Base de dados : LILACS
Pesquisa : A10.165.114.830.500.500 [Categoria DeCS]
Referências encontradas : 58 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6 ir para página                

  1 / 58 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-950175
Autor: Oishi, Jorge Camargo; Castro, Cynthia Aparecida; Silva, Karina Ana; Fabricio, Victor; Cárnio, Evelin Capelari; Phillips, Shane A; Duarte, Ana Claudia Garcia de Oliveira; Rodrigues, Gerson Jhonatan.
Título: Endothelial Dysfunction and Inflammation Precedes Elevations in Blood Pressure Induced by a High-Fat Diet / Disfunção Endotelial e Inflamação Precedem a Elevação da Pressão Arterial Induzida por Dieta Hiperlipídica
Fonte: Arq. bras. cardiol;110(6):558-567, June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Background: Obesity leads to a chronic inflammatory state, endothelial dysfunction and hypertension. Objective: To establish the time-course of events regarding inflammatory markers, endothelial dysfunction, systolic blood pressure (SBP) in obesity in only one experimental model. Methods: We fed male Wistar rats (eight-week age) with a standard diet (Control - CT, n = 35), or palatable high-fat diet (HFD, n = 35) for 24 weeks. Every six weeks, 7 animals from each group were randomly selected for euthanasia. SBP and serum levels of interleukin-6, tumor necrosis factor-α, C-reactive protein, adiponectin and nitric oxide were determined. Endothelial and vascular smooth muscle functions were determined in dissected aorta and lipid peroxidation was measured. Statistical significance was set at p < 0.05. Results: Levels of pro-inflammatory cytokines began to increase after six weeks of a high-fat diet, while those of the anti-inflammatory cytokine adiponectin decreased. Interestingly, the endothelial function and serum nitric oxide began to decrease after six weeks in HFD group. The SBP and lipid peroxidation began to increase at 12 weeks in HFD group. In addition, we showed that total visceral fat mass was negatively correlated with endothelial function and positively correlated with SBP. Conclusion: Our results show the time-course of deleterious effects and their correlation with obesity.

Resumo Fundamento: A obesidade leva a um estado de inflamação crônica, disfunção endotelial e hipertensão. Objetivo: Estabelecer a sequência de eventos relacionados a marcadores inflamatórios, disfunção endotelial e pressão arterial sistólica (PAS) na obesidade em um modelo experimental. Métodos: Ratos Wistar machos (8 semanas de idade) receberam dieta padrão (Controle - CT, n = 35) ou uma dieta palatável hiperlipídica (DHL, n = 35) por 24 semanas. A cada seis semanas, 7 animais de cada grupo foram aleatoriamente selecionados para eutanásia. Foram determinados a PAS, e níveis séricos de interleucina-6, fator de necrose tumoral-a, proteína C reativa, adiponectina e óxido nítrico. As funções do músculo liso endotelial e vascular foram determinadas na aorta dissecada, e medida a peroxidação lipídica. A significância estatística foi estabelecida em p < 0,05. Resultados: os níveis das citocinas pró-inflamatórias começaram a aumentar após seis semanas de dieta hiperlipídica, enquanto os níveis da citocina anti-inflamatória adiponectina diminuíram. Um resultado interessante foi a redução da função endotelial e do óxido nítrico após seis semanas no grupo DHL. Além disso, mostramos que a massa de tecido adiposo visceral total esteve negativamente correlacionada com função endotelial e positivamente correlacionada com a PAS. Conclusão: Nossos resultados demonstram a progressão temporal dos efeitos deletérios e sua correlação com a obesidade.
Descritores: Endotélio Vascular/fisiopatologia
Dieta Hiperlipídica/efeitos adversos
Hipertensão/fisiopatologia
Inflamação/fisiopatologia
Obesidade/fisiopatologia
-Fatores de Tempo
Pressão Sanguínea/fisiologia
Ensaio de Imunoadsorção Enzimática
Endotélio Vascular/metabolismo
Peroxidação de Lipídeos
Distribuição Aleatória
Citocinas/análise
Ratos Wistar
Modelos Animais de Doenças
Gordura Intra-Abdominal
Hipertensão/metabolismo
Inflamação/metabolismo
Óxido Nítrico/sangue
Obesidade/complicações
Obesidade/metabolismo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  2 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1038532
Autor: Scorsatto, Mauara; Rosa, Glorimar; Pimentel, Aline de Castro; Luiz, Ronir Raggio; Oliveira, Gláucia Maria Moraes de.
