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Id: biblio-1119554
Autor: Ramos, Érika Antônia dos Anjos.
Título: Análise da qualidade óssea de pacientes com fratura de mandíbula submetidos ao tratamento de fixação interna rígida, por meio de tomografia computadorizada / Bone quality assessment of patients with mandible fixed rigid internal fixation by computed tomography.
Fonte: São Paulo; s.n; 20200000. 93 p.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Odontologia para obtenção do grau de Mestre.
Descritores: Calo Ósseo
Fixação Interna de Fraturas
Mandíbula
-Densidade Óssea
Responsável: BR97.1 - Serviço de Documentação Odontológica


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Volpon, José Batista
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Id: biblio-983685
Autor: Botega, Iara Inácio; Zamarioli, Ariane; Guedes, Patrícia Madalena San Gregório; Silva, Raquel Assed Bezerra da; Issa, João Paulo Mardegan; Butezloff, Mariana Maloste; Sousa, Yara Terezinha Corrêa Silva; Ximenez, João Paulo Bianchi; Volpon, José Batista.
Título: Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture
Fonte: Acta cir. bras;34(1):e20190010000002, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the effects of food restriction on fracture healing in growing rats. Methods: Sixty-eight male Wistar rats were assigned to two groups: (1) Control and (2) Dietary restriction. After weaning the dietary restricted animals were fed ad libitum for 42 days with 50% of the standard chow ingested by the control group. Subsequently, the animals underwent bone fracture at the diaphysis of the right femur, followed by surgical stabilization of bone fragments. On days 14 and 28 post-fracture, the rats were euthanized, and the fractured femurs were dissected, the callus was analyzed by dual-energy X-ray absorptiometry, micro-computed tomography, histomorphometry, mechanical tests, and gene expression. Results: Dietary restriction decreased body mass gain and resulted in several phenotypic changes at the bone callus (a delay in cell proliferation and differentiation, lower rate of newly formed bone and collagen deposition, reductions in bone callus density and size, decrease in tridimensional callus volume, deterioration in microstructure, and reduction in bone callus strength), together with the downregulated expression of osteoblast-related genes. Conclusion: Dietary restriction had detrimental effects on osseous healing, with a healing delay and a lower quality of bone callus formation.
Descritores: Calo Ósseo/fisiologia
Densidade Óssea/fisiologia
Consolidação da Fratura/fisiologia
Desnutrição
Fraturas do Fêmur/fisiopatologia
Fraturas Fechadas/fisiopatologia
-Osteoporose/prevenção & controle
Ratos Wistar
Fraturas do Fêmur/diagnóstico por imagem
Fixação Intramedular de Fraturas
Fraturas Fechadas/diagnóstico por imagem
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Volpon, José Batista
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Id: biblio-886184
Autor: Guimarães, Ana Paula Franttini Garcia Moreno; Butezloff, Mariana Maloste; Zamarioli, Ariane; Issa, João Paulo Mardegan; Volpon, José Batista.
Título: Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture
Fonte: Acta cir. bras;32(11):924-934, Nov. 2017. graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats. Methods: Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate. Fractures were created at the mid-diaphysis of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire. The DN was injected intramuscularly twice per week (10 mg/kg of body mass). The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia. The newly formed bone and collagen type I levels were quantified in the callus. Results: The treated animals had longer femurs after 28 days. The quality of the intact bone was not significantly different between groups. The bone callus did show a larger mass in the treated rats. Conclusion: The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.
Descritores: Calo Ósseo/fisiologia
Consolidação da Fratura/efeitos dos fármacos
Fraturas do Fêmur/tratamento farmacológico
Anabolizantes/farmacologia
Nandrolona/análogos & derivados
-Densidade Óssea/fisiologia
Ratos Wistar
Consolidação da Fratura/fisiologia
Nandrolona/farmacologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-771937
Autor: Paiva, A G; Yanagihara, G R; Macedo, A P; Ramos, J; Issa, J P M; Shimano, A C.
Título: Analysis of fracture healing in osteopenic bone caused by disuse: experimental study
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(3):e5076, Mar. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP; . CnPq.
