Base de dados : LILACS
Pesquisa : A11.284.180 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Id: lil-595038
Autor: Zhou, Liping; Guo, Xiaolin; Ba, Jing; Zhao, Lianshuang.
Título: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Fonte: Biocell;34(2):91-94, Aug. 2010. ilus, graf.
Idioma: en.
Resumo: CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Descritores: /imunologia
Extensões da Superfície Celular/metabolismo
Leucemia Mieloide/imunologia
Movimento Celular/fisiologia
-Polaridade Celular
Ácido Hialurônico
Limites: Humanos
Responsável: AR40.1 - Biblioteca de la Facultad de Ciencias Médicas de la UNCuyo

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Id: lil-384241
Autor: Lopez, L. M; Dubin, M; Carrizo, P. H; Burgos, M. H; Pellegrino de Iraldi, A; Stoppani, A. O.
Título: Apoptogenic effect of the lipophilic o-naphthoquinone CG 10-248 on rat hepatocytes: light and electron microscopy studies
Fonte: Biocell;27(2):213-224, Aug. 2003.
Idioma: en.
Resumo: CG 10-248 (3,4-dihydro-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran-5,6-dione; CG-NQ), a beta-lapachone analogue, modified the ultrastructure of rat hepatocytes, as demonstrated by light and electron microscopy. After 4 h incubation with 100 microM CG-NQ, the following effects were observed: (a) nuclear chromatin condensation; (b) chromatin fragmentation; (c) displacement of mitochondria, concentrated around the nucleus; (d) disruption or expansion of mitochondrial outer or inner membranes, respectively; (e) displacement and alteration of endoplasmic reticulum (rough and smooth); (f) decrease of microvilli; (g) blebbing of plasma membrane and production of apoptotic bodies formed by folding of plasma membrane fragments around mitochondria or peroxysomes; and (h) production of hydrogen peroxide. Expression of such effects varied according to hepatocyte samples and taken together strongly support an apoptotic action of CG-NQ dependent on reactive oxygen species.
Descritores: Apoptose/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Células Cultivadas
Cromatina/efeitos dos fármacos
Extensões da Superfície Celular/efeitos dos fármacos
Extensões da Superfície Celular/patologia
Extensões da Superfície Celular/ultraestrutura
Fragmentação do DNA/efeitos dos fármacos
Fragmentação do DNA/fisiologia
Microscopia Eletrônica
Membranas Intracelulares/efeitos dos fármacos
Membranas Intracelulares/patologia
Membranas Intracelulares/ultraestrutura
Microvilosidades/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Peróxido de Hidrogênio/metabolismo
Ratos Wistar
Retículo Endoplasmático/efeitos dos fármacos
Retículo Endoplasmático/patologia
Retículo Endoplasmático/ultraestrutura
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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Id: lil-332486
Autor: Gicovate, D. G; Berría, M. I.
Título: Theiler virus-GDVII strain (TMEV-GDVII) infection of cultured astrocytes. An image analysis of its effects on cell activation
Fonte: Rev. argent. microbiol;33(3):155-159, jul.-sept. 2001.
Idioma: en.
Resumo: Our original aim was to determine whether dBcAMP-induced activation of cultured astrocytes affected the course of subsequent viral infection. After 2 h exposure of 2-day-old first subculture of mouse astrocytes to dBcAMP 1 mM, cell monolayers grown in glass coverslips of Leighton tubes were inoculated with 10(3) PFU of Theiler virus-GDVII strain (TMEV-GDVII). At 9 days post-infection (pi), viral infectivity persisted in supernatants from dBcAMP-treated cultures, but was no longer detectable in non-stimulated controls. The relatively spared astroglial monolayer at day 1 pi, hardly affected by progressive viral cytolytic effect, was chosen for immunolabeled cell count, whether by viral antigen or GFAP. To this end, 20 fields for each coverslip were digitalized at 250x final magnification. In dBcAMP treated cultures, viral antigen(+) cells were fewer and lower in percentage versus infected cultures lacking stimulation. As regards GFAP staining, stimulation or infection per se induced a greater number and percentage of labeled astrocytes. According to morphometric characterization, such increase was due to a greater number of process-bearing astrocytes. It may be concluded that, regardless of previous dBcAMP treatment, early TMEV-GDVII infection enhanced immunocytochemical and morphological differentiation in cultured astrocytes.
Descritores: Astrócitos
-Antígenos Virais/análise
Tamanho Celular
Células Cultivadas/efeitos dos fármacos
Efeito Citopatogênico Viral
Diferenciação Celular/efeitos dos fármacos
Extensões da Superfície Celular/ultraestrutura
Processamento de Imagem Assistida por Computador
Camundongos Endogâmicos BALB C
Proteína Glial Fibrilar Ácida/análise
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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