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Id: lil-755544
Autor: Pellón, Mario; Rojas, Mariana; Yaikin, Pabla; del Sol, Mariano.
Título: Estudio morfológico de la retina de salmones (Salmo salar) / Morphological study of the retina of salmon (Salmo salar)
Fonte: Int. j. morphol;33(2):788-793, jun. 2015. ilus.
Idioma: es.
Projeto: Universidad de La Frontera.
Resumo: La retina de peces teleósteos como pez cebra, se ha transformado en un importante modelo para el estudio de la plasticidad neuronal y la neurogénesis. Se ha demostrado además que la retina experimenta cambios ontogenéticos para adaptarse a distintos medios ambientes durante su vida. Este estudio tiene como objetivo describir el desarrollo ontogenético de la retina del alevín de salmón desde la eclosión hasta la fase de juvenil. Se trabajó con 30 salmones divididos en tres grupos de 10. Grupo I: recién eclosionados, con saco vitelino y 18 mm de longitud. Grupo II: sin saco vitelino y 30 mm de longitud. Grupo III: 100 mm de longitud. Cinco alevinesde cada grupo fueron procesados según el protocolo de Hanken & Wassersug para medir los diámetros dorsoventral y nasal-temporal utilizando el cartílago que protege al globo ocular. Los restantes cinco ejemplares fueron seccionados con micrótomo Microm en forma seriada (5 µm) y procesados con técnica H&E/Azul de Alcián. Se midieron las capas de la retina en un microscopio óptico Zeiss, con cámara Powershot incorporada y con un software Image Tool 3.0. El Grupo 1 presentó grandes ojos pigmentados, con aspecto de copa óptica embrionaria, la retina está estratificada en capas. La Capa Nuclear Interna (CNI) mide 62±10 µm y la capa plexiforme interna (CPI) 10±2 µm. El Grupo 2 presenta cambios en el espesor de ellas. La CNI disminuye su espesor a 45±8 µm y la Plexiforme aumenta a 25±5 µm. En los peces juveniles del Grupo 3, la CNI alcanza el espesor mínimo (15±3 µm), por el contrario, la capa Plexiforme interna aumenta su espesor hasta alcanzar (70±10 µm). En los tres grupos estudiados observamos en la periferia de la retina una zona proliferativa germinativa, que corresponde a un remanente del neuroepitelio embrionario, responsable del crecimiento continuado de la retina. La retina de los salmones puede ser también un importante modelo para el estudio de la ontogenia, la plasticidad neuronal y la neurogénesis. Esta neurogénesis en la retina de peces facilita la reordenación celular a lo largo de la ontogenia, lo que potencialmente permite la optimización del sistema visual a los cambios en las demandas visuales. Este estudio puede ser de utilidad para facilitar el diagnóstico en las patologías de ojo en salmonicultura y también puede contribuir a conocer mejor la regeneración de tejidos. Por otro lado, con estudios posteriores, la neurogénesis de la retina de peces podría extrapolarse al tratamiento de enfermedades humanas con daño a nivel retineal, tales como glaucoma, desprendimiento de retina y retinopatía diabética.

