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Pesquisa : A11.329.427 [Categoria DeCS]
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Id: biblio-977936
Autor: Silva, Diogo Tiago da; Alves, Maria Luana; Spada, Júlio Cesar Pereira; Silveira, Rita de Cássia Viveiros da; Oliveira, Trícia Maria Ferreira de Sousa; Starke-Buzetti, Wilma Aparecida.
Título: Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum / Neutrófilos, eosinófilos e mastócitos na parede intestinal de cães naturalmente infectados com Leishmania infantum
Fonte: Rev. bras. parasitol. vet;27(4):430-438, Oct.-Dec. 2018. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophils, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. infantum amastigotes in the intestine; group 2 (G2, n=9), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). Granulocytic cells were counted in the crypt-villus unit (mucosa), submucosa, and muscle layer of the intestinal mucosa. Cell counts were higher in the intestinal wall of dogs from G2 followed by G1 and G3 (p≤0.05). In G1, there was a low inverse correlation between parasite burden of the small intestine and granulocyte counts (r= -0.1, p≤0.01). However, in G2 dogs, mast cell and eosinophil numbers showed positive correlation (r=0.85, p≤0.01). The granulocytic cell hyperplasia observed in the intestine of L. infantum-infected dogs suggests that these cells may be involved in the cell-mediated immune response for parasite elimination.

Resumo A leishmaniose visceral (LV) é uma doença causada pelo protozoário Leishmania infantum e pode causar uma reação inflamatória no trato gastrointestinal, entretanto o papel das células granulocíticas (neutrófilos, eosinófilos e mastócitos) no intestino de cães infectados não é totalmente compreendido. Neste estudo realizamos uma análise quantitativa dessas células na parede intestinal de cães com LV. Vinte cães foram distribuídos em três grupos: grupo 1 (G1, n=8), cães com LV e amastigotas de L. infantum no intestino; grupo 2 (G2, n=9), cães com LV, mas sem amastigotas intestinais; e grupo 3 (G3, n=3), não infectados (grupo controle). Células granulocíticas foram contadas na unidade cripta-vilo (mucosa), submucosa e camada muscular da mucosa intestinal. Observamos hiperplasia dessas células na parede intestinal de cães do G2, seguidas das G1 em relação ao G3 (p≤0,05). No G1, houve uma correlação inversa baixa entre a carga parasitária do intestino delgado e a contagem de granulócitos (r= -0,1; p≤0,01). No entanto, nos cães do G2, os números de mastócitos e eosinófilos apresentaram correlação positiva (r=0,85; p≤0,01). A hiperplasia de células granulocíticas observada no intestino de cães infectados por L. infantum sugere que essas células podem estar envolvidas na resposta imune mediada por células para a eliminação do parasita.
Descritores: Leishmania infantum
Doenças do Cão/patologia
Mucosa Intestinal/patologia
Leishmaniose Visceral/patologia
-Estudos de Casos e Controles
Doenças do Cão/parasitologia
Eosinófilos/patologia
Mucosa Intestinal/parasitologia
Leishmaniose Visceral/parasitologia
Mastócitos/patologia
Neutrófilos/patologia
Limites: Animais
Masculino
Feminino
Cães
Responsável: BR1.1 - BIREME


