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Id: biblio-1124212
Autor: Jiang, Su; Zhao, Gaonian; Lu, Jun; Jiang, Min; Wu, Zhenggang; Huang, Yujing; Huang, Jing; Shi, Jinghua; Jin, Jing; Xu, Xinxuan; Pu, Xuehua.
Título: Silencing of circular RNA ANRIL attenuates oxygen-glucose deprivation and reoxygenation-induced injury in human brain microvascular endothelial cells by sponging miR-622
Fonte: Biol. Res;53:27, 2020. graf.
Idioma: en.
Resumo: BACKGROUND: Circular RNA (circRNA) is highly expressed in the brain tissue, but its molecular mechanism in cerebral ischemia-reperfusion remains unclear. Here, we explored the role and underlying mechanisms of circRNA antisense non-coding RNA in the INK4 locus (circ_ANRIL) in oxygen-glucose deprivation and reoxygenation (OGD/R)-induced cell injury. RESULTS: The expression of circ_ANRIL in OGD/R-induced human brain microvascular endothelial cells (HBMECs) was significantly up-regulated, while that of miR-622 was significantly down-regulated. Overexpression of circ_ANRIL significantly inhibited the proliferation of OGD/R-induced HBMECs and aggravated OGD/R-induced cell apoptosis. Moreover, circ_ANRIL overexpression further increased the secretion of interleukin (IL)-1ß, IL-6, tumor necrosis factor-a, and monocyte chemoattractant protein-1 in OGD/R-treated HBMECs. The results of bioinformatics analysis and luciferase reporter assay indicated that circ_ANRIL served as an miR-622 sponge to negatively regulate the expression of miR-622 in OGD/R-treated HBMECs. Additionally, circ_ANRIL silencing exerted anti-apoptotic and anti-inflammatory effects by positively regulating the expression of miR-622. Furthermore, inhibition of OGD/R-induced activation of the nuclear factor (NF)-kB pathway by circ_ANRIL silencing was significantly reversed by treatment with miR-622 inhibitor. CONCLUSIONS: Knockdown of circ_ANRIL improved OGD/R-induced cell damage, apoptosis, and inflammatory responses by inhibiting the NF-κB pathway through sponging miR-622.
Descritores: Traumatismo por Reperfusão/metabolismo
Hipóxia Encefálica/metabolismo
MicroRNAs/fisiologia
MicroRNAs/genética
RNA Circular
-Oxigênio
Encéfalo
Apoptose
Inibidor p16 de Quinase Dependente de Ciclina
Células Endoteliais
RNA Longo não Codificante
Glucose/metabolismo
Inflamação
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1123341
Autor: Rassier Isolan, Gustavo; Campero, Alvaro; Ajler, Pablo; Garcete Farina, Edgar Manuel; Frigeri, Thomas M; Infantini Dini, Leandro.
Título: Parte I: Anatomía microquirúrgica tridimensional de la ínsula / Part I: Three-dimensional microsurgical anatomy of the insula
Fonte: Rev. argent. neurocir;34(2):100-115, jun. 2020. ilus.
Idioma: es.
