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Id: lil-584329
Autor: Soberón Varela, Iris; Concepción de la Peña, Ada Hilda de la; Fernández González, Juan; Hernández Varea, José Antonio; Blanco Selles, Raymundo Abel.
Título: Resultados de la sutura primaria de colon en lesiones penetrantes de abdomen / Results of the colonic primary suture of penetrating abdominal lesions
Fonte: Rev. cuba. cir;49(4):43-51, oct.-dic. 2010.
Idioma: es.
Resumo: INTRODUCCIÓN. La mortalidad por heridas de colon debidas a traumatismos penetrantes del abdomen ha disminuido, pero en algunos centros sanitarios se mantiene una controversia en relación con efectuar o no la sutura primaria de dichas heridas. En este trabajo se buscó presentar los resultados del uso de la sutura primaria de colon en heridas penetrantes de abdomen en pacientes atendidos por un grupo básico de trabajo de cirugía del Hospital Clinicoquirúrgico Joaquín Albarrán Domínguez (La Habana). METODOS. Se realizó un estudio prospectivo de todos los pacientes con heridas penetrantes de abdomen y lesión de colon a los cuales se les realizó sutura primaria de colon, que fueron atendidos por nuestro grupo básico de trabajo entre enero de 2005 y mayo de 2008. Los criterios de exclusión comprendieron solamente el estado de choque hipovolémico, la demora de más de 6 h entre el momento de la lesión y la cirugía y la contaminación fecal grave. RESULTADOS. En el período citado fueron intervenidos quirúrgicamente de urgencia 17 pacientes: 94 por ciento de ellos del sexo masculino, rango de edad de entre 16 y 43 años, el 76,4 por ciento de ellos con lesiones intraabdominales asociadas. El agente causal de la herida fue un arma blanca en el 100 por ciento de los casos. El colon izquierdo fue el sitio más afectado (53 por ciento). El 100 por ciento de los pacientes recibieron antibióticos, y los más empleados fueron las cefalosporinas de tercera generación asociadas siempre con metronidazol. Hubo 3 reintervenciones, ninguna por dehiscencia de suturas. No hubo muertes y la estadía promedio fue de 6,9 días. CONCLUSIONES. La sutura primaria de las heridas de colon producidas por arma blanca es segura, aun cuando éstas se localicen en el colon izquierdo y existan lesiones asociadas en otros órganos(AU)

INTRODUCTION. Mortality due to colon due to penetrating abdominal traumata has decreased but in some health centers there is a controversy related to primary stitch or not such wounds. In present paper authors showed the results of colonic primary suture in penetrating abdominal wounds in patients seen by a surgery working basic team from the Joaquín Albarrán Domínguez Clinical Surgical Hospital (La Habana). METHODS. A prospective study was performed in all patients presenting with abdominal penetrating wounds and colonic lesions who underwent colon primary suture seen by our working basic team between January, 2005 and May, 2008. The exclusion criteria included only the hypovolemic shock status, delay for more than 6 hours from the moment of lesion and surgery as well as the severe fecal contamination. RESULTS. During the above period 17 male patients aged 16 and 43 were operated on the 76,4 percent with associated intra-abdominal lesions. The causal agent of wound was a steel in the 100 percent of cases. Left colon was the more involved site (53 percent). The 100 percent of patients received antibiotics and the more used were third-generation cephalosporins associated always with the Metrodinazole. There were re-surgical interventions without dehiscence suture. No death occurred and man stay was of 6,9 days. CONCLUSIONS.The suture of colonic wounds produced by steel safe even though these be located in the left colon and there are lesions associated with other organs(AU)
Descritores: Colo/lesões
Ferimentos Penetrantes/epidemiologia
Técnicas de Sutura
-Estudos Prospectivos
Limites: Seres Humanos
Masculino
Adolescente
Adulto
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-975977
Autor: Sepehrimanesh, Masood; Samimi, Nastaran; Koohi-Hosseinabadi, Omid; Mokhtari, Maral; Amiri-Zadeh, Saeed; Farjam, Mojtaba.
Título: Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat / Efeitos do extrato de Cupressus sempervirens na cicatrização de colite ulcerativa induzida por ácido acético em ratos
Fonte: J. coloproctol. (Rio J., Impr.);38(4):309-313, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Projeto: Fasa University of Medical Sciences.