Resumo: Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture healing has been investigated in several previous studies because there is still controversy over the effect osteoporosis has on the healing process. The current study aimed to analyze two different periods of bone healing in normal and osteopenic rats. Sixty, 7-week-old female Wistar rats were randomly divided into four groups: unrestricted and immobilized for 2 weeks after osteotomy (OU2), suspended and immobilized for 2 weeks after osteotomy (OS2), unrestricted and immobilized for 6 weeks after osteotomy (OU6), and suspended and immobilized for 6 weeks after osteotomy (OS6). Osteotomy was performed in the middle third of the right tibia 21 days after tail suspension, when the osteopenic condition was already set. The fractured limb was then immobilized by orthosis. Tibias were collected 2 and 6 weeks after osteotomy, and were analyzed by bone densitometry, mechanical testing, and histomorphometry. Bone mineral density values from bony calluses were significantly lower in the 2-week post-osteotomy groups compared with the 6-week post-osteotomy groups (multivariate general linear model analysis, P<0.000). Similarly, the mechanical properties showed that animals had stronger bones 6 weeks after osteotomy compared with 2 weeks after osteotomy (multivariate general linear model analysis, P<0.000). Histomorphometry indicated gradual bone healing. Results showed that osteopenia did not influence the bone healing process, and that time was an independent determinant factor regardless of whether the fracture was osteopenic. This suggests that the body is able to compensate for the negative effects of suspension.
Descritores: Doenças Ósseas Metabólicas/fisiopatologia
Consolidação da Fratura/fisiologia
Fraturas da Tíbia/fisiopatologia
-Densidade Óssea/fisiologia
Calo Ósseo/fisiopatologia
Colágeno/análise
Elevação dos Membros Posteriores/efeitos adversos
Elevação dos Membros Posteriores/fisiologia
Modelos Animais
Osteotomia/efeitos adversos
Distribuição Aleatória
Ratos Wistar
Fatores de Tempo
Torção Mecânica
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Volpon, José Batista
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Id: lil-767596
Autor: Butezloff, Mariana Maloste; Zamarioli, Ariane; Leoni, Graziela Bianchi; Sousa-Neto, Manoel Damião; Volpon, Jose Batista.
Título: Whole-body vibration improves fracture healing and bone quality in rats with ovariectomy-induced osteoporosis
Fonte: Acta cir. bras;30(11):727-735, Nov. 2015. tab, graf.
Idioma: en.
Resumo: PURPOSE: To investigate the effect of vibration therapy on the bone callus of fractured femurs and the bone quality of intact femurs in ovariectomized rats. METHODS: Fifty-six rats aged seven weeks were divided into four groups: control with femoral fracture (CON, n=14), ovariectomized with femoral fracture (OVX, n=14), control with femoral fracture plus vibration therapy (CON+VT, n=14), and ovariectomized with femoral fracture plus vibration therapy (OVX+VT, n=14). Three months after ovariectomy or sham surgery, a complete fracture was produced at the femoral mid-diaphysis and stabilized with a 1-mm-diameter intramedullary Kirschner wire. X-rays confirmed the fracture alignment and fixation. Three days later, the VT groups underwent vibration therapy (1 mm, 60 Hz for 20 minutes, three times per week for 14 or 28 days). The bone and callus quality were assessed by densitometry, three-dimensional microstructure, and mechanical test. RESULTS : Ovariectomized rats exhibited a substantial loss of bone mass and severe impairment in bone microarchitecture, both in the non-fractured femur and the bone callus. Whole-body vibration therapy exerted an important role in ameliorating the bone and fracture callus parameters in the osteoporotic bone. CONCLUSION: Vibration therapy improved bone quality and the quality of the fracture bone callus in ovariectomized rats.