The retina of teleost fish zebrafish, has become an important model for studying neuronal plasticity and neurogenesis. It was further shown that the retina undergoes ontogenetic changes to adapt to different environments during their lifetime. This study aims to describe the ontogenetic development of the retina of juvenile salmon from hatching to the juvenile stage. We worked with 30 salmon divided into three groups of 10. Group I: newly hatched with yolk sac and 18 mm in length. Group II: without yolk sac and 30 mm in length. Group III: 100 mm long. Five fry each group were processed according to the protocol of Hanken & Wassersug to measure dorsoventral and nasal-temporal diameters using the cartilage that protects the eyeball. The remaining five specimens were sectioned with a microtome Microm serially (5 µm) and processed with technical H-E / Alcian blue. The layers of the retina were measured on a Zeiss optical microscope with camera Powershot built and with Image Tool 3.0 software. Group 1 showed large pigmented eyes, looking embryonic optic cup, the retina is stratified in layers. The inner nuclear layer (CNI) measured 62±10 microns and the inner plexiform layer (CPI) 10±2 µm. Group 2 presents changes in the thickness of them. The CNI decreases in thickness to 45±8 µm and the plexiform increased to 25±5 µm. In juvenile fish of group 3, the CNI reaches the minimum thickness (15±3 µm), by contrast, the inner plexiform layer thickness increases up to (70±10 µm). In the three groups observed in the periphery of the retina one proliferative germinative zone, which corresponds to a remnant of the embryonic neural epithelium responsible for the continued growth of the retina. The retina of the salmon can also be an important model for the study of ontogeny, neuronal plasticity and neurogenesis. This retinal neurogenesis fish rearrangement facilitates cell along ontogeny, potentially allowing optimization of the visual system to changes in the visual demands. This study may be useful to help diagnose pathologies in eye salmon and can also contribute to better understand tissue regeneration. On the other hand, with later studies, fish's retinal neurogenesis could be extrapolated to the treatment of human retinal diseases, such us glaucoma, retinal detachment o diabetic retinopathy.
Descritores: Retina/anatomia & histologia
Retina/crescimento & desenvolvimento
Salmo salar/anatomia & histologia
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-734647
Autor: Najafdari, Simin; Rezaei, Noorallah; Shafaroodi, Majid Malekzadeh; Ghafari, Soraya; Golalipour, Mohammad Jafar.
Título: Ganglionic cells apoptosis in retinal layer of rat offspring due to gestational diabetes / Células ganglionares apoptóticas en la capa de la retina de crías de ratas debido a la diabetes gestacional
Fonte: Int. j. morphol;32(4):1131-1135, Dec. 2014. ilus.
Idioma: en.
Projeto: Mazandaran University of Medical Sciences. Deputy Research; . Golestan University of Medical Sciences; . Gorgan Congenital Malformations Research Center.
Resumo: Previous studies have shown the adverse effects of gestational diabetes on hippocampal neuronal density in animal models. This study was conducted to determine the effect of gestational diabetes on retinal ganglionic cell density, the thickness of the retinal layer and apoptotic ganglionic cell density in 28-day-old of rat offspring. In this experimental study, 10 Wistar rat dams were randomly allocated in control and diabetic groups. Gestational diabetes was induced by 40 mg/kg/body weight of streptozotocin at the first day of gestation, intraperitoneally, dams in control group received an equivalent volume normal saline. At postnatal day 28, six offspring of each gestational diabetes and controls were randomly selected, sacrificed and sections (6 micrometer) were taken from the eye and stained with hematoxylin and eosin. The density of ganglionic cells and the number of dUTP end-labeling (TUNEL)-positive cells were evaluated in 20000 mm2 area of ganglion layer of the retina. The ganglionic cells density were reduced (27.4%) in gestational diabetic offspring in compared to controls (22.5±1.5 vs. 31.0±0.9, P<0.01). The apoptotic ganglionic cells of retina in interventional group significantly increased in compared to controls (6.74±0.60 vs. 5.12±0.26, P<0.02). This study showed that the uncontrolled gestational diabetes can reduce the number of ganglionic cells and increase apoptotic ganglionic cells of retina layer in rat offspring.