Resumo: ABSTRACT Ulcerative colitis is a chronic inflammatory condition of the colon with an unknown etiology. In this study, we aimed to evaluate the therapeutic effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. Fifty-five male rats divided into five equal treatment groups were used for this study and received the following treatments: Group 1, 250 mg/kg asacol; Group 2, 1 ml gel base (carboxymethyl cellulose); Group 3, 0.5% gel form of C. sempervirens extract; Group 4, 1% gel form of C. sempervirens extract, and; Group 5, considered as negative control and received 1 ml of normal saline. Body weight changes, histopathological and antioxidant changes in the colon tissue were evaluated. Significant weight gain was observed in rats that received 1% gel extract of C. sempervirens. Significant superoxide dismutase activity was also detected in 0.5 and 1% gel extract groups compared to C. sempervirens extract, Asacol and in 1% gel extract groups compared to the gel base group. Furthermore, both gel extract groups had significant lower total antioxidant capacity compared to Asacol group. Several histopathological lesions including inflammation, ulceration, crypt disarray, and goblet cell depletion were detected in the different groups, however, the mean rank of pathological changes showed no significant difference among the five groups. In summary, our results showed that hydroalcoholic extracts of C. sempervirens leaves produces healing effects in acetic acid induced ulcerative colitis.

RESUMO A colite ulcerativa é uma doença inflamatória crônica do cólon com uma etiologia desconhecida. O objetivo deste estudo foi avaliar os efeitos terapêuticos do extrato de Cupressus sempervirens na cicatrização de colite ulcerativa induzida por ácido acético em ratos. Cinquenta e cinco ratos machos divididos em cinco grupos de tratamento iguais foram utilizados para este estudo e receberam os seguintes tratamentos: Grupo 1: 250 mg/kg de asacol; Grupo 2: 1 mL de gel base (carboximetilcelulose); Grupo 3: extrato de C. sempervirens a 0,5% em gel; Grupo 4: extrato de C. sempervirens a 1% em gel e; Grupo 5: considerado controle negativo que recebeu 1 mL de solução salina normal. Alterações no peso corporal, alterações histopatológicas e antioxidantes no tecido do cólon foram avaliadas. Ganho de peso significativo foi observado em ratos que receberam extrato em gel de C. sempervirens a 1%. Atividade significativa de superóxido dismutase também foi detectada em grupos de extrato em gel de 0,5 e 1% em comparação com o extrato de C. sempervirens, Asacol e em grupos de extrato em gel a 1% em comparação com o grupo base de gel. Além disso, ambos os grupos de extrato em gel apresentaram capacidade antioxidante total significativamente menor em comparação ao grupo Asacol. Várias lesões histopatológicas, incluindo inflamação, ulceração, desarranjo da cripta e depleção de células caliciformes foram detectadas nos diferentes grupos; no entanto, a classificação média de alterações patológicas não apresentou diferença significativa entre os cinco grupos. Em resumo, nossos resultados mostraram que extratos hidroalcoólicos de folhas de C. sempervirens produzem efeitos cicatrizantes em colite ulcerativa induzida por ácido acético.
Descritores: Colite Ulcerativa
Cupressus australis/uso terapêutico
Colo/patologia
Antioxidantes
-Cicatrização/efeitos dos fármacos
Extratos Vegetais
Limites: Animais
Ratos
Responsável: BR545.3 - Biblioteca ICBS


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Id: biblio-1039050
Autor: Guo, Jian; Fang, Huihui; Gui, Shuangying; Huang, Yuzhe.
Título: Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
Fonte: Braz. J. Pharm. Sci. (Online);55:e17309, 2019. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowability, friability, yields and dissolution rate. Subsequently, the pH-dependent layer (Eudragit L30D55) and time-dependent layer (Eudragit NE30D and L30D55) were coated on the SDP to form tacrolimus colon-specific pellets (CSP) using a fluidized bed coater. Under in vitro gradient pH environment, tacrolimus only released from CSP after changing pH to 6.8 and then quickly released in the phosphate buffer solution of pH 7.2. The Cmax of CSP was 195.68 ± 3.14 ng/mL at Tmax 4.5 ± 0.24 h where as in case of SDP, the Cmax was 646.16 ± 8.15 ng/mL at Tmax 0.5 ± 0.03 h, indicating the ability of CSP targeted to colon. The highest area under the curve was achieved 2479.58 ± 183.33 ng·h/mL for SDP, which was 2.27-fold higher than tacrolimus suspension. However, the best biodistribution performance was achieved from CSP. In conclusion, SDP combining of pH- and time-dependent approaches was suitable for targeted delivery of tacrolimus to colon.
