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Pesquisa : A11.284.180.290 [Categoria DeCS]
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Id: biblio-912054
Autor: Coelho, Willian Marinho Dourado; Bresciani, Katia Denise Saraiva; Coêlho, Juliana de Carvalho Apolinário; Anjos, Luciano Alves dos; Buzetti, Wilma Aparecida Starke.
Título: Are Aedes aegypti mosquitoes potential vectors for leishmaniasis? ­ Case report / Mosquitos Aedes aegypti são vetores potenciais de leishmaniose? ­ Relato de caso
Fonte: Braz. J. Vet. Res. Anim. Sci. (Online);54(4):416-419, 2017. ilus.
Idioma: en.
Resumo: In Brazil dipters of the Lutzomyia genus are the main vectors of leishmaniasis for humans and animals. However, other hematophagous insects such as ticks, fleas, and horse flies may also be considered potential vectors of this protozoon. This paper, regarding an endemic area for visceral leishmaniasis, is the the first description of the Leishmania spp. presence in Aedes aegypti mosquitoes. Two A. aegypti mosquitoes were captured: one of them was feeding on a polysymptomatic dog with leishmaniasis, confirmed by parasitic demonstration and positive PCR for Leishmania spp., and the other was collected in the environment where the dog was isolated. The mosquito engorged with dog's blood was crushed between two microscopic slides and the other one was processed by the polymerase chain reaction assay (PCR) searching for the presence of Leishmania spp. DNA. Amastigote forms of Leishmania sp, were observed in the smear prepared from one mosquito by microscopic examination, as well as other protozoa's flagellated forms. In the other insect it was observed Leishmania DNA amplification. This observation reinforces the role of dogs as sources of infection of Leishmania spp. even to other potential vector species.(AU)

No Brasil, os dípteros do gênero Lutzomyia são os principais vetores da leishmaniose para humanos e animais. No entanto, tem sido constatado que outras espécies de invertebrados hematófagos, como carrapatos, pulgas e mutucas, também podem ser vetores desse protozoário. Este trabalho, realizado em uma área endêmica de leishmaniose visceral, é a primeira descrição da presença de Leishmania spp. em mosquitos da espécie A. aegypti. Dois mosquitos A. aegypti foram capturados no local onde estava isolado um cão polissintomático acometido por leishmaniose visceral, confirmada pela demonstração do parasita em biópsias de órgãos e por resultado positivo na prova de PCR para Leishmania spp. Um dos mosquitos estava sugando o sangue do cão e o outro estava livre no ambiente. O mosquito ingurgitado com o sangue do animal foi esmagado entre duas lâminas de microscopia e o outro foi processado por meio da reação em cadeia pela polimerase (PCR) aplicada à pesquisa do ADN de Leishmania spp. Ao exame microscópico do esfregaço preparado com o mosquito que estava parasitando o cão foram observadas formas amastigotas de Leishmania spp., bem como formas flageladas de outra espécie de protozoário. No outro inseto foi detectada amplificação de ADN do gênero Leishmania. Esta constatação reforça o papel dos cães como fontes de infecção de Leishmania spp. até mesmo para outras espécies de vetores potenciais.(AU)
Descritores: Aedes/patogenicidade
Leishmaniose/etiologia
Leishmaniose/veterinária
Leishmania/isolamento & purificação
-Vetores de Doenças
Flagelos/parasitologia
Limites: Animais
Cães
Tipo de Publ: Relatos de Casos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  2 / 21 LILACS  
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Id: biblio-889180
Autor: Barbosa, Fernanda de Oliveira; Freitas Neto, Oliveiro Caetano de; Batista, Diego Felipe Alves; Almeida, Adriana Maria de; Rubio, Marcela da Silva; Alves, Lucas Bocchini Rodrigues; Vasconcelos, Rosemeire de Oliveira; Barrow, Paul Andrew; Berchieri Junior, Angelo.
Título: Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken
Fonte: Braz. j. microbiol;48(4):754-759, Oct.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . National Council of Technological and Scientific Development.
