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Id: biblio-1012395
Autor: Al-Doaiss, Amin A; Ali, Daoud; Ali, Bahy A; Jarrar, Bashir M.
Título: Renal histological alterations induced by acute exposure of titanium dioxide nanoparticles / Alteraciones histológicas renales inducidas por la exposición aguda de nanopartículas de dióxido de titanio
Fonte: Int. j. morphol;37(3):1049-1057, Sept. 2019. graf.
Idioma: en.
Resumo: SUMMARY: Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate the renal damage that might be induced by the acute toxicity TiO2 NPs. A total of 40 healthy male adult Wistar albino rats (Rattus norvegicus) were exposed to TiO2 NPs (126, 252, 378 mg/kg bw) for 24 and 48 h. Fresh portions of the kidneys from each rat were processed for histological and histochemical alterations. In comparison with respective control rats, exposure to TiO2 NPs has marked the following glomerular, tubular and interstitial alterations including the followings: glomerular congestion, Bowman's capsule swelling and dilatation, inflamed glomeruli, renal tubules cloudy swelling, karyorrhexis, karyolysis, infiltration of inflammatory cells, congestion, necrosis, hydropic degeneration, dilatation and congestion of blood vessels, hyaline droplets and hyaline casts precipitation, interstitial edema and fibrosis. From the findings of the current work one may conclude that TiO2 NPs are capable of inducing kidney damage with more insulation in the cortex and the proximal convoluted tubules than the medulla and the distal ones respectively. In addition, it might be concluded that renal damage induced by these nanomaterials is dose and duration of exposure dependent. Further hematological, biochemical, immunohistochemical, and ultra-structural studies are recommended.

RESUMEN: Las nanopartículas de dióxido de titanio (TiO2 NP) se usan ampliamente en muchos productos comerciales, nanomedicina, agricultura, productos para el cuidado personal, diferentes industrias y preparaciones farmacéuticas con riesgo potencial para la salud humana y el medio ambiente. El trabajo actual se realizó para investigar el daño renal que podría ser inducido por la toxicidad aguda NP de TiO2. Un total de 40 ratas Wistar albinas adultas sanas (Rattus norvegicus) fueron expuestas a TiO2 NP (126, 252, 378 mg / kg de peso corporal) durante 24 y 48 h. Las muestras de los riñones de las ratas se procesaron para estudios histológicos e histoquímicos. En comparación con las ratas control, la exposición de las ratas a TiO2 NP presentaron las siguientes alteraciones glomerulares, tubulares e intersticiales: congestión glomerular, dilatación de la cápsula de Bowman, inflamación glomerular, túbulos renales aumentados, cariorrexis, cariólisis, infiltración de células inflamatorias, congestión, necrosis, degeneración hidrópica, dilatación y congestión de vasos sanguíneos, gotas y precipitaciones hialina, edema intersticial y fibrosis. A partir de los hallazgos del trabajo actual, se puede concluir que las NP de TiO 2 son capaces de inducir daño renal con más aislamiento en la corteza y en los túbulos contorneados proximales que en la médula y los túbulos contorneados distales, respectivamente. Además, se podría concluir que el daño renal inducido por estos nanomateriales depende de la dosis y la duración de la exposición. Se recomiendan estudios adicionales hematológicos, bioquímicos, inmunohistoquímicos y ultraestructurales.
Descritores: Titânio/toxicidade
Nanopartículas/toxicidade
Rim/efeitos dos fármacos
-Ratos Wistar
Rim/patologia
Glomérulos Renais/efeitos dos fármacos
Glomérulos Renais/patologia
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/patologia
Necrose/induzido quimicamente
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-226107
Autor: Therezo, Altino Luiz Silva.
Título: Histogênese da doença renal policística autossômica dominante: estudo imuno-histoquímico / Histogenesis of the cysts in the autosomal dominant polycystic kidney disease. Immunohistochemistry study.