Título: Is it Possible to Easily Identify Metabolically Healthy Obese Women? / É Possível Identificar Facilmente Mulheres Obesas Metabolicamente Saudáveis?
Fonte: Arq. bras. cardiol;111(5):733-737, Nov. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Background: Obesity is recognized as a major risk factor for the development of several metabolic complications. However, some obese individuals have a favorable metabolic profile. Objective: The aim of this study was to identify an easy parameter for recognizing metabolically healthy obese (MHO) women. Methods: A total of 292 non-diabetic women with a body mass index (BMI) ≥ 30 kg/m2 were selected, and 239 composed the final cohort. We classified the participants according to their metabolic state determined by homeostasis model assessment (HOMA) into MHO or metabolically unhealthy obese (MUO). Both groups were compared regarding biochemical, anthropometric, and body composition characteristics. Results: The average age of the cohort was 43.9 ± 10.9 years and the average BMI was 37.2 ± 5.3 kg/m2. In total, 75.7% of the participants were classified as MHO by HOMA. A cutoff of 108.2 cm for waist circumference (WC) identified MHO participants with a sensitivity of 72.4% (95% confidence interval [CI]: 59.8-82.3%), specificity of 66.9% (95% CI: 59.71-73.3%), and negative likelihood ratio of 0.41 (95% CI: 0.36-0.47). Additionally, a visceral adiposity index cutoff value of 99.2 identified MHO women with a sensitivity of 89.7% (95% CI: 79.2-95.2%), specificity of 48.6% (95% CI: 41.4-55.9%), and negative likelihood ratio of 0.21 (95% CI: 0.15-0.30). Conclusion: Women classified as MHO exhibited smaller WC measurements and lower body fat percentages, as well as lower blood glucose and insulin levels. WC emerged as an easy parameter for identifying MHO women.

Resumo Fundamento: A obesidade é reconhecida como um fator de risco importante no desenvolvimento de várias complicações metabólicas. Porém, alguns indivíduos obesos apresentam um perfil metabólico favorável. Objetivo: O objetivo do presente estudo foi identificar um parâmetro fácil para reconhecer mulheres obesas metabolicamente saudáveis (OMS) Métodos: Foram selecionadas 292 mulheres não diabéticas com índice de massa corporal (IMC) ≥ 30 kg/m2 e a coorte final foi composta de 239. De acordo com o estado metabólico determinado pelo modelo de avaliação da homeostase (HOMA), as participantes foram classificadas como obesas metabolicamente saudáveis (OMS) ou obesas metabolicamente não saudáveis (OMNS). Compararam-se ambos os grupos quanto às características bioquímicas, antropométricas e de composição corporal. Resultados: A idade média da coorte foi de 43,9 ± 10,9 anos e o IMC médio foi 37,2 ± 5,3 kg/m2. No total, 75,7% das participantes foram classificadas como OMS pelo HOMA. O ponto de corte para a circunferência da cintura (CC) de 108,2 identificou mulheres OMS com sensibilidade de 72,4% (intervalo de confiança [IC] de 95%: 59,8-82,3%), especificidade de 66,9% (IC 95%: 59,71-73,3%) e razão de verossimilhança negativa (RVN) de 0,41 (IC 95%: 0,36-0,47). Adicionalmente, o ponto de corte de 99,2 para o índice de adiposidade visceral (IAV) identificou mulheres OMS com sensibilidade de 89,7% (IC 95%: 79.2-95.2%), especificidade de 48,6% (IC 95%: 41,4-55,9%) e RVN de 0,21 (IC 95%: 0.15-0.30). Conclusões: Mulheres classificadas como OMS apresentaram menor CC, menor percentual de gordura corporal e menores níveis séricos de glicose e de insulina. A CC foi identificada como um parâmetro fácil para identificar mulheres OMS.