Resumo: ABSTRACT Salmonella Enteritidis causes fowl paratyphoid in poultry and is frequently associated to outbreaks of food-borne diseases in humans. The role of flagella and flagella-mediated motility into host-pathogen interplay is not fully understood and requires further investigation. In this study, one-day-old chickens were challenged orally with a wild-type strain Salmonella Enteritidis, a non-motile but fully flagellated (SE ΔmotB) or non-flagellated (SE ΔfliC) strain to evaluate their ability to colonise the intestine and spread systemically and also of eliciting gross and histopathological changes. SE ΔmotB and SE ΔfliC were recovered in significantly lower numbers from caecal contents in comparison with Salmonella Enteritidis at early stages of infection (3 and 5 dpi). The SE ΔmotB strain, which synthesises paralysed flagella, showed poorer intestinal colonisation ability than the non-flagellated SE ΔfliC. Histopathological analyses demonstrated that the flagellated strains induced more intense lymphoid reactivity in liver, ileum and caeca. Thus, in the present study the flagellar structure and motility seemed to play a role in the early stages of the intestinal colonisation by Salmonella Enteritidis in the chicken.
Descritores: Flagelos/fisiologia
Intestinos/microbiologia
Doenças das Aves Domésticas/microbiologia
Salmonella enteritidis/crescimento & desenvolvimento
Salmonella enteritidis/patogenicidade
Salmonelose Animal/microbiologia
-Galinhas
Flagelos/genética
Intestinos/patologia
Doenças das Aves Domésticas/patologia
Salmonella enteritidis/genética
Salmonella enteritidis/fisiologia
Salmonelose Animal/patologia
Virulência
Limites: Animais
Responsável: BR1.1 - BIREME


  3 / 21 LILACS  
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Texto completo SciELO Brasil
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Id: lil-724000
Autor: Díaz-Chiguer, Dylan L; Hernández-Luis, Francisco; Nogueda-Torres, Benjamín; Castillo, Rafael; Reynoso-Ducoing, Olivia; Hernández-Campos, Alicia; Ambrosio, Javier R.
Título: JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotes
Fonte: Mem. Inst. Oswaldo Cruz;109(6):757-760, 09/09/2014. graf.
Idioma: en.
Projeto: DGAPA-UNAM; . DGAPA-UNAM; . DGAPA-IXTLI-UNAM.
Resumo: Trypanosoma cruzi has a particular cytoskeleton that consists of a subpellicular network of microtubules and actin microfilaments. Therefore, it is an excellent target for the development of new anti-parasitic drugs. Benzimidazole 2-carbamates, a class of well-known broad-spectrum anthelmintics, have been shown to inhibit the in vitro growth of many protozoa. Therefore, to find efficient anti-trypanosomal (trypanocidal) drugs, our group has designed and synthesised several benzimidazole derivatives. One, named JVG9 (5-chloro-1H-benzimidazole-2-thiol), has been found to be effective against T. cruzi bloodstream trypomastigotes under both in vitro and in vivo conditions. Here, we present the in vitro effects observed by laser scanning confocal and scanning electron microscopy on T. cruzi trypomastigotes. Changes in the surface and the distribution of the cytoskeletal proteins are consistent with the hypothesis that the trypanocidal activity of JVG9 involves the cytoskeleton as a target.
Descritores: Benzimidazóis/farmacologia
Citoesqueleto/efeitos dos fármacos
Estágios do Ciclo de Vida/efeitos dos fármacos
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
-Actinas/isolamento & purificação
Flagelos/efeitos dos fármacos
Microscopia Eletrônica de Varredura
Microscopia de Fluorescência
Trypanosoma cruzi/crescimento & desenvolvimento
Trypanosoma cruzi/ultraestrutura
Tubulina (Proteína)/isolamento & purificação
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  4 / 21 LILACS  
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Id: lil-697162
Autor: Zhang, Hui; Zhu, Ling; Zhou, Yuancheng; Ji, Hongwei; Dai, Hongbo; Guo, Wanzhu; Xu, Zhiwen.