Fonte: Botucatu; s.n; 1997. 163 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade Estadual Paulista \"Júlio de Mesquita Filho\" para obtenção do grau de Doutor.
Resumo: A histogênese dos cistos na doença policística autossômica dominante (DRPAD) foi investigada em 33 pacientes por imuno-histoquímica. A idade média dos pacientes foi 46,4 anos e a relaçäo masculino:feminino foi 16:17. A maioria dos pacientes apresentou hipertensäo arterial (88 por cento), insuficiência renal crônica (92 por cento) e hematúria (70 por cento). Aneurismas cerebrais, diverticulose colônica e cistos hepáticos e pancreáticos foram encontrados em 56 por cento dos casos. O peso médio dos 53 rins estudados foi 1468 g e o diâmetro médio dos cistos foi 4,2 cm. Em 4 casos, material histológico de 1 dos rins näo esteve disponível. Os anticorpos e lectinas utilizados para identificar os diferentes segmentos dos néfrons foram: vimentina (Vim)-epitélio parietal da cápsula glomerular (G); Lotus tetragonolubus (LTA) e anti-antígeno CD 15 (Cd 15)-túbulo proximal (TP); anti-proteína de Tamm-Horsfall (PTH)-túbulo distal (TD), e anti-antígeno epitelial de membrana (EMA), anti-citoceratina (Ck) 19, Ulex europaeus (UEA-I), Arachis hypogaea (PNA), Dolichos biflorus (DBA) e Glycine maximum (SBA)-túbulo distal (TD) e ducto coletor (DC). Em estudo piloto, analisaram-se 3 rins normais obtidos de autópsias (rins controles-RC) e áreas preservadas de 2 rins com DRPAD (áreas de controle interno-CI), obtendos-e em todos os casos coloraçäo de: G por Vim, TP-LTA e CD15; TD-PTH; TD e DC-EMA, Ck 19, UEA-I, PNA e DBA. Näo houve coloraçäo com SBA. Os 49 rins com DRPAD produziram o seguinte perfil imuno-histoquímico: i) áreas preservadas: anti-Vim-G=82 por cento; LTA-TP=96 por cento; anti-CD 15-anti-Ck 19-TD e Dc=86 por cento e 89 por cento dos casos, respectivamente; ii) Áreas císticas: LTA, anti-CD 15, anti-PTH, anti EMA e anti-Ck 19=7 por cento, 6 por cento, 18 por cento, 97 por cento e 95 por cento dos casos, respectivamente. Näo houve coloraçäo com anti-Vim. Os resultados indicaram que os cistos em casos de DRPAD têm perfil imuno-histoquímico de túbulos distais e ductos coletores.
Descritores: Lectinas
Anticorpos Monoclonais
Rim Policístico Autossômico Dominante/patologia
-Imuno-Histoquímica
Lectinas/análise
Antígenos
Túbulos Renais
Túbulos Renais Distais
Túbulos Renais Proximais/patologia
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação
BR33.1


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Id: biblio-1098291
Autor: Haidara, Mohamed A; Al-Ani, Bahjat; Eid, Refaat A; Mohammed, Muataz E. D; Al-Hashem, Fahaid; Dallak, Mohammad.
Título: Acetaminophen induces alterations to the renal tubular ultrastructure in a rat model of acute nephrotoxicity protected by resveratrol and quercetin / El acetaminofeno induce alteraciones en la ultraestructura tubular renal en un modelo de rata con nefrotoxicidad aguda protegida por resveratrol y quercetina
Fonte: Int. j. morphol;38(3):585-591, June 2020. graf.
Idioma: en.
Projeto: King Khalid University.
