Base de dados : LILACS
Pesquisa : A05.810.453.736 [Categoria DeCS]
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Fotocópia
Id: lil-224936
Autor: Whittembury, Guillermo; Hernández, Celia Sofía.
Título: Absorción renal de agua: del nefrón aislado a los canales de agua a aquaporinas / Renal water absorption: the isolation nephron and water channells
Fonte: Rev. méd. hered;8(4):159-62, dic. 1997.
Idioma: es.
Resumo: Se revisan brevemente: Los sitios de absorción del filtrado glomerular en diversos segmentos del nefrón, los sitios de acción de la hormona antidiurética (HAD), los conceptos que llevan a proponer que existen canales de agua en el túbulo renal proximal, llamados ahora aquaporinas (AQP), algunas características biofísicas (diámetro equivalente y longitud) del filtro de selectividad de la AQP-1 en el túbulo renal proximal, estructura molecular de las AQP, algunas características de las AQP-1-5, localización de las AQP 1-4 en el nefrón y algunos ejemplos de "fisiopatogía molecular", que muestran que fallas genéticas en etapas de la acción de HAD en los túbulos colectores de los nefrones permiten describir varias fibromas de "diabetes insípida" renal. Hay métodos para dosar AQP-2 en orina. Esto simplificará el diagnóstico diferencial entre diversas formas de diabetes insípida. Estos hallazgos han sido posibles por los avances recientes en la biología molecular de las AQP. Sólo se citan algunas referencias críticas.
Descritores: Vasopressinas
Néfrons
Diabetes Insípido
Rim
Taxa de Filtração Glomerular
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-830404
Autor: Haladyj, Eva; Mejía, Juan Carlos; Cervera, Ricard.
Título: Is the renal biopsy still necessary in lupus nephropathy? / ¿Sigue siendo necesaria la biopsia renal en la nefropatía lúpica?
Fonte: Rev. colomb. reumatol;23(2):69-72, Apr.-June 2016.
Idioma: en.
Descritores: Reumatologia
Biópsia
Néfrons
Limites: Humanos
Tipo de Publ: Editorial
Responsável: CO356.9


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Id: biblio-836574
Autor: Hellerstein, Stanley.
Título: Utilización de los estudios de reserva funcional renal en pediatría / Role of renal functional reserve in pediatrics
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);16(5):553-562, nov. 2008.
Idioma: es.
Resumo: Se midió la reserva funcional renal en 14 pacientes pediátricos. Estos niños mostraban pruebas de una disminución de la cantidad de nefronas debido al daño de las vías urinarias superiores o a la ausencia de un riñón. Los estudios se realizaron porque se consideró que corrían riesgo de hiperfiltración glomerular en ausencia de pruebas de insuficiencia renal crónica. Los pacientes presentaban electrolitos normales en suero, análisis de orina normal e índices de filtración glomerular mayores de 60 ml/min/1.73 m2. Siete estudios mostraron ausencia de hiperfiltración glomerular, dos confirmaron la hiperfiltración glomerular y uno arrojó un resultado ®dudoso¼ para hiperfiltración glomerular. El estudio fue poco satisfactorio desde el punto de vista técnico en cuatro casos, dos de los cuales fueron en niños con anomalías anatómicas macroscópicas. El informe muestra el uso de la reserva funcional renal en la evaluación de los niños en un centro nefrológico infantil.
Descritores: Creatinina
Rim
Insuficiência Renal Crônica
-Filtração
Taxa de Filtração Glomerular
Néfrons
Proteínas
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Texto completo SciELO Brasil
Texto completo
Id: lil-741031
Autor: Dias, Paulo Henrique Goulart Fernandes; Oliveira, Gabriel Augusto; Dias, Fernando Goulart Fernandes; Gomes, Regina de Paula Xavier; Tambara Filho, Renato; Fraga, Rogério de.
Título: Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion
Fonte: Acta cir. bras;30(2):127-133, 02/2015. tab, graf.
Idioma: en.
Resumo: PURPOSE: To evaluate renal histological changes and renal function in single kidney rats submitted to renal ischemia-reperfusion and to immunosuppression with tacrolimus and mycophenolate-mofetil. METHODS: Experimental study with 80 Wistar rats distributed into control, Sham and six other groups treated with immunosuppressive drugs. Animals undergoing surgery, right nephrectomy and left renal clamping, killed on the 14th day and analyzed for renal histology, urea and creatinine. RESULTS: The group receiving tacrolimus at higher doses (T3) showed renal histological lesions indicative of early nephrotoxicity, and significant increase in urea and creatinine. The group M (mycophenolate-mofetil alone) and the group M2 (mycophenolate-mofetil combined with half the usual dose of tacrolimus) presented a slight rise in serum urea. The groups using mycophenolate-mofetil alone or combined with tacrolimus showed creatinine levels similar to that of the group T3. CONCLUSIONS: Histologically, the association of injury by ischemia-reperfusion with the use of tacrolimus or mycophenolate-mofetil alone demonstrated a higher rate of renal changes typical of early nephrotoxicity. In laboratory, the combination of injury by ischemia-reperfusion with tacrolimus at higher doses proved to be nephrotoxic. .
Descritores: Imunossupressores/efeitos adversos
Isquemia/complicações
Nefropatias/etiologia
Rim/irrigação sanguínea
Ácido Micofenólico/análogos & derivados
Traumatismo por Reperfusão/complicações
Tacrolimo/efeitos adversos
-Inibidores de Calcineurina/efeitos adversos
Creatinina/sangue
Imunossupressão/efeitos adversos
Imunossupressores/sangue
Nefropatias/patologia
Nefropatias/fisiopatologia
Rim/patologia
Ácido Micofenólico/efeitos adversos
Néfrons/efeitos dos fármacos
Distribuição Aleatória
Ratos Wistar
Fatores de Tempo
Tacrolimo/sangue
Ureia/sangue
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-676264
Autor: Chen, Wei; Wang, Linhui; Yang, Qing; Liu, Bing; Sun, Yinghao.
Título: Comparison of radiographic and pathologic sizes of renal tumors
Fonte: Int. braz. j. urol;39(2):189-194, Mar-Apr/2013. tab, graf.
Idioma: en.
Projeto: Municipal Hospital's Project for Emerging and Frontier Technology of Shanghai China.
Resumo: Purpose The determination of the size of a renal tumor is important for staging, prognosis and selection of the appropriate surgical treatment. We investigated the difference of radiographic and pathologic size of renal tumors in a contemporary cohort of patients who underwent nephron sparing surgery and evaluated its clinical implications. Materials and Methods The records of 169 patients who received nephron sparing surgery for renal lesions suspicious for malignancy between January 2006 and December 2010 were reviewed retrospectively. Radiographic tumor size, defined as the largest diameter of tumor measured by CT images, and pathologic size, the largest diameter of tumor measured in the surgical specimen, were compared and analyzed. Results Among all subjects, mean radiographic and pathologic tumor size were 3.25 ± 1.78 cm and 3.03 ± 1.91 cm, respectively (P < 0.001), with a discrepancy of just 0.22 cm. When the patients were categorized according to radiographic tumor size in the 1 cm range, the mean radiographic tumor size was significantly greater than pathologic tumor size in the following groups: 2 to 3 cm (P < 0.001), 3 to 4 cm (P < 0.001), and 4 to 5 cm (P = 0.028). When radiographic and pathologic tumor sizes were compared according to the pathologic tumor subtype, a significant difference was observed only among those with clear cell renal carcinoma (P < 0.001). Conclusions Renal tumor size was overestimated by radiography as compared with pathology. The difference was just 0.22 cm with little clinical significance, suggesting that CT provides an accurate method to estimate renal tumor size preoperatively. .
Descritores: Carcinoma de Células Renais/patologia
Carcinoma de Células Renais
Neoplasias Renais/patologia
Neoplasias Renais
Carga Tumoral
-Análise de Variância
Néfrons/cirurgia
Valores de Referência
Tomografia Computadorizada por Raios X
Limites: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-649441
Autor: Porpiglia, Francesco; Bertolo, Riccardo; Morra, Ivano; Fiori, Cristian.
Título: Clampless laparoscopic partial nephrectomy: a step towards a harmless nephron-sparing surgery?
Fonte: Int. braz. j. urol;38(4):480-488, July-Aug. 2012. ilus, tab.
Idioma: en.
Resumo: PURPOSE: To evaluate the results of our technique of clampless laparoscopic partial nephrectomy (LPN) and its impact as an emerging treatment for small renal masses (SMRs). MATERIALS AND METHODS: We reviewed our prospectively maintained database: data of 117 patients who consecutively underwent LPN at our Institution from January 2009 to December 2011 were studied. Patients were divided into 2 Groups based on operative technique: Group A: clampless-LPN (cl-LPN); Group B: conventional LPN (clamping of renal artery). Demographic and peri-operative data, complications, pre- and post-operative serum creatinine and estimated glomerular filtration rate (eGFR) were registered and compared by Student’s t- and Chi-square-tests (p-values < 0.05 considered statistically significant). RESULTS: 41 patients were in Group A and 76 in Group B. Groups were comparable in terms of preoperative data except for tumour’s size (2.35 ± 1.10 vs. 3.19 ± 1.57, Group A vs. B, respectively, p = 0.0029). Concerning perioperative data, warm ischemia time (WIT) was 0 min. in all Group A cases; mean WIT in Group B was 20.90 ± 9.27 min. One case (2.4%) in Group A (central tumour) was converted to conventional LPN. Mean eGFR postoperative decrease was higher in Group B (0.17 ± 9.30 vs. 4.38 ± 11.37 mL/min., A vs B, respectively, p = 0.0445). CONCLUSIONS: Notwithstanding the limits of the study, our results suggest that cl-LPN is a safe and effective technique, which allows surgeon to surgically treat SRMs even in case of complex location, without injuring kidney by ischemia.
Descritores: Laparoscopia/métodos
Nefrectomia/métodos
Néfrons/cirurgia
Tratamentos com Preservação do Órgão/métodos
-Distribuição de Qui-Quadrado
Taxa de Filtração Glomerular
Laparoscopia/estatística & dados numéricos
Nefrectomia/estatística & dados numéricos
Período Pós-Operatório
Período Pré-Operatório
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
Limites: Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-644956
Autor: Palao Varela, Kennet Ricardo; Paz Haslam, Carlos.
Título: Agenesia renal bilateral / Bilateral renal agenesia
Fonte: Rev. méd. hondur;79(2):79-80, abr.-jun. 2011. ilus.
Idioma: es.
Resumo: Introducción. La agenesia renal bilateral es una anomalía congénita mortal rara, originada por la ausencia del desarrollo de las nefronas y fallo de la división del esbozo ureteral. Caso clínico. Paciente femenino de 25 años de edad con embarazo de 33 semanas 3 días de gestación referida para nuevos estudios de imagen por su médico tratante debido a sospecha de agenesia renal bilateral en su feto, en ultrasonido convencional. No había historia personal o familiar relevante. Se le practicó un ultrasonido obstétrico convencional y doppler color con reconstrucciones tridimensionales, demostrando en el feto, la ausencia de las arterias renales y riñones, con signo de la suprarrenal tumbada. Se observó, además agenesia vesical, mesocardia con dextroposición, tórax en campana con hipoplasia pulmonar y anhidramnios. Ocurrió óbito a las 35 semanas. Conclusión. Los hallazgos fueron congruentes con agenesia renal bilateral, con pronóstico fatal en el tercer trimestre del embarazo.
Descritores: Néfrons/anormalidades
Complicações na Gravidez
Rim/anormalidades
-Transmissão Vertical de Doença Infecciosa
Ultrassonografia Doppler/métodos
Limites: Humanos
Adulto
Feminino
Tipo de Publ: Ensaio Clínico
Responsável: HN1.1 - Biblioteca Médica Nacional


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Srougi, Miguel
Texto completo
Id: lil-643034
Autor: Dall'Oglio, Marcos F.; Ballarotti, Lucas; Passerotti, Carlo C.; Paluello, Davi V.; Colombo Junior, Jose Roberto; Crippa, Alexandre; Srougi, Miguel.
Título: Anatrophic nephrotomy as nephron-sparing approach for complete removal of intraparenchymal renal tumors
Fonte: Int. braz. j. urol;38(3):356-361, May-June 2012. ilus, tab.
Idioma: en.
Resumo: OBJECTIVE: Partial nephrectomy for small kidney tumors has increased in the last decades, and the approach to non-palpable endophytic tumors became a challenge, with larger chances of positive margins or complications. The aim of this study is to describe an alternative nephron-sparing approach for small endophytic kidney tumors through anatrophic nephrotomy. PATIENTS AND METHODS: A retrospective analysis of patients undergoing partial nephrectomy at our institution was performed and the subjects with endophytic tumors treated with anatrophic nephrotomy were identified. Patient demographics, perioperative outcomes and oncological results were evaluated. RESULTS: Among the partial nephrectomies performed for intraparenchymal tumors between 06/2006 and 06/2010, ten patients were submitted to anatrophic nephrotomy. The mean patient age was 42 yrs, and the mean tumor size was 2.3 cm. Mean warm ischemia time was 22.4 min and the histopathological analysis showed 80% of clear cell carcinomas. At a mean follow-up of 36 months, no significant creatinine changes or local or systemic recurrences were observed. CONCLUSION: The operative technique described is a safe and effective nephron-sparing option for complete removal of endophytic renal tumors.
Descritores: Carcinoma de Células Renais/cirurgia
Neoplasias Renais/cirurgia
Nefrectomia/métodos
Néfrons/cirurgia
Tratamentos com Preservação do Órgão/métodos
-Carcinoma de Células Renais/patologia
Estudos de Viabilidade
Neoplasias Renais/patologia
Estudos Retrospectivos
Resultado do Tratamento
Carga Tumoral
Isquemia Quente
Limites: Adulto
Feminino
Humanos
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-560455
Autor: Sánchez Klinge, Marta Elena.
Título: Cambios en la presión sanguínea y en las concentraciones de electrolitos causados por falla renal en caninos / Changes in blood pressure and electrolitic concentrations due to renal failure in dogs
Fonte: Rev. med. vet. (Bogota);(8):9-25, nov. 2004. ilus.
Idioma: es.
Resumo: La falla renal aguda (FRA) y la falla renal crónica (FRC), en las cuales se afecta el 75 por ciento de las nefronas, son comunes en perros; los riñones no limpian la sangre de sustancias tóxicas, que se acumulan elevando los niveles de Nitrógeno Ureico Sanguíneo (BUN) y la creatinina, que al ser medidas en el laboratorio, sirven para dar el diagnostico de la falla; además se genera un desbalance electrolítico por la incapacidad del riñón de reabsorber o secretar iones. La presión sistólica y diastólica, que pueden ser detectadas, como en el presente estudio, mediante una manga de presión pediátrica colocada sobre la arteria humeral, aumento especialmente en el FRC. Todo esto lleva a cambios en el corazón y por tanto a cambios del electrocardiograma (ECG)...
Descritores: Pressão Sanguínea
Néfrons
Nitrogênio
Limites: Cães
Responsável: CO149 - Facultad de Medicina Veterinária


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Texto completo
Id: lil-527199
Autor: Park, Dong Soo; Jang, Woong Ki.
Título: Secure reconstruction technique after partial nephrectomy irrespective of tumor size and location
Fonte: Int. braz. j. urol;35(4):416-426, July-Aug. 2009. ilus, tab.
Idioma: en.
Resumo: Introduction: Nephron-sparing surgery for large renal masses is not considered a safe procedure because of high complication rate. We present our experience using expanded polytetrafluoroethylene (Gore-Tex®) and Hem-O-Lok® (Weck® Clip) as hemostatic agents during open partial nephrectomy (OPN) to perform nephron-sparing surgery for large renal masses. Materials and Methods: Sixty patients underwent OPN for suspicious renal cell carcinomas. Thirty-four patients with tumors < 2.5 cm in size underwent OPN with Gore-Tex® alone (group 1). Clinical data from a computerized database were reviewed and compared to a contemporary group of 26 patients with tumors ≥ 2.5 cm in size who underwent OPN with Gore-Tex® and Hem-O-Lok® (group 2). Results: The mean patient age was 53 years (range, 35-85 years), and the mean duration of follow-up was 41.8 months (range, 6-56 months). The mean cold ischemic times were 24.0 minutes (range, 12-37 minutes) and 35.3 minutes (range, 18-65 minutes) respectively in group 1 and 2. The tumor sizes in groups 1 and 2 were 1.7 ± 0.4 cm and 4.74 ± 2.75 cm, respectively. No major complications, such as urine leakage or delayed bleeding, were noted in either group. Conclusions: Nephron-sparing surgery using Gore-Tex® alone or a Gore-Tex® and Hem-O-Lok® combination was safe without high-priced hemostatic agents because the tensile strength was sufficient to maintain firmness in the repaired parenchyma. In addition, the procedure is easy to perform and takes less time to complete. Furthermore, major complications, recurrence, and impaired renal function did not occur with this procedure.
Descritores: Angiomiolipoma/cirurgia
Carcinoma de Células Renais/cirurgia
Hemostasia Cirúrgica/instrumentação
Neoplasias Renais/cirurgia
Nefrectomia/métodos
Politetrafluoretileno/uso terapêutico
-Imagem por Ressonância Magnética
Néfrons/cirurgia
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Limites: Idoso
Idoso de 80 Anos ou mais
Humanos
Responsável: BR1.1 - BIREME



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