Título: Rapid and sensitive detection of Bordetella bronchiseptica by loop-mediated isothermal amplification (LAMP)
Fonte: Pesqui. vet. bras = Braz. j. vet. res;33(10):1222-1226, Oct. 2013. ilus, tab.
Idioma: en.
Resumo: Bordetella bronchiseptica causes acute and chronic respiratory infections in diverse animal species and occasionally in humans. In this study, we described the establishment of a simple, sensitive and cost-efficient loop-mediated isothermal amplification (LAMP) assay for the detection of B. bronchiseptica. A set of primers towards a 235 bp region within the flagellum gene of B. bronchiseptica was designed with online software.. The specificity of the LAMP assay was examined by using 6 porcine pathogens and 100 nasal swabs collected from healthy pigs and suspect infected pigs. The results indicated that positive reactions were confirmed for all B. bronchiseptica and no cross-reactivity was observed from other non-B. bronchiseptica. In sensitivity evaluations, the technique successfully detected a serial dilutions of extracted B. bronchiseptica DNA with a detection limit of 9 copies, which was 10 times more sensitive than that of PCR. Compared with conventional PCR, the higher sensitivity of LAMP method and no need for the complex instrumentation make this LAMP assay a promising alternative for the diagnosis of B. bronchiseptica in rural areas and developing countries where there lacks of complex laboratory services.
Descritores: Bordetella bronchiseptica/genética
Flagelos/genética
Técnicas de Amplificação de Ácido Nucleico/economia
Testes Genéticos
Testes Laboratoriais/análise
-Infecções por Bordetella/diagnóstico
Reação em Cadeia da Polimerase
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  5 / 21 LILACS  
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Id: lil-694714
Autor: Zukas, Randi; Chang, Alex J.; Rice, Marian; Springer, Amy L..
Título: Structural analysis of flagellar axonemes from inner arm dynein knockdown strains of Trypanosoma brucei
Fonte: Biocell;36(3):133-142, Dec. 2012. ilus, graf, tab.
Idioma: en.
Resumo: Trypanosoma brucei is a protozoan flagellate that causes African sleeping sickness. Flagellar function in this organism is critical for life cycle progression and pathogenesis, however the regulation of flagellar motility is not well understood. The flagellar axoneme produces a complex beat through the precisely coordinated firing of many proteins, including multiple dynein motors. These motors are found in the inner arm and outer arm complexes. We are studying one of the inner arm dynein motors in the T. brucei flagellum: dynein-f. RNAi knockdown of genes for two components of dynein-f: DNAH10, the a heavy chain, and IC138, an intermediate chain, cause severe motility defects including immotility. To determine if motility defects result from structural disruption of the axoneme, we used two different flagellar preparations to carefully examine axoneme structure in these strains using transmission electron microscopy (TEM). Our analysis showed that inner arm dynein size, axoneme structural integrity and fixed central pair orientation are not significantly different in either knockdown culture when compared to control cultures. These results support the idea that immotility in knockdowns affecting DNAH10 or IC138 results from loss of dynein-f function rather than from obvious structural defects in the axoneme.
Descritores: Axonema/metabolismo
Dineínas/química
Trypanosoma brucei brucei/metabolismo
-Ciclo Celular
Movimento Celular
Dineínas/metabolismo
Flagelos/metabolismo
Modelos Biológicos
Microscopia Eletrônica de Transmissão/métodos
Interferência de RNA
Limites: Animais
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


  6 / 21 LILACS  
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Steindel, Mário
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Id: lil-649484
Autor: Prestes, Elisa Beatriz; Bayer-Santos, Ethel; Hermes Stoco, Patrícia; Sincero, Thaís Cristine Marques; Wagner, Glauber; Umaki, Adriana; Fragoso, Stenio Perdigão; Bordignon, Juliano; Steindel, Mário; Grisard, Edmundo Carlos.
Título: Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
Fonte: Mem. Inst. Oswaldo Cruz;107(6):713-719, set. 2012. ilus, tab.