Descritores: Técnicas In Vitro/classificação
Tacrolimo/análise
Fator de Crescimento de Hepatócito/farmacocinética
Colo/metabolismo
-Colite Ulcerativa/prevenção & controle
Sistemas de Liberação de Medicamentos/efeitos adversos
Concentração de Íons de Hidrogênio
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-781329
Autor: Aslaner, Arif; Çakır, Tuğrul; Tekeli, Seçkin Özgür; Avcı, Sema; Doğan, Uğur; Tekeli, Feyza; Soylu, Hakan; Akyüz, Cebrail; Koç, Süleyman; Üstünel, İsmail; Yılmaz, Necat.
Título: Medical ozone treatment ameliorates the acute distal colitis in rat
Fonte: Acta cir. bras;31(4):256-263, Apr. 2016. graf.
Idioma: en.
Resumo: PURPOSE: To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS: Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-α and IL-1β levels. Histolopatological examination was evaluated with Ki-67, IL-1β and VEGF immunostaining densities. RESULTS: There was significant increase in tissue MDA, MPO activity, TNF-α and IL-1β after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSIONS: Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.
Descritores: Oxidantes Fotoquímicos/uso terapêutico
Ozônio/uso terapêutico
Colite Ulcerativa/tratamento farmacológico
-Fatores de Tempo
Imuno-Histoquímica
Colite Ulcerativa/patologia
Distribuição Aleatória
Doença Aguda
Reprodutibilidade dos Testes
Fator de Necrose Tumoral alfa/sangue
Resultado do Tratamento
Ratos Wistar
Colo/patologia
Peroxidase/análise
Ácido Acético
Fator A de Crescimento do Endotélio Vascular/análise
Modelos Animais de Doenças
Interleucina-1beta/sangue
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-775561
Autor: Çakır, Tuğrul; Aslaner, Arif; Tekeli, Seçkin Özgür; Avcı, Sema; Doğan, Uğur; Tekeli, Feyza; Soylu, Hakan; Akyüz, Cebrail; Koç, Süleyman; Üstünel, İsmail; Yılmaz, Necat.
Título: Effect of ozone on colon anastomoses in rat peritonitis model
Fonte: Acta cir. bras;31(2):111-118, Feb. 2016. graf.
Idioma: en.
Resumo: PURPOSE: To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS: Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-α and IL-1β, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels. Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1β and the VEGF immunostaining densities were also compared. RESULTS: Intraperitoneal ozone administration reversed TNF-α, IL-1β, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSION: Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.
Descritores: Ozônio/farmacologia
Peritonite/induzido quimicamente
Cicatrização/efeitos dos fármacos
Colo/cirurgia
-Anastomose Cirúrgica
Distribuição Aleatória
Fator de Necrose Tumoral alfa/análise
Fator de Necrose Tumoral alfa/efeitos dos fármacos
Ratos Wistar
Colo/patologia
Peroxidase/análise
Peroxidase/efeitos dos fármacos
Modelos Animais de Doenças
Interleucina-1beta/análise
Interleucina-1beta/efeitos dos fármacos
Malondialdeído/análise
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-837703
Autor: Nunes, Vinicius Rodrigues Taranto; Vidigal, Paula Vieira Teixeira; Pereira, Márcio Tadeu; Ladeira, Luís Carlos Duarte; Barbuto, Rafael Calvão; Duval-Araujo, Ivana.
Título: Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator
Fonte: Acta cir. bras;32(4):319-324, Apr. 2017. graf.
Idioma: en.
Resumo: Abstract Purpose: To describe a new model of actinic enteritis that does not use radiotherapy machines. Methods: Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (group C) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. Results: In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon. Conclusion: We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.
Descritores: Lesões Experimentais por Radiação/patologia
Radioisótopos de Cobalto
Colo/efeitos da radiação
Relação Dose-Resposta à Radiação
-Ratos Wistar
Colo/patologia
Modelos Animais de Doenças
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-837695
Autor: Alves Júnior, Antonio José Tiburcio; Pereira, José Aires; Pansani, Adrieli Heloísa Campardo; Magro, Daniela Oliveira; Coy, Cláudio Saddy Rodrigues; Martinez, Carlos Augusto Real.
Título: Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with Curcuma longa (curcumin)
Fonte: Acta cir. bras;32(3):182-193, Mar. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Purpose: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods: Thirty-six rats were subjected to proximal right colostomy and distal mucous fistula. They were divided into two groups according to whether sacrifice was performed two or four weeks after the intervention. Each group was divided into three subgroups according to the enema applied daily: saline alone; curcumin at 50 mg/kg/day or curcumin at 200 mg/kg/day. Acid mucins were diagnosed using the Alcian blue technique. The mucin content was quantified by means of computer-assisted image analysis. The significance level of 5% was used throughout (p < 0.05). Results: There were dose-related increases in the quantities of sulfomucins in the animals subjected to interventions with curcumin, both after two weeks (p < 0.00001) and after four weeks (p < 0.00001). There were increases in sialomucin quantity that were concentration-related (p < 0.00001) and time-related (p < 0.00001). Conclusion: Curcumin enemas increase the quantity of acid mucins in the intestinal flow in the excluded colon, with dose and time dependency.
