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Id: biblio-954932
Autor: Badilla García, Jenny.
Título: Sinusitis en Pediatría / Sinutisis in Pediatrics
Fonte: Med. leg. Costa Rica;35(2):62-70, sep.-dic. 2018.
Idioma: es.
Resumo: Resumen Sinusitis, definida como enfermedad inflamatoria de la mucosa de los senos paranasales, es una enfermedad con alta prevalencia e incidencia en la población general, especialmente en Pediatría.1 Los padecimientos alérgicos e infecciosos de la mucosa nasal representan dos de las enfermedades más frecuentes de las vías aéreas superioras crónicas en niños y adultos jóvenes. Es un problema de salud pública de gran magnitud debido a su alta prevalencia, lo que ocasiona gran presión asistencial en términos de consultas ambulatorias, deterioro significativo de la calidad de vida para el paciente y sus familiares además, implica un fuerte impacto en la comunidad por los altos costos socioeconómicos que generan.2 Su etiología multifactorial y la creciente resistencia bacteriana a antibióticos, especialmente a penicilinas naturales o sintéticas sugiere reconsiderar los fundamentos anatómicos y funcionales con la finalidad de establecer conductas razonables de diagnóstico, terapéutica médica y quirúrgica que permitan un diagnóstico y tratamiento apropiado para disminuir su recurrencia.1,2

Abstract Sinusitis, defined as an inflammatory disease of the paranasal sinuses, is a disease with high prevalence and incidence in the general population, especially among children. The allergic and infectious diseases of the nasal mucosa represent two of the most frequent diseases of the chronic upper airways in children and young adults. It is a public health problem of great magnitude due to its high prevalence, which causes great assistance pressure in terms of outpatient consultations, significant deterioration of the quality of life for the patient and their families, and it also implies a strong impact on the community due to the high socio-economic costs. Its multifactorial etiology and the increasing bacterial resistance to antibiotics, especially natural or synthetic penicillins, suggest reconsidering the anatomical and functional foundations in order to establish reasonable diagnostic, medical and surgical therapeutic behaviors that allow a diagnosis and appropriate treatment to decrease its recurrence.
Descritores: Seios Paranasais
Pediatria
Sinusite/diagnóstico
Sinusite/etiologia
Anti-Infecciosos/uso terapêutico
Antibacterianos/uso terapêutico
Mucosa Nasal
Limites: Humanos
Pré-Escolar
Criança
Tipo de Publ: Revisão
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Id: biblio-887201
Autor: Xavier Júnior, José Cândido Caldeira; Ocanha-Xavier, Juliana Polizel.
Título: What does the 4th edition of the World Health Organization Classification of Head and Neck Tumors (2017) bring new about mucosal melanomas?
Fonte: An. bras. dermatol;93(2):259-260, Mar.-Apr. 2018. tab.
Idioma: en.
Resumo: Abstract: The recently published 4th Edition of the World Health Organization Classification of Head and Neck Tumors addresses the most relevant and updated aspects of tumor biology, including clinical presentation, histopathology, immunohistochemistry, and prognosis of head and neck tumors. The objective of the present study is to compare these updates to the 3rd edition of that book with regard to mucosal melanomas and to highlight the potential factors that differ those tumors from cutaneous melanomas. We observed progress in the understanding of oral and sinonasal mucosal melanomas, which also present themselves, in the molecular scope, differently form cutaneous melanomas.
Descritores: Organização Mundial da Saúde
Neoplasias Bucais/classificação
Neoplasias Laríngeas/classificação
Neoplasias Nasais/classificação
Neoplasias de Cabeça e Pescoço/classificação
Melanoma/classificação
-Neoplasias Cutâneas/classificação
Neoplasias Cutâneas/patologia
Neoplasias Bucais/patologia
Neoplasias Laríngeas/patologia
Neoplasias Nasais/patologia
Melanoma/patologia
Mucosa Bucal/patologia
Mucosa Nasal/patologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1047898
Autor: Bozola, Antônio Roberto; Bozola, Alexandre Caroni; Sommer, Camila Garcia.
Título: Aumento da projeção da ponta nasal com "pseudo-retalhos" obtidos dos excessos cefálicos laterais das cartilagens alares / Increased nasal tip projection with "pseudo-flaps" using excess lateral cephalic alar cartilage
Fonte: Rev. bras. cir. plást;34(4):445-451, oct.-dec. 2019. ilus.
Idioma: en; pt.