Idioma: en.
Resumo: Protein tyrosine phosphatases (PTPs) play an essential role in the regulation of cell differentiation in pathogenic trypanosomatids. In this study, we describe a PTP expressed by the non-pathogenic protozoan Trypanosoma rangeli (TrPTP2). The gene for this PTP is orthologous to the T. brucei TbPTP1 and Trypanosoma cruzi (TcPTP2) genes. Cloning and expression of the TrPTP2 and TcPTP2 proteins allowed anti-PTP2 monoclonal antibodies to be generated in BALB/c mice. When expressed by T. rangeli epimastigotes and trypomastigotes, native TrPTP2 is detected as a ~65 kDa protein associated with the parasite's flagellum. Given that the flagellum is an important structure for cell differentiation in trypanosomatids, the presence of a protein responsible for tyrosine dephosphorylation in the T. rangeli flagellum could represent an interesting mechanism of regulation in this structure.
Descritores: Anticorpos Monoclonais/imunologia
Flagelos/enzimologia
Proteínas Tirosina Fosfatases/metabolismo
Trypanosoma rangeli/enzimologia
-Imunização
Camundongos Endogâmicos BALB C
Filogenia
Proteínas Tirosina Fosfatases/genética
Trypanosoma rangeli/genética
Trypanosoma rangeli/imunologia
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 21 LILACS  
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Id: lil-595049
Autor: Parodi, Elisa R; Cáceres, Eduardo J; Westermeier, Renato; Müller, Dieter G.
Título: Secondary zoospores in the algal endoparasite Maullinia ectocarpii (Plasmodiophoromycota)
Fonte: Biocell;34(1):45-52, Apr. 2010. ilus.
Idioma: en.
Resumo: The present paper deals with the ultrastructure of zoospores produced by the plasmodiophorid Maullinia ectocarpii, living in the marine algal host Ectocarpus siliculosus. The zoospores described here are very similar to secondary zoospores of Polymyxa graminis and Phagomyxa sp. (the latter an algal endoparasite, also). Our results indicate that M. ectocarpii produces two types of plasmodia, and suggest that is a species with a complete life cycle, as it is known for all the Plasmodiophormycota that have been studied. Sporogenic and sporangial plasmodia produce, respectively, primary zoospores with parallel flagella within thick walled resting sporangia, and secondary zoospores with opposite flagella within thin walled sporangia.
Descritores: Esporos de Protozoários/ultraestrutura
Flagelos/ultraestrutura
Feófitas/parasitologia
-Microscopia Eletrônica de Transmissão
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR40.1 - Biblioteca de la Facultad de Ciencias Médicas de la UNCuyo


  8 / 21 LILACS  
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Id: lil-522338
Autor: Diniz, Michely C; Costa, Marcília P; Pacheco, Ana C. L; Kamimura, Michel T; Silva, Samara C; Carneiro, Laura D. G; Sousa, Ana P. L; Soares, Carlos E. A; Souza, Celeste S. F; Oliveira, Diana Magalhães de.
Título: Actin-interacting and flagellar proteins in Leishmania spp: bioinformatics predictions to functional assignments in phagosome formation
Fonte: Genet. mol. biol;32(3):652-665, 2009. ilus, tab.
Idioma: en.
Resumo: Several motile processes are responsible for the movement of proteins into and within the flagellar membrane, but little is known about the process by which specific proteins (either actin-associated or not) are targeted to protozoan flagellar membranes. Actin is a major cytoskeleton protein, while polymerization and depolymerization of parasite actin and actin-interacting proteins (AIPs) during both processes of motility and host cell entry might be key events for successful infection. For a better understanding the eukaryotic flagellar dynamics, we have surveyed genomes, transcriptomes and proteomes of pathogenic Leishmania spp. to identify pertinent genes/proteins and to build in silico models to properly address their putative roles in trypanosomatid virulence. In a search for AIPs involved in flagellar activities, we applied computational biology and proteomic tools to infer from the biological meaning of coronins and Arp2/3, two important elements in phagosome formation after parasite phagocytosis by macrophages. Results presented here provide the first report of Leishmania coronin and Arp2/3 as flagellar proteins that also might be involved in phagosome formation through actin polymerization within the flagellar environment. This is an issue worthy of further in vitro examination that remains now as a direct, positive bioinformatics-derived inference to be presented.
