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Pesquisa : A10.272.497.500 [Categoria DeCS]
Referências encontradas : 105 [refinar]
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Id: biblio-1045999
Autor: Ma, Sen; Zhou, Guangxian; Chen, Yulin.
Título: Effects of all-trans retinoic acid on goat dermal papilla cells cultured in vitro
Fonte: Electron. j. biotechnol;34:43-50, july. 2018. tab, graf, ilus.
Idioma: en.
Projeto: National Natural Science Foundation of China; . China Agriculture Research System.
Resumo: Background: All-trans retinoic acid (ATRA), a vitamin A-derived active metabolite, exerts important functions in hair biology. Previous studies indicated that excess ATRA hampered hair follicle morphogenesis and cyclic regeneration in adulthood, but other studies stated that ATRA promoted hair growth. Dermal papilla (DP), a cluster of specialized fibroblasts, plays pivotal roles in controlling development and regeneration of hair follicle. Several lines of evidence indicated that DP might be the target cells of ATRA in the hair follicle. To confirm this hypothesis, the present study was performed to explore the biological effects of ATRA on goat dermal papilla cells (DPCs) and clarify the roles of ATRA in hair biology. Results: Our experimental results indicated that key signaling transducers of ATRA were dynamically expressed in distinct stages of goat cashmere growth cycle, and high-dose ATRA treatment (10-5 M) significantly impaired the viability of goat DPCs and lowered the ratio of proliferating cells. Otherwise, goat DPCs were stimulated to enter apoptosis and their cell cycle progression was severely blocked by ATRA. Moreover, the expression of fibroblast growth factor 7 (Fgf7), one of the potent hair growth stimulators secreted by DPCs, was transcriptionally repressed following ATRA treatment. Conclusion: DPCs are the targets of ATRA in the hair follicle, and ATRA negatively regulates hair growth by the targeted suppression of cell viability and growth factor expression of goat DPCs. Through these observations, we offer a new mechanistic insight into the roles of ATRA in hair biology.
Descritores: Tretinoína/farmacologia
Cabras
Folículo Piloso/efeitos dos fármacos
-Regeneração
Técnicas In Vitro
Imuno-Histoquímica
Receptores do Ácido Retinoico
Folículo Piloso/citologia
Folículo Piloso/crescimento & desenvolvimento
Proliferação de Células/efeitos dos fármacos
Fator 7 de Crescimento de Fibroblastos/genética
Reação em Cadeia da Polimerase em Tempo Real
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


  2 / 105 LILACS  
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Id: lil-486949
Autor: Guercio, Gabriela; Rivarola, Marco A; Belgorosky, Alicia; Martinitto, R(edt); Campmany, L(edt).
Título: Pubarca precoz / Pubarca precocious
Fonte: Med. infant;14(3):264-266, sept. 2007.
Idioma: es.
Descritores: Adrenarca
Androgênios
Cabelo/crescimento & desenvolvimento
Folículo Piloso/metabolismo
-Diagnóstico Diferencial
Limites: Humanos
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


  3 / 105 LILACS  
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Id: biblio-1177401
Autor: Yin, Rong H; Wang, Yan R; Zhao, Su J; Yin, Rong L; Bai, Man; Wang, Ze Y; Zhu, Yu B; Cong, Yu Y; Liu, Hai Y; Bai, Wen L.
Título: LncRNA-599554 sponges miR-15a-5p to contribute inductive ability of dermal papilla cells through positive regulation of the expression of Wnt3a in cashmere goat
Fonte: Electron. j. biotechnol;45:19-29, May 15, 2020. tab, ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Key Project Foundation of Educational Department of Liaoning Province, China; . Innovative Talent Support Program Foundation of Universities and Colleges in Liaoning Province, China; . Science and; . Technology Innovation Talent Support Foundation for Young and Middle-aged People of Shenyang City, China.
Resumo: BACKGROUND: Long non-coding RNAs (lncRNAs), as post-transcriptional regulators, were thought to function in the inductive property of dermal papilla cells (DPCs) in cashmere goat. Previously, lncRNA-599554 was identified in secondary hair follicle (SHF) of cashmere goat, but its functional significance is unknown. RESULTS: In the present investigation, we verified that lncRNA-599554 had significantly higher expression at the anagen dermal papilla of cashmere goat SHF than that at telogen. Based on overexpression and knockdown techniques, we found that lncRNA-599554 contributes the inductive property of DPCs of cashmere goat, which was assessed by detecting the changes in the expression of several typical indictor genes in DPCs including ET-1, SCF, Versican, ALP, Lef1 and Ptc-1. Based on RNA pull-down assay, we verified that lncRNA-599554 directly interacted with chi-miR-15a-5p. Also, we showed that lncRNA-599554 positively regulated the Wnt3a expression in DPCs but which did not appear to involve its modulating of promoter methylation. Based on the use of Dual-luciferase reporter assays, our data indicated that lncRNA-599554 regulated the Wnt3a expression through chi-miR-15a-5p-mediated post-transcriptional level. CONCLUSIONS: We showed that lncRNA-599554 contributes the inductive property of DPCs in cashmere goat which might be achieved through sponging chi-miR-15b-5p to promote the Wnt3a expression. The results from the present investigation provided a novel insight into the functional mechanism of lncRNA-599554 in the SHF regeneration of cashmere goat along with the formation and growth of cashmere fiber.
Descritores: Folículo Piloso/citologia
Folículo Piloso/metabolismo
Derme/citologia
Proteína Wnt3A/metabolismo
RNA Longo não Codificante/metabolismo
-Bioensaio/métodos
Cabras
RNA Longo não Codificante/genética
Luciferases
Metilação
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