Descritores: Calo Ósseo/fisiologia
Fraturas do Fêmur/terapia
Consolidação da Fratura/fisiologia
Osteoporose/fisiopatologia
Ovariectomia/efeitos adversos
Vibração/uso terapêutico
-Absorciometria de Fóton
Densidade Óssea/fisiologia
Fraturas do Fêmur/etiologia
Fraturas do Fêmur/fisiopatologia
Fraturas por Osteoporose/etiologia
Fraturas por Osteoporose/fisiopatologia
Fraturas por Osteoporose/terapia
Distribuição Aleatória
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Resultado do Tratamento
Limites: Animais
Feminino
Tipo de Publ: Estudo de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-747272
Autor: Milanetti, Márcia Regina; Alves, José Marcos; Silva, Alessandro Hakme da; Introini, Simone Orlandi.
Título: Avaliação do reparo ósseo por microtomografia por raio-X / Fracture healing valuation using X-ray microtomography
Fonte: Rev. med. (Säo Paulo);90(2):89-93, abr.-jun. 2011. ilus.
Idioma: pt.
Resumo: A microtomografia 3D por raio-X proporciona medidas quantitativas e tridimensionais da estrutura do calo eessas medidas podem potencialmente estar relacionadas com a resistência do calo. A avaliação quantitativa do reparo ósseo por meio de novas metodologias tem importante aplicação nas pesquisas experimentais relacionadas a tecnologias invasivas e não invasivas para a estimulação do mesmo. O objetivo desse estudo foi avaliar o reparo ósseo por meio da µCT em defeito ósseo em fêmur de rato. Trinta ratos machos da classe Wistar com peso médio de 300g foram divididos em grupos experimentais de 10 animais em cada grupo. Os animais foram anestesiados e um furo com 1,2mm de diâmetro foi realizada na porção medialdo fêmur utilizando-se uma broca odontológica. No 7º, 14º e 21ºpós-cirúrgico, os animais dos grupos experimentais 1, 2 e 3, respectivamente, foram sacrificados e o fêmur esquerdo excisado. Os fêmures foram envolvidos em gaze e mergulhas em solução PBS e armazenados em um saco plástico em freezer a -20º atéa análise microtomográfica. Os fêmures foram escaneados pelo microtomógrafo 1172 (SkyScan, Bélgica). Os softwares NRecon, Dataviewer, CT-Analyzer and CT-Vol, fornecidos pelo fabricantedo microtomógrafo, foram utilizados para as seguinte análises: a) análise visual das reconstruções microtomográficas dos fêmures através de secções transversais, coronais e sagitais; b) segmentação do calo ósseo nas reconstruções através de algoritmo de processamento de imagem para quantificação dos parâmetros volume total do calo ósseo (TV), volume do calo ósseo mineralizado (BV), relação BV/TV e densidade mineral óssea volumétrica do calo ósseo (BMD); c) visualização 3D do calo ósseo. A análise estatística dos parâmetros medidos utilizou o teste t de Student com um nível de significância p < 0,05. Houve um aumento estatisticamente significante nos valores dos parâmetros BV/TVe BMD na comparação entre os grupos experimentais 1 e 2...

X-ray microtomography (uCT) provides quantitative and three dimensional measurements of the callus structure and these measurements could potentially be related to callus strength. The assessment of bone repair through new methodologies hasimportant application in animal investigations regarding invasive ornon invasive technologies for the stimulation of bone healing. The aim of this investigation was the use of µCT for the assessment of bone repair in a rat femur bone defect. Thirty male Wistar rats weighting about 300g were divided in three experimental groupswith 10 animals on each group. The animals were anesthetized and a circular hole with a 1.2mm diameter was generated at the medial region of the left femur using a dental drill. At the 7th, 14th and 21st day after surgery the animals of experimental groups 1, 2 and 3, respectively, were sacrificed and the left femur excised. The femurs were wrapped in gauze immersed in phosphate-bufferedsolution and stored in a plastic bag at -20o C until the analysis bymicrotomograph. The femurs were scanned by the 1172 microtomograph(SkyScan, Belgium). The softwares NRecon, Dataviewer, CT-Analyzer and CT-Vol, provided by the microtomograph manufacture, were used for the following assessments: a) visual examination of the femurs microtomographic reconstructions usingtransversal, coronal and sagittal sections; b) segmentation of the bone callus in the reconstructions using an image processing algorithm to quantify the parameters total bone callus volume(TV), volume of the mineralized bone callus (BV), the ratio BV/TV and the volumetric bone callus mineral density (BMD); c) 3D rendering of the bone callus. The statistical analysis of themeasured parameters was performed by the Student t test with a level of significance p < 0.05. There was a statistically significant increase in the mean values of the parameters BV/TV and BMD in the comparison of experimental groups 1 and 2...