Resumo: Acetaminophen (also called paracetamol, or APAP) induced nephrotoxicity is reported after accidental or intentional ingestion of an overdose of the drug. Renal tubular ultrastructural alterations induced by APAP overdose associated with the induction of biomarkers of kidney injury have not been investigated before. Also, we investigated whether the combined polyphenolic anti-inflammatory and antioxidants agents, resveratrol (RES) and quercetin (QUR) can protect against APAP-induced acute kidney injury. The model group of rats received a single dose of APAP (2 g/kg), whereas the protective group of rats was pre-treated for 7 days with combined doses of RES (30 mg/kg) and QUR (50 mg/kg) before being given a single dose of APAP. All rats were then sacrificed one day post APAP ingestion. Harvested kidney tissues were prepared for transmission electron microscopy (TEM) staining and blood samples were assayed for urea, creatinine, and biomarkers of inflammation and oxidative stress. TEM images and blood chemistry analysis showed that APAP overdose induced kidney damage as demonstrated by substantial alterations to the proximal convoluted tubule ultrastructure, and a significant (p<0.05) increase in urea, creatinine, tumor necrosis factor-alpha (TNF-a), and malondialdehyde (MDA) blood levels, which were protected by RES+QUR. These findings indicate that APAP induces alterations to the renal tubular ultrastructure, which is inhibited by resveratrol plus quercetin, which also decreases blood levels of kidney injury biomarkers.

El objetivo de este trabajo fue estudiar la nefrotoxicidad inducida por acetaminofeno (también llamado paracetamol o APAP) después de la ingestión accidental o intencional de una sobredosis de la droga. Las alteraciones ultraestructurales tubulares renales inducidas por sobredosis de APAP asociadas con la inducción de biomarcadores de daño renal no se han investigado. Además, estudiamos si los agentes combinados antiinflamatorios y antioxidantes polifenólicos, el resveratrol (RES) y la quercetina (QUR) pueden proteger contra la lesión renal aguda inducida por APAP. El grupo modelo de ratas recibió una dosis única de APAP (2 g / kg), mientras que el grupo protector de ratas se trató previamente durante 7 días con dosis combinadas de RES (30 mg / kg) y QUR (50 mg / kg) antes de recibir una dosis única de APAP. Todas las ratas se sacrificaron un día después de la ingestión de APAP. Los tejidos renales fueron preparados para el análisis a través de la microscopía electrónica de transmisión (MET). En las muestras de sangre se determinaron la urea, creatinina y los biomarcadores de inflamación y estrés oxidativo. Las imágenes MET y el análisis químico de la sangre mostraron que la sobredosis de APAP inducía daño renal, como lo demuestran las alteraciones sustanciales en la ultraestructura del túbulo contorneado proximal, y además, de un aumento significativo (p <0,05) de la urea, creatinina, factor de necrosis tumoral alfa y niveles sanguíneos de malondialdehído, protegidos por RES + QUR. Estos hallazgos indican que APAP induce alteraciones en la ultraestructura tubular renal, inhibida por el resveratrol más quercetina, que también disminuye los niveles sanguíneos de biomarcadores de daño renal.
Descritores: Quercetina/administração & dosagem
Resveratrol/administração & dosagem
Túbulos Renais/efeitos dos fármacos
Acetaminofen/toxicidade
-Quercetina/farmacologia
Ureia/sangue
Ratos Sprague-Dawley
Creatinina/sangue
Microscopia Eletrônica de Transmissão
Modelos Animais de Doenças
Overdose de Drogas
Resveratrol/farmacologia
Túbulos Renais/patologia
Anti-Inflamatórios/administração & dosagem
Antioxidantes/administração & dosagem
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-760428
Autor: Soeiro, Emília Maria Dantas; Helou, Claudia Maria de Barros.
Título: Aspectos clínicos, fisiopatológicos e genéticos das tubulopatias hereditárias na infância / Clinical, pathophysiological and genetic aspects of inherited tubular disorders in childhood
Fonte: J. bras. nefrol;37(3):385-398, July-Sept. 2015. tab, ilus.
Idioma: pt.