Resumo: Introducción: El lóbulo de la ínsula, o ínsula, se encuentra oculto en la superficie lateral del cerebro. La ínsula está localizada profundamente en el surco lateral o cisura silviana, recubierta por los opérculos frontal, parietal y temporal. Objetivo: Estudiar la compleja anatomía del lóbulo de la ínsula, una de las regiones de mayor complejidad quirúrgica del cerebro humano, y su correlación anatómica con casos quirúrgicos. Material y Métodos: En la primera parte de este estudio presentamos los resultados de nuestras disecciones microquirúrgicas en fotografías 2 D y 3D; en la segunda parte de nuestro trabajo, la correlación anatómica con una serie de 44 cirugías en pacientes con tumores de la ínsula, principalmente gliomas, operados entre 2007 y 2014. Resultados: Extenso conjunto de fibras subcorticales, incluyendo el fascículo uncinado, fronto-occipital inferior y el fascículo arcuato, conectan la ínsula a las regiones vecinas. Varias estructuras anatómicas responsables por déficits neurológicos severos están íntimamente relacionadas con la cirugía de la ínsula, tales como lesiones de la arteria cerebral media, cápsula interna, áreas del lenguaje en el hemisferio dominante y arterias lenticuloestriadas. Conclusión: El entrenamiento en laboratorio de neuroanatomía, estudio de material impreso en 3D, el conocimiento sobre neurofisiología intra-operatoria y el uso de armamento neuroquirúrgico moderno son factores que influencian en los resultados quirúrgicos

Introduction: The insular lobe, or insula, is the cerebral lobe sitting deep in the sylvian fissure and hidden by the lateral surface of the brain. It is covered by the frontal, parietal and temporal operculum. Objectives: To study the anatomy of the insular lobe, one of the most complex parts of the human brain, and to correlate this anatomy with intraoperative findings. Materials and Methods: In the first part of this article we show the results of our dissections, documented in 2D and 3D, and focus on microsurgical anatomy. In the second part we correlate the anatomical structures with intraoperative findings from 44 insular tumor surgeries, mainly gliomas, of patients operated on from 2007 to 2014. Results: Huge bundles of subcortical fibers, like uncinate, inferior fronto-occipital and arcuate fascicles, connect the insula to the neighboring structures. Several anatomical structures related to neurological disabilities are closely related to insular surgery, like the middle cerebral artery, internal capsule, lenticulostriate arteries and cortical and subcortical language circuits. Conclusions: Microsurgical laboratory training, 3D documentation, knowledge of brain mapping and modern neurosurgical armamentarium are important factors in achieving good results with insular glioma tumors.
Descritores: Lobo Temporal
-Encéfalo
Mapeamento Encefálico
Cérebro
Anatomia
Neuroanatomia
Limites: Humanos
Responsável: AR423.1 - Biblioteca


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Tsunechiro, Maria Alice
Bonadio, Isabel Cristina
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Id: lil-731285
Autor: Corrêa, Marianne Dias; Tsunechiro, Maria Alice; Lima, Marlise de Oliveira Pimentel; Bonadio, Isabel Cristina.
Título: Evaluation of prenatal care in unit with family health strategy / Evaluación del cuidado prenatal en unidad con estrategia salud de la familia / Avaliação da assistência pré-natal em unidade com estratégia saúde da família
Fonte: Rev. Esc. Enferm. USP;48(spe):23-31, 08/2014. tab.
Idioma: en.
Projeto: CNPq.
Resumo: We analyzed prenatal care (PN) provided at a unit of the Family Health Strategy Service in São Paulo, according to the indicators of the Program for the Humanization of Prenatal and Birth (PHPB). We compared adequacy of PN in terms of sociodemographic variables, procedures, examinations and maternal and perinatal outcomes. Cross-sectional study with data from records of 308 pregnant women enrolled in 2011. We observed early initiation of PN (82.1%), conducting of a minimum of six consultations (84.1%), puerperal consultation (89.0%); to the extent that there is a sum of the actions, there is a significant drop in the proportion of adequacy. Prenatal care was adequate for 67.9%, with a significant difference between adequacy groups in relation to gestational age and birth weight. Prenatal care deficiencies exist, especially in regards to registration of procedures, exams and immunization. The difference between adequacy groups with respect to perinatal outcomes reinforces the importance of prenatal care that adheres to the parameters of the PHPB.
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Se evaluó el prenatal (PN) de un servicio de salud que cuenta con Estratégia Salud de la Familia, de la ciudad de São Paulo, conforme indicadores del Programa de Humanización del Prenatal y Nacimiento (PHPN) y se comparó la adecuación del PN con variables sociodemográficas, procedimientos, exámenes y los resultados maternos y perinatales. Estudio transversal con datos de los registros de 308 embarazadas inscritas en 2011. Se observó el inicio precoz de PN (82,1%), realización del mínimo de seis consultas (84,1%) y la consulta puerperal (89%) y, en la medida en que hay una suma de las acciones, hay una caída significativa en coeficiente de adecuación. El PN fue adecuado para el 67,9%, con una diferencia significativa entre los grupos de adecuación en relación a la edad gestacional y el peso al nacer. Hay deficiencias en el PN, especialmente en los registro de procedimientos, exámenes y vacunas. La diferencia entre los grupos en adecuación con respecto a los resultados perinatales refuerza la importancia de un PN conforme parámetros del PHPN.
