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Pesquisa : A15.382 [Categoria DeCS]
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Id: biblio-947409
Autor: Herrerro, T V.
Título: IMPORTANCIA FISIOPATOLÓGICA SISTÉMICA DE LA MICROBIOTA INTESTINAL ASOCIADA AL SISTEMA INMUNE DE MUCOSAS / Systemic physiopathologic significance of the intestinal microbiota associated to mucosal immune system
Fonte: Arch. alerg. inmunol. clin;45(2):71-78, 2014. ilus.
Idioma: es.
Resumo: La microbiota intestinal representa una unidad biológica dinámica que ejerce su influencia sistémica no solamente a nivel gastrointestinal sino también metabólico-endocrino, inmunológico, neurológico. Está implicada en la regulación de procesos fisiopatológicos que se pueden manifestar en disbiosis y enfermedad inflamatoria, con impacto intestinal, metabólico, alérgico, del sistema nervioso central, y en autoinmunidad. Los conocimientos de la genética microbiana, la interacción con el sistema inmune de mucosas y con el ecosistema entériconutricional de cada individuo permiten establecer proyecciones muy interesantes para modular preventiva y terapéuticamente diversas enfermedades.(AU)

The intestinal microbiota is a dynamic biological unit with systemic influences not only gastrointestinal but also at metabolic-endocrine, and at immunologic and neurological levels. The microbiota is involved in pathophysiological processes regulation that could manifest as dysbiosis and inflammatory disease with gastrointestinal impact, also metabolic and/or allergic manifestations, in central nervous system, and autoimmunity. The knowledge of microbial genetics, the interaction with the mucosal immune system, and the enteric-nutritional ecosystem of each individual, will allow to develop very interesting designs to prevent and therapeutically modulate various diseases(AU)
Descritores: Microbiota
Microbioma Gastrointestinal/fisiologia
Sistema Imunitário
-Doenças Inflamatórias Intestinais
Hipersensibilidade
Limites: Humanos
Criança
Adulto
Tipo de Publ: Revisão
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: lil-486899
Autor: Marciano, Beatriz E; Elmeaudy, Patricia; Rosenzweig, D.
Título: La historia de Pedro y el Lobo de los pacientes con Infecciones Frecuentes e Inmunodeficiencias Primarias / The Story of Peter and the Wolf of patients with Frequent Infections and Primary Immunodeficiencies
Fonte: Med. infant;15(1):42-45, mar. 2008. tab.
Idioma: es.
Descritores: Infecções/complicações
Infecções/etiologia
Sistema Imunitário/patologia
Limites: Criança
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-978319
Autor: Aleem, Daniyal; Tohid, Hassaan.
Título: Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis / Citocinas proinflamatorias, biomarcadores, genética y sistema inmunológico: un enfoque mecanicista de la depresión y la psoriasis
Fonte: Rev. colomb. psiquiatr;47(3):177-186, jul.-set. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Objective: To highlight the inflammatory and immunological mechanisms involved in depression and psoriasis. Methods: A comprehensive literature search was performed in various databases, in total 145 studies were selected. Results: Depression and psoriasis have an association. Immune mechanisms -the actions of tumor necrosis factor-a, interleukin 1 (IL-1), IL-2, IL-10, IL-22, IL-17, interferon-7, IL-1ß, prostaglandin E2, C-reactive protein, IL-6, and IL-8 etc.-, and some genetic changes are involved. Conclusions: A possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to psoriasis, and psoriasis leads to depression. We recommend more studies in the future to get a deeper and better understanding about this relationship.

RESUMEN Objetivo: Poner de relieve los mecanismos inflamatorios e inmunológicos involucrados en la depresión y la psoriasis. Métodos: Se realizó en varias bases de datos una búsqueda bibliográfica completa; en total se incluyeron 145 estudios. Resultados: Hay asociación entre depresión y psoriasis y están involucrados mecanismos inmunitarios -las acciones del factor de necrosis tumoral alfa, las interleucinas (IL) 1, 2, 10, 22 y 17, el interferón gamma, la IL-1ß, la prostaglandina E2, la proteína C reactiva, la IL-6 y la IL-8, etc. - y algunos cambios genéticos. Conclusiones: Hay una posible relación bidireccional entre psoriasis y depresión, es decir, la depresión lleva a psoriasis y la psoriasis lleva a depresión. Se recomiendan más estudios en el futuro para obtener una comprensión más profunda y mejor sobre esta relación.
Descritores: Biomarcadores
Citocinas
Genética
-Proteína C
Interferon gama
Interleucina-1
Interleucina-2
Interleucina-10
Interleucina-17
Depressão
Sistema Imunitário
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CO78 - Asociación Colombiana de Psiquiatría


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Texto completo SciELO Cuba
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Id: biblio-1093795
Autor: Padrón González, Alexander Ariel; Martínez Infante, Anisleidys.
Título: Estrés, psiconeuroendocrinoinmunología y enfermedades reumatológicas. Actualización del tema / Stress, Psychoneuroendocrinoimmunology and rheumatological diseases. Actualization of this topic
Fonte: Rev. cuba. reumatol;20(3):e628, sept.-dic. 2018.
Idioma: es.
Resumo: El estrés se define como el estado de alarma de los organismos ante diversos desafíos. La Psiconeuroendocrinoinmunología es una ciencia que integra la psiquis, el sistema nervioso, endocrino e inmune; y estudia las múltiples y complejas interrelaciones entre ellos lo cual permite tratar de manera integral el proceso salud-enfermedad. La alteración del equilibrio entre la psiquis y los sistemas mencionados puede ocasionar daños al organismo como es el caso de algunas enfermedades reumatológicas(AU)

Stress is defined as the state of alarm of living beings in case of various challenges. Psycho-neuro-endocrine-immunology is a science that integrates the psyche with the nervous, endocrine and immune systems. It studies the multiple and complex interrelations among them, which allows us to deal comprehensively with the health-disease process. The alteration if the balance between the psyche and the aforementioned systems can cause damage to the organism, as in the case of some rheumatologic diseases(AU)
Descritores: Alergia e Imunologia
Sistema Imunitário
Sistema Nervoso
-Estresse Psicológico/epidemiologia
Neuroimunomodulação/imunologia
Processo Saúde-Doença
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-963707
Autor: Cavallo, M C.
Título: La administración de probióticos a edades tempranas, atopia y asma: un metaanálisis de ensayos clínicos / Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials
Fonte: Arch. alerg. inmunol. clin;44(3):120-121, 2013.
Idioma: es.
Descritores: Asma
Probióticos/administração & dosagem
Hipersensibilidade
-Sistema Imunitário
Limites: Humanos
Recém-Nascido
Lactente
Tipo de Publ: Comentário
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-1177447
Autor: Bai, Yu; Li, Wenliang; Xu, Guangyu; Cui, Guihua.
Título: A bioinformatics approach revealed the transcription factors of Helicobacter pylori pathogenic genes and their regulatory network nodes
Fonte: Electron. j. biotechnol;45:53-59, May 15, 2020. tab, ilus.
Idioma: en.
Projeto: Department of Education of Jilin Province; . Jilin Province Traditional Chinese Medicine Science and Technology Project; . Jilin Province Health and Family Planning Commission; . Jilin Science and Technology Innovation Development Plan Project.
Resumo: BACKGROUND: Helicobacter pylori is a chronic pathogenic bacteria that causes gastric mucosal damage through various host-related and pathogen-related factors. Thus, a single gene research cannot fully explain its pathogenicity. PURPOSE OF STUDY: It is necessary to establish a Helicobacter pylori pathogenic gene transcription factor regulatory network (TFRN) and study its central nodes. RESULTS: The expression data of Helicobacter pylori pathogenic genes were obtained through GEO Datasets of NCBI. The genes were screened using linear model-empirical Bayesian statistics in R language Limma package combined with the conventional t-test; the results identified 1231 differentially expressed genes. The functional analysis (gene ontology-analysis) and signal pathway analysis (pathway-analysis) of differentially expressed genes were performed using the DAVID and KEGG databases, respectively. The pathogenic gene regulatory network was constructed by integrating transcriptional regulatory element database (TRED); the disease-related analysis of the pathogenic genes was conducted using the DAVID annotation tool. Five pathogenic genes (Nos2, Il5, Colla1, Tnf, and Nfkb1) and their transcription factors (Jun, Cebpa, Egrl, Ppara, and Il6) were found to suppress the host immune function and enhance the pathogenicity of Helicobacter pylori by regulating the host immune system. CONCLUSIONS: This effect was largely mediated via three signaling pathways: Tnf pathway, PI3K Akt pathway, and Jak­STAT pathway. The pathogenicity of Helicobacter pylori is closely related to the body's immune and inflammatory system. A better understanding of the correlation of the pathogenic factors with the host immune and inflammatory factors may help to determine the precise pathogenic mechanism of H. pylori infection.
Descritores: Helicobacter pylori/genética
Helicobacter pylori/patogenicidade
Biologia Computacional
-Fatores de Transcrição
Citocinas
Fatores de Virulência
Gastrite/imunologia
Gastrite/microbiologia
Genes Bacterianos
Sistema Imunitário
Inflamação
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-1154767
Autor: Ramos, Luís Felipe Costa; Rangel, João Henrique de Oliveira; Andrade, Guilherme Caldas; Lixa, Carolina; Castilho, Livia Vieira Araujo de; Nogueira, Fábio César Sousa; Pinheiro, Anderson S; Gomes, Fabio Mendonça; AnoBom, Cristiane Dinis; Almeida, Rodrigo Volcan; Oliveira, Danielle Maria Perpétua de.
Título: Identification and recombinant expression of an antimicrobial peptide (cecropin B-like) from soybean pest Anticarsia gemmatalis
Fonte: J. venom. anim. toxins incl. trop. dis;27:e20200127, 2021. graf, tab.
Idioma: en.
Resumo: Insects can be found in numerous diverse environments, being exposed to pathogenic organisms like fungi and bacteria. Once these pathogens cross insect physical barriers, the innate immune system operates through cellular and humoral responses. Antimicrobial peptides are small molecules produced by immune signaling cascades that develop an important and generalist role in insect defenses against a variety of microorganisms. In the present work, a cecropin B-like peptide (AgCecropB) sequence was identified in the velvetbean caterpillar Anticarsia gemmatalis and cloned in a bacterial plasmid vector for further heterologous expression and antimicrobial tests. Methods AgCecropB sequence (without the signal peptide) was cloned in the plasmid vector pET-M30-MBP and expressed in the Escherichia coli BL21(DE3) expression host. Expression was induced with IPTG and a recombinant peptide was purified using two affinity chromatography steps with Histrap column. The purified peptide was submitted to high-resolution mass spectrometry (HRMS) and structural analyses. Antimicrobial tests were performed using gram-positive (Bacillus thuringiensis) and gram-negative (Burkholderia kururiensis and E. coli) bacteria. Results AgCecropB was expressed in E. coli BL21 (DE3) at 28°C with IPTG 0.5 mM. The recombinant peptide was purified and enriched after purification steps. HRMS confirmed AgCrecropB molecular mass (4.6 kDa) and circular dichroism assay showed α-helix structure in the presence of SDS. AgCrecropB inhibited almost 50% of gram-positive B. thuringiensis bacteria growth. Conclusions The first cecropin B-like peptide was described in A. gemmatalis and a recombinant peptide was expressed using a bacterial platform. Data confirmed tertiary structure as predicted for the cecropin peptide family. AgCecropB was capable to inhibit B. thuringiensis growth in vitro.(AU)
Descritores: Peptídeos
Soja/microbiologia
Proteínas Citotóxicas Formadoras de Poros/classificação
Cecropinas/administração & dosagem
-Sistema Imunitário
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1251718
Autor: Soler Noda, Gilberto.
Título: Implicaciones clínicas de las quimiocinas y sus receptores en la medicina transfusional y el trasplante / Clinical implications of chemokines and their receptors in transfusion medicine and transplantation
Fonte: Rev. cuba. hematol. inmunol. hemoter;37(1):e1101, ene.-mar. 2021. graf.
Idioma: es.
Resumo: Introducción: Las quimiocinas son proteínas secretadas con tamaño en el rango de 8-10 kDa, con numerosas funciones en la fisiología normal y patológica. El término deriva de las palabras citocinas quimiotácticas, que refleja su importante participación en la quimioatracción de leucocitos. Sin embargo, las evidencias muestran que las quimiocinas tienen muchas otras funciones como la comunicación intercelular, la activación celular y la regulación del ciclo celular. Objetivo: Analizar los conocimientos actuales sobre las quimiocinas y sus receptores, y la significación clínica de estas en la medicina transfusional y el trasplante. Métodos: Se realizó revisión de la literatura, en inglés y español, a través del sitio web PubMed y el motor de búsqueda Google académico de artículos publicados en los últimos 10 años. Se efectuó análisis y resumen de la bibliografía revisada. Análisis y síntesis de la información: La transcripción de la mayoría de los genes de quimiocinas es inducible y se produce en respuesta a estímulos celulares específicos. Las quimiocinas son importantes en la movilización de células progenitoras hematopoyéticas para el trasplante y localización de células progenitoras hematopoyéticas trasplantadas. En los modelos de incompatibilidad ABO, las quimiocinas CXC y CC se producen en niveles elevados. Conclusiones: Muchas son las oportunidades de futuras investigaciones sobre las quimiocinas en la medicina transfusional por la considerable redundancia y superposición en la función biológica de estas moléculas y sus receptores. Son solo una parte de un proceso mucho más grande y complejo dentro de la red de citoquinas y otras moléculas del sistema inmune(AU)

Introduction: Chemokines are secreted proteins with size in the range of 8-10 kDa, with numerous functions in normal and pathological physiology. The term derives from the words chemotactic cytokines, reflecting its important role in the chemoattraction of leukocytes. However, the evidence shows that chemokines have many other functions such as intercellular communication, cell activation and cell cycle regulation. Objetive: To present current knowledge about chemokines and their receptors, and the clinical significance of these in transfusion medicine and transplantation. Method: A review of the literature was made, in English and Spanish, through the PubMed website and the Google academic search engine of articles published in the last 10 years. An analysis and summary of the revised bibliography was made. Developing: The transcription of most of the chemokine genes is inducible and occurs in response to specific cellular stimuli. Chemokines play an important role in the mobilization of hematopoietic progenitor cells for the transplantation and localization of transplanted hematopoietic progenitor cells. In the ABO incompatibility models, the CXC and CC chemokines are produced at high levels. Conclusions: There are many opportunities for future research on chemokines in transfusion medicine due to their considerable redundancy and superposition in the biological function of these molecules and their receptors. They are just one part of a much larger and more complex process within the network of cytokines and other molecules of the immune system(AU)
Descritores: Citocinas
Quimiocinas
Medicina Transfusional
Sistema Imunitário
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1251720
Autor: Duarte Pérez, Yaneisy; Triana Marrero, Yenisey; Marsán Suárez, Vianed.
Título: Síndromes mielodisplásicos y sistema inmunitario / Myelodysplastic Syndrome and Immune System
Fonte: Rev. cuba. hematol. inmunol. hemoter;37(1):e1310, ene.-mar. 2021.
Idioma: es.
Resumo: Introducción: Los síndromes mielodisplásicos constituyen un grupo heterogéneo de desórdenes hematológicos clonales adquiridos, que afectan la célula madre. Se caracterizan morfológicamente por: hematopoyesis ineficaz, citopenias periféricas progresivas, displasia en uno o más linajes celulares y tendencia evolutiva a leucemia aguda. Los avances recientes en la comprensión de los mecanismos genéticos y moleculares de los síndromes mielodisplásicos, han revelado la asociación entre alteraciones inmunológicas y las mutaciones recurrentes. Las células de la respuesta inmune innata y adaptativa, así como diversos mediadores solubles liberados por ellas, pueden establecer una respuesta antitumoral protectora o, por el contrario, inducir eventos de inflamación crónica que favorezcan la promoción