Descritores: Extratos Vegetais/administração & dosagem
Colo/efeitos dos fármacos
Colo/química
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/química
Mucinas/análise
-Valores de Referência
Fatores de Tempo
Processamento de Imagem Assistida por Computador
Óleos Vegetais/administração & dosagem
Trânsito Gastrointestinal/efeitos dos fármacos
Colostomia
Reprodutibilidade dos Testes
Ratos Wistar
Colite/patologia
Colite/tratamento farmacológico
Colo/patologia
Curcuma
Enema/métodos
Sialomucinas/efeitos dos fármacos
Fezes
Mucosa Intestinal/patologia
Mucinas/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-837665
Autor: Martinez, Carlos Augusto Real; Kadri, Caled Jaoudat; Kanno, Danilo Toshio; Alves Júnior, Antônio José Tibúrcio; Coy, Cláudio Saddy Rodrigues; Pereira, José Aires.
Título: Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa
Fonte: Acta cir. bras;32(1):65-73, Jan. 2017. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Purpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, curcumin at 50 mg/kg/day or 200 mg/kg/day. Colitis was diagnosed by histological analysis. Claudin-3 and occludin were determined by immunohistochemistry. The tissue content of claudin-3 and occludin were quantified by computer-assisted image analysis. Mann-Whitney, Student t and ANOVA tests were used to analyze the results establishing the level of significance of 5% for both (p<0.05). Results: Curcumin at both concentrations reduces the inflammation and preserves the tissue content of the proteins claudin-3 and occludin, which was related to the concentration used and to the time of the intervention. Conclusion: The application of enemas with curcumin reduces inflammation and preserves the tissue content of the proteins claudin-3 and occludin in the colonic mucosa devoid from the fecal stream.
Descritores: Óleos Vegetais/farmacologia
Colo/química
Curcuma/química
Enema/métodos
Ocludina/análise
Claudina-3/análise
Mucosa Intestinal/química
-Imuno-Histoquímica
Colostomia
Ratos Wistar
Colo/efeitos dos fármacos
Colo/patologia
Fezes
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/patologia
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-893067
Autor: Hou, Qihang; Xia, Mi; Hu, Wiwei; Yu, Qinghua; Zhang, Bingkun.
Título: The effect of low protein on colonic mucosal barrier in pigs / El efecto de baja proteína en la barrera mucosa colónica en cerdos
Fonte: Int. j. morphol;35(3):877-882, Sept. 2017. ilus.
Idioma: en.
Projeto: National Basic Research Program of China; . National Natural Science Foundation of China; . State Key Laboratory of Animal Nutrition Fund of China; . Priority Academic Program Development of Jiangsu Higher Education Institutions.
Resumo: Reducing nitrogen nutrients concentration in dairy food is economic for pig industry. Here, we used finishing pig as model to investigate the effect on colon mucosal barrier and nutrients absorption after reducing crude protein (CP) in dietary from 16 % to 13 %. The results showed that crypt depth, cells, claudin-1 and E-cadherin expression level will not be changed, which implied the integrity of colon mucosal structure. Furthermore, the expressions of ASCT1, EAAT3 and SGLT1 in colon were also maintained at normal levels in 13 % CP dietary. Interestingly, the CAT1 and GLUT2 expression were increased significantly after reducing CP level to 13 %, which might be attributed to the compensatory nutrients absorption. This study implied that 13 % CP was sufficient to maintain normal colon structure and will not change intestinal morphology, which provided a basis for an ideal economic protein feed formula.

La reducción de concentración de nitrógeno en los alimentos lácteos es económicamente favorable para la industria porcina. En este trabajo se utilizó el cerdo de acabado como modelo para investigar el efecto sobre la barrera de la mucosa del colon y la absorción de nutrientes después de reducir la proteína bruta (CP) en la dieta del 16 % al 13 %. Los resultados mostraron que la profundidad de la cripta, las células globulares, el nivel de expresión de Claudin-1 y E-cadherina no cambiaron, lo que implicaría la integridad de la estructura de la mucosa del colon. Además, las expresiones de ASCT1, EAAT3 y SGLT1 en el colon también se mantuvieron en niveles normales en el 13 % de la dieta de CP. Sin embargo, la expresión de CAT1 y GLUT2 incrementó significativamente después de reducir el nivel de CP a 13 %, lo que podría atribuirse a la absorción de nutrientes compensatorios. Este estudio indicó que el CP del 13 % era suficiente para mantener la estructura normal del colon y no cambiaría la morfología intestinal, lo que proporcionó una base para una fórmula económica ideal para la alimentación con proteínas.