Descritores: Síndrome Metabólica/diagnóstico
Circunferência da Cintura
Obesidade/diagnóstico
-Fenótipo
Triglicerídeos/sangue
Glicemia/análise
Resistência à Insulina
Biomarcadores/metabolismo
Índice de Massa Corporal
Sensibilidade e Especificidade
Síndrome Metabólica/metabolismo
Gordura Intra-Abdominal/metabolismo
Confiabilidade dos Dados
Insulina/sangue
Obesidade/metabolismo
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  3 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-1143267
Autor: Ascar, Graciela Inés; Bassino, Cintia; Huespe, Cristina Beatriz; Hernández, María Mercedes; Aparicio, Lourdes.
Título: Correlación de parámetros antropométricos predictores del riesgo de aparición de diabetes mellitus / Correlation of the anthropometric parameters predictors of emerging risk for diabetes mellitus
Fonte: Medisan;24(6)graf.
Idioma: es.
Resumo: Introducción: Existen parámetros antropométricos predictivos del riesgo de padecer diabetes mellitus que pueden correlacionarse, tal como el índice de masa corporal, el porcentaje de grasa corporal, el perímetro de la cintura y el porcentaje de grasa visceral. Objetivo: Establecer el riesgo potencial de padecer diabetes mellitus de tipo 2 mediante la correlación de indicadores y medidas antropométricas aplicables a la población local. Métodos: Se realizó un estudio epidemiológico, transversal, observacional y analítico de 118 individuos jóvenes, en la Universidad Católica de Córdoba, en Córdoba, Argentina, durante el mes de septiembre de 2019, en el cual se aplicó el FINnish Diabetes Risk Score, tomando además como indicadores los porcentajes de grasa corporal y de grasa visceral. En el análisis estadístico de las variables cuantitativas y cualitativas se utilizaron el promedio y la desviación estándar como medidas descriptivas; asimismo, se aplicaron las pruebas de normalidad de Shapiro-Wilk y de Kolmogorow-Smirnov y el coeficiente de correlación de Spearman para probar las hipótesis estadísticas planteadas. Resultados: Se encontró que la mayoría de la población era de bajo riesgo y la correlación entre el índice de masa corporal y la grasa corporal que se ajustaba era Y=1,18X+4,06; donde Y fue el porcentaje de grasa corporal y X el índice de masa corporal. Para correlacionar el perímetro de la cintura y el porcentaje de grasa visceral se ajustaban Y=0,21X-10,21 para hombres y Y=0,17X-7,84 para mujeres, donde Y fue el porcentaje de grasa visceral y X el perímetro de la cintura. Conclusiones: El conocimiento del estado de salud de una población lleva a la capacitación y asistencia para el autocuidado y la adquisición de hábitos saludables, que contribuyan a una adultez con calidad de vida.

Introduction: There are risk anthropometric predictors parameters of suffering from diabetes mellitus that can be correlated, such as the body mass index, body fat percentage, waist perimeter and visceral fat percentage. Objective: To establish the potential risk of suffering from type2 diabetes mellitus by means of the correlation of indicators and anthropometric measures applicable to a local population. Methods: An epidemiological, cross-sectional, observational and analytic study of 118 young individuals was carried out in the Catholic University of Córdoba, in Córdoba, Argentina, during the month of September, 2019, in which the FINnish Diabetes Risk Score was implemented, the body fat and visceral fat percentages were also taken as warning signs. In the statistical analysis of the quantitative and qualitative variables the average and the standard deviation were used as descriptive measures; also, the Shapiro-Wilks and Kolmogorow-Smirnov normality tests and the Spearman correlation test were implemented to prove the outlined statistical hypotheses. Results: It was found that it was a low risk population and the correlation between the body mass index and the body fat that was adjusted was Y=1.18X+4.06; where Y was the body fat percentage and X the body mass index. To correlate the waist perimeter and the visceral fat percentage Y=0,21X-10,21 for men and Y=0,17X-7,84 for women were adjusted, where Y was the visceral fat percentage and X the waist perimeter. Conclusions: The knowledge of the population health condition leads to the training and assistance for the selfcare and to the acquisition of healthy habits that contribute to an adulthood with life quality.
Descritores: Pesos e Medidas Corporais
Diabetes Mellitus/prevenção & controle
-Gordura Intra-Abdominal
Obesidade Abdominal
Responsável: CU418.1 - Centro Provincial de Información de Ciencias Médicas de Santiago de Cuba


  4 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Texto completo
Id: biblio-1126439
Autor: Basurto Acevedo, Lourdes; Córdova Pérez, Nydia; García Vega, Jessica Michel; Robledo Bandala, Ariadna; Luqueño de la Rosa, Eva; Díaz Martínez, Alma Grisel; Vega García, Sara; García de la Torre, Paola; Basurto Acevedo, Norma Eleanne.