Resumo: Introdução: O aumento da projeção da ponta nasal às vezes se torna necessário para a obtenção de uma boa proporção entre ela e o dorso. Inúmeras técnicas e táticas são descritas com essa finalidade utilizando enxertos cartilaginosos obtidos do septo nasal, concha auricular e cartilagem costal. Quando esse aumento deve ser discreto é proposto o uso dos excedentes de cartilagens alares laterais em forma de "pseudo-retalhos". Métodos: Em rinoplastias abertas primárias os excedentes das cartilagens alares, geralmente removidas, são utilizados como "pseudo-retalhos", dobrados sobre si mesmos, em forma de "suspensório de soldado francês", sobre o domus das cartilagens alares, tendo como acolchoamento de apoio os tecidos moles delas próprias, e o tecido mole interdomal, geralmente desprezado, que é liberado, e elevado para sobre os domus. Ele é mantido, descolado e deslocado para a ponta nasal, e fica contido pelos "pseudo-retalhos" das cartilagens alares ali suturados ou cobrindo o extremo do enxerto estrutural da columela. Foram operados com essa tática 36 pacientes. Resultados: 35 com bons resultados e um apresentou um abcesso de ponta nasal, provocado pela exposição endonasal de um fio de sutura não absorvível, que foi removido. Houve necessidade de uma segunda intervenção, utilizando novo enxerto auricular, ainda com resultado insatisfatório. O método é relativamente simples para quem opera narizes. Conclusão: A ponta nasal pode ser discretamente mais projetada utilizando os excessos de cartilagens alares, "pediculadas" no domus.

Introduction: An increased nasal tip projection is sometimes necessary to achieve an appropriate proportion between nasal tip and dorsum. Numerous techniques and tactics have been described for this purpose using cartilaginous grafts obtained from the nasal septum, auricular concha, and costal cartilage. When this increased projection must be discrete, the use of excess lateral alar cartilage in the form of "pseudo-flaps" is proposed. Methods: In primary open rhinoplasty, excess alar cartilage, which is generally removed, was used to produce "pseudo-flaps". The cartilages were folded over themselves in the form of a "French soldier's suspender" over the domes of the alar cartilage and supported by interdomal soft tissue padding raised over the domus. It was kept detached, and relocated to the nasal tip and was contained by "pseudoflaps" of the alar cartilages sutured there or covering the columella's structural graft. Thirty-six patients underwent surgery using this technique. Results: Thirty-five had good results and one had a nasal tip abscess, caused by endonasal exposure to a non-absorbable suture, which was removed. A second intervention was then performed using a new auricular graft, but the result was still unsatisfactory. The "pseudoflaps" method is relatively simple for those performing nasal surgery. Conclusion: The nasal tip can be projected discretely using the excess of alar cartilage "pedicled" in the domus.
Descritores: Rinoplastia
Nariz
Estudos Retrospectivos
Procedimentos Cirúrgicos Reconstrutivos
Estética
Cartilagens Nasais
Mucosa Nasal
-Rinoplastia/métodos
Nariz/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Cartilagens Nasais/anormalidades
Cartilagens Nasais/cirurgia
Mucosa Nasal/cirurgia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
História do Século XXI
Tipo de Publ: Relatos de Casos
Estudo Comparativo
Revisão
Responsável: BR32.1 - Serviço de Biblioteca e Informação Biomédica


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Id: lil-787423
Autor: Utiyama, Daniela Mitiyo Odagiri; Yoshida, Carolina Tieko; Goto, Danielle Miyuki; de Santana Carvalho, Tômas; de Paula Santos, Ubiratan; Koczulla, Andreas Rembert; Saldiva, Paulo Hilário Nascimento; Nakagawa, Naomi Kondo.
Título: The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation
Fonte: Clinics;71(6):344-350tab, graf.
Idioma: en.
Projeto: Fundação de Amparo è Pesquisa do Estado de São Paulo.
Resumo: OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550. RESULTS: Smokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations. CONCLUSION: This study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation.
Descritores: Fumar/efeitos adversos
Abandono do Hábito de Fumar
Muco/química
-Fatores de Tempo
Monóxido de Carbono/análise
Fumar/metabolismo
Contagem de Células
Depuração Mucociliar
Estudos Longitudinais
Interleucina-8/metabolismo
Interleucina-6/metabolismo
Líquido da Lavagem Nasal/química
Cotinina/análise
Inflamação/patologia
Mucosa Nasal/patologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-834408
Autor: Procianoy, Elenara da Fonseca Andrade.