.

Analisou-se a assistência pré-natal (PN) de uma unidade com Estratégia Saúde da Família do Município de São Paulo, conforme os indicadores do Programa de Humanização do Pré-Natal e Nascimento (PHPN), e comparou-se adequação do PN com variáveis sociodemográficas, procedimentos, exames e desfechos maternos e perinatais. Estudo transversal com dados de registros de 308 gestantes inscritas em 2011. Observou-se início precoce do PN (82,1%), realização do mínimo de seis consultas (84,1%), consulta puerperal (89,0%) e, à medida que há um somatório das ações, há uma queda importante na proporção de adequação. O PN foi adequado para 67,9%, com diferença significante entre os grupos de adequação em relação à idade gestacional e peso ao nascer. No PN existem deficiências, especialmente no registro de procedimentos, exames e imunização. A diferença nos grupos de adequação com relação aos desfechos perinatais reforça a importância de um PN, conforme os parâmetros do PHPN.

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Descritores: Convulsões/fisiopatologia
-Encéfalo/patologia
Encéfalo/fisiopatologia
Convulsivantes
Modelos Animais de Doenças
Epilepsia/fisiopatologia
Rede Nervosa
Convulsões/induzido quimicamente
Limites: Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1055020
Autor: Wasinski, Frederick; Frazão, Renata; Donato Jr, Jose.
Título: Effects of growth hormone in the central nervous system
Fonte: Arch. endocrinol. metab. (Online);63(6):549-556, Nov.-Dec. 2019. graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . São Paulo Research Foundation; . São Paulo Research Foundation.
Resumo: ABSTRACT Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain. The objective of the present review is to summarize and discuss the potential physiological importance of GH action in the central nervous system. We provide evidence that GH signaling in the brain regulates the physiology of numerous functions such as cognition, behavior, neuroendocrine changes and metabolism. Data obtained from experimental animal models have shown that disruptions in GH signaling in specific neuronal populations can affect the reproductive axis and impair food intake during glucoprivic conditions, neuroendocrine adaptions during food restriction, and counter-regulatory responses to hypoglycemia, and they can modify gestational metabolic adaptions. Therefore, the brain is an important target tissue of GH, and changes in GH action in the central nervous system can explain some dysfunctions presented by individuals with excessive or deficient GH secretion. Furthermore, GH acts in specific neuronal populations during situations of metabolic stress to promote appropriate physiological adjustments that restore homeostasis. Arch Endocrinol Metab. 2019;63(6):549-56
Descritores: Encéfalo/metabolismo
Fármacos Neuroprotetores/metabolismo
Hormônio do Crescimento Humano/metabolismo
Redes e Vias Metabólicas/fisiologia
-Transdução de Sinais
Regeneração Nervosa/fisiologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1088770
Autor: Batistuzzo, Alice; Ribeiro, Miriam Oliveira.
Título: Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
Fonte: Arch. endocrinol. metab. (Online);64(1):89-95, Jan.-Feb. 2020. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95
Descritores: Complicações na Gravidez/fisiopatologia
Encéfalo/embriologia
Disfunção Cognitiva/etiologia
Hipotireoidismo/complicações
Troca Materno-Fetal/fisiologia
-Complicações na Gravidez/sangue
Trimestres da Gravidez
Efeitos Tardios da Exposição Pré-Natal
Encéfalo/fisiopatologia
Resultado da Gravidez
Limites: Humanos
Animais
Feminino
Gravidez
Ratos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-770318
Autor: Nunes, Annelise Castanha Barreto Tenório; Silva, Edna Maria Vieira da; Oliveira, José Aelson de; Yamasaki, Elise Myuki; Kim, Pomy de Cássia Peixoto; Almeida, Jonatas Campos de; Nunes, Kleber Barros; Mota, Rinaldo Aparecido.
Título: Application of different techniques to detect Toxoplasma gondii in slaughtered sheep for human consumption / Utilização de diferentes técnicas para detecção de Toxoplasma gondii em ovinos abatidos para consumo humano
Fonte: Rev. bras. parasitol. vet;24(4):416-421, Oct.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: Abstract The aim of this study was to investigate occurrence of Toxoplasma gondii in sheep slaughtered in the state of Alagoas, Brazil, by means of different diagnosis techniques. Serum samples and tissues from 100 slaughtered sheep were used. To detect antibodies, the indirect immunofluorescence antibody test (IFAT) was used, and tissues from seropositive animals (cut-off ≥1:64) were submitted to Polymerase Chain Reaction (PCR) and immunohistochemistry (IHC). To assess the concordance between the direct techniques, the kappa test was used. In the IFAT, it was observed that 14% (14/100) of the ovine samples were serum-positive. In the PCR, 21.43% (3/14) of the animals were positive and in IHC, it was observed that 7.14% (1/14) were positively stained for T. gondii in cerebral tissue. Histopathologically, the predominant finding was the presence of mononuclear cell infiltrate in the heart and a perivascular cuff in the cerebrum and cerebellum. The concordance between the direct diagnosis techniques was moderate (k=0.44). Thus, it is important to use different direct techniques in diagnosing toxoplasmosis in naturally infected sheep.

Resumo O objetivo deste estudo foi pesquisar a ocorrência de Toxoplasma gondii em ovinos abatidos no Estado de Alagoas, Brasil por meio de diferentes técnicas de diagnóstico. Foram utilizadas amostras de soros e tecidos de 100 ovinos abatidos. Para a pesquisa de anticorpos foi utilizada a Reação de Imunofluorescência Indireta (RIFI), e os tecidos dos animais soropositivos (ponto de corte ≥1:64) foram submetidos às técnicas de Reação de Cadeia da Polimerase (PCR) e Imunohistoquímica (IHQ). Para o estudo da concordância entre as técnicas diretas foi empregado o teste Kappa. Na RIFI, 14% (14/100) das amostras foram soro-positivas. Na PCR, 21,43% (3/14) dos animais foram positivos e, na IHC, 7,14% (1/14) apresentaram marcação positiva para T. gondii no tecido cerebral. Na histopatologia, o achado predominante foi o infiltrado celular mononuclear no coração e manguito perivascular no cérebro e cerebelo. A concordância entre as técnicas diretas de diagnóstico foi moderada (K= 0,44). Desse modo, é importante utilizar diferentes técnicas diretas no diagnóstico da toxoplasmose em ovinos naturalmente infectados.
Descritores: Doenças dos Ovinos/parasitologia
Toxoplasma/imunologia
Ovinos/parasitologia
Anticorpos Antiprotozoários/análise
Toxoplasmose Animal/parasitologia
-Doenças dos Ovinos/diagnóstico
Encéfalo/parasitologia
Brasil
Imuno-Histoquímica/veterinária
Reação em Cadeia da Polimerase/veterinária
Técnica Indireta de Fluorescência para Anticorpo/veterinária
Responsável: NI15.1 - CEDOC - Centro de Documentación e Información


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Monserrat, José M
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Id: biblio-886809
Autor: STRINGHETTA, GIOVANNA R; BARBAS, LUIS A L; MALTEZ, LUCAS C; SAMPAIO, LUÍS A; MONSERRAT, JOSÉ M; GARCIA, LUCIANO O.
Título: Oxidative stress responses of juvenile tambaqui Colossoma macropomum after short-term anesthesia with benzocaine and MS-222
Fonte: An. acad. bras. ciênc;89(3,supl):2209-2218, 2017. graf.
Idioma: en.