Descritores: Leishmania/genética
PROTEINA ABATTOIRS RELACIONADA A ACTINA
PROTEINA TEMEFOS RELACIONADA A ACTINA
-Actinas/metabolismo
Biologia Computacional
Flagelos
Fagossomos
Limites: Animais
Responsável: BR26.1 - Biblioteca Central


  9 / 21 LILACS  
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Id: lil-520065
Autor: Gouveia, J. J. S; Vasconcelos, E. J. R; Pacheco, A. C. L; Araújo-Filho, R; Maia, A. R. S; Kamimura, M. T; Costa, M. P; Viana, D. A; Costa, R. B; Maggioni, R; Oliveira, D. M.
Título: Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function
Fonte: Genet. mol. res. (Online);6(4):766-798, 2007. ilus, tab.
Idioma: en.
Conferência: Apresentado em: X-Meeting 2006 - International Conference of the AB3C, 2, Apresentado em: Annual International Conference on Intelligent Systems for Molecular Biology, 14, Fortaleza, Aug. 6-10, 2006.
Resumo: Flagella are constructed and maintained through the highly conserved process of intraflagellar transport (IFT), which is a rapid movement of particles along the axonemal microtubules of cilia/flagella. Particles that are transported by IFT are composed of several protein subunits comprising two complexes (A and B), which are conserved among green algae, nematodes, and vertebrates. To determine whether or not homologues to members of the IFT complex proteins are conserved in Leishmania spp, we scanned genomes, transcriptomes and proteomes of Leishmania species in a search for putative IFT factors, which were then identified in silico, compared, cataloged, and characterized. Since a large proportion of newly identified genes in L. major remain unclassified, with many of these being potentially Leishmania- (or kinetoplastid-) specific, there is a need for detailed analyses of homologs/orthologs that could help us understand the functional assignment of these gene products. We used a combination of integrated bioinformatics tools in a pathogenomics approach to contribute to the annotation of Leishmania genomes, particularly regarding flagellar genes and their roles in pathogenesis. This resulted in the formal in silico identification of eight of these homologs in Leishmania (IFT subunits, 20, 27, 46, 52, 57, 88, 140, and 172), along with others (IFTs 71, 74/72, and 81), as well as sequence comparisons and structural predictions. IFT, an important flagellar pathway in Leishmania, begins to be revealed through screening of trypanosomatid genomes; this information could also be used to better understand fundamental processes in Leishmania, such as motility and pathogenesis.
Descritores: Biologia Computacional/métodos
Flagelos/genética
Genes de Protozoários
Genoma de Protozoário
Leishmania/genética
-Sequência de Aminoácidos
Transporte Biológico
Sequência Conservada
Cílios/genética
Dados de Sequência Molecular
Estrutura Terciária de Proteína
Análise de Sequência de DNA
Homologia de Sequência de Aminoácidos
Subunidades Proteicas/genética
Subunidades Proteicas/química
Limites: Animais
Responsável: BR26.1 - Biblioteca Central


  10 / 21 LILACS  
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Texto completo SciELO Venezuela
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Id: lil-518696
Autor: Mosca, Walter; Briceño, Luis.
Título: Proliferation and bystander suppression induced by membrane and flagellar antigens of Trypanosoma cruzi
Fonte: Invest. clín;50(1):77-87, mar. 2009. tab, graf.
Idioma: en.