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Id: lil-646599
Autor: Mayta Tristán, Percy.
Título: Mastocitos y síndrome de intestino irritable, ¿falta de asociación o de potencia del estudio? / Mast cells and Irritable bowel syndrome
Fonte: Rev. gastroenterol. Perú;32(1):98-99, ene.-mar. 2012.
Idioma: es.
Descritores: Mastócitos
Síndrome do Intestino Irritável
Tipo de Publ: Carta
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-613791
Autor: Arévalo, F; Aragon, V; Montes, P; Guzmán, E; Monge, E.
Título: Incremento de linfocitos intraepiteliales en pacientes con sindrome de intestino irritable / Increase of intraepithelial lymphocytes in patients with irritable bowel syndrome
Fonte: Rev. gastroenterol. Perú;31(4):315-318, oct.-dic. 2011. ilus, tab.
Idioma: es.
Resumo: Diversos trabajos reportan aumento en el número de linfocitos intraepiteliales (LIE), mastocitos y células enterocromafines en pacientes con Sindrome de Intestino Irritable (SII). Muchos de estos hallazgos se basan en el uso de inmunohistoquímica que son de poca disponibilidad en hospitales generales. El objetivo del presente trabajo es estudiar los hallazgos histológicos en la biopsia de colon sólo con histoquimica en pacientes con SII comparándolos con un grupo sin SII. Fueron incluidos 25 pacientes: 16 (64%), con criterios diagnósticos de SII y 9 (36%), sin SII. Se encontró un mayor número de LIE en el grupo de SII (p=0,002). Un grupo de pacientes con criterios Roma III (41,9%) presentó LIE en el rango de Colitis Linfocitica por lo que fueron excluidos de este estudio. No se encontró diferencia estadísticamente significativa en el número de mastocitos, células enterocromafines y eosinofilos.

Several studies have shown increased numbers of intraepithelial lymphocytes (IEL), mast cells, enterochromaffin cells in colonic mucosa of patients with Irritable Bowel Syndrome (IBS). Many of these findings are based is based on immunohistochemistry results, which is not available in general hospitals. Our objective is to study the histological findings observed in colon biopsies from patients with IBS compared with a group without IBS, using only histochemistry. Twenty five (25) patients were included: 16 with IBS and 9 without IBS. We found increased numbers of IEL in patients with IBS (p=0,002). A group of patients with IBS(41.9%) who fulfilled histological criteria for lymphocytic colitis were excluded. There was no significant difference in mast cells, enterochromaffin cells or eosinophils.
Descritores: Colonoscopia
Células Enterocromafins
Imuno-Histoquímica
Linfócitos
Mastócitos
Síndrome do Intestino Irritável/diagnóstico
-Epidemiologia Descritiva
Estudos Transversais
Limites: Humanos
Masculino
Feminino
Adulto Jovem
Pessoa de Meia-Idade
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-765203
Autor: Valdivia-Silva, Julio E.
Título: Mastocitos y basófilos y sus nuevas funciones en inmunología / Mast cells and basophils: its new functions in immunity
Fonte: Dermatol. peru;23(2):98-105, abr.-jun. 2013. ilus.
Idioma: es.
Resumo: Los mastocitos y basófilos han demostrado tener múltiples funciones dentro del sistema inmune. Además de su clásico rol de respuesta inflamatoria en contra de alérgenos también se les ha visto participando en respuestas directas contra diversos agentes infecciosos. Diversas funciones in vivo de estas células han permanecido poco conocidas debido a la usencia de modelos animales que puedan investigar su desarrollo y su real importancia durante salud y enfermedad. Sin embargo, recientes estudios han podido caracterizar y aislar las células precursoras de estos linajes, y así entender nuevas funciones efectoras que eran desconocidas in vivo. Esta revisión brinda conceptos básicos e importantes del desarrollo y la acción efectora de estas células enfatizando conceptos inmunológicos necesarios para la comprensión de los mecanismos de enfermedad en diversos estados patológicos.