Resumo: ResumoNesta revisão, descrevemos a função tubular de cada segmento do néfron seguida das descrições das principais alterações moleculares que possam ocorrer nos transportadores expressos nestes locais. Assim, o conhecimento das modificações na função tubular renal permite o entendimento e o reconhecimento clínico das doenças tubulares renais que podem causar a morte fetal, neonatal ou infantil. Além disso, as crianças com tubulopatias podem evoluir para doença renal crônica terminal numa fase precoce da vida e também podem apresentar distúrbios do crescimento e do desenvolvimento acompanhados ou não de alterações neurológicas. Então, nós utilizamos o unitermo "inherited tubular disorders" a fim de selecionar na base de dados do PubMed os estudos publicados desde 2006. Esperamos que a leitura desta revisão auxilie no rápido diagnóstico dos pacientes com tubulopatias, o que poderá permitir o tratamento especializado e a possível melhora do prognóstico e qualidade de vida destes indivíduos.

AbstractIn this review, we described the tubular function of each nephron segment followed by the most important changes that may occur in the transporters expressed therein. Thus, knowledge of the changes in renal tubular function allows the understanding and recognition of renal tubular diseases that can cause stillbirth or death in newborns or in childhood. Moreover, children with tubular disorders may progress to chronic renal disease at an early stage of life and they may also show disturbances of growth and development associate or not with neurological dysfunction. Therefore, we used the keyword "inherited tubular disorders" to select the children studies that have been published in the PubMed database since 2006. We hope that this review may help physicians to perform an early diagnosis in patients with tubular disorders allowing a specialized treatment and an improvement in their prognosis and quality of life.
Descritores: Túbulos Renais
-Nefropatias/diagnóstico
Nefropatias/fisiopatologia
Nefropatias/genética
Limites: Humanos
Criança
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Módolo, Norma Sueli Pinheiro
Castiglia, Yara Marcondes Machado
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Id: lil-787265
Autor: Marques, Christiane D'Oliveira; Diego, Luis Antonio dos Santos; Marcondes-Machado, Jussara; Amorim, Renée Lauffer; Carvalho, Lídia Raquel; Módolo, Norma Sueli Pinheiro; Braz, Leandro Gobbo; Castiglia, Yara Marcondes Machado.
Título: Serum concentrations and renal expressions of IL-1 and TNF-a early after hemorrhage in rats under the effect of glibenclamide
Fonte: Acta cir. bras;31(7):434-441tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 µg/g i.v.); hemorrhage of 30% blood volume (10% every 10 min), with replacement using Ringer solution, 5 ml/kg/h. Serum concentrations of IL-1 and TNF-α were studied in the first hemorrhage (T1) and 50 min later (T2), renal expression, at T2. RESULTS: In serum, G1 TNF-α (pg/mL) was T1=178.6±33.5, T2=509.2±118.8 (p<0.05); IL-1 (pg/mL) was T1=148.8±31.3, T2=322.6±115.4 (p<0.05); in G2, TNF-α was T1=486.2±83.6, T2=261.8±79.5 (p<0.05); IL-1 was T1=347.0±72.0, T2= 327.3±90.9 (p>0.05). The expression of TNF-α and IL-1 in the glomerular and tubular cells was significantly higher in the G2 group. CONCLUSIONS: Hemorrhage and glibenclamide elevated TNF-α and IL-1 concentrations in serum and kidneys. High levels of TNF-α already present before the hemorrhage in the glibenclamide group may have attenuated the damages found in the kidneys after the ischemia event.
Descritores: Choque Hemorrágico/metabolismo
Interleucina-1/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Glibureto/farmacologia
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
-Peso Corporal/efeitos dos fármacos
Distribuição Aleatória
Ratos Wistar
Anestésicos Inalatórios/administração & dosagem
Modelos Animais
Canais KATP/antagonistas & inibidores
Rim/irrigação sanguínea
Rim/metabolismo
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/metabolismo
Éteres Metílicos/administração & dosagem
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-840044
Autor: Shuiai, Zhao; Huijun, Shen; Weizhong, Gu; Aimin, Liu; Jianhua, Mao.