Título: Diferença de potencial nasal: um novo teste para diagnóstico de fibrose cística / Nasal potential difference: a new test for cystic fibrosis diagnosis
Fonte: Rev. HCPA & Fac. Med. Univ. Fed. Rio Gd. do Sul;31(2):125-130, 2011. tab, graf.
Idioma: pt.
Resumo: Introdução: Fibrose Cística (FC) é uma doença cujo diagnóstico é essencialmente clínico, confirmada por dosagem de cloro no suor acima de 60 mEq/L e/ou identificação das mutações do CFTR causadoras da doença nos dois alelos. Casos atípicos necessitam ser investigados através do exame da diferença de potencial nasal (DPN). Na FC a DPN é mais negativa, há maior despolarização com o amiloride e pouca resposta ao isoproterenol. Objetivo: Determinar os valores da DPN para portadores de FC e grupos controle. Métodos: A DPN foi medida em 24 portadores de FC, 19 portadores de outras doenças não FC e 18 sadios e foram determinadas a média e desvio-padrão da DPN máxima, 8 amil, 8ØCl, 8iso, 8Cl, 8amil+iso e index DPN. Resultados: A média da DPN máxima foi -32 mV no grupo FC, -14 mV no grupo Não FC e -16 mV no grupo Sadio (P<0,0001). No grupo FC a média do 8 amil foi -18 mV, no grupo Não FC -6 mV e no grupo Sadio -7mV (P<0,0001). No grupo FC a média do 8Cl foi 4mV, 17mV no grupo Não FC e 11mV no grupo Sadio. A média do index 8 amil + iso foi - 16mV e o index DPN foi 0,85 no grupo FC, comparado com -0,6 mV e 0,26 no grupo Não FC e -2mV e 0,23 no grupo Sadio. Conclusões: O teste da DPN pode claramente diferenciar o grupo FC, com valores semelhantes aos descritos na literatura, possibilitando seu emprego futuro como teste diagnóstico complementar nos casos atípicos de FC.

Cystic Fibrosis (CF) is a disease whose diagnosis is essentially clinical, confirmed by measurement of sweatchloride above 60mEq / L and / or identification of CFTR mutations that cause disease in two alleles. Atypical cases need to be investigated by the nasal potential difference test (NPD). In CF the NPD is more negative, there is increased depolarization with amiloride (Eamil ) and a poor response to the isoproterenol (Eiso). Aim: To determine the values of NPD for CF patients and control groups. Methods: DPN was measured in 24 CF patients, 19 carriers of other diseases non-CF and 18 healthy and the mean plus standard deviation of NPD maximum, E amyl, EØCl, Eiso, ECl, E amil+iso and index NPD were determined. Results: NPD maximum in the FC group was -32 mV, -14 mV In the non-CF and-16mV in healthy group (p <0.0001). In the CF group the mean Eamil was - 18mV, -6mV in the non-FC group and -7mV in healthy (p <0.0001). The ECl mean was 4mV in CF group, 17mV in non-CF and 11mV in healthy. The average of the index E amil+iso was-16mV and DPN index was 0.85 in FC group compared with -0.6 mV and 0.26 in non-CF and -2mV, and 0.23 in healthy. Conclusions: The test of DPN can clearly distinguish the CF group, with values similar to those described in the literature, enabling their future use as a complementary diagnostic test in atypical cases of CF.
Descritores: Fibrose Cística/diagnóstico
Mucosa Nasal/fisiopatologia
Potenciais da Membrana
Transporte de Íons
Limites: Humanos
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Id: lil-78593
Autor: Cristofolini, Lúcia; Ogusku, Eliana Fonseca.
Título: Proposta para avaliaçäo e cuidados nasais na hanseníase / Proposal for nasal assessment and care in leprosy
Fonte: Rev. Salusvita (Impr.);7(1):129-36, 1988.
Idioma: pt.