Título: El perímetro de cuello y su relación con los factores de riesgo cardiometabólico en las mujeres / Neck´s perimeter and its relation with the cardiometabolic risk factors in women
Fonte: Rev. cuba. endocrinol;30(3):e155, sept.-dic. 2019. tab, graf.
Idioma: es.
Resumo: RESUMEN Introducción: El perímetro de cuello en la actualidad es una medida útil asociada de manera significativa a la resistencia a la insulina y al riesgo cardiometabólico. Objetivo: Determinar la relación entre el perímetro de cuello y los factores de riesgo cardiometabólico en mujeres de 45 a 60 años de edad. Métodos: Se realizó un estudio en 270 mujeres aparentemente sanas, de 45 a 60 años de edad. Se tomaron medidas antropométricas como peso corporal, índice de masa corporal, perímetro de cintura, perímetro de cuello y el tejido adiposo visceral por bioimpedancia. Se determinaron niveles séricos de glucosa, perfil lipídico (colesterol, triglicéridos, HDL-colesterol, LDL-colesterol), HbA1c, insulina y proteína C reactiva. Resultados: El índice de masa corporal de las participantes fue de 28,2 ± 4,2. Se encontró que 38,1 por ciento de las mujeres presentaban síndrome metabólico y mayor perímetro de cuello, en comparación con las participantes sin síndrome (36,8 + 2,1 vs 35,1 + 1,6 cm, respectivamente, p< 0,0001). El perímetro de cuello se asoció positivamente con índice de masa corporal (r= 0,690, p= 0,0001), tejido adiposo visceral (r= 0,548, p= 0,0001), circunferencia de Cintura (r= 0,640, p< 0,0001), glucosa (r= 0,251, p= 0,0001), triglicéridos (r= 0,143, p= 0,019), HbA1c (r= 0,160, p= 0,010) y proteína C reactiva (r= 0,342, p= 0,001). Conclusiones: Las mujeres con incremento en el perímetro de cuello presentan un perfil de riesgo cardiometabólico aumentado. La medición del perímetro de cuello representa un método útil y práctico en la predicción del riesgo cardiometabólico(AU)

ABSTRACT Introduction: Neck´s perimeter is nowadays a useful measure significantly associated to insulin resistance and to cardiometabolic risk. Objective: To determine the relation between the neck´s perimeter and the cardiometabolic risk factors in women from 45 to 60 years old. Methods: A study was performed in 270 apparently healthy women, aging 45 to 60 years old. Anthropometric measurements were taken such as weight, body mass index, waist circumference, neck´s perimeter and visceral adipose tissue by bioelectrical impedance analysis. There were identified serum levels of glucose, lipid profile (cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol), HbA1c, insulin and C-reactive protein. Results: The body mass index of the participants was 28.2 ± 4.2. It was found that 38.1 percent of the women had a metabolic syndrome and a higher perimeter of neck, in comparison with participants without the syndrome (36.8 + 2.1 vs 35.1 + 1.6 cm, respectively, p< 0.0001). The neck´s perimeter was positively associated with body mass index (r = 0.690, p= 0.0001), visceral adipose tissue (r = 0.548, p= 0.0001), waist circumference (r = 0.640, p< 0.0001), glucose (r = 0.251, p= 0.0001), triglycerides (r = 0.143, p = 0.019), HbA1c (r = 0.160, p = 0.010) and C-reactive protein (r = 0.342, p = 0.001). Conclusions: Women with an increase in the neck´s perimeter have a profile of increased cardiometabolic risk. The measurement of neck´s perimeter represents a useful and practical method for the prediction of cardiometabolic risk(AU)
Descritores: Medidas, Métodos e Teorias
Fatores de Risco
Síndrome Metabólica/epidemiologia
Circunferência da Cintura
Pescoço/crescimento & desenvolvimento
-Índice de Massa Corporal
Gordura Intra-Abdominal
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: CU1.1 - Biblioteca Médica Nacional


  5 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1118805
Autor: Estay H, Camila; Simian M, Daniela; Escaffi F, María José; Figueroa C, Carolina; Ibañéz L, Patricio; Lubascher C, Jaime; Kronberg, Udo; Flores P, Lilian; Quera P, Rodrigo.