Mast cells and basophils have demonstrated to have both beneficial and detrimental functions for the immune system. Additionally to their classic role in pro-inflammatory responses to allergens, they are also involved directly in immunity against different pathogens. Because there are few anima/s models developed to investigate these cells in vivo, their functions during health and disease remain poorly understood. This review gives a short glance in the development and functional status of mast cells and basophils focusing on immunology concepts necessary to get a major understanding of the mechanisms of disease in different pathological states.
Descritores: Basófilos
Imunidade Inata
Mastócitos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Souza, Lélia Batista de
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Id: biblio-874178
Autor: Santos, Pedro Paulo de Andrade; Freitas, Valéria Souza; Freitas, Roseana de Almeida; Pinto, Leão Pereira; Souza, Lélia Batista de.
Título: Relação entre mastócitos e células T na inflamação / Relationship between mast cels and T cells in inflamation
Fonte: Odontol. clín.-cient;9(3):215-217, jul.-set. 2010.
Idioma: pt.
Resumo: Os mastócitos são tipos celulares que executam uma série de funções por meio da liberação de mediadores químicos, quando devidamente estimulados, interagindo com várias células das mais diferentes origens. Sabe-se, ainda, que as interações entre mastócitos e células T existem, porém ainda não são muito claras. O objetivo deste trabalho foi o de realizar uma revisão de literatura dos aspectos atuais a respeito da possível relação entre mastócitos e células T em processos inflamatórios.

The mast cells are cellular types that execute a series of functions through the release of chemical mediators when duly stimulated, interacting with some cells of the most different origins. It is known despite the interactions between mast cells and cells T exist, however aren't very clear yet. The objective of this work was to carry through a literary revision of the related current aspects of a possible relationship between mast cells and T cells in inflammatory process.
Descritores: Células Th1
CELULAS THTEMEFOS
Linfócitos T
Mastócitos
Tipo de Publ: Artigo Clássico
Responsável: BR310.1 - Biblioteca Professor Guilherme Simões Gomes


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Id: biblio-1056800
Autor: Riaño-Quintero, Camilo; Gómez-Ramírez, Edwin; Hurtado-Giraldo, Hernán.
Título: Glyphosate commercial formulation effects on preoptic area and hypothalamus of Cardinal Neon Paracheirodon axelrodi (Characiformes: Characidae)
Fonte: Neotrop. ichthyol;17(4):e190025, 2019. tab, graf.
Idioma: en.
Projeto: Universidad Militar Nueva Granada.
Resumo: In Colombia the use of glyphosate commercial formulations (Roundup™) for spraying have left deleterious effects on animals and humans. Much of this spraying takes place at the Orinoco basin, habitat of one of the most exported ornamental fish in Colombia, Cardinal neon. To evaluate the effect of Roundup Activo™ four experimental treatments were carried out with 0 mg/L (T1), 0.1 mg/L (T2), 1 mg/L (T3) and 5 mg/L (T4) during 30 days of exposure. The fishes were processed for high-resolution optical microscopy. The main finding of Roundup Activo™ exposure was an increase in mast cells number in brain blood vessels and some neuronal nuclei of the preoptic and posterior diencephalic areas, including hypothalamus. A correlation between concentrations and mast cells number was observed, with the largest mast cells number in T4 treatment. Mast cells presence is a stress benchmark, suggesting the beginning of allergic, inflammatory and apoptotic events. Presence of mast cells in these brain areas may lead to alterations on reproduction, visual and olfactory information integration among other processes. These alterations may result in diminished survival, affecting the conservation of this species in its natural habitat.(AU)