  4 / 105 LILACS  
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Texto completo SciELO Brasil
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Id: biblio-1153089
Autor: Díez-Montero, Cecilia; Alonso, Miguel Diego; Marquez, Pilar I. Gonzalez; Schellini, Silvana Artioli; Galindo-Ferreiro, Alicia.
Título: Solitary fibrofolliculoma: a retrospective case series review over 18 years / Fibrofoliculoma solitário: revisão de série retrospectiva de casos de 18 anos
Fonte: Arq. bras. oftalmol;83(6):485-489, Nov.-Dec. 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: The purpose of this study was to report a series of cases of solitary fibrofolliculoma, a lesion seldom observed in the lids. Demographics, as well as clinical and histological aspects of the lesion were evaluated. Methods: This was a retrospective case series spanning a period of 18 years. All the included patients were diagnosed with solitary fibrofolliculoma confirmed by histological examination. Data regarding patient demographics, signs, and symptoms, course of the disease, location of the lesion, clinical and histological diagnosis, and outcome were collected. Results: Eleven cases of solitary fibrofolliculoma were diagnosed in the study period. The median age of patients was 51 ± 16.3 years (range: 27-78 years). Most patients were females (7/11; 64%). Five of the patients (45%) were asymptomatic; four (36%) reported bleeding, one (9%) had referred itching, and one (9%) rubbing of the lesion. The lesion occurred in a wide range of locations; one of them was located in the lids. The diagnosis for all lesions was histological based on characteristic findings of a hair follicle occasionally dilated and containing keratin material surrounded by a moderately well-circumscribed thick mantle of fibrous tissue. The infundibular follicular epithelium extended out into this fibrous mantle forming epithelial strands or cords. There were no relapses after exeresis. Conclusion: Solitary fibrofolliculoma is a rare lesion, seldom affecting the eyelids. We reported 11 cases, and the third case reported thus far in the literature affecting the lids. Diagnosis may be easily missed due to the nonspecific symptoms and clinical appearance. Therefore, it is necessary to perform excisional biopsy and histological examination for the recognition of this lesion.