Título: Evaluation of TGF-beta1 and MCP-1 expression and tubulointerstitial fibrosis in children with Henoch-Schönlein purpura nephritis and IgA nephropathy: A clinical correlation
Fonte: Clinics;72(2):95-102, Feb. 2017. tab, graf.
Idioma: en.
Projeto: National Natural Foundation; . Specialized Research Fund for the Doctoral Program of Higher Education; . Natural Science Foundation of Zhejiang Province; . Medicine & Health Technology Innovation Project of Zhejiang Province.
Resumo: OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We examined the development of tubulointerstitial fibrosis and its relationship with Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in these patients. METHODS: Renal tissue samples were collected by renal biopsy from 50 children with Henoch-Schönlein purpura nephritis and 50 children with immunoglobulin A nephropathy. Hematoxylin and eosin and Masson's trichrome-stained tissues were examined using light microscopy. Tubulointerstitial fibrosis was graded using the method described by Bohle et al. (1). The immunohistochemical detection of Transforming growth factor β1 and monocyte chemoattractant protein-1 expression was correlated with the tubulointerstitial fibrosis grade. Clinical Trial registration number: ZJCH-2012-0105. RESULTS: Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in the renal tissues was significantly greater in the patients with immunoglobulin A nephropathy than in the patients with Henoch-Schönlein purpura nephritis (both p<0.001). The immunoglobulin A nephropathy patients had a higher tubulointerstitial fibrosis grade than the Henoch-Schönlein purpura nephritis patients (p<0.001). The tubulointerstitial fibrosis grade was in accordance with the Transforming growth factor β1 and monocyte chemoattractant protein-1 expression levels in both diseases (both p<0.001). CONCLUSION: Transforming growth factor β1 and monocyte chemoattractant protein-1 expression was associated with the development of immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis. Further studies are needed to better evaluate this association.
Descritores: Púrpura de Schoenlein-Henoch/metabolismo
Quimiocina CCL2/metabolismo
Fator de Crescimento Transformador beta1/metabolismo
Glomerulonefrite por IGA/metabolismo
Túbulos Renais/metabolismo
-Prognóstico
Púrpura de Schoenlein-Henoch/patologia
Fibrose
Glomerulonefrite por IGA/patologia
Túbulos Renais/patologia
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-906579
Autor: Acosta de Camargo, María Gabriela; Oliveros Dorta, Jorge; Coronel, Valerio; Tami Maury, Irene.
Título: Asociación entre hallazgos bucales y enfermedad renal en pacientes pediátricos en Venezuela / Association between oral findings and renal disease among pediatric patients in Venezuela
Fonte: Rev. ADM = ADM;75(2):71-79, mar.-abr. 2018. ilus, tab.
Idioma: es.