Resumo: We have studied, in vitro, proliferation induced by flagella (FE) and membrane (ME) antigenic fractions of T. cruzi epimastigotes, as well as their regulatory effect on the proliferative response to PPD (Protein Purified Derivative). Crude flagella as well as bands from Western blots of flagella and membrane of epimastigotes were tested. Crude flagella elicited higher proliferation in mononuclear cells from patients with Chagasic cardiomyopathy (CDM) than in patients with no evidence of cardiac pathology (INF). Fractionated antigens induced a lower proliferative response, in intensity as well as in frequency, than the crude extracts. With FE, bands between 150 and 24.3 kDa (B3 to B18 with the exception of B4 and B13) induced higher CPM (Counts Per Minute) in CDM. In INF only bands B7 (87.3 to 80.1 kDa), 9 (69.8 to 64.6 kDa) and 13 (45.4 to 41.5 kDa) had high CPM. ME bands also elicited higher proliferation in CDM. However, only 5 out of 14 bands gave CPM higher than 1000 in CDM and none in INF. The mean down regulation (DR) of most bands was similar in both groups. But the frequency of relevant DR elicited by FE was significantly higher in CDM. In contrast the frequency of up regulation (UR) was higher in INF. Bands 13 and 14 of ME did not induce DR in most INF. The discordance between the frequency of relevant DR in CDM and INF was more evident with ME than with FE. The frequency of (UR) was 50% or higher with all ME bands in INF, but, lower than 12% in CDM. The higher UR in INF and of DR in CDM, suggest the presence of some balance or interaction in INF that is lost in CDM. In ME there might be antigens that could be relevant for the immunoprofilaxis of Chagas' disease. The difference in the clinical status of the two groups seems to be associated with the recognition of different groups of antigens together with variations in the nature of the regulation of the response of mononuclear cells to these antigens.

Hemos estudiado, in vitro, la respuesta proliferativa de células mononucleares a antígenos de Flagelo (FE) y Membrana (ME) de epimastigotes de T. cruzi, así como su efecto regulador en la respuesta proliferativa a PPD (Protein Purified derivative). Fue evaluada tanto la respuesta a Flagelo crudo como a las bandas de Western blots de FE y ME. El flagelo crudo indujo una proliferación de las células mononucleares más intensa en los pacientes con cardiomiopatía (CDM) que en los pacientes sin evidencia de patología cardiaca (INF). Los antígenos fraccionados causaron una menor respuesta proliferativa, tanto en intensidad como en frecuencia, que los antígenos crudos. Las bandas de FE, entre 150 y 24,3 kDa (B3 a B18 con la excepción de B4 y B13), indujeron CPM mas altas en CDM. En INF solo las bandas B7 (87,3 a 80,1 kDa), 9 (69,8 a 64,6 kDa) y 13 (45,4 a 41,5 kDa) causaron CPM (Cuentas Por Minuto) altas. Las bandas de ME también indujeron una proliferación mayor en CDM. Sin embargo, solo 5 de 14 bandas tuvieron CPM promedio mayores de 1000 en INF. La mayor parte de las bandas causaron una baja regulación (BR) que fue similar en ambos grupos. Sin embargo, la frecuencia de BR relevante producida por FE fue significativamente mayor en CDM. Por el contrario la sobre regulación (SB) fue mayor en INF. Las bandas 13 y 14 de ME no indujeron BR en la mayor parte de los INF. La discordancia entre la frecuencia de BR relevante en CDM e INF fue mas evidente con ME que con FE. La frecuencia de SB fue 50% o mas con todas las bandas de ME en INF, pero menor que 12% en los CDM. El predominio de SB en INF y de BR en CDM sugiere la presencia, en los INF, de algún tipo de equilibrio o interacción que esta ausente en los CDM. En ME pudieran estar presente antígenos relevantes para la inmunoprofilaxis de la enfermedad de Chagas. En conjunto nuestros resultados sugieren que las diferencias en los cuadros clínicos pudieran tener relación con la respuesta observada a los diferentes...
Descritores: Doença de Chagas
Flagelos/parasitologia
Imunidade Celular
Membranas
Trypanosoma cruzi
Limites: Seres Humanos
Masculino
Feminino
Tipo de Publ: Estudo Comparativo
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha



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