Resumo: O comprometimento nasal é muito comum em todas as formas de hanseníase, atingindo de modo especial os pacientes portadores das formas virchowiana e dimorfa. Na mucosa nasal, podem ser encontrados bacilos antes que apareçam outros sintomas da doença. Pacientes sem tratamento eliminam milhoes de bacilos pelo muco nasal, sendo esta a principal rota de disseminaçäo da hanseníase. Na mucosa do nariz, o bacilo multiplica-se, resultando em infiltraçäo obstrutiva, abundante secreçäo viscosa, crostas e ulceraçöes, podendo atingir as cartilagens laterais e o septo cartilaginoso com perfuraçöes. Como conseqüência, desaba a pirâmide nasal, produzindo deformaçäo estigmatizante, além de comprometer as funçöes respiratórias e olfativa do nariz. O diagnóstico e tratamento precoces da doença evitam a progressäo das lesöes. Casos mais avançados exigem cuidados locais diários, com o objetivo de diminuir o acúmulo de secreçäo e a formaçäo de crostas e úlceras, impedindo a perfuraçäo do septo. Cabe especialmente a enfermagem orientar o paciente nos cuidados com o seu nariz
Descritores: Higiene
Doenças Nasais
Hanseníase
-Autocuidado
Mucosa Nasal
Doenças Nasais/etiologia
Doenças Nasais/prevenção & controle
Hanseníase/complicações
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-839489
Autor: Mandal, Snigdha Das; Mandal, Surjyanarayan; Patel, Jayvadan.
Título: Intranasal mucoadhesivemicroemulsion for neuroprotective effect of curcuminin mptp induced Parkinson model
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e15223, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT This study was to investigate the neuroprotective effect of curcumin against inflammation-mediated dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD). Curcumin loaded sodium hyaluronate based mucoadhesive microemulsion (CMME) was developed by using Box Behnken design of Response surface method (RSM) and was characterized. Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed CMME intranasal administration for 14 days at 2.86 mg of curcumin/kg of body weight per once a day. Optimal CMME containing 3% Capmul MCM as oil phase, 37 % of Accenon CC and Transcutol HP at 2.5:1 ratio and 0.5% sodium hyaluronate was stable, non-ciliotoxic with 57.66 nm±3.46 as average globule size. PdI value (0.190 ± 0.19) and TEM result depicted the narrow size distribution of CMME.All three independent variables had a significant effect (p<0.05) on the responses and the designed model was significant for all taken responses. In-vivo results revealed significant reduction of MPTP-mediated dopamine depletion after nasal administration of CMME. MPTP intoxication significantly decreased striatal DA content to 21.29 % which was then elevated to 55.37% after intranasal curcumin treatment. Significant improvement in motor performance as well as gross behavioural activity of mice was observed from rota-rod and open field test findings. Findings of the investigation revealed the symptomatic neuroprotection of curcumin against MPTP-induced neurodegradation in the striatum and hence could be considered as a promising approach to treat PD.
Descritores: Doença de Parkinson/prevenção & controle
Curcumina/efeitos adversos
-Administração Intranasal/estatística & dados numéricos
Metodologia
Mucosa Nasal
Limites: Animais
Masculino
Ratos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


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Chamon, Wallace
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Id: biblio-1015650
Autor: Pezato, Rogerio; Voegels, Richard Louis; Pignatari, Shirley; Gregório, Luiz Carlos; Bezerra, Thiago Freire Pinto; Gregorio, Luciano; Balsalobre, Leonardo; Tepedino, Miguel Soares; Coronel, Nathália; Pinna, Fabio de Rezende; Mendes Neto, José; Oliveira, Pedro; Macoto, Eduardo; Stefanini, Renato; Figueiredo, Claudia; Haddad, Fernanda; Pilan, Renata; Soter, Ana Bezerra; Melo, Nelson Almeida; Candido, Danilo Almeida; Amaral, Jonatas do; Santos, Rodrigo de Paula; Zele, Thibaut Van; Fujita, Reginaldo; Dreyfuss, Juliana L; Chamon, Wallace; Alencar, Adriano Mesquita; Perez-Novo, Claudina; Stamm, Aldo Cassol.
Título: Nasal polyposis: more than a chronic inflammatory disorder-a disease of mechanical dysfunction - the São paulo position
Fonte: Int. arch. otorhinolaryngol. (Impr.);23(2):241-249, 2019. ilus, tab.
Idioma: en.
Resumo: Introduction: The importance of our study lies in the fact that we have demonstrated the occurrence ofmechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity. Objective: To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data: Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension. Conclusion: The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP (AU)
Descritores: Pólipos Nasais/fisiopatologia
Pólipos Nasais/patologia
Inflamação/fisiopatologia
-Sinusite/fisiopatologia
Fenômenos Biomecânicos
Brasil
Mecânica de Fluídos
Doença Crônica
Edema/fisiopatologia
Matriz Extracelular/patologia
Pressão Hidrostática
Mucosa Nasal/fisiopatologia
Mucosa Nasal/patologia
Limites: Humanos
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-1015598
Autor: Rodrigues, Fernanda; Freire, Ana Paula; Uzeloto, Juliana; Xavier, Rafaella; Ito, Juliana; Rocha, Marceli; Calciolari, Renata; Ramos, Dionei; Ramos, Ercy.