RESUMO Objetivo: o objetivo deste estudo foi relatar uma série de casos de fibrofoliculoma solitário, uma lesão raramente observada nas pálpebras. Demografia, bem como aspectos clínicos e histológicos da lesão foram avaliados. Métodos: Trata-se de uma série de casos retrospectivos, com um período de 18 anos. Todos os pacientes incluídos foram diagnosticados com fibrofoliculoma solitário confirmado por exame histológico. Foram coletados dados referentes à demografia, sinais e sintomas dos pacientes, evolução da doença, localização da lesão, diagnóstico clínico e histológico e desfecho. Resultados: Onze casos de fibrofoliculoma solitário foram diagnosticados no período do estudo. A média de idade dos pacientes de 51 ± 16,3 anos (variação: 27-78 anos). A maioria dos pacientes era do sexo feminino (7/11, 64%). Cinco dos pacientes (45%) eram assintomáticos; quatro (36%) relataram sangramento, um (9%) referiu coceira e um (9%) fricção da lesão. A lesão ocorreu em luma ampla variedade de locais; um deles sendo nas pálpebras. O diagnóstico de todas as lesões foi histológico com base nos achados característicos de um folículo piloso ocasionalmente dilatado e contendo material de queratina, cercado por um manto espesso de tecido fibroso moderadamente bem circunscrito. O epitélio infundibular folicular se estendeu até esse manto fibroso, formando cordões ou cordões epiteliais. Não houve recaídas após exérese. Conclusão: Fibrofoliculoma solitário é uma lesão rara, mais ainda quando afeta as pálpebras. Relatamos 11 casos, e o terceiro relatado até o momento na literatura que afeta as pálpebras. O diagnóstico pode ser facilmente esquecido devido a sintomas inespecíficos e aparência clínica. Portanto, é necessário realizar biópsia excisional e exame histológico para o reconhecimento dessa lesão.
Descritores: Neoplasias Cutâneas
Folículo Piloso
Doenças do Cabelo
-Pele
Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/patologia
Estudos Retrospectivos
Recidiva Local de Neoplasia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-950746
Autor: Bae, Seunghee; Lim, Kyung Mi; Cha, Hwa Jun; An, In-Sook; Lee, Jeong Pyo; Lee, Kwang Sik; Lee, Ghang Tai; Lee, Kun Kook; Jung, Ho Jung; Ahn, Kyu Joong; An, Sungkwan.
Título: Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells
Fonte: Biol. Res;47:1-11, 2014. graf, tab.
Idioma: en.
Projeto: Korean Health Technology R& D Project; . Ministry of Health & Welfare, Republic of Korea.
Resumo: BACKGROUND: Accumulating evidence indicates that reactive oxygen species (ROS) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. In the present study, we found that arctiin exerts anti-oxidative effects on human hair dermal papilla cells (HHDPCs). RESULTS: To better understand the mechanism, we analyzed the level of hydrogen peroxide (H2O2)-induced cytotoxicity, cell death, ROS production and senescence after arctiin pretreatment of HHDPCs. The results showed that arctiin pretreatment significantly inhibited the H2O2-induced reduction in cell viability. Moreover, H2O2-induced sub-G1 phase accumulation and G2 cell cycle arrest were also downregulated by arctiin pretreatment. Interestingly, the increase in intracellular ROS mediated by H2O2 was drastically decreased in HHDPCs cultured in the presence of arctiin. This effect was confirmed by senescence associated-beta galactosidase (SA-ß-gal) assay results; we found that arctiin pretreatment impaired H2O2-induced senescence in HHDPCs. Using microRNA (miRNA) microarray and bioinformatic analysis, we showed that this anti-oxidative effect of arctiin in HHDPCs was related with mitogen-activated protein kinase (MAPK) and Wnt signaling pathways. CONCLUSIONS: Taken together, our data suggest that arctiin has a protective effect on ROS-induced cell dysfunction in HHDPCs and may therefore be useful for alopecia prevention and treatment strategies.
Descritores: Envelhecimento/metabolismo
Espécies Reativas de Oxigênio/antagonistas & inibidores
Folículo Piloso/efeitos dos fármacos
MicroRNAs/metabolismo
Furanos/farmacologia
Glucosídeos/farmacologia
-Envelhecimento/efeitos dos fármacos
Regulação para Baixo/efeitos dos fármacos
Regulação para Cima/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Morte Celular/efeitos dos fármacos
beta-Galactosidase/análise
Folículo Piloso/citologia
Folículo Piloso/metabolismo
Derme/citologia
Derme/efeitos dos fármacos
Derme/metabolismo
Análise de Sequência com Séries de Oligonucleotídeos
MicroRNAs/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Peróxido de Hidrogênio/farmacologia
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Id: biblio-896296
Autor: Cheng, Yi; Gao, Yang; Zhao, Lu; Gao, Shunqiang; Zhang, Guoqiang; Zhang, Yan.
Título: Knockout of p16INK4a promotes aggregative growth of dermal papilla cells
Fonte: Rev. Assoc. Med. Bras. (1992);63(10):883-889, Oct. 2017. tab, graf.
Idioma: en.
Resumo: Summary Objective: Dermal papilla cells (DPCs) are located in the hair follicles and play an important role in hair growth. These cells have the ability to induce hair follicle formation when they display aggregative behavior. DPCs derived from the androgenetic alopecia (AGA) area undergo premature senescence in vitro, associated with p16INK4a expression. The aim of the current study was to investigate the expression of p16INK4a in aggregative and non-aggregative DPCs and the effect of p16INK4a down-regulation in these cells by adenovirus-mediated RNA interference (RNAi). Method: DPCs were isolated and cultured from healthy human scalp. p16INK4a gene and protein were detected in aggregative and non-aggregative cells. Expression of p16INK4a in DPCs was silenced by infection with rAd5-CDKN1A-1p2shRNA. Cell fate was monitored after infection. The growth of cells was measured by MTT assay. Cell cycle was evaluated by flow cytometry (FCM). Results: DPCs were isolated by digestion and showed aggregative behavior for six passages. The expression of p16INK4a showed a clear upward trend in non-aggregative cells when compared with aggregative group. p16INK4a expression was silenced by rAd5-CDKN1A-1p2shRNA (p<0.05). The p16INK4a-silenced cells grew more rapidly and exhibited a trend towards aggregative growth. There was an increase in the proportion of cells in G1 phase, while those in S phase were reduced after p16INK4a gene silencing (p<0.05). Conclusion: Our results suggest that p16INK4a plays an important role in the premature senescence and aggregative behavior of DPCs. These observations can lead to novel therapeutic strategies for treatment of AGA.
Descritores: Couro Cabeludo/citologia
Folículo Piloso/citologia
Genes p16/fisiologia
-Valores de Referência
Fatores de Tempo
Imuno-Histoquímica
Transfecção
Agregação Celular/genética
Ciclo Celular/genética
Células Cultivadas
Senescência Celular/genética
Derme/citologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Proliferação de Células/genética
Alopecia/genética
Técnicas de Inativação de Genes/métodos
Citometria de Fluxo
Limites: Humanos
Masculino
Responsável: BR1.1 - BIREME