En Colombia, el uso de formulaciones comerciales de glifosato (Roundup™) para la fumigación ha producido efectos nocivos en animales y humanos. Gran parte de esta fumigación se realiza en la cuenca del Orinoco, hábitat de uno de los peces ornamentales más exportados de Colombia, el Neón Cardenal. Para evaluar el efecto de Roundup Activo™ se realizó un experimento con cuatro tratamientos 0 mg/L (T1), 0,1 mg/L (T2), 1 mg/L (T3) y 5 mg/L (T4) durante 30 días. Los peces fueron procesados para microscopía óptica de alta resolución. El principal hallazgo fue el aumento del número de mastocitos en los vasos sanguíneos cerebrales y algunos núcleos neuronales del área preóptica y diencefálica posterior, incluido el hipotálamo. Identificamos una correlación entre las concentraciones y el número de mastocitos, que alcanzó su máximo en T4. La presencia de mastocitos evidencia estrés, promoviendo eventos alérgicos, inflamatorios y apoptóticos. La presencia de mastocitos en estas áreas del cerebro puede llevar a alteraciones en la reproducción e integración de la información visual y olfativa entre otros procesos. Estas alteraciones pueden resultar en una disminución de la supervivencia, afectando la conservación de esta especie en su hábitat natural.(AU)
Descritores: Caraciformes/fisiologia
Mastócitos/citologia
-Herbicidas
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-973477
Autor: Simsek, Tuncer; Erbas, Mesut; Buyuk, Basak; Pala, Cigdem; Sahin, Hasan; Altinisik, Betul.
Título: Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits
Fonte: Acta cir. bras;33(11):954-963, Nov. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study. Methods: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study. Results: There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p> 0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482). Conclusions: Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.
Descritores: Fármacos Neuromusculares não Despolarizantes/efeitos adversos
Iridoides/administração & dosagem
Rocurônio/efeitos adversos
Anestesia Geral/efeitos adversos
Mastócitos/efeitos dos fármacos
Anti-Inflamatórios/administração & dosagem
-Aspartato Aminotransferases/sangue
Albumina Sérica/análise
Distribuição Aleatória
Degranulação Celular/efeitos dos fármacos
Agregação Celular/efeitos dos fármacos
Reprodutibilidade dos Testes
Cromatografia Líquida de Alta Pressão
Dietoterapia/métodos
Alanina Transaminase/sangue
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle
Profilaxia Pré-Exposição/métodos
Fígado/efeitos dos fármacos
Fígado/enzimologia
Mastócitos/patologia
Limites: Animais
Masculino
Coelhos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1094900
Autor: Souto, Giovanna Ribeiro; Jesus, Alessandro Oliveira de; Segundo, Takeshi Kato; Perdigão, Paôlla Freitas; Abreu, Lucas Guimarães; Costa, Fernando Oliveira; Mesquita, Ricardo Alves.
Título: Mast cell degranulation in periodontal disease from HIV-infected individuals
Fonte: Braz. j. oral sci;18:e191445, jan.-dez. 2019. ilus.
Idioma: en.
Resumo: Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and tained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.
Descritores: Doenças Periodontais
HIV
Periodontite Crônica
Gengivite
Mastócitos
Mucosa Bucal
Limites: Humanos
Masculino
Feminino
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Id: biblio-949901
Autor: Peres, Letícia Pargendler; Oliveira, Fabiana Bazanella; Cartell, André; Mazzotti, Nicolle Gollo; Cestari, Tania Ferreira.
Título: Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study
Fonte: An. bras. dermatol;93(3):368-372, May-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract: BACKGROUND: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established. OBJECTIVE: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. METHODS: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. RESULTS: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). STUDY LIMITATIONS: The small sample size may be considered the main limitation of our study. CONCLUSIONS: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.
Descritores: Prurido/patologia
Psoríase/patologia
Pele/patologia
Mastócitos/patologia
-Prurido/terapia
Biópsia
Estudos Transversais
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-827757
Autor: Henriques, Águida Cristina Gomes; Freitas, Roseana de Almeida; Pires, Bruno Cunha; Gurgel, Clarissa Araújo; Santos, Jean Nunes dos.
Título: Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
Fonte: An. bras. dermatol;91(5):589-594, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results: The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion: These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.
Descritores: Dermatoses Faciais/patologia
Fibroma/patologia
-Fibrose/metabolismo
Imuno-Histoquímica
Colágeno/metabolismo
Elastina/metabolismo
Triptases/metabolismo
Dermatoses Faciais/metabolismo
Fibroblastos/metabolismo
Fibroma/metabolismo
Mastócitos/metabolismo
Mucosa Bucal/metabolismo
Limites: Humanos
Responsável: BR1.1 - BIREME



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