Título: Obesidad y enfermedad inflamatoria intestinal / Obesity and inflammatory bowel disease
Fonte: Gastroenterol. latinoam;28(3):177-184, 2017.
Idioma: es.
Resumo: Incidence of obesity is rising worldwide, Chile is no exception with obese patients representing up to one third of general population. This parallels with increasing prevalence of inflammatory bowel disease (IBD). Contrary to conventional belief, comorbidity is high (15-40%), where both diseases present with chronic inflammation and dysbiosis which alters intestinal barrier. Causality between obesity and IBD is difficult to stablish and evidence is scarce to determine association. Obesity would be a risk factor for IBD, particularly in Crohn´s Disease (CD), females and obesity at young age. Other than body mass index (BMI), visceral adipose tissue (VAT) has been recently determined as the best indicator of metabolic and endocrine consequences of obesity. Increasing values of VAT have been related to complicated IBD and worst prognosis. On IBD-related therapy, increasing BMI has been related to suboptimal doses and in biologic therapy, obesity raises the probability of flares, loss of response and therapy optimization. Obese patients require IBD-related surgery before non-obese patients and present more postoperative complications. Similarly, VAT is an independent risk factor for postoperative recurrence in CD. Altogether this evidence suggests that obesity does have an influence on IBD, therefore, multidisciplinary healthcare providers should prevent, educate and intervene actively in obesity in order to improve results in intestinal disease

La obesidad ha ido aumentando progresivamente a nivel mundial. Chile no es la excepción, donde un tercio de la población es obesa. Así mismo, la incidencia y prevalencia de la enfermedad inflamatoria intestinal (EII) también ha ido en aumento. La comorbilidad entre obesidad y EII es alta (15-40%) donde ambas presentan inflamación crónica y dentro de su patogenia tienen en común la disbiosis, que altera la función de barrera intestinal. Establecer una asociación de causalidad es difícil y la evidencia es escasa en relación a su asociación. La obesidad puede ser considerada como factor de riesgo para EII, particularmente en pacientes con Enfermedad de Crohn (EC), mujeres y obesidad temprana. Además, se ha establecido que el tejido adiposo visceral (TAV) es mejor indicador de las consecuencias metabólicas de la obesidad en comparación al índice de masa corporal (IMC) y se ha asociado a EII más complicada y peor evolución natural. Con respecto a la terapia, los pacientes con mayor IMC tienen con mayor frecuencia, dosis subóptima de los fármacos, y en terapia biológica, la obesidad aumenta la probabilidad de crisis, pérdida de respuesta al fármaco u optimización de la terapia. Los pacientes obesos requieren cirugía relacionada a EII antes que los pacientes no obesos, presentan más complicaciones postoperatorias y el TAV es un factor de riesgo independiente para recurrencia postoperatoria en EC. Todos estos resultados sugieren que la obesidad influye en la EII, por lo que una intervención activa y multidisciplinaria pudiese mejorar también los resultados en la enfermedad intestinal.
Descritores: Doenças Inflamatórias Intestinais/complicações
Doenças Inflamatórias Intestinais/epidemiologia
Obesidade/complicações
Obesidade/epidemiologia
-Doenças Inflamatórias Intestinais/fisiopatologia
Doenças Inflamatórias Intestinais/terapia
Colite Ulcerativa
Doença de Crohn
Comorbidade
Fatores de Risco
Gordura Intra-Abdominal
Obesidade/fisiopatologia
Obesidade/terapia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL61.1 - Biblioteca Central Campus Sur


  6 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
Id: biblio-1047917
Autor: Terra, Marcella Martind; Machado, Hussen; Pinheiro, Hélady Sanders; Guerra, Martha de Oliveira; Peters, Vera Maria.
Título: Avaliação do efeito da quercetina em ratos Wistar com síndrome metabólica / Evaluation of the effect of quercetin in Wistar rats with metabolic syndrome
Fonte: HU rev;44(2):149-155, 2018.
Idioma: pt.