Resumo: La cavidad oral puede mostrar signos clínicos de enfermedades renales que pasan desapercibidos. El objetivo de este estudio fue evaluar la asociación entre defectos del esmalte (DDE), cálculo dental, bajo peso, baja talla y el diagnóstico de disfunciones tubulares simples o tubulopatías entre 256 pacientes pediátricos (160 con tubulopatías simples y 96 controles sanos) en un importante hospital urbano de Valencia, Venezuela. La frecuencia de DDE en el grupo con tubulopatías fue de 56.25% y en controles de 29.2%, cálculo dental 26.9% y 10.4%, respectivamente. Los modelos de regresión logística revelaron la presencia de DDE (p = 0.000), cálculo dental (p = 0.002), bajo peso (p = 0.000) y baja talla (p = 0.000); cada una de estas características por separado presentó una asociación estadísticamente significativa con tubulopatías. Los niños con DDE tienen 2.7 más posibilidades de afección renal que los que no presentan DDE (Wald = 11.263 y p-valor = 0.001), también los pacientes con cálculo dental son 2.3 veces más propensos a padecer tubulopatías que los que no lo tienen (Wald = 4.076 y p-valor = 0.043) y los niños con bajo peso tienen 53.7% más probabilidad de presentar disfunción tubular simple (Wald = 4.751 y p-valor = 0.029). De allí que se puede afi rmar que la ocurrencia de tubulopatías tiene una asociación estadísticamente significativa con la presencia de DDE, cálculo dental y bajo peso. Estos datos pueden contribuir a que en la consulta odontopediátrica se aumente el número de referencia de niños con tubulopatías por la asociación de las variables mencionadas (AU)

The oral cavity may show clinical signs of renal diseases that go unnoticed. The aim of this study was to evaluate the association between enamel dental defects (EDD), dental calculus, low weight, low height and the diagnosis of simple tubular dysfunctions or tubulopathies among 256 pediatric patients (160 with simple tubulopathies and 96 healthy controls) in an important urban hospital of Valencia, Venezuela. The frequency of EDD in the group with tubulopathies was 56.25% and in controls 29.2%, dental calculus 26.9%, and 10.4%, respectively. The logistic regression models re-vealed that the presence of DDE (p = 0.000), dental calculus (p = 0.002), low weight (p = 0.000) and low size (p = 0.000), each of these characteristics Patients presented a statistically signifi cant association with the presence of tubulopathies. Children with EDD are 2.7 times more likely to have renal disease than those without EDD (Wald = 11.263 and p-value = 0.001); patients with dental calculus are 2.3 times more likely to have tubulopathies than (Wald = 4.076 and p-value = 0.043) and children with low weight were 53.7% more likely to have simple tubular dysfunction (Wald = 4.751 and p-value = 0.029). Hence, it can be affi rmed that the occurrence of tubulopathies has a statistically signifi cant association with the presence of DDE, dental calculus, and low weight. These data may contribute to the increase in the reference number of children with tubulopathies by the association of the mentioned variables (AU)
Descritores: Assistência Odontológica para Doentes Crônicos
Nefropatias
Túbulos Renais
Manifestações Bucais
-Estudos Transversais
Cálculos Dentários
Esmalte Dentário
Recém-Nascido de Baixo Peso
Análise Estatística
Anormalidades Dentárias
Venezuela
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Responsável: AR29.1 - Biblioteca


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Texto completo SciELO Costa Rica
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Id: lil-757313
Autor: Chacón-Garita, Lindsay; Moreira-Carvajal, Manuel.
Título: Carcinoma de células renales: descripción de casos / Renal cell carcinoma: case description of cases
Fonte: Acta méd. costarric;57(3):113-116, jul.-sep. 2015. graf.
Idioma: es.
Resumo: Justificación: los carcinomas de células renales son un grupo de neoplasias malignas originadas del epitelio de los túbulos renales. Estas neoplasias representan en promedio un 90% de todas las neoplasias malignas renales en adultos de ambos sexos. El tabaco ha sido descrito en la bibliografía como el principal factor de riesgo; otras variables como el sobrepeso y la obesidad se han ligado a los mecanismos que participan en la inducción de estos tumores malignos. Se ha descrito además, una mayor incidencia en pacientes con hipertensión arterial. El objetivo fue determinar la incidencia, los factores de riesgos asociados y las características clínico-patológicas de los carcinomas de célulasrenales, con base en los resultados de las biopsias del Servicio de Patología del Hospital San Rafael de Alajuela.Métodos: se revisó los expedientes clínicos y las láminas histológicas de cada una de las biopsias diagnosticadas como carcinomas de células renales, en el periodo comprendido entre enero de 2009 y diciembre de 2013, para determinar la incidencia, los factores de riesgo asociados y las características clínico- patológicas.Resultados: en este periodo se diagnosticó un total de 36 carcinomas de células renales, 27 de los cuales se presentaron en pacientes de sexo masculino. La edad promedio de presentación fue de 60,1 años (43 a 79 años). Del total de los casos, 21 presentaron índices de masa corporal por encima de rangos normales, 26 pacientes eran hipertensos y 15 eran tabaquistas. El diagnóstico clínico de estos tumores fue incidental en la mayoría de los casos. El tamaño del tumor fue en promedio de 5,7cm; en el 86,1% de los casos se trató de CCR de tipo células claras; un 58,3% tuvo un grado histológico de Fuhrman II y un 47,2% corresponde a tumores con un estadio temprano (T1)...