Título: Particularities and clinical applicability of saccharin transit time test
Fonte: Int. arch. otorhinolaryngol. (Impr.);23(2):229-240, 2019. tab, ilus.
Idioma: en.
Resumo: Introduction: The importance ofmucociliary clearance (MCC) for the respiratory system homeostasis is clear. Therefore, evaluating this defense mechanism is fundamental in scientific research and in the clinical practice of pulmonology and of associated areas. However, MCC evaluation has not been so usual due to the complexity ofmethods that use radiolabeled particles. Nevertheless, as an interesting alternative, there is the saccharin transit time (STT) test. This method is reproducible, simple to perform, noninvasive, does notdemand high costs, and has been widely used in studies of nasalMCC. Although the STT test is widely used, there is still lack of a detailed description of its realization. Objective: The present literature review aims to provide basic information related to the STT test andto present the findings of the previous studies that usedthismethod, discussing variations in its execution, possible influences on the obtained results and limitations of the method, as well as to relate our experience with the use of STT in researches. Data Synthesis: There are several factors that can alter the results obtained from STT tests, which would raise difficulties with proper interpretation and with the discussion of the results among different studies. Conclusions: Saccharin transit time is awidely usedmethod for the evaluation of nasal MCC, and therefore, the standardization related to the previous and concurrent to test orientations, and also its execution, become essential to improve its accuracy, and allow comparisons among different studies (AU)
Descritores: Sacarina/farmacologia
Depuração Mucociliar
-Fenômenos Fisiológicos Respiratórios
Reprodutibilidade dos Testes
Fatores de Risco
Técnicas de Diagnóstico do Sistema Respiratório
Homeostase
Mucosa Nasal/fisiologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-1010208
Autor: Balsalobre, Leonardo; Pezato, Rogerio; Mangussi-Gomes, João; Gregorio, Luciano; Haddad, Fernanda Louise Martinho; Gregorio, Luiz Carlos; Fujita, Reginaldo.
Título: What is the impact of positive airway pressure in nasal polyposis? An experimental study
Fonte: Int. arch. otorhinolaryngol. (Impr.);23(2):147-151, 2019. ilus, tab.
Idioma: en.
Resumo: Introduction: It has been hypothesized that increasing the interstitial hydrostatic pressure within the sinonasal mucosa of patients with nasal polyposis (NP) might decrease the size of nasal polyps. Objective: To evaluate the effects of positive airway pressure, delivered by a continuous positive airway pressure (CPAP) device, in patients with NP and in control subjects. Methods: Twelve patients with NP and 27 healthy subjects were exposed to CPAP (20 cm H2O) for 2 hours. Visual analog scale (VAS), Nasal Obstruction Symptom Evaluation (NOSE) scale, acoustic rhinometry (AR), peak nasal inspiratory flow (PNIF) and nasal endoscopy (NE-Meltzer polyp grading system) were performed before and after the intervention, for all patients. Results: The control group showed a significant worsening in nasal obstruction symptoms, as measured by VAS and NOSE (p < 0.01), and a significant decrease in nasal patency, as measured by the PNIF and AR (p < 0.01). For the NP group, VAS, NOSE, and AR did not differ significantly (p = 0.72, p = 0.73, and p = 0.17, respectively), but PNIF values worsened (p = 0.04) after exposure to CPAP. There was a statistically significant reduction in the nasal polyps' size (p = 0.04). Conclusions: Positive pressure worsened the nasal obstruction symptoms and decreased objective parameters of nasal patency in control subjects. In patients with NP, exposure to CPAP reduced the nasal polyps' size, and the nasal patency, asmeasured by PNIF. However, it had no significant effects in AR and in nasal obstruction symptoms (AU)
Descritores: Pólipos Nasais
Pressão Positiva Contínua nas Vias Aéreas/efeitos adversos
-Obstrução Nasal/diagnóstico
Pico do Fluxo Expiratório
Estudos Transversais
Rinometria Acústica
Endoscopia
Matriz Extracelular
Escala Visual Analógica
Mucosa Nasal/fisiopatologia
Limites: Humanos
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: BR66.1 - Divisão de Biblioteca e Documentação



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