery for acute acromioclavicular joint dislocation and who had radiological indication of glenohumeral capsule alteration based on arthroscopic evaluation. mRNA expression in the synovium/capsule specimens was analyzed by quantitative reverse transcription PCR. The B2M and HPRT1 genes were used as references to normalize target gene expression in the shoulder tissue samples. RESULTS: The synovium/capsule samples from the patients with adhesive capsulitis had significantly higher TNC and FN1 expression than those from the controls. Additionally, symptom duration directly correlated with expression of TGFβ1 receptor I. CONCLUSION: Elevated levels of TNC and FN1 expression may be a marker of capsule injury. Upregulation of TGFβ1 receptor I seems to be dependent on symptom duration; therefore, TGFβ signaling may be involved in adhesive capsulitis. As such, TNC, FN1 and TGFβ1 receptor I may also play roles in adhesive capsulitis by contributing to capsule inflammation and fibrosis.
Descritores: Bursite/metabolismo
Fibronectinas/metabolismo
Articulação do Ombro/metabolismo
Membrana Sinovial/metabolismo
Tenascina/metabolismo
Fator de Crescimento Transformador beta1/genética
-Articulação Acromioclavicular/lesões
Articulação Acromioclavicular/metabolismo
Bursite/genética
Estudos de Casos e Controles
Proteínas da Matriz Extracelular/metabolismo
Expressão Gênica
Luxações Articulares/metabolismo
Projetos Piloto
RNA Mensageiro/metabolismo
Fator de Crescimento Transformador beta1/metabolismo
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-722175
Autor: Kunz, R.I.; Coradini, J.G.; Silva, L.I.; Bertolini, G.R.F.; Brancalhão, R.M.C.; Ribeiro, L.F.C..
Título: Effects of immobilization and remobilization on the ankle joint in Wistar rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(10):842-849, 10/2014. tab, graf.
Idioma: en.
Resumo: A sprained ankle is a common musculoskeletal sports injury and it is often treated by immobilization of the joint. Despite the beneficial effects of this therapeutic measure, the high prevalence of residual symptoms affects the quality of life, and remobilization of the joint can reverse this situation. The aim of this study was to analyze the effects of immobilization and remobilization on the ankle joint of Wistar rats. Eighteen male rats had their right hindlimb immobilized for 15 days, and were divided into the following groups: G1, immobilized; G2, remobilized freely for 14 days; and G3, remobilized by swimming and jumping in water for 14 days, performed on alternate days, with progression of time and a series of exercises. The contralateral limb was the control. After the experimental period, the ankle joints were processed for microscopic analysis. Histomorphometry did not show any significant differences between the control and immobilized/remobilized groups and members, in terms of number of chondrocytes and thickness of the articular cartilage of the tibia and talus. Morphological analysis of animals from G1 showed significant degenerative lesions in the talus, such as exposure of the subchondral bone, flocculation, and cracks between the anterior and mid-regions of the articular cartilage and the synovial membrane. Remobilization by therapeutic exercise in water led to recovery in the articular cartilage and synovial membrane of the ankle joint when compared with free remobilization, and it was shown to be an effective therapeutic measure in the recovery of the ankle joint.
Descritores: Traumatismos do Tornozelo/patologia
Cartilagem Articular/patologia
Imobilização/efeitos adversos
Membrana Sinovial/patologia
-Traumatismos do Tornozelo/terapia
Peso Corporal
Cartilagem Articular/crescimento & desenvolvimento
Condrócitos/citologia
Deambulação Precoce
Ratos Wistar
Entorses e Distensões/terapia
Natação/fisiologia
Fatores de Tempo
Articulações Tarsianas/patologia
Perda de Peso
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-707180
Autor: Klein, Daniel Rodrigo.
Título: Lipoma arborescente de joelho: relato de caso / Lipoma arborescens of the knee: a case report
Fonte: Rev. bras. ortop;49(1):74-77, Jan-Feb/2014. graf.
Idioma: pt.
Resumo: Relato de caso de um paciente do sexo feminino de 26 anos que apresentava queixas de dores eventuais e episódios recorrentes de derrame articular no joelho esquerdo havia aproximadamente 10 anos. Após anamnese, exame físico, exames radiográficos e exames de imagem por ressonância magnética foi firmado o diagnóstico de lipoma arborescente de joelho. A paciente foi submetida a tratamento artroscópico para ressecção da lesão. No pós-operatório foi encaminhada para reabilitação fisioterápica, com boa evolução.

Case report of a female patient of 26 years who complained of pain and recurrent episodes of joint swelling in his left knee about 10 years ago. After anamnesis, physical examination and radiographic imaging and magnetic resonance were diagnosed with arborescent lipoma of the knee, and the patient underwent arthroscopic treatment for resection of the lesion. Postoperatively the patient was referred to physical therapy rehabilitation with good evolution.
Descritores: Joelho
Lipoma
Membrana Sinovial
Limites: Humanos
Feminino
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: BR26.1 - Biblioteca Central



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