Objective: Renal cell carcinoma (RCC) is a group of malignant neoplasms with origin in the renal tubular epithelia. These neoplasms represent an average of 90% of all malignant renal neoplasms in adults of both genders. Tobacco has been described in the literature as the main risk factor, other variables such as overweight and obesity have been linked to the mechanisms that participate in inducing these malignant tumors. An increased incidence of RCC has also been described in patients with hypertension. The objective was to determine incidence, risk factors and the clinical and pathological characteristics of renal cell carcinoma based on the results of biopsies performed at the Pathology Department of the San Rafael Hospital in Alajuela.Methods: A review of clinical records and histological boards for each of the biopsies diagnosed as RCC between January 2009 and December 2013 was performed to determine incidence, risk factors, as well as clinical and pathological characteristics.Results: A total of 36 RCC were diagnosed during the period, 27 of them were male patients. The average age of presentation was 60.1 years (43 to 79 years). Out of the total, 21 cases presented a body mass index above the normal range, 26 patients had hypertension and 15 were smokers. The clinical diagnosis of these tumors was incidental in most cases. The average tumor size was 5.7 cm; 86.1% of cases were a RCC with a clear cell type, 58.3% had a histological Fuhrman grade II and 47.2% were early stage tumors (T1)...
Descritores: Carcinoma de Células Renais
Costa Rica
Epitélio
Hipertensão
Neoplasias Renais
Túbulos Renais
Neoplasias
Obesidade
Sobrepeso
Fumar
Limites: Humanos
Masculino
Adulto
Feminino
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Id: lil-742556
Autor: Valenzuela, Sergio; Aliaga, Verónica; Burdiles, Patricio; Carvallo, Aurelio; Díaz, Eduardo; Guerrero, Manuel; Rueda, Laura; Valenzuela, Carlos.
Título: Reflexiones en torno a la ley N° 20.584 y sus implicancias para la investigación biomédica en Chile / Considerations on the new Chilean law about rights and duties of patients
Fonte: Rev. méd. Chile;143(1):96-100, ene. 2015.
Idioma: es.
Resumo: After years of discussion by the Chilean legislature, the Law Nº 20.584, which regulates health care related rights and duties of people, entered into force in Chile in October 2012. This bill represents an important step in the recognition and protection of health care related rights, welfare, dignity and duties of persons. It also intends to protect potential participants in clinical research. However such protective measures include explicit prohibitions such as the review of clinical records or the inclusion of people with mental or psychological handicaps as research participants. We herein discuss the implications of this law in medical research.
Descritores: Regulação da Expressão Gênica
MicroRNAs/genética
MicroRNAs/metabolismo
-Modelos Animais de Doenças
Glomerulonefrite/metabolismo
Hipertensão/patologia
Glomérulos Renais/metabolismo
Túbulos Renais/metabolismo
Rim/lesões
Rim/metabolismo
Ratos Endogâmicos WKY
Fatores de Tempo
Fator de Crescimento Transformador beta/metabolismo
Ureter/patologia
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-734375
Autor: Manucha, Walter.
Título: Papel de las mitocondrias y el estrés oxidativo en el proceso inflamatorio renal / Mitochondria and oxidative stress participation in renal inflammatory process
Fonte: Medicina (B.Aires);74(3):254-258, jun. 2014. ilus.
Idioma: es.
Resumo: La muerte celular programada y la fibrosis renal son procesos inherentes a la enfermedad renal crónica y, en tal sentido, ha sido recientemente descripta una clara desregulación de la maquinaria respiratoria mitocondrial en pacientes con enfermedad renal crónica asociada con un aumento del estrés oxidativo. Las células tubulares lesionadas vinculadas a los macrófagos intersticiales y miofibroblastos producen citoquinas y factores de crecimiento que promueven un estado inflamatorio, inducen la apoptosis de las células tubulares y facilitan la acumulación de matriz extracelular. La angiotensina II desempeña un papel central en la fibrogénesis renal y conduce a una rápida progresión de la enfermedad renal crónica. Los niveles crecientes de la angiotensina II inducen citoquinas pro-inflamatorias, la activación de NF-kB, moléculas de adhesión, quimiocinas, factores de crecimiento y estrés oxidativo. Toda la evidencia actual sugiere que la angiotensina II aumenta el estrés oxidativo mitocondrial, regula la inducción de apoptosis y condiciona al estado inflamatorio. Por lo tanto, existiría un papel determinante de las mitocondrias y el estrés oxidativo en el proceso inflamatorio renal. Finalmente, esta revisión resume nuestro actual conocimiento acerca de los posibles mecanismos que contribuirían con la apoptosis modulada por la inflamación y/o el estrés oxidativo durante la enfermedad renal crónica. Además, se propone un nuevo concepto de herramientas anti-inflamatorias que regulan el estrés oxidativo mitocondrial lo cual afectaría directamente al proceso inflamatorio y la apoptosis. Esta idea podría tener consecuencias atractivas sobre el tratamiento de patologías inflamatorias renales y de otras afines.

The apoptosis and renal fibrosis are processes inherent to the chronic kidney disease, and consequently a clear deregulation of the mitochondrial respiratory mechanism has been described in patients with chronic renal disease associated to an increase of the oxidative stress. The injured tubular cells linked to the interstitial macrophages and myofibroblasts produce cytokines and growth factors that encourage an inflammatory condition, inducing the apoptosis of the tubular cells and enabling the accumulation of the extracellular matrix. The angiotensin II has a central role in the renal fibrogenesis leading to a rapid progression of the chronic kidney disease. The growing levels of the angiotensin II induce pro-inflammatory cytokines, the activation of NF-kB, adhesion molecules,chemokines, growth factors, and oxidative stress. The current evidence suggests that the angiotensin II increases the mitochondrial oxidative stress, regulates the induction of the apoptosis and conditions the inflammatory process. Therefore the mitochondria and the oxidative stress would play a determinant role in the renal inflammatory process. Finally, this review summarizes our present knowledge regarding the possible mechanisms that would contribute to the apoptosis conditioned by inflammation and/or oxidative stress during the chronic renal disease. Additionally, a new concept of the anti-inflammatory tools is proposed to regulate the mitochondrial oxidative stress that would directly affect the inflammatory process and apoptosis. This concept could have positive consequences on the treatment of renal inflammatory pathologies and related diseases.
Descritores: Apoptose/fisiologia
Mitocôndrias/metabolismo
Mitocôndrias/patologia
Nefrite/etiologia
Estresse Oxidativo/fisiologia
Insuficiência Renal Crônica/etiologia
-Angiotensina II/metabolismo
Citoproteção
Ergocalciferóis/farmacologia
Córtex Renal/efeitos dos fármacos
Córtex Renal/patologia
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/patologia
NF-kappa B/metabolismo
Nefrite/metabolismo
Insuficiência Renal Crônica/metabolismo
Insuficiência Renal Crônica/patologia
Vitaminas/farmacologia
Limites: Animais
Humanos
Tipo de Publ: Revisão
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas



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