  7 / 105 LILACS  
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Id: biblio-969262
Autor: Meza, Julián Andrés; Rojas Gutierrez, Andrés Felipe; Pantoja Burbano, Sandra; Moreno Torres, Andrey.
Título: Tumor tricolémico proliferante maligno en cuero cabelludo con extensión al cuello Reporte de caso / Malignant proliferative trichilemmal tumour of neck and scalp Case report
Fonte: Acta otorrinolaringol. cir. cabeza cuello;45(2):132-134, 2017. ilus.
Idioma: es.
Resumo: El tumor tricolémico maligno de cabeza y cuero cabelludo es un tumor que se origina de la vaina radicular externa del folículo piloso, fue descrito por primera vez por Wilson-Jones en 1966 como "proliferación de quiste epidermoide'', su frecuencia de presentación es rara y se encuentran pocos casos reportados en la literatura. Es un tipo de tumor que tiene un comportamiento biológicamente benigno aunque puede presentar transformación maligna y puede confundirse con carcinoma escamocelular, por lo que es importante la experiencia de clínico y el patólogo es este tipo de casos. A continuación se presenta un caso clínico en cuero cabelludo y cuello del instituto nacional de cancerología y la forma de abordaje quirúrgico

Malignant Trichilemmal tumor of neck and scalp are tumors that originate from the outer root sheath of the hair follicle, was first described by Wilson-Jones in 1966 as "proliferation of epidermoid cyst", its frequency is extremely rare and there are very few cases reported, is considered biologically benign but may present malignant transformation can be confused with squamous cell carcinoma, is important the experience of clinical and pathologist is this type of case. A clinical case is presented in scalp and the National Cancer Institute and the form of surgical approach neck.
Descritores: Neoplasias de Cabeça e Pescoço
-Couro Cabeludo
Folículo Piloso
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: CO361.9


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Texto completo SciELO Cuba
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Id: biblio-902201
Autor: Montenegro Valera, Isora; Moreno Kim, Silvia Elena; González Vázquez, Elian; Intriago Álvarez, María Belén.
Título: Pilomatrixoma ampollar en caso pediátrico / Bullous pilomatrixoma in pediatric case
Fonte: Rev. medica electron;39(3):577-583, may.-jun. 2017.
Idioma: es.
Resumo: Se realiza la presentación de un caso clínico en edad pediátrica con diagnóstico de pilomatrixoma, variedad ampollar. Este tumor benigno originado en la vaina del folículo piloso muestra una incidencia elevada en las dos primeras décadas de vida. El objetivo de este artículo es presentar un caso con diagnóstico de un tumor, con características clínicas atípicas e inusuales. En ocasiones este tipo de tumor, conllevan al diagnóstico erróneo de la entidad, realizándose el diagnóstico de certeza mediante el estudio histopatológico una vez que se procede a la exéresis quirúrgica de la lesión (AU).

A clinical case with diagnosis of bullous variety pilomatrixoma in pediatric age is presented. This benign tumor originated in the sheath of the hair follicle shows a high incidence in the first 20 years of life. The aim of this work is presenting a case with tumor diagnosis, the clinical characteristics of which sometimes leads to an erroneous diagnosis of the entity in the atypical and unusual varieties. The accurate diagnosis was made through the pathologic study after the surgical excision of the lesion (AU).
Descritores: Criança
Pilomatrixoma/epidemiologia
-Biópsia/métodos
Pilomatrixoma/diagnóstico
Pilomatrixoma/reabilitação
Pilomatrixoma/terapia
Folículo Piloso/anormalidades
Neoplasias/diagnóstico
Neoplasias/epidemiologia
Limites: Humanos
Masculino
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: CU424.1 - Centro Provincial de Información de Ciencias Médicas


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Texto completo SciELO Brasil
Texto completo
Id: biblio-1088973
Autor: Harbiyeli, Ibrahim Inan; Ozcan, Altan A; Acıkalin, Arbil; Ciloglu, Emine; Shields, Carol L.
Título: Pilomatrix carcinoma of the lacrimal caruncle: a case report / Carcinoma pilomatricial da carúncula lacrimal: relato de caso
Fonte: Arq. bras. oftalmol;83(2):153-156, Mar.-Apr. 2020. graf.
Idioma: en.
Resumo: ABSTRACT A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. A histological diagnosis of pilomatrix carcinoma was established. To prevent recurrence after surgery, we added bevacizumab (25 mg/mL, 1.25 mg/mL per drop) eye drops four times per day for three months. At the one-year follow-up, the patient showed no evidence of local recurrence or distant metastasis after initial excision and remains under close follow-up. Pilomatrix carcinoma should be considered in the differential diagnosis of a caruncular mass.

RESUMO Um homem de 45 anos apresentou história de massa na carúncula no olho direito durante 3 meses. Uma biópsia incisional foi realizada 1 mês antes por outro especialista e o laudo histopatológico mostrava carcinoma basocelular. A massa foi completamente excisada, com uma margem de segurança de 2 mm, e a grande lesão conjuntival foi reconstruída com uma folha de aloenxerto de membrana amniótica. Foi estabelecido um diagnóstico histológico de carcinoma pilomatricial. Para evitar a recorrência após a cirurgia, adicionamos colírio de bevacizumabe (25 mg/mL, 1,25 mg/mL por gota) quatro vezes ao dia durante três meses. No seguimento de 1 ano, o paciente não apresentou evidência de recidiva local ou metástase distante após a excisão inicial e continua sob acompanhamento próximo. O carcinoma pilomatricial deve ser considerado no diagnóstico diferencial de uma massa caruncular.
Descritores: Carcinoma Basocelular/patologia
Pilomatrixoma/patologia
Neoplasias da Túnica Conjuntiva/patologia
Doenças do Aparelho Lacrimal/patologia
-Biópsia
Carcinoma Basocelular/cirurgia
Pilomatrixoma/cirurgia
Neoplasias da Túnica Conjuntiva/cirurgia
Folículo Piloso/patologia
Doenças do Cabelo/patologia
Doenças do Aparelho Lacrimal/cirurgia
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


  10 / 105 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886861
Autor: HOU, CHUN; MIAO, YONG; JI, HANG; WANG, SUSHENG; LIANG, GANG; ZHANG, ZHIHUA; HONG, WEIJIN.
Título: 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression
Fonte: An. acad. bras. ciênc;89(4):2707-2717, Oct.-Dec. 2017. graf.
Idioma: en.
Projeto: Guangzhou Traditional Chinese Medicine and Integrative.
Resumo: ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.
Descritores: Extratos Vegetais/farmacologia
Catecóis/farmacologia
Folículo Piloso/efeitos dos fármacos
Metaloproteinase 2 da Matriz/biossíntese
Metaloproteinase 9 da Matriz/biossíntese
Álcoois Graxos/farmacologia
-Fator de Crescimento Insulin-Like I/biossíntese
Distribuição Aleatória
Indução Enzimática
Fator de Crescimento Transformador beta/biossíntese
Folículo Piloso/patologia
Fator A de Crescimento do Endotélio Vascular/biossíntese
Fator 7 de Crescimento de Fibroblastos/biossíntese
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Feminino
Coelhos
Responsável: BR1.1 - BIREME



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