Resumo: Introdução: O tratamento da síndrome metabólica (SM) é um desafio, uma vez que terapias não medicamentosas são de difícil implementação e o tratamento farmacológico ideal não está totalmente estabelecido. Objetivo: Avaliar o efeito da quercetina na pressão arterial (PA), dislipidemia e acúmulo de gordura visceral em modelo experimental de SM induzida por dieta hiperlipídica. Material e Métodos: Ratos Wistar receberam ração hiperlipídica a partir da quarta semana de vida, por 20 semanas. O grupo tratado recebeu quercetina a partir da oitava semana de vida. Avaliou-se semanalmente o peso corporal e a PA de cauda por pletismografia. Ao final do experimento foram realizados testes de perfil glicêmico e lipídico. Resultados:A administração de dieta hiperlipídica se associou ao desenvolvimento de SM, caracterizada por acúmulo central de gordura, hipertensão arterial, hiperglicemia e hipertrigliceridemia. A quercetina não apresentou eficácia no tratamento das comorbidades que compõem a SM. Conclusão: A administração crônica diária da quercetina em modelo experimental de SM induzida por dieta hiperlipídica não alterou de forma significante o perfil nutricional, metabólico e pressórico dos animais.

Introduction: The treatment of the metabolic syndrome (MetS) is a challenge, since nonpharmacologic therapies are difficult to implement and the ideal pharmacologic treatment has not been completely established. Aim: To evaluate the effect of quercetin in blood pressure (BP), dyslipidemia, visceral fat accumulation, in an experimental model of MetS induced by a hyperlipidic diet. Material and Methods: Wistar rats received high fat diet feed from the fourth week of life for 20 weeks. The treatment group received quercetin from the eighth week of life. Body weight and tail BP through pletysmography were evaluated weekly. At the end of the experiment, tests of glucose and lipid profile. Results: The administration of a high fat diet was associated to the development of MetS, characterized by an accumulation of central fat, arterial hypertension, hyperglycemia, and hypertriglyceridemia. Quercetin was not effective in the treatment of comorbidities associated with MetS. Conclusion: Chronic daily administration of quercetin in an experimental model of MetS induced by a hyperlipidic diet did not significantly alter the nutritional, metabolic, and pressure profile of the animals.
Descritores: Síndrome Metabólica
Obesidade
-Quercetina
Fatores de Risco
Tratamento Farmacológico
Gordura Intra-Abdominal
Dislipidemias
Dieta Hiperlipídica
Doenças Metabólicas
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


  7 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-887565
Autor: Haymana, Cem; Sonmez, Alper; Aydogdu, Aydogan; Tapan, Serkan; Basaran, Yalcin; Meric, Coskun; Baskoy, Kamil; Dinc, Mustafa; Yazici, Mahmut; Taslipinar, Abdullah; Barcin, Cem; Yilmaz, Mahmut Ilker; Bolu, Erol; Azal, Omer.
Título: Visceral adiposity index and triglyceride/high-density lipoprotein cholesterol ratio in hypogonadism
Fonte: Arch. endocrinol. metab. (Online);61(3):282-287, May-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and independent predictors of cardiaovascular risk. To date, no study has evaluated VAI levels and TG/HDL-C ratio in hypogonadism. Subjects and methods A total of 112 patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age, 21.7 ± 2.06 years) and 124 healthy subjects (mean age, 21.5 ± 1.27 years) were enrolled. The demographic parameters, VAI, TG/HDL-C ratio, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants. Results The patients had higher total cholesterol (p = 0.04), waist circumference, triglycerides, insulin, and HOMA-IR levels (p = 0.001 for all) than the healthy subjects. VAI and ADMA and TG/HDL-C levels were also higher in patients than in healthy subjects (p < 0.001 for all). VAI was weakly correlated with ADMA (r = 0.27, p = 0.015), HOMA-IR (r = 0.22, p = 0.006), hs-CRP (r = 0.19, p = 0.04), and total testosterone (r = −0.21, p = 0.009) levels, whereas TG/HDL-C ratio was weakly correlated weakly with ADMA (r = 0.30, p = 0.003), HOMA-IR (r = 0.22, p = 0.006), and total testosterone (r = −0.16, p = 0.03) levels. Neither VAI nor TG/HDL-C ratio determined ADMA, HOMA-IR, and hs-CRP levels. Conclusions The results of this study demonstrate that patients with hypogonadism have elevated VAI and TG/HDL-C ratio. These values are significantly correlated with the surrogate markers of endothelial dysfunction, inflammation, and insulin resistance. However, the predictive roles of VAI and TG/HDL-C ratio are not significant. Prospective follow-up studies are warranted to clarify the role of VAI and TG/HDL-C ratio in predicting cardiometabolic risk in patients with hypogonadism.