Estudios previos en un modelo animal han demostrado los efectos adversos de la diabetes gestacional en la densidad neuronal del hipocampo. El objetivo fue determinar el efecto de la diabetes gestacional en la densidad de las células ganglionares de la retina, en el espesor de la capa de la retina y en la densidad de las células apoptóticas ganglionares, en crías de ratas de 28 días. En este estudio experimental, 10 ratas Wistar fueron asignadas aleatoriamente en grupos control y diabéticos. La diabetes gestacional se indujo a partir de la administración de 40 mg/kg/peso corporal de estreptozotocina en el primer día de la gestación, por vía intraperitoneal. Al grupo control se administró un volumen equivalente de solución salina normal. En el día 28 luego del nacimiento, se seleccionaron aleatoriamente seis crías procedentes de los grupos con diabetes gestacional y controles, se eutanasiaron y se tomaron muestras de los ojos, en forma de secciones de 6 micrómetros, las cuales se tiñeron con H & E. La densidad de las células ganglionares y el número final de células dUTP positivas (TUNEL) se evaluaron a nivel de la capa ganglionar de la retina, en un área de 20.000 mm2. La densidad de las células ganglionares se redujo un 27,4% en la descendencia con diabetes gestacional en comparación con los controles (22,5±1,5 vs. 31,0±0,9, P<0,01). Las células ganglionares apoptóticas de la retina en el grupo con diabetes gestacional aumentaron significativamente en comparación con los controles (6,74±0,60 vs. 5,12 ± 0,26, P <0,02). Este estudio demostró que la diabetes gestacional no controlada puede reducir el número de células ganglionares y aumentar el número de células ganglionares apoptóticas de la capa de la retina en las crías de las ratas con diabetes gestacional.
Descritores: Retina/patologia
Células Ganglionares da Retina/patologia
Diabetes Gestacional/patologia
Apoptose
Diabetes Mellitus Experimental
-Efeitos Tardios da Exposição Pré-Natal
Retina/citologia
Glicemia
Contagem de Células
Ratos Wistar
Marcação In Situ das Extremidades Cortadas
Limites: Animais
Feminino
Gravidez
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-976383
Autor: Braga-Sá, Michelle B. P; Barros, Paulo S. M; Jorge, Juliana S; Dongo, Pamela; Finkensieper, Paula; Bolzan, Aline A; Watanabe, Sung S; Safatle, Angélica M. V.
Título: Retina assessment by optical coherence tomography of diabetic dogs / Avaliação da retina de cães diabéticos pela tomografia de coerência óptica
Fonte: Pesqui. vet. bras = Braz. j. vet. res;38(10):1966-1971, out. 2018. tab, ilus.
Idioma: en.
Projeto: FAPESP.
Resumo: Diabetes mellitus is one of the most common endocrine disorders characterized by relative or absolute lack of insulin; this can lead to several ocular manifestations, among them diabetic retinopathy and cataracts. Diabetic retinopathy (DR) is a microangiopathy that involves retinal precapillary arterioles, postcapillary venules, and large vessels, causing them to be functionally and anatomically incompetent. Hyperglycemia seems to be the most probable cause of damage to the retina due to interference in cellular metabolism and transduction processes. The aim of this study was to evaluate retinal thickness in eight diabetic dogs, four females and four males of different breeds and ages ranging from 6 to 15 years, by optical coherence tomography (OCT) and to compare them with non-diabetic dogs. Assessment provided by OCT in diabetic dogs showed retinal layers thinning and loss of stratification when compared to non-diabetic dogs (198μm versus 219μm respectively), with statistical significance (p=0.008). OCT images may suggest that diabetes mellitus causes retinal neuropathy in dogs, as also seen in diabetic humans.(AU)

Diabete melito é umas das principais endocrinopatias, caracterizada pela deficiência relativa ou absoluta de insulina, que pode resultar em diversas manifestações oculares, sendo as mais frequentes a retinopatia diabética e a catarata. Retinopatia diabética (RD) é uma microangiopatia que afeta primeiramente as arteríolas pré-capilares, capilares, vênulas pós-capilares e vasos de maior calibre, causando incompetência funcional e anatômica dos vasos retinianos. A hiperglicemia parece ser a causa mais provável da lesão retiniana, interferindo nas vias de metabolismo celular e no processo de transdução. Objetivou-se neste estudo avaliar e comparar a espessura retiniana total em oito cães diabéticos, quatro fêmeas e quatro machos, de diversas raças, com idade variando de seis a 15 anos, com auxílio de tomografia de coerência óptica (OCT) e comparar com a de cães não diabéticos. A espessura e arquitetura retiniana realizada pela OCT nos cães diabéticos, demonstrou afinamento das camadas da retina e perda da estratificação em comparação com os cães não diabéticos (198μm versus 219μm, respectivamente), sendo esta redução estatisticamente significante (p=0,008). Baseado nas imagens da OCT pode-se sugerir que a diabete melito, no cão, cause neuropatia retiniana como descrito em humanos diabéticos.(AU)
Descritores: Retina/diagnóstico por imagem
Diabetes Mellitus/veterinária
Retinopatia Diabética/veterinária
Cães
-Tomografia de Coerência Óptica/veterinária
Complicações do Diabetes
Limites: Animais
Cães
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-840045
Autor: Preti, Rony C; Mutti, Anibal; Ferraz, Daniel A; Zacharias, Leandro C; Nakashima, Yoshitaka; Takahashi, Walter Y; Monteiro, Mario LR.
Título: The effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on the OCT-measured macular choroidal thickness of eyes with proliferative diabetic retinopathy
Fonte: Clinics;72(2):81-86, Feb. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVES: To investigate the effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on macular choroidal thickness parameters in eyes with high-risk proliferative diabetic retinopathy. METHODS: High-risk proliferative diabetic retinopathy patients undergoing laser treatment were prospectively enrolled in this study. One eye was randomly selected for laser treatment combined with bevacizumab injections, study group, whereas the corresponding eye was subjected to laser treatment alone, control group. Spectral-domain optical coherence tomography with enhanced depth imaging was used to measure the macular choroidal thickness prior to and 1 month after treatment. Measurements in both groups were compared. Clinicaltrials.gov: NCT01389505. RESULTS: Nineteen patients (38 eyes) with a mean±standard deviation age of 53.4±9.3 years were evaluated, and choroidal thickness measurements for 15 patients were used for comparison. The greatest measurement before treatment was the subfoveal choroidal thickness (341.68±67.66 μm and 345.79±83.66 μm for the study and control groups, respectively). No significant difference between groups was found in terms of macular choroidal thickness measurements at baseline or after treatment. However, within-group comparisons revealed a significant increase in choroidal thickness parameters in 10 measurements in the study group and in only 5 temporal measurements in the control group when 1-month follow-up measurements were compared to baseline values. CONCLUSIONS: The macular choroidal thickness does not appear to be significantly influenced by laser treatment alone but increases significantly when associated with bevacizumab injections in patients with proliferative diabetic retinopathy and macular edema. Because bevacizumab injections reduce short-term laser pan-retinal photocoagulation-induced macular edema, our findings suggest that the choroid participates in its pathogenesis.
Descritores: Retina/patologia
Corioide/patologia
Inibidores da Angiogênese/administração & dosagem
Retinopatia Diabética/terapia
Bevacizumab/administração & dosagem
-Acuidade Visual
Estudos Retrospectivos
Resultado do Tratamento
Fotocoagulação a Laser
Terapia Combinada
Tomografia de Coerência Óptica
Retinopatia Diabética/patologia
Injeções Intravítreas
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-505562
Autor: Palheta-Neto, Francisco Xavier; Silva, Dorivaldo Lopes da; Almeida, Hirlena Gomes; D'Oliveira, Marcelo Silveira; Neiva, Murilo Miglio; Pezzin-Palheta, Angélica Cristina.
Título: Síndrome de Stickler: aspectos gerais / Stickler syndrome: general aspects
Fonte: Pediatr. mod;44(6):235-240, nov.-dez. 2008.
Idioma: pt.
Resumo: A síndrome de Stickler é a principal causa de descolamento de retina entre os fatores hereditários, sendo ainda pouco conhecida, apesar de comum na Europa. Constitui-se em doença autossômica dominante, progressiva, causada a partir de mutações em genes responsáveis pela síntese de colágeno, como COL2A1, COL11A1 e COL11A2. Possui variada sintomatologia, inclusive dentro de uma mesma família. Ocorrem alterações otorrinolaringológicas, oftalmológicas, ortopédicas e sistêmicas, como hipoacusia, fenda palatina, face plana, nariz achatado, miopia intensa, catarata, glaucoma, articulações hiperflexíveis e prolapso da valva mitral. Dentre as principais complicações dos indivíduos afetados se encontram surdez neurossensorial, descolamento da retina e cegueira. O artigo se constituiu em uma revisão bibliográfica sobre a síndrome de Stickler, abordando os principais sinais e sintomas clínicos, diagnóstico e tratamento, através da pesquisa e seleção de artigos científicos na biblioteca virtual BIREME, predominantemente de 2000 a 2006, associados a artigos clássicos sobre o tema. Devido a seu caráter progressivo, torna-se fundamental o diagnóstico precoce, na tentativa de evitar complicações que prejudiquem o desenvolvimento do indivíduo, havendo necessidade de tratamento multidisciplinar, devido ao acometimento de múltiplas estruturas.
Descritores: Retina/anormalidades
Tecido Conjuntivo/anormalidades
Vias Auditivas/anormalidades
-Anormalidades Congênitas/diagnóstico
Limites: Seres Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Revisão
Responsável: BR12.1 - Biblioteca Setorial da Ciências da Saúde


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Id: biblio-1005453
Autor: Varón-Plata, Clara Leonor; Jaramillo-Ángel, Sergio; Tello-Hernández, Alejandro.
Título: La retina para el médico no oftalmólogo / The retina for the non-oftalmologist doctor
Fonte: MedUNAB;13(1):31-37, 2010.
Idioma: es.
Resumo: La retina es un tejido fundamental en el órgano de la visión. En este artículo hacemos una revisión sobre la anatomía y fisiología de esta estructura así como sobre las principales patologías que la pueden afectar, entre ellas: desprendimiento de retina, retinopatía diabética y la enfermedad macular relacionada con la edad. Aunque actualmente contamos con técnicas médicas y quirúrgicas seguras y efectivas para el manejo de estas patologías, aún representan un reto para la ciencia médica, y en estados avanzados comprometen seriamente la función visual, por ello es de gran importancia que el médico general tenga claros los conceptos básicos sobre el diagnóstico de estas enfermedades, para realizar una remisión adecuada y así poder evitar al máximo secuelas visuales en el paciente. En este artículo revisamos libros de texto reconocidos y empleando MEDLINE, algunos artículos representativos sobre este tema, para mostrar un panorama general del estado actual, clínico e investigativo, del diagnóstico y tratamiento de las enfermedades más importantes que afectan la retina y el vítreo. [Varón CL, Jaramillo S, Tello A. La retina para el médico no oftalmólogo. MedUNAB 2010; 13:31-37].

The retina is a fundamental tissue of the visual organ. In this article we make a review of the anatomy and physiology of this structure as well as the main pathologies that may affect it like: retinal detachment, diabetic retinopathy, and age related macular degeneration. Although currently there are safe medical and surgical alternatives for the management of these diseases, they still represent a challenge for the medical science, and in advanced stages they seriously compromise visual function. For this reason it is of vital importance that the primary care physician has clear concepts about the diagnosis of these diseases, to perform an adequate referral, avoiding visual sequelae as much as possible. In this article we reviewed recognized textbooks and using MEDLINE we found some representative articles on this subject. We provide an overview of the current clinical and research status on the diagnosis and treatment of the most important diseases affecting retina and vitreous. [Varón CL, Jaramillo S, Tello A. The retina for non-ophthalmologist physician. MedUNAB 2010; 13:31-37].
Descritores: Retina
-Descolamento Retiniano
Retinopatia Diabética
Epitélio Pigmentado da Retina
Responsável: CO179.1 - Biblioteca


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Id: biblio-999030
Autor: Maza C, M. Pía de la; Algarin C, Cecilia; Rodríguez S, Juan Manuel.