Descritores: Calo Ósseo/fisiologia
Calo Ósseo
Osteotomia
Osso e Ossos/lesões
Osso e Ossos
Ratos Wistar
Regeneração Óssea/fisiologia
Microtomografia por Raio-X
-Epidemiologia Experimental
Fêmur/lesões
Fraturas do Fêmur/fisiopatologia
Fraturas do Fêmur/prevenção & controle
Fraturas do Fêmur
Limites: Animais
Masculino
Ratos
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Barbieri, Cláudio Henrique
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Id: lil-725403
Autor: Barbieri, Giuliano; Barbieri, Cláudio Henrique.
Título: A comparative in vivo ultrasonometric evaluation of normal and delayed fracture healing in sheep tibiae
Fonte: Clinics;69(9):634-640, 9/2014. tab, graf.
Idioma: en.
Projeto: São Paulo State Research Support Foundation (FAPESP, Fundação de Amparo è Pesquisa do Estado de São Paulo).
Resumo: OBJECTIVE: To compare normal and delayed bone healing by measuring ultrasound conduction velocity across the bone callus. METHODS: A model of transverse linear and 5 mm resection osteotomies of sheep tibiae was used. Fourteen sheep were operated on and were divided into two groups of seven according to osteotomy type. The procedure was performed on the right tibiae and the intact left tibiae were used as controls. The transverse and axial ultrasound velocities were measured at 30-day intervals for 90 days, after which the animals were killed and both the right and left tibiae were resected for in vitro biomechanical analysis. RESULTS: Both the transverse and axial ultrasound velocities progressively increased, but the increase was smaller for the delayed union that resulted from the resection osteotomy. The mechanical resistance was higher for the normally healed tibiae that resulted from a linear osteotomy; this result closely correlated with the ultrasound velocity results. Significant differences were found for the comparisons between the intact and operated tibiae in both groups and between the groups for both the transverse and axial ultrasound velocities, but the differences were greater for the latter. CONCLUSION: We conclude that in vivo transverse and axial ultrasound velocities provide highly precise information about the healing state of both linear and resection diaphyseal osteotomies, but the axial ultrasound velocity most likely has greater discriminatory power. This method has the potential for clinical application in humans. .
Descritores: Consolidação da Fratura/fisiologia
Tíbia
Fraturas da Tíbia
-Fenômenos Biomecânicos
Calo Ósseo
Calo Ósseo
Modelos Animais de Doenças
Osteotomia/métodos
Valores de Referência
Reprodutibilidade dos Testes
Ovinos
Fatores de Tempo
Tíbia/fisiopatologia
Tíbia
Fraturas da Tíbia/fisiopatologia
Fraturas da Tíbia
Limites: Animais
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-617966
Autor: Sharifi, Davood; Khoushkerdar, Hamid Reza; Abedi, Gholamreza; Asghari, Ahmad; Hesaraki, Saeed.
Título: Mechanical properties of radial bone defects treated with autogenous graft covered with hydroxyapatite in rabbit / Propriedades mecânicas de defeito de osso radial tratado com enxerto autógeno coberto com nano-hydroxyapatite em coelho
Fonte: Acta cir. bras;27(3):256-259, Mar. 2012. ilus, graf, tab.
Idioma: en.
Resumo: PURPOSE: To determine biomechanical property of autogenous bone graft covered with hydroxyapatite in the defect of radial bone in rabbit. METHODS: Eighteen adult male New Zealand white rabbits were used which were divided into three groups (I, II, III) of six rabbits each. A segmental bone defect of 10 mm in length was created in the middle of the right radial shaft under general effective anesthesia in all rabbits and were stabilized using mini-plate with four screws. The defects In group I were left as such without filler, whereas in group II the defect were filled up with harvested 10 mm rib bone and in group III the defect were packed with rib bone covered with nano-hydroxyapatite. All rabbits in three groups were divided into two subgroups (one month and three months duration with three rabbits in each one). RESULTS: The mechanical property and the mean load for fracturing normal radial bone was recorded 388.2±6 N whereas it was 72.4±12.8 N for group I in 1 month duration which was recorded 182.4±14.2 N for group II and 211.6±10.4 N for group III at the end of 1 month. These values were 97.6±10.2 N for group I and 324.6±8.2 N for group II and 372.6±17.4 N for group III at the end of three months after implantation. CONCLUSION: Implantation of autologous graft covered with hydroxyapatite indicated to have positive effect in integral formation of qualitative callus at the site of fracture and early re-organization of callus to regain mechanical strength too.

OBJETIVO: Determinar as propriedades biomecânicas de enxerto ósseo autógeno coberto com hidroxiapatita em defeito do osso radial em coelhos. MÉTODOS: Foram utilizados 18 coelhos adultos, machos, brancos, Nova Zelândia, distribuídos em três grupos (I, II, III) de seis coelhos cada. Um defeito segmentar de 10 mm de comprimento foi criado no meio do eixo radial direito sob anestesia geral efetiva em todos os coelhos e foram fixados usando mini-placa com quatro parafusos. Os defeitos no grupo I foram deixados sem preenchimento, enquanto no grupo II o defeito foi preenchido com 10 mm de costela recoberta com nano-hidroxiapatita. Os coelhos nos três grupos foram distribuídos em dois subgrupos (Um e três meses, com três coelhos cada um). RESULTADOS: A propriedade mecânica e a média do peso para fraturar o osso radial normal foi 388,2±6 N, enquanto para o Grupo I, com um mês foi 72,4±12,8 N, para o grupo II 182,4±14,2 N e para o Grupo III 211,6±10,4 N. Após três meses de implantação, os valores foram 97,6±10,2 N para o Grupo I, 324,6±8,2 N para o Grupo II e 372,6±17,4 N para o Grupo III. CONCLUSÃO: A implantação de enxerto autólogo recoberto com hidroxiapatita indicou ter um efeito positivo na formação integral qualitativa do calo ósseo no local da fratura e precoce reorganização do calo com recuperação da força mecânica.
Descritores: Substitutos Ósseos/uso terapêutico
Transplante Ósseo/métodos
Calo Ósseo/fisiopatologia
Consolidação da Fratura/efeitos dos fármacos
Hidroxiapatitas/uso terapêutico
Fraturas do Rádio/fisiopatologia
Costelas/transplante
-Fenômenos Biomecânicos
Materiais Biocompatíveis/uso terapêutico
Modelos Animais de Doenças
Nanocompostos/uso terapêutico
Distribuição Aleatória
Fraturas do Rádio/cirurgia
Transplante Autólogo
Limites: Animais
Masculino
Coelhos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-593853
Autor: Estai, Mohamed Abdalla; Suhaimi, Farihah Haji; Das, Srijit; Fadzilah, Fazalina Mohd; Alhabshi, Sharifah Majedah Idrus; Shuid, Ahmad Nazrun; Soelaiman, Ima-Nirwana.
Título: Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study
Fonte: Clinics;66(5):865-872, 2011. ilus, graf, tab.
Idioma: en.
Resumo: INTRODUCTION: Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES: To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS: A total of 24 female Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: (i) the sham-operated group; (ii) the ovariectomized-control group; (iii) the ovariectomized + estrogen-replacement therapy (ovariectomized-control + estrogen replacement therapy) group, which was supplemented with estrogen (100 μg/kg/day); and (iv) the ovariectomized + Piper sarmentosum (ovariectomized + Piper sarmentosum) group, which was supplemented with a water-based Piper sarmentosum extract (125 mg/kg). Six weeks after an ovariectomy, the right femora were fractured at the mid-diaphysis, and a K-wire was inserted. Each group of rats received their respective treatment for 6 weeks. Following sacrifice, the right femora were subjected to radiological assessment. RESULTS: The mean axial callus volume was significantly higher in the ovariectomized-control group (68.2 + 11.74 mm³) than in the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups (20.4 + 4.05, 22.4 + 4.14 and 17.5 + 3.68 mm³, respectively). The median callus scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups had median (range, minimum - maximum value) as 1.0 (0 - 2), 1.0 (1 - 2) and 1.0 (1 - 2), respectively, which were significantly lower than the ovariectomized-control group score of 2.0 (2 - 3). The median fracture scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups were 3.0 (3 - 4), 3.0 (2 - 3) and 3.0 (2 - 3), respectively, which were significantly higher than the ovariectomized-control group score of 2.0 (1 - 2) (p<0.05). CONCLUSION: The Piper sarmentosum extract improved fracture healing, as assessed by the reduced callus volumes and reduced callus scores. This extract is beneficial for fractures in osteoporotic states.
Descritores: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Consolidação da Fratura/efeitos dos fármacos
Fraturas por Osteoporose/tratamento farmacológico
Piper/química
Extratos Vegetais/uso terapêutico
-Calo Ósseo/efeitos dos fármacos
Calo Ósseo
Estrogênios/deficiência
Consolidação da Fratura/fisiologia
Ovariectomia
Fraturas por Osteoporose
Distribuição Aleatória
Ratos Sprague-Dawley
Limites: Animais
Feminino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-552027
Autor: Paganini, Federico; Allende, Christian; Marchegiani, Silvio.
Título: Valor de la ecografia en el seguimiento de los procesos de consolidacion de fracturas y seudoartrosis / Value of ultrasound to diagnose fracture healing and non-union
Fonte: Rev. Asoc. Argent. Ortop. Traumatol;75(1):82-87, mar. 2010. ilus, tab.
Idioma: es.
Resumo: Introducción: El objetivo de este trabajo prospectivo de investigación fue determinar el valor de la ecografía en la consolidación de las fracturas y las seudoartrosis, y correlacionar entre sí las imágenes ecográficas y radiográficas. Materiales y métodos: Se evaluaron 22 pacientes con 24 fracturas y 6 seudoartrosis ubicadas en las diáfisis de los huesos largos. Los pacientes fueron de ambos sexos, con cartílago del crecimiento cerrado. Se evaluó comparativamente el desarrollo del callo óseo en cada una de las caras con radiografías y ecografías alas 3, 6 y 8 semanas, y a los 3 y 5 meses. Los huesos fueron divididos en caras y estas en zonas (-1, 0, A, B, C) de acuerdo con el grado de desarrollo del callo óseo. Mediante un análisis estadístico se determinó la validez (sensibilidad y especificidad) y seguridad (valor predictivo positivo y negativo) de la ecografía y su correlación con la radiografía (índice kappa). Resultados: En las fracturas, hubo escasa concordancia en las primeras semanas; recién al quinto mes se observó una buena concordancia (kappa = 0,6). La sensibilidad fue aumentando con el correr de las semanas, mientras que la especificidad fue similar a lo largo de los controles. En las seudoartrosis el tamaño de la muestra fue escaso y la sensibilidad fue aumentando para estabilizarse en el tercer mes, a diferencia de la especificidad, que fue disminuyendo. No hubo concordancia en el primero ni en los últimos controles (kappa = 0). Conclusiones: La ecografía representa un excelente método de diagnóstico; sin embargo, tiene indicaciones precisas y en la evaluación de los procesos de consolidación ha mostrado tener escaso valor diagnóstico y pronóstico. Por tal motivo, la radiografía continúa siendo en método diagnóstico de referencia para la evaluación de esos procesos.
Descritores: Fraturas Ósseas
Pseudoartrose/diagnóstico
Pseudoartrose
Ultrassonografia
-Calo Ósseo
Fêmur
Fíbula
Úmero
Estudos Prospectivos
Rádio
Tíbia
Ulna
Limites: Humanos
Adulto
Responsável: AR337.1 - Biblioteca A.A.O.T.



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