Descritores: Triglicerídeos/sangue
Gordura Intra-Abdominal/metabolismo
Adiposidade/fisiologia
Hipogonadismo/metabolismo
Lipoproteínas HDL/sangue
-Arginina/análogos & derivados
Arginina/sangue
Algoritmos
Proteína C-Reativa/análise
Resistência à Insulina/fisiologia
Endotélio Vascular/fisiopatologia
Biomarcadores/sangue
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/metabolismo
Estudos de Casos e Controles
Valor Preditivo dos Testes
Hipogonadismo/complicações
Limites: Humanos
Masculino
Adulto Jovem
Responsável: BR1.1 - BIREME


  8 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Bettiol, Heloisa
Barbieri, Marco Antonio
Texto completo
Id: biblio-950068
Autor: Barroso, Lygia N; Farias, Dayana R; Soares-Mota, Marcia; Bettiol, Heloisa; Barbieri, Marco Antônio; Foss, Milton Cesar; Silva, Antônio Augusto M da; Kac, Gilberto.
Título: Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism
Fonte: Arch. endocrinol. metab. (Online);62(3):285-295, May-June 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: The role of bone markers on insulin resistance (IR) remains controversial. The objective of this study is to evaluate the association between bone mineral density (BMD) and glucose metabolism and investigate if visceral hyperadiposity, evaluated by waist circumference (WC), is an effect modifier of this association. Subjects and methods: Cross-sectional analysis with 468 young adults from the fourth follow-up of the 1978/79 Ribeirão Preto prospective birth cohort, Brazil. BMD, total osteocalcin (OC), fasting plasma glucose and insulin concentrations were assessed. IR, sensitivity (S) and secretion (β) were estimated by homeostasis model assessment (HOMA) indexes. Multiple linear regression models were constructed to estimate the association between BMD and glucose metabolism. Beta coefficient, R2 and p-values were provided. WC was tested as an effect modifier and OC as a confounder. The covariates were selected based on Direct Acyclic Graph. Results: Significant interaction between BMD (femoral neck and proximal femur areas) and WC on glucose metabolism was observed in the adjusted models. Subjects with increased WC presented a positive association between BMD and log HOMA1-IR while an inverse association was found in those with normal WC (femoral neck R2 = 0.17, p = 0.036; proximal femur R2 = 0.16, p = 0.086). BMD was negatively associated with log HOMA2-S in individuals with increased WC and positively in those with normal WC (femoral neck R2 = 0.16, p = 0.042; proximal femur R2 = 0.15, p = 0.097). No significant associations between BMD, log HOMA2-β and OC and glucose metabolism markers were observed. Conclusions: BMD was associated with glucose metabolism, independently of OC, and WC modifies this association.
Descritores: Glicemia/metabolismo
Densidade Óssea/fisiologia
Gordura Intra-Abdominal/fisiologia
Circunferência da Cintura/fisiologia
Fatores Imunológicos/fisiologia
-Glicemia/fisiologia
Osteocalcina/sangue
Estudos Transversais
Jejum
Insulina/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


  9 / 58 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Arruda, Ilma Kruze Grande de
Texto completo
Id: biblio-950076
Autor: Pinho, Cláudia Porto Sabino; Diniz, Alcides da Silva; Arruda, Ilma Kruze Grande de; Leite, Ana Paula Dornelas Leão; Petribu, Marina de Moraes Vasconcelos; Rodrigues, Isa Galvão.
Título: Waist circumference measurement sites and their association with visceral and subcutaneous fat and cardiometabolic abnormalities
Fonte: Arch. endocrinol. metab. (Online);62(4):416-423, July-Aug. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Objectives: To estimate the degree of variability of the waist circumference (WC) when obtained in different anatomical sites and compare the performance of the measurement sites as predictors of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and cardiometabolic abnormalities. Subjects and methods: Cross-sectional study involving 119 individuals with overweight (50.3 ± 12.2 years), in which six WC measurement sites were evaluated (minimal waist, immediately below the lowest rib, midpoint between the lowest rib and the iliac crest, 2 cm above the umbilicus, immediately above the iliac crest, umbilicus level), in addition to the VAT and SAT (quantified by computed tomography) and cardiometabolic parameters. Results: The differences between the measurements ranged from 0.2 ± 2.7 cm to 6.9 ± 6.7 cm for men, and from 0.1 ± 3.7 cm to 10.1 ± 4.3 cm for women. The minimum waist showed significant correlation with VAT (r = 0.70) and with a higher number of cardiometabolic parameters among men. Regarding women, the WC measurement showed high correlation with SAT and moderate correlation with VAT, not being found superiority of one measurement protocol in relation to the others when assessed the correlation with VAT and with cardiometabolic parameters. Conclusions: Greater variability between the measuring sites was observed among women. With respect to men, the minimum waist performed better as a predictor of VAT and cardiometabolic alterations.
Descritores: Anormalidades Cardiovasculares/sangue
Gordura Intra-Abdominal/diagnóstico por imagem
Gordura Subcutânea/diagnóstico por imagem
Sobrepeso/diagnóstico
Circunferência da Cintura
-Triglicerídeos/sangue
Proteína C-Reativa/análise
Hemoglobina A Glicada/análise
Tomografia Computadorizada por Raios X
Fatores Sexuais
Antropometria/métodos
Colesterol/sangue
Estudos Transversais
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Medição de Risco/normas
Anormalidades Cardiovasculares/prevenção & controle
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  10 / 58 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Reis, Rosana Maria dos
Texto completo
Id: biblio-1019352
Autor: Ribeiro, Victor Barbosa; Kogure, Gislaine Satyko; Lopes, Iris Palma; Silva, Rafael Costa; Pedroso, Daiana Cristina Chielli; Ferriani, Rui Alberto; Furtado, Cristiana Libardi Miranda; Reis, Rosana Maria dos.
Título: Association of measures of central fat accumulation indices with body fat distribution and metabolic, hormonal, and inflammatory parameters in women with polycystic ovary syndrome
Fonte: Arch. endocrinol. metab. (Online);63(4):417-426, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To investigate the associations among visceral adiposity index (VAI), lipid accumulation product (LAP), body fat percentage (%), and android/gynoid ratio (A/G ratio) in women with polycystic ovary syndrome (PCOS) and verify if the parameters representative of visceral obesity correlate with and exhibit the same frequency as body composition variables; anthropometric indices; and metabolic, hormonal, and inflammatory parameters. Subjects and methods This was a cross-sectional study that included 94 women with PCOS. Hormonal, metabolic, and inflammatory parameters were analyzed in all women. Free androgen index (FAI) and homeostasis model assessment (HOMA-IR), as well as LAP, VAI, and anthropometric indices, were calculated. The regions of interest (ROIs) in body composition and body composition indices were evaluated using a dual X-ray absorptiometry (DXA). Overall, 32 variables were selected as markers of body fat distribution. Results Among the 32 markers evaluated, 29 correlated with LAP, whereas 25 correlated with VAI, 19 with body fat (%), and 30 with A/G ratio. Additionally, some markers correlated with the four adiposity indices evaluated: ROIs, except for total mass and leg fat (%); body composition (body mass index, waist circumference, and hip circumference) indices; fasting insulin; and C-reactive protein. Conclusion LAP and VAI may be sensitive measures for screening and preventing metabolic syndrome and insulin resistance in PCOS, with LAP being more sensitive than VAI, and the A/G ratio may be more sensitive than body fat percentage.
Descritores: Síndrome do Ovário Policístico/sangue
Gordura Intra-Abdominal
Distribuição da Gordura Corporal
-Testosterona/sangue
Glicemia/análise
Composição Corporal
Proteína C-Reativa/análise
Globulina de Ligação a Hormônio Sexual/análise
Biomarcadores/sangue
Estudos Transversais
Sensibilidade e Especificidade
Mediadores da Inflamação/sangue
Sobrepeso/sangue
Produto da Acumulação Lipídica
Insulina/sangue
Limites: Humanos
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME



página 1 de 6 ir para página                
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde