Base de dados : LILACS
Pesquisa : A08.186.854.697.500.500 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Id: biblio-1132184
Autor: Trela, Valeria Daiana; Ramallo, Ana Laura; Albani, Oscar Alfredo.
Título: Synthesis and Characterization of Acetylated Cassava Starch with Different Degrees of Substitution
Fonte: Braz. arch. biol. technol;63:e20180292, 2020. tab, graf.
Idioma: en.
Resumo: Abstract Acetylated cassava starch with low and medium degrees of substitution (DS) were synthesized. Also, the effect of DS on swelling power, solubility, morphological properties, gelatinization temperature, paste clarity and moisture sorption were studied. Swelling power and solubility in water between 50ºC and 90°C were determined. Acetylated cassava starches with low DS showed an increased in both parameters, while at higher DS values a reduction of them was observed. Maximum swelling power values were measured in acetylated starch with DS of 0.2 and maximum solubility was registered at DS of 0.72. Equilibrium moisture content values from sorption isotherms presented a good fit using the GAB model (R2>0.96). SEM micrographs showed that as acetyl groups are incorporated the granules suffer surface changes and eventually lose their structure at DS of 1.5. Clarity of acetylated starch pastes with low DS was lighter than native starch paste. In addition, the increase in DS produced a reduction in gelatinization temperature.
Descritores: Acetilação
Solubilidade
Substância Gelatinosa
Temperatura
Amidos e Féculas
-Microscopia Eletrônica de Varredura
Responsável: BR1.1 - BIREME


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Id: lil-787544
Autor: DEMİRKAYA, Kadriye; AKGÜN, Özlem Martı; ŞENEL, Buğra; ÖNCEL TORUN, Zeynep; SEYREK, Melik; LACİVİTA, Enza; LEOPOLDO, Marcello; DOĞRUL, Ahmet.
Título: Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice
Fonte: J. appl. oral sci;24(3):218-222graf.
Idioma: en.
Resumo: ABSTRACT The most recently identified serotonin (5-HT) receptor is the 5-HT7 receptor. The antinociceptive effects of a 5-HT7 receptor agonist have been shown in neuropathic and inflammatory animal models of pain. A recent study demonstrated the functional expression of 5-HT7 receptors in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis, which receives and processes orofacial nociceptive inputs. Objective To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. Material and Methods Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0–12 min) and the late phase (Phase II: 12–30 min). Results LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test. Conclusion Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain.
Descritores: Analgésicos/uso terapêutico
Dor Facial/tratamento farmacológico
Piperazinas/uso terapêutico
Receptores de Serotonina
Agonistas do Receptor de Serotonina/uso terapêutico
-Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Dor Facial/induzido quimicamente
Formaldeído
Camundongos Endogâmicos BALB C
Reprodutibilidade dos Testes
Substância Gelatinosa/efeitos dos fármacos
Fatores de Tempo
Resultado do Tratamento
Nervo Trigêmeo/efeitos dos fármacos
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-751354
Autor: Jin, Xiaoqing; Cao, Guangxiang; Zhang, Xiaoxiao; Chen, Yuguo; Wang, Liang; Zhong, Chuanqing.
Título: Studies on the formation and synthetic mechanism of related substance G in potassium clavulanate production
Fonte: Braz. j. pharm. sci;51(1):77-83, Jan-Mar/2015. graf.
Idioma: en.
Projeto: Shandong Science and Technology Development Project.
Resumo: The objective of this study was to investigate the formation and synthetic mechanism of related substance G in potassium clavulanate production. The impurity in the potassium clavulanate final product, with a retention time of 13.5 min, was confirmed as related substance G by high performance liquid chromatography-mass spectrometry/mass spectrometry. Related substance G analysis during the production of clavulanic acid showed that this impurity could be synthesized during fermentation, and the amount increased with the fermentation time. Studies on its synthetic mechanism showed that L-tyrosine and succinic acid were the precursors for biosynthesis of related substance G in vivo. The reaction was deduced to be catalyzed by an enzyme. The enzyme was a type of extracellular enzyme present in the fermentation supernatant.

O objetivo deste estudo foi investigar a formação e o mecanismo sintético da substância G relacionada na produção de clavulanato de potássio. A impureza do produto final clavulanato de potássio, com tempo de retenção de 13,5 min, foi confirmada como substância G relacionada por cromatografia líquida de alta eficiência-espectrometria de massas/espectrometria de massas. A análise da substância G relacionada durante a produção do ácido clavulânico mostrou que essa impureza poderia ser sintetizada durante a fermentação e que a quantidade aumenta com o tempo de fermentação. Estudos do seu mecanismo sintético mostraram que a L-tirosina e o ácido succínico foram os precursores in vivo para a biossíntese da substância G relacionada. Deduziu-se que a reação foi catalisada por uma enzima. A enzima foi do tipo extracelular, presente no sobrenadante da fermentação.
Descritores: Substância Gelatinosa
-Cromatografia Líquida
Ácido Clavulânico
Espectrometria de Massas/métodos
Responsável: BR1.1 - BIREME



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