Resumo: ABSTRACT The present study aimed to evaluate the effects of benzocaine and tricaine methanesulfonate on oxidative stress parameters of juvenile tambaqui tissues. Fish (n=80) were anesthetized with benzocaine (100 mg L-1) or tricaine (240 mg L-1) and two control groups were used (non-anesthetized fish and fish exposed to ethanol-only). After anesthetic induction 10 fish/anesthetic were euthanized after 3, 12 and 24 hours post-anesthesia and tissue samplings (gills, liver and brain) were performed. Samples were submitted to analyses of enzyme activity glutathione-S-transferase (GST), cellular lipid peroxidation (TBARS) and total antioxidant capacity (ACAP). ACAP increased in gills of benzocaine treatment after 12 hours. The liver showed a reduction in ACAP of tricaine treatment after 12 hours. Both anesthetic treatments showed an increase of ACAP at 24 hours compared to control group. The activity of the GST enzyme increased in the gills for treatments benzocaine and tricaine after 3 and 12 hours. Liver showed increased GST activity (benzocaine after 24 hours and tricaine after 3 and 24 hours). Lipid damage decreased in gills (both anesthetics) and brain (tricaine) after 24 hours. The results demonstrate that benzocaine and tricaine did not cause oxidative damage in juvenile tambaqui under the experimental conditions herein established.
Descritores: Benzocaína/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Aminobenzoatos/farmacologia
Anestésicos/farmacologia
-Encéfalo/efeitos dos fármacos
Peixes
Brânquias/efeitos dos fármacos
Anestésicos/administração & dosagem
Fígado/efeitos dos fármacos
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-886645
Autor: SILVA, LUANA C A; VIANA, MILENA B; ANDRADE, JOSÉ S; SOUZA, MELYSSA A; CÉSPEDES, ISABEL C; D'ALMEIDA, VÂNIA.
Título: Tryptophan overloading activates brain regions involved with cognition, mood and anxiety
Fonte: An. acad. bras. ciênc;89(1):273-283, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Tryptophan is the only precursor of serotonin and mediates serotonergic activity in the brain. Previous studies have shown that the administration of tryptophan or tryptophan depletion significantly alters cognition, mood and anxiety. Nevertheless, the neurobiological alterations that follow these changes have not yet been fully investigated. The aim of this study was to verify the effects of a tryptophan-enriched diet on immunoreactivity to Fos-protein in the rat brain. Sixteen male Wistar rats were distributed into two groups that either received standard chow diet or a tryptophan-enriched diet for a period of thirty days. On the morning of the 31st day, animals were euthanized and subsequently analyzed for Fos-immunoreactivity (Fos-ir) in the dorsal and median raphe nuclei and in regions that receive serotonin innervation from these two brain areas. Treatment with a tryptophan-enriched diet increased Fos-ir in the prefrontal cortex, nucleus accumbens, paraventricular hypothalamus, arcuate and ventromedial hypothalamus, dorsolateral and dorsomedial periaqueductal grey and dorsal and median raphe nucleus. These observations suggest that the physiological and behavioral alterations that follow the administration of tryptophan are associated with the activation of brain regions that regulate cognition and mood/anxiety-related responses.
Descritores: Ansiedade/tratamento farmacológico
Encéfalo/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-fos/efeitos dos fármacos
Cognição/efeitos dos fármacos
Antidepressivos de Segunda Geração/administração & dosagem
Afeto/efeitos dos fármacos
-Ansiedade/metabolismo
Fatores de Tempo
Triptofano/administração & dosagem
Encéfalo/metabolismo
Imuno-Histoquímica
Serotonina/metabolismo
Reprodutibilidade dos Testes
Resultado do Tratamento
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos Wistar
Suplementos Nutricionais
Dietoterapia/métodos
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1041874
Autor: Sartori, Pablo; Sgarbi, Nicolás.
Título: Tomografía computada y resonancia magnética de variantes normales/congénitas de apariencia quística y presentación frecuente en el encéfalo / CT and MRI of Normal/Congenital Variables with Cystic Appearance and Frequent Presence in the Brain
Fonte: Rev. argent. radiol;83(1):12-22, mar. 2019. ilus, tab.
Idioma: es.
Resumo: La presentación de una imagen de apariencia quística durante el estudio del encéfalo constituye un hallazgo incidental cada vez más frecuente, pudiendo encontrarse en el espacio extra o intraaxial. Las mismas pueden ser de naturaleza congénita o adquirida, benigna o maligna, ocupantes de espacio con desplazamiento de la línea media o simplemente presentarse sin efecto compresivo alguno. De localización supra o infratentorial, esas imágenes constituyen un desafío diagnóstico, siendo imprescindible su reconocimiento para no solicitar estudios o tratamientos innecesarios. Valoraremos las imágenes de apariencia quística más frecuentes empleando tomografía computada o imágenes de resonancia magnética.

Presence of a cystic formation in brain examination is frequently an incidental finding. They can be intra or extra-axial in location, congenital or acquired, benign or malignant with or without mass effect. Intracranial cysts can be a diagnostic challenge and we should know them to avoid unnecessary exams or treatment. We will analyze the most common cystic formations seen in computed tomography and magnetic resonance.
Descritores: Encéfalo/diagnóstico por imagem
Espectroscopia de Ressonância Magnética/métodos
Tomografia Computadorizada por Raios X/métodos
Cistos/diagnóstico por imagem
-Cisto Dermoide/diagnóstico por imagem
Encefalocele/diagnóstico por imagem
Epêndima/anormalidades
Tipo de Publ: Ensaio Clínico
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-1057416
Autor: Surur, Alberto; Pessini Ferreira, Lucas M; Galíndez, Jorge A; Martín, Juan J.
Título: Análisis de las lesiones encefálicas en resonancia magnética en pacientes con señales transitorias de alta intensidad detectadas por Doppler transcraneal / Analysis of Encephalic Lesions in Magnetic Resonance Imaging in patients with High Intensity Transient Signals detected on Transcranial Doppler
Fonte: Rev. argent. radiol;83(4):141-150, oct. 2019. tab, graf.
Idioma: es.
Resumo: Resumen Objetivo: Describir los hallazgos en resonancia magnética (RM) de encéfalo en pacientes menores de 65 años que fueron estudiados por Doppler transcraneal (DTC) con contraste de microburbujas, con antecedentes de accidente cerebrovascular (ACV) criptogénico y sospecha de foramen oval permeable (FOP). Materiales y métodos: Este estudio transversal retrospectivo incluyó pacientes de ambos sexos, menores de 65 años. Resultados: Nuestra muestra (n = 47, 47% masculino y 53% femenino, edad media de 42 años) presentó señales transitorias de alta intensidad (HITS, por su sigla en inglés) positivo en el 61,7% y HITS-negativo en el 38,3%. En pacientes HITS-positivo, predominaron las lesiones a nivel de las fibras en U subcorticales, únicas o múltiples con distribución bilateralmente simétrica. En pacientes con HITS moderados, predominaron las lesiones en el territorio vascular de la circulación posterior. Conclusión: En pacientes menores de 65 años con ACV criptogénico y lesiones en fibras en U subcorticales, únicas o múltiples con distribución bilateral y simétrica, debe tenerse en cuenta un FOP como posible causa de dichas lesiones.

Abstract Objectives: To analyze the findings on brain magnetic resonance imaging (MRI) in patients less than 65 years of age with history of cryptogenic stroke and suspected patent foramen ovale (PFO) who were studied with Contrast-Transcranial Doppler. Materials and Methods: This transversal retrospective study included both, men and women less than 65 years of age. Results: Our sample (n = 47, 47% male and 53% female, average age 42 years old) had High Intensity Transient Signals (HITS)-positive in 61.7% and HITS-negative in 38.3%. In HITS-positive patients, lesions were predominantly located on the subcortical U fibers, lone or multiple bilateral symmetric distributions. In patients with moderate-severity HITS, the posterior circulation was the most affected. Conclusion: In patients less than 65 years of age with cryptogenic stroke with lesions affecting the subcortical U fibers, with unique or multiple bilateral symmetric distributions, a PFO should be considered as an underlying cause.
Descritores: Encéfalo
Lesões Encefálicas
Lesões Encefálicas/diagnóstico por imagem
Espectroscopia de Ressonância Magnética
-Ferimentos e Lesões
Imagem por Ressonância Magnética
Causalidade
Estudos Retrospectivos
Ultrassonografia Doppler Transcraniana/métodos
Acidente Vascular Cerebral
Forame Oval Patente
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde