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Id: biblio-1052120
Autor: Bezerra, Ulisses de Sá; Sousa, Erick Thiago de; Oliveira, Lucas Portela; Oliveira, Marisa Coragem Alves de; Bernardino, Raíssa Marielly Parente; Silva, Aryvelto Miranda.
Título: Revascularização pulpar em dentes permanentes imaturos sem vitalidade pulpar: uma revisão integrativa / Pulp revascularization in immature permanent teeth without pulp vitality: an integrative review
Fonte: Rev. Salusvita (Online);38(3):781-794, 2019.
Idioma: pt.
Resumo: Introdução: Dentes permanentes imaturos que evoluem para necrose pulpar representam um desafio para tratamento endodôntico. A endodontia regenerativa e técnicas de revascularização pulpar surgem como um campo dinâmico e potencialmente ideal para terapia clínica em dentes com desenvolvimento radicular incompleto. Objetivo: Revisar a literatura sobre as técnicas de revascularização pulpar no tratamento de dentes com ausência de vitalidade pulpar com ápice radicular imaturo. Métodos: Os descritores "pulp revascularization", "pulp necrosis", "immature permanent tooth", "revascularization", "revitalization", "dental pulp", "regeneration" foram utilizados para obtenção de artigos em língua inglesa, que apresentassem conteúdo disponibilizado na íntegra e publicados nos últimos 15 anos. Foram excluídos os trabalhos de relatos de caso e/ou séries de casos. Conclusão: Artigos revisados apresentaram uma heterogeneidade de resultados quanto à efetividade da técnica de revascularização pulpar, visto que os critérios estabelecidos para determinação do sucesso variavam entre os autores. O material mais comumente utilizado na técnica empregada consiste no Agregado Trióxido Mineral (MTA) em consistência pastosa aplicada sobre coágulo sanguíneo com formação induzida no interior do canal. Foi observada escassez de estudos laboratoriais e clínicos sobre as técnicas e materiais em revascularização pulpar, que suportem sua indicação, o que representa uma lacuna em potencial na literatura e requer cautela na indicação desta técnica.

Introduction: Immature permanent teeth that evolve to pulp necrosis represent a challenge for endodontic treatment. Regenerative endodontics and pulp revascularization techniques appear as a dynamic and potentially ideal field for clinical therapy in teeth with incomplete root development. Objective: To review the literature on pulpal revascularization techniques in the treatment of teeth with absence of pulp vitality with immature root apex. Methods: The descriptors "pulp revascularization", "pulp necrosis", "immature permanent tooth", "revascularization", "revitalization", "dental pulp" and "regeneration" were used to obtain articles in English that presented content available in full and published in the last 15 years. Works of case reports and/or series of cases were excluded. Conclusion: Reviewed articles presented a heterogeneity of results regarding the effectiveness of the pulp revascularization technique, since the established criteria for determining success varied among the authors. The material most commonly used in the technique used consists of the Mineral Trioxide Aggregate (MTA) in paste consistency applied on blood clot with induced formation inside the canal. A shortage of laboratory and clinical studies on pulp revascularization techniques and materials that support its indication has been observed, which represents a potential gap in the literature and requires caution in the indication of this technique.
Descritores: Necrose da Polpa Dentária
-Polpa Dentária
Tipo de Publ: Revisão
Responsável: BR36.1 - Biblioteca


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Id: biblio-1015462
Autor: Caballero Méndez, Lyda; Rivera Cano, Juliana; Gaviria Arias, Duverney.
Título: Evaluación de la fibroína de seda como biomaterial de soporte para el crecimiento de células mesenquimales estromales de pulpa dental / Evaluation of silk fibroin as a support biomaterial for the growth of stromal mesenchymal cells of dental pulp
Fonte: ARS med. (Santiago, En línea);41(1):5-13, 2016. ilus, Graf, Tab.
Idioma: es.
Resumo: La regeneración de tejidos usando células, factores de crecimiento y soportes constituyen una alternativa en la Medicina Regenerativa. La fibroína de seda es un excelente biosoporte, sus propiedades mecánicas únicas le permiten soportar procesos de adhesión y crecimiento celular. Objetivo. Evaluar la fibroína de la seda obtenida del gusano de seda Bombyx mori L como material de soporte para el crecimiento de células mesenquimales estromales de pulpa dental (CMPD). Métodos. La fibroína obtenida a partir de capullos de gusanos de seda Bombyx mori L criados en la Granja El Pílamo, propiedad de la Universidad Tecnológica de Pereira, se empleó para la fabricación de películas de fibroína íntegras y resistentes a condiciones de cultivo. Las CMPD fueron obtenidas a partir de un donante de diente premolar, la pieza dental se cortó con disco de diamante para la obtención de la pulpa que fue sometida a disgregación enzimática. Las células obtenidas se subcultivaron hasta el segundo pase, para posteriormente transferirse a cajas de cultivo que contenían películas de fibroína, se sometieron a condiciones inherentes al proceso de incubación siguiendo su crecimiento y viabilidad celular durante 27 días. Resultados. Al final del periodo de incubación, se observaron películas integras, estables y resistentes que permitieron el crecimiento celular. Conclusión. Se plantea el uso de fibroína como un biopolímero natural que brinda un soporte mecánico, un microambiente óptimo y un mimetismo de la estructura organizacional de los tejidos, postulándose como un potencial biomaterial para procesos de crecimiento celular en Medicina Regenerativa e Ingeniería de Tejidos.(AU)

Tissue regeneration using cells, growth factors and supports are an alternative in Regenerative Medicine. Silk fibroin is an excellent biosupport, its unique mechanical properties allow it to support processes of cell adhesion and growth. Objective: Evaluating the obtained silk´s fibroin from silkworm (Bombyx mori L) as a scaffold material for growth of dental pulp mesenchymal stromal cells (CMPD). Methods: The fibroin was obtained from silkworm (Bombyx mori L) cocoons reared at "The Pilamo" Farm, owned by the Universidad Tecnológica de Pereira. Procedures for obtaining full and resistant fibroin films to culture conditions were performed. The CMPD were obtained from a premolar tooth, the tooth was cut with a diamond blade to obtain the pulp which was subjected to enzymatic digestion. The cells obtained were subcultured until the second pass, and then, transferred to culture dishes containing fibroin films. This cells were cultured in standard conditions and tracking incubation with cell viability and growth for 27 days. Results: At the end of the incubation period, we realize that the fibroin films were intact and also this fibroin films allows cell growth.Conclusion: The use of fibroin as a natural biopolymer provides mechanical support, also an optimal microenvironment and mimic the organizational structure of tissues, so we postulated fibroin as a potential biomaterial for cell growth to be used in regenerative medicine and tissue engineering.(AU)
Descritores: Materiais Biocompatíveis
Fibroínas
-Células Estromais
Engenharia Tecidual
Polpa Dentária
Medicina Regenerativa
Limites: Seres Humanos
Masculino
Feminino
Tipo de Publ: Artigo Clássico
Responsável: CL10.1 - Biblioteca Biomédica


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Id: biblio-1048552
Autor: Teicher, Clara; Ensinck, Ileana; Nannini, Alicia; Lurati, Analía; Valvo, Alejandrina; Romero, Valeria.
Título: La reparación de la pulpa dental. Materiales y alternativas de tratamiento: revisión de la información bibliográfica / Dental pulp repair. Materials and alternative therapies: review of the literature
Fonte: Rev. Asoc. Odontol. Argent;107(3):110-115, jul.-sept. 2019.
Idioma: es.
Resumo: Este trabajo pretende actualizar los conocimientos acerca de los diversos materiales utilizados en las terapias pulpares (tanto en dientes primarios como en permanentes) que buscan una respuesta reparativa cada vez más conservadora, biológica y sustentable. Se trata de un recorrido por el uso de agentes como el agregado de trióxido mineral (MTA), el láser, Biodentine® y los concentrados de plasma rico en plaquetas, con sus características, sus posibles aplicaciones y su eficacia, evaluadas clínica y radiográficamente en múltiples trabajos de investigación, informes de casos, estudios comparativos (in vitro e in vivo) y ensayos experimentales en animales que documentan sus resultados (AU)

This literature review aims to update knowledge about the different materials used in pulp therapies (both in primary and permanent teeth) that seek for an increasingly conservative, biological and sustainable reparative response. It is a journey through the use of agents such as mineral trioxide aggregate (MTA), lasers, biodentine and platelet rich plasma concentrates, their properties, applications and efficacy, clinically and radiographically evaluated in multiple research papers, case reports, comparative studies (in vitro and in vivo) and experimental studies in animals that document their results
Descritores: Materiais Biocompatíveis/uso terapêutico
Polpa Dentária/efeitos dos fármacos
Plasma Rico em Plaquetas
-Dente Decíduo
Dentição Permanente
Terapia a Laser
Limites: Seres Humanos
Animais
Tipo de Publ: Revisão
Responsável: AR29.1 - Biblioteca


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Id: lil-797983
Autor: Vaz, Maysa Magalhães; Lopes, Lawrence Gonzaga; Cardoso, Paula Carvalho; Souza, João Batista de; Batista, Aline Carvalho; Costa, Nádia Lago; Torres, Érica Miranda; Estrela, Carlos.
Título: Inflammatory response of human dental pulp to at-home and in-office tooth bleaching
Fonte: J. appl. oral sci;24(5):509-517, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Projeto: CAPES.
Resumo: ABSTRACT Tooth bleaching is a technique of choice to obtain a harmonious smile, but bleaching agents may damage the dental pulp. Objective: This study evaluated the inflammatory responses of human dental pulp after the use of two bleaching techniques. Material and Methods: Pulp samples were collected from human third molars extracted for orthodontic reasons and divided into three groups: control - no tooth bleaching (CG) (n=7); at-home bleaching with 15% carbamide peroxide (AH) (n = 10), and in-office bleaching with 38% hydrogen peroxide (IO) (n=12). Pulps were removed and stained with hematoxylin-eosin for microscopic analysis of inflammation intensity, collagen degradation, and pulp tissue organization. Immunohistochemistry was used to detect mast cells (tryptase+), blood vessels (CD31+), and macrophages (CD68+). Chi-square, Kruskal-Wallis, and Mann Whitney tests were used for statistical analysis. The level of significance was set at p<.05. Results: The inflammation intensity and the number of macrophages were significantly greater in IO than in AH and CG (p<0.05). The results of CD31+ (blood vessels per mm2) were similar in CG (61.39±20.03), AH (52.29±27.62), and IO (57.43±8.69) groups (p>0.05). No mast cells were found in the pulp samples analyzed. Conclusion: In-office bleaching with 38% hydrogen peroxide resulted in more intense inflammation, higher macrophages migration, and greater pulp damage then at-home bleaching with 15% carbamide peroxide, however, these bleaching techniques did not induce migration of mast cells and increased the number of blood vessels.
Descritores: Pulpite/induzido quimicamente
Clareamento Dental/efeitos adversos
Polpa Dentária/efeitos dos fármacos
Clareadores Dentários/toxicidade
-Peróxidos/toxicidade
Pulpite/patologia
Fatores de Tempo
Clareamento Dental/métodos
Ureia/análogos & derivados
Ureia/toxicidade
Vasos Sanguíneos/efeitos dos fármacos
Vasos Sanguíneos/patologia
Imuno-Histoquímica
Antígenos de Diferenciação Mielomonocítica
Distribuição Aleatória
Antígenos CD
Contagem de Células
Colágeno/efeitos dos fármacos
Estatísticas não Paramétricas
Molécula-1 de Adesão Celular Endotelial de Plaquetas
Polpa Dentária/patologia
Peróxido de Hidrogênio/toxicidade
Limites: Seres Humanos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Bramante, Clóvis Monteiro
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Id: lil-797979
Autor: Rodrigues, Clarissa Teles; Oliveira-Santos, Christiano de; Bernardineli, Norberti; Duarte, Marco Antonio Hungaro; Bramante, Clovis Monteiro; Minotti-Bonfante, Paloma Gagliardi; Ordinola-Zapata, Ronald.
Título: Prevalence and morphometric analysis of three-rooted mandibular first molars in a Brazilian subpopulation
Fonte: J. appl. oral sci;24(5):535-542, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT The knowledge of the internal anatomy of three-rooted mandibular molars may help clinicians to diagnose and plan the root canal treatment in order to provide adequate therapy when this variation is present. Objectives: To determine the prevalence of three-rooted mandibular molars in a Brazilian population using cone beam computed tomography (CBCT) and to analyze the anatomy of mandibular first molars with three roots through micro-CT. Material and Methods: CBCT images of 116 patients were reviewed to determine the prevalence of three-rooted first mandibular molars in a Brazilian subpopulation. Furthermore, with the use of micro-CT, 55 extracted three-rooted mandibular first molars were scanned and reconstructed to assess root length, distance between canal orifices, apical diameter, Vertucci's classification, presence of apical delta, number of foramina and furcations, lateral and accessory canals. The distance between the orifice on the pulp chamber floor and the beginning of the curvature and the angle of canal curvature were analyzed in the distolingual root. Data were compared using the Kruskal-Wallis test (α=0.05). Results: The prevalence of three-rooted mandibular first molars was of 2.58%. Mesial roots showed complex distribution of the root canal system in comparison to the distal roots. The median of major diameters of mesiobuccal, mesiolingual and single mesial canals were: 0.34, 0.41 and 0.60 mm, respectively. The higher values of major diameters were found in the distobuccal canals (0.56 mm) and the lower diameters in the distolingual canals (0.29 mm). The lowest orifice distance was found between the mesial canals (MB-ML) and the highest distance between the distal root canals (DB-DL). Almost all distal roots had one root canal and one apical foramen with few accessory canals. Conclusions: Distolingual root generally has short length, severe curvature and a single root canal with low apical diameter.
Descritores: Raiz Dentária/anatomia & histologia
Mandíbula/anatomia & histologia
Dente Molar/anatomia & histologia
-Valores de Referência
Raiz Dentária/diagnóstico por imagem
Brasil
Estatísticas não Paramétricas
Anatomia Transversal
Imagem Tridimensional
Polpa Dentária/anatomia & histologia
Polpa Dentária/diagnóstico por imagem
Cavidade Pulpar/anatomia & histologia
Cavidade Pulpar/diagnóstico por imagem
Tomografia Computadorizada de Feixe Cônico/métodos
Variação Anatômica
Mandíbula/diagnóstico por imagem
Dente Molar/diagnóstico por imagem
Odontometria
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Briso, André Luiz Fraga
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Id: lil-779901
Autor: CINTRA, Luciano Tavares Angelo; BENETTI, Francine; FERREIRA, Luciana Louzada; RAHAL, Vanessa; ERVOLINO, Edilson; JACINTO, Rogério de Castilho; GOMES FILHO, João Eduardo; BRISO, André Luiz Fraga.
Título: Evaluation of an experimental rat model for comparative studies of bleaching agents
Fonte: J. appl. oral sci;24(2):171-180, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP; . FAPESP.
Resumo: ABSTRACT Dental materials in general are tested in different animal models prior to the clinical use in humans, except for bleaching agents. Objectives To evaluate an experimental rat model for comparative studies of bleaching agents, by investigating the influence of different concentrations and application times of H2O2 gel in the pulp tissue during in-office bleaching of rats’ vital teeth. Material and Methods The right and left maxillary molars of 50 Wistar rats were bleached with 20% and 35% H2O2 gels, respectively, for 5, 10, 15, 30, or 45 min (n=10 rats/group). Ten animals were untreated (control). The rats were killed after 2 or 30 days, and the maxillae were examined by light microscopy. Inflammation was evaluated through histomorphometric analysis with inflammatory cell count in the coronal and radicular thirds of the pulp. Fibroblasts were also counted. Scores were attributed to odontoblastic layer and vascular changes. Tertiary dentin area and pulp chamber central area were measured histomorphometrically. Data were compared by analysis of variance and Kruskal-Wallis test (p<0.05). Results After 2 days, the amount of inflammatory cells increased in the coronal pulp occlusal third up to the 15-min application groups of each bleaching gel. In the groups exposed to each concentration for 30 and 45 min, the number of inflammatory cells decreased along with the appearance of necrotic areas. After 30 days, reduction on the pulp chamber central area and enlargement of the tertiary dentin area were observed, without the detection of inflammation areas. Conclusion The rat model of extracoronal bleaching showed to be adequate for studies of bleaching protocols, as it was possible to observe alterations in the pulp tissues and tooth structure caused by different concentrations and application periods of bleaching agents.
Descritores: Clareamento Dental/métodos
Polpa Dentária/efeitos dos fármacos
Clareadores Dentários/administração & dosagem
Peróxido de Hidrogênio/administração & dosagem
-Fatores de Tempo
Contagem de Células
Reprodutibilidade dos Testes
Ratos Wistar
Modelos Animais
Polpa Dentária/patologia
Cavidade Pulpar
Fibroblastos/efeitos dos fármacos
Géis
Odontoblastos/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Publicação Retratada
Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Briso, André Luiz Fraga
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Id: lil-777358
Autor: Cintra, Luciano Tavares Angelo; Benetti, Francine; Ferreira, Luciana Lousada; Rahal, Vanessa; Ervolino, Edilson; Jacinto, Rogério de Castilho; Gomes Filho, João Eduardo; Briso, André Luiz Fraga.
Título: Evaluation of an experimental rat model for comparative studies of bleaching agents
Fonte: J. appl. oral sci;24(1):95-104, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP’s; . FAPESP’s.
Resumo: ABSTRACT Dental materials, in general, are tested in different animal models prior to their clinical use in humans, except for bleaching agents. Objectives To evaluate an experimental rat model for comparative studies of bleaching agents by investigating the influence of different concentrations and application times of H2O2 gel in the pulp tissue during in-office bleaching of rats’ vital teeth. Material and methods The right and left maxillary molars of 50 Wistar rats were bleached with 20% and 35% H2O2 gels, respectively, for 5, 10, 15, 30, or 45 min (n=10 rats/group). Ten animals (control) were untreated. The rats were killed after 2 or 30 days, and the maxillae were examined by light microscopy. Inflammation was evaluated by histomorphometric analysis with inflammatory cell counting in the coronal and radicular thirds of the pulp. The counting of fibroblasts was also performed. Scores were attributed to the odontoblastic layer and to vascular changes. The tertiary dentin area and the pulp chamber central area were histomorphometrically measured. Data were compared by the analysis of variance and the Kruskal-Wallis test (p<0.05). Results After 2 days, the amount of inflammatory cells increased in the occlusal third of the coronal pulp until the time of 15 min for both concentrations of bleaching gels. In 30 and 45 min groups of each concentration, the number of inflammatory cells decreased along with the appearance of necrotic areas. After 30 days, a reduction in the pulp chamber central area and an enlargement of tertiary dentin area were observed without the detection of inflammation areas. Conclusion The rat model of extra coronal bleaching showed to be adequate for bleaching protocols studies, as it was possible to observe alterations in the pulp tissues and in the tooth structure caused by different concentrations and periods of application of bleaching agents.
Descritores: Clareamento Dental/métodos
Polpa Dentária/efeitos dos fármacos
Clareadores Dentários/administração & dosagem
Peróxido de Hidrogênio/administração & dosagem
-Fatores de Tempo
Contagem de Células
Reprodutibilidade dos Testes
Ratos Wistar
Modelos Animais
Polpa Dentária/patologia
Cavidade Pulpar
Fibroblastos/efeitos dos fármacos
Géis
Odontoblastos/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-893667
Autor: Lee, Bin-Na; Chun, Soo-Ji; Chang, Hoon-Sang; Hwang, Yun-Chan; Hwang, In-Nam; Oh, Won-Mann.
Título: Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride
Fonte: J. appl. oral sci;25(6):680-688, Nov.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: Chonnam National University Hospital Biomedical Research Institute; . Korea government (MSIP).
Resumo: Abstract Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. This study assessed the influence of MC as an anti-washout ingredient and CaCl2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl2; Group 3: 2% MC/CaCl2. Compressive strength, pH, flowability and cell viability were tested. The gene expression of bone sialoprotein (BSP) was detected by RT-PCR and real­ time PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/CaCl2 were not significantly different compared to the control group. The flowability of MTA with MC/CaCI2 has decreased significantly when compared to the control (p<.05). The mRNA level of BSP has increased significantly in MTA with MC/CaCl2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl2 compared to the control (p<.05). Conclusions: MC decreased the flowability of MTA and did not interrupt the physical and biological effect of MTA. It suggests that these cements may be useful as a root-end filling material.
Descritores: Óxidos/farmacologia
Óxidos/química
Materiais Restauradores do Canal Radicular/química
Cloreto de Cálcio/farmacologia
Silicatos/farmacologia
Silicatos/química
Compostos de Cálcio/farmacologia
Compostos de Cálcio/química
Compostos de Alumínio/farmacologia
Compostos de Alumínio/química
Metilcelulose/farmacologia
-Teste de Materiais
Células Cultivadas/efeitos dos fármacos
Força Compressiva
Polpa Dentária/efeitos dos fármacos
Combinação de Medicamentos
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-893662
Autor: Öncel Torun, Zeynep; Torun, Deniz; Baykal, Barış; Öztuna, Ali; Yeşildal, Fatih; Avcu, Ferit.
Título: Effects of triethylene glycol dimethacrylate (TEGDMA) on the odontoclastic differentiation ability of human dental pulp cells
Fonte: J. appl. oral sci;25(6):631-640, Nov.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: Scientific and Technological Research Council of Turkey.
Resumo: Abstract Objectives: The primary purpose of this study was to examine the effects of triethylene glycol dimethacrylate (TEGDMA) on odontoclastic differentiation in the dental pulp tissue. Material and Methods: The effects of different TEGDMA dosages on the odontoclastic differentiation capability of dental pulp cells were analyzed in vitro using the following methodologies: i) flow cytometry and tartrate-resistant acid phosphatase (TRAP) staining; ii) apoptotic effects using Annexin V staining; iii) mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor (NF)-kB ligand (RANKL) genes by quantitative Real-time PCR (qRT-PCR); and iv) OPG and RANKL protein expression by enzyme-linked immunosorbent assay (ELISA). Results: TEGDMA caused relatively less odontoclastic differentiation in comparison with the control group; however, odontoclastic differentiation augmented with increasing doses of TEGDMA (p<0.05). The mRNA and protein expression of OPG was lower in TEGDMA treated pulp cells than in the control group (p<0.05). While the mRNA expression of RANKL remained unchanged compared to the control group (p>0.05), its protein expression was higher than the control group (p<0.05). In addition, TEGDMA increased the apoptosis of dental pulp cells dose dependently. Conclusions: TEGDMA reduced the odontoclastic differentiation ability of human dental pulp cells. However, odontoclastic differentiation ratios increased proportionally with the increasing dose of TEGDMA.
Descritores: Polietilenoglicóis/farmacologia
Ácidos Polimetacrílicos/farmacologia
Diferenciação Celular/efeitos dos fármacos
Polpa Dentária/efeitos dos fármacos
Fosfatase Ácida Resistente a Tartarato/efeitos dos fármacos
-Ensaio de Imunoadsorção Enzimática
Receptores de Lipopolissacarídeos/metabolismo
Polpa Dentária/citologia
Ligante RANK/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Citometria de Fluxo
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-888699
Autor: Estrela, Carlos; Oliveira, Keila SA; Alencar, Ana Helena G; Barletta, Fernando B; Estrela, Cyntia RA; Felippe, Wilson T.
Título: Oxygen Saturation in the Dental Pulp of Maxillary and Mandibular Molars - Part 2
Fonte: Braz. dent. j;28(6):704-709, Nov.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: National Council for Scientific and Technological Development (CNPq.
Resumo: Abstract This study determined the oxygen saturation (SaO2) in dental pulp of healthy maxillary and mandibular molars. Mean of SaO2 was evaluated in 112 maxillary and mandibular molars using pulse oximetry. Quantitative variables were described by mean and standard deviation. Variables with symmetric distribution were compared by Student t test and Mann-Whitney test. Pearson's correlation coefficient was used to correlate quantitative variables. Analysis of variance was used to assess differences in SaO2 levels between the molar groups, followed by post-hoc Tukey. The significance level established at p<0.05. Mean of oxygen saturation for the 112 molar dental pulps was 85.09%. There was no significant correlation (r=-0.007; p=0.977) between the mean of SaO2 of molar pulps with patient´s indicator finger (92.89%). There was a significant difference (p=0.037) between the mean of SaO2 of the first (85.76%) and second maxillary molars (81.87%), and it was not significant (p=0.1775) between the first and second mandibular molars. Maxillary molars had lower pulpal SaO2 (83.59%) than mandibular molars (86.89%) (p=0.018). The mean of the patient's response time to the cold stimulus was 1.12 s (maxillary molars 1.25 s and mandibular molars 0.99 s)(p=0.052). There was no significant correlation between the time response of the patient to the cold stimulus and the SaO2 for molars. The mean oxygen saturation level was 85.09%. The mandibular molars presented higher SaO2 level than maxillary molars.

Resumo Este estudo determinou o nível de saturação de oxigênio (SaO2) em polpas dentais hígidas de molares. O nível de SaO2 foi avaliado em 112 molares superiores e inferiores usando oxímetro de pulso. As variáveis quantitativas foram descritas pela média e desvio padrão. As variáveis com distribuição simétrica foram comparadas pelo teste t de Student e teste de Mann-Whitney. O coeficiente de correlação de Pearson foi utilizado para correlacionar variáveis quantitativas. A análise de variância foi utilizada para avaliar as diferenças nos níveis de SaO2 entre os grupos de molares, seguido de Tukey pós-hoc. A significância foi estabelecida em 0,05. O nível médio de SaO2 para as polpas de 112 molares foi de 85,09%, não havendo correlação com a média de SaO2 do dedo indicador do paciente (92,89%). Houve diferença significativa entre o nível médio de SaO2 dos primeiros molares superiores (85,76%) e os segundos molares superiores (81,87%) e não foi significativo entre os primeiros e os segundos molares inferiores. Os molares superiores apresentaram menor nível de SaO2 (83,59%) do que os molares inferiores (86,89%). A média do tempo de resposta do paciente ao estímulo com frio foi de 1,12 s (molares superiores 1,25 segundos e molares inferiores 0,99 segundos). Não houve correlação significativa entre o tempo de resposta do paciente ao estímulo com frio e o nível de saturação de oxigênio para os molares. Em resumo, o nível médio de saturação de oxigênio foi de 85,09%. Os molares inferiores apresentaram maior nível de SaO2 do que os molares superiors
Descritores: Oxigênio/metabolismo
Polpa Dentária/metabolismo
Mandíbula/metabolismo
Maxila/metabolismo
Dente Molar/metabolismo
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME



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