Descritores: Colo/metabolismo
Dieta com Restrição de Proteínas
Mucosa Intestinal/metabolismo
-Suínos
Absorção Intestinal
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1040329
Autor: Shahawy, Mohamed S. El; Fayoumy, Mohamed El.
Título: The significance of retroflexion technique in the right colon on adenoma detection rates during colonoscopy / O significado da técnica de retroflexão no cólon direito nas taxas de detecção de adenomas durante a colonoscopia
Fonte: J. coloproctol. (Rio J., Impr.);39(3):197-202, June-Sept. 2019. tab, graf, ilus.
Idioma: en.
Resumo: ABSTRACT Background and aim: Right colon adenomas can easily missed with significant adenoma miss rate particularly when they are located behind the haustral folds and anatomical flexures. The aim of this study was to assess the significance of retroflexion technique in the right colon for improving adenoma detection rates compared with forward-view technique. Methods: A total of 200 patients scheduled for elective colonoscopy were recruited. During the standard forward-view examination, the colonoscope was withdrawn from the cecum to the hepatic flexure while under meticulous observation. Subsequently, the cecum was reintubated and the right side of the colon was assessed in the retroflexed-view to the hepatic flexure. The primary outcome of this study was comparison of the adenoma detection rates and adenoma miss rate of the retroflexed-view versus forward-view examination of the right colon. Results: Of the 200 enrolled patients, retroflexion was successful in 182 (91%). Forward-view examination of the right colon detected 88 polyps, of which 66 were adenomas yielding a polyp and adenoma detection rates of 25.5% and 19%, respectively. Additionally, retroflexion detected a further 30 polyps of which 23 were adenomas, accordingly improving the polyp and adenoma detection rates to 29.5% and 25%, respectively. Furthermore, the polyp and adenoma miss rate in the right colon was 24.1% and 25.8% respectively. Conclusion: Colonoscopy with right-sided retroflexion after forward-view examination significantly increases the detection of adenomas compared with standard forward-view examination with a high success rate and small risk of adverse events.

RESUMO Antecedentes e objetivo: Os adenomas do cólon direito podem não ser diagnosticados, apresentando uma elevada taxa de não detecção de adenoma, especialmente quando estão localizados atrás das pregas haustrais e flexões anatômicas. O objetivo deste estudo foi comparar, no cólon direito, a técnica de visualização retroflexionada com a técnica de visualização frontal quanto à taxa de detecção de adenoma. Métodos: Um total de 200 pacientes agendados para colonoscopia eletiva foram recrutados para o presente estudo. Durante o exame de visualização frontal padrão, o colonoscópio foi retirado do ceco em direção à flexão hepática sob observação meticulosa. Posteriormente, o ceco foi reintubado e o lado direito do cólon foi avaliado na visualização retroflexionada em direção à flexão hepática. O objetivo primário deste estudo foi comparar a taxa de detecção de adenoma e a taxa de não detecção de adenoma do exame de visualização retroflexionada e visualização frontal do cólon direito. Resultados: Dos 200 pacientes inscritos, a retroflexão foi bem sucedida em 182 (91%). A visualização frontal do cólon direito detectou 88 pólipos, dos quais 66 eram adenomas, com uma taxa de detecção de pólipos e taxa de detecção de adenoma de 25,5% e 19%, respectivamente. Além disso, a visualização retroflexionada detectou mais 30 pólipos, dos quais 23 eram adenomas, aumentando a taxa de detecção de pólipos e adenoma para 29,5% e 25%, respectivamente. Além disso, a taxa não detecção de pólipos e a taxa de não detecção de adenoma no cólon direito foram de 24,1% e 25,8%, respectivamente. Conclusão: A colonoscopia com visualização retroflexionada direita após visualização frontal aumenta significativamente a detecção de adenomas em comparação com a visualização frontal padrão, com uma alta taxa de sucesso e baixo risco de eventos adversos.
Descritores: Adenoma/diagnóstico
Colonoscopia
-Pólipos
Colo/patologia
Neoplasias do Colo
Limites: Seres Humanos
Masculino
Feminino
Tipo de Publ: Estudo Clínico
Responsável: BR545.3 - Biblioteca ICBS



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