Título: Evaluación piloto de la reducción de niveles séricos de productos de glicación avanzada (AGEs) sobre la electrofisiología de la visión, en pacientes con diabetes mellitus tipo 2 / Pilot evaluation of the serum levels reduction of advanced glication products (AGEs) on the vision electrophysiology in type 2 diabetic patients
Fonte: Rev. chil. endocrinol. diabetes;11(1):20-27, 2018. tab.
Idioma: es.
Resumo: BACKGROUND: Diabetic vascular complications are associated with elevated concentrations of advanced glycation end-products (AGEs). These substances can be originated endogenously by hyperglycaemia and oxidative stress, but also by dietary intake. There is indirect evidence suggesting that these complications can be prevented by lowering AGEs levels by dietary or pharmacological interventions, however its clinical benefits are still not clear enough because this would require long periods of treatment. Specific neuro-ophthalmologic tests like Multifocal Electroretinogram (MFERG) and visual evoked potentials (VEP) can detect retinal and myelinic nerve early changes, and thus could represent good methods to study the results of certain interventions in shorter lapses. The aim of this preliminary study was to evaluate the effects of a pharmacological intervention designed to lower AGEs levels, on these variables. PATIENTS AND METHODS: We included 7 patients with type 2 diabetes (DM2), with more than 5 and less than 10 years of disease, without clinically evident micro and macrovascular disease, without renal failure, hypothyroidism nor vitamin B12 deficiency, whose AGEs dietary intake was moderately elevated or high (according to dietary recalls). Upon admission, a clinical evaluation, urine and blood samples were obtained for routine labs, plus ultrasensitive C Reactive Protein (usCRP) as an inflammatory marker, and carboxymethyl-lysine (CML) as representative of AGEs. Then a complete ophthalmologic evaluation was performed, including fundus, MFERG and VEP. After the initial evaluation, placebo capsules were prescribed (12 daily capsules, 4 with each main meal) during 3 months, repeating the same initial evaluation at completion of this period. Then the active treatment followed, with capsules containing cholestyramine (4 capsules containing 500 mg each, totaling 6 g per day). Patients were cited each month, to register adverse events and repeating the same evaluation after this second 3 months period. RESULTS: The sample was composed of 2 male patients, mean age was 55.1 ± 3.8 years, and diabetes was managed with metformin plus other oral agents or o insulin (4 cases). In addition, 4 patients received lipid lowering and 4 antihypertensive drugs. Metabolic control and lipid levels were variable (ranges of HbA1c 6.2-8.4%, LDL cholesterol 45-141 mg/dL, triglycerides 70-220 mg/dL). AGEs levels represented by CML were highly variable (median 31.7, range min-max 3.4-58.9 ug/uL). Basal usCRP was also variable (median 405.9, range min-max 265.6-490.7 mg/L). The treatment was well tolerated, except for mild constipation associated with cholestiramine intake. No significant changes in electroretinography or evoked potentials were observed when comparing the initial placebo period with cholestyramine treatment. A significant increase in triglyceride levels and decrease of vitamin D levels after cholestyramine treatment was observed. No changes were detected in serum concentrations of CML, usCRP or glycemic control, after treatment. The latter variables were not correlated with neurophthalmologic studies. DISCUSSION: In this preliminary study we did not observe changes in MFERG nor VEP after 6 g/day cholestyramine treatment, which did not induce lowering of CML levels. This could be attributed to the many limitations of a pilot study, such as a small sample size, short duration of treatment, reduced doses. However this design allowed to evaluate the patients´ tolerance to the drug and rule out adverse effects, in order to plan further studies using the necessary doses to obtain lowering of AGEs
Descritores: Retina
Resina de Colestiramina/administração & dosagem
Produtos Finais de Glicação Avançada/efeitos dos fármacos
Diabetes Mellitus Tipo 2
Eletrorretinografia
-Projetos Piloto
Produtos Finais de Glicação Avançada/sangue
Potenciais Evocados Visuais
Lisina/análogos & derivados
Lisina/efeitos dos fármacos
Lisina/sangue
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-911265
Autor: Okunlola, A. I; Okunlola, C. K; Okani, C. O; Adewole, O. S; Ofusori, D. A; Komolafe, O. A; Ojo, S. K; Bejide, R. A; Ayoka, A. O; Ojewole, J. A. O.
Título: Histological studies on the retina and cerebellum of Wistar rats treated with ArteetherTM
Fonte: Braz. j. morphol. sci = Rev. bras. ciênc. morfol;31(1):28-32, 1/3/2014. ilus.
Idioma: en.
Resumo: Introduction: Arteether TM, a derivative of artemisinin, is among the recent drugs that have given renewed hope for combating malarial menace. The present study investigated the effects of arteetherTM on the histology of the retina and cerebellum of Wistar rats. Materials and Methods: Twenty adult albino Wistar rats weighing 150-200 g, were randomly divided into four groups (A, B, C and D) of five animals each and used for this study. Group A rats were given intramuscular (i.m.) arteetherTM (3 mg/kg b.w.) daily for 3 days. Group B rats were given i.m. arteetherTM (6 mg/kg b.w.) daily for 3 days. Group C rats were also given i. m. of arteetherTM (3 mg/kg b. w.) daily for 3 days, and the same dose was repeated at two-weekly intervals for 4 further weeks; while Group D rats which received normal saline (0.9 % w/v, 3 ml/kg b.w.), served as controls. At the end of the experiment, the rats were sacrificed by cervical dislocation. The retina and cerebellum were excised and processed routinely for histopathology changes, using haematoxylin and eosin stain (H & E), as well as Nissl stain. Results: Results obtained showed normal cellular components of the retina and cerebellum in all groups, and no cyto-pathological changes were observed. Conclusion: Thus, this study showed that under light microscopic examination, therapeutic doses of arteetherTM caused no significant cyto-pathologic changes in the retina and cerebellum of Wistar rats.(AU)
Descritores: Retina/anatomia & histologia
Cerebelo/anatomia & histologia
Artemisininas/farmacologia
Malária/prevenção & controle
-Técnicas Histológicas
Ratos Wistar
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-975677
Autor: Coli, Alessandra; Stornelli, Maria Rita; Lenzi, Carla; Giannessi, Elisabetta.
Título: Retinal ganglion cells in Strigidae raptors: distribution and morphometry / Células ganglionares de la retina en aves rapaces Strigidae: distribución y morfometría
Fonte: Int. j. morphol;36(4):1175-1179, Dec. 2018. tab, graf.
Idioma: en.
Resumo: The authors studied the morphometry and the topographical distribution of Retinal Ganglion Cells (RGCs) in four nocturnal raptors of the order of Strigiformes, family of Strigidae: little owl, tawny owl, scops owl, eared owl. In order to recognize specialized retinal vision areas (fovea and visual streak), the number of RGCs/mm2 and the soma size in the four retinal fields (dorsal, ventral, temporal and nasal) by the histological analysis of retinal radial sections were recorded. A temporal fovea was identified in little owl, tawny owl and eared owl while in scops owl this visual area was localized near the fundus oculi. A radial visual streak ventrally directed was pointed out in the retinas of the four raptors with different shape according to its width. The Authors linked the obtained data with the predatory behavior of nocturnal raptors in their habitat.

Se estudió la morfometría y la distribución topográfica de las células ganglionares de la retina (CGR) en cuatro aves rapaces nocturnas del orden de los Strigiformes, familia Strigidae: búho pequeño, mochuelo, autillo, y cárabo. Con el objetivo de definir las áreas de visión retiniana especializadas (fóvea y campo visual), se registró el número de CGRs/mm2 y el tamaño del soma en los cuatro campos retinianos (dorsal, ventral, temporal y nasal), mediante análisis histológico de las secciones radiales de la retina. Se identificó una fóvea temporal en mochuelo, búho leonado y búho pequeño, mientras que en el búho real, esta área visual se localizó cerca del fondo de ojo. Se observó un campo radial visual dirigido ventralmente en las retinas de las cuatro aves rapaces, con diferentes formas según su extensión. Se relacionaron los datos obtenidos con el comportamiento predatorio de aves rapaces nocturnas en su hábitat.
Descritores: Retina/citologia
Células Ganglionares da Retina/citologia
Estrigiformes/anatomia & histologia
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-728288
Autor: She, Qiusheng; An, Zhenqiang; Xia, Chengqiang; Kong, Yunfei; Chen, Enxiang.
Título: Study on comparative histology of retinas in Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans, Gekko japonicus, and Columba livia / Estudio histológico comparado de la retina en Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans, Gekko japonicus, y Columba livia
Fonte: Int. j. morphol;32(3):918-922, Sept. 2014. ilus.
Idioma: en.
Resumo: The objective of this study was to explore the relationship between the retinal structure and its life adaptation to the environment of Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans, Gekko japonicus and Columba livia . Measuring retinal thickness of each layer, the nuclei layer, and the diameter of each nuclear layer of the five animals, the statistical data analysis shows that: the nuclei layers of five animals are all 4, and their structures can be divided to 10 layers when observing with optical microscope. The retinal thickness of Ctenopharyngodon idella was 190.49 mm, Cynops orientalis was 173.07 µm, and the Bufo bufo gargarizans was 195.06 µm, Gekko japonicus was 224.32 µm and Columba livia was 174.10 µm. The number of retinal inner nuclear layers of Bufo bufo gargarizans and Gekko japonicus and Columba livia are more than their outer nuclear layers, on the contrary, retinal inner nuclear layers of Ctenopharyngodon idella and Cynops orientalis are less than their outer nuclear layers. The rod and cone layer of retina of Cynops orientalis were more advanced, but their nerve fiber layer (NFL) degraded highly, revealing a strong photosensitivity but a low visual sensitivity; to Columba livia , their NFL of retina are highly developed, so as their vision. The different structures and functions of the retina of Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans, Gekko japonicus and Columba livia correspond with their behavioral characteristics and the living environment's change from aquatic to amphibious to land.

El objetivo de este estudio fue explorar la relación entre las estructuras de la retina y su adaptación al medioambiente en Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans,Gekko japonicus y Columba livia . La medición del espesor de cada capa de la retina, la capa nuclear y su diámetro en los cinco animales, mostró a través del análisis estadístico que las capas nucleares en todos ellos fueron 4, y sus estructuras se pueden dividir en 10 capas cuando se observan con el microscopio óptico. El espesor de la retina de Ctenopharyngodon idella fue 190,49 µm, de Cynops orientalis fue 173,07 µm, de Bufo bufo gargarizans fue 195,06 µm, de Gekko japonicus fue 224,32 µm y de Columba livia fue 174,10 µm. El número de capas nucleares internas de la retina de Bufo gargarizans, Gekko japonicus y Columba livia fue mayor que sus capas nucleares externas, mientras que las capas nucleares internas de Ctenopharyngodon idella y Cynops orientalis fueron menos que las capas nucleares externas. La capa de conos y bastones de la retina de Cynops orientalis fue más desarrollada, pero su capa de fibras nerviosas presentó una elevada degeneración, lo que muestra una gran fotosensibilidad, pero una sensibilidad visual baja. En Columba livia, la capa de fibras nerviosas de la retina estuvo muy desarrollada, y de esta manera, su visión. El grado de desarrollo de las diferentes estructuras y funciones de la retina de Ctenopharyngodon idella, Cynops orientalis, Bufo bufo gargarizans, Gekko japonicus y Columba livia está relacionada con sus características de comportamiento y el cambio de las condiciones de las vidas acuática y anfibia en la tierra.
Descritores: Columbidae/anatomia & histologia
Retina/anatomia & histologia
Salamandridae/anatomia & histologia
Bufo bufo/anatomia & histologia
Carpas/anatomia & histologia
Lagartos/anatomia & histologia
-Adaptação
Histologia Comparada
Limites: Animais
Responsável: CL1.1 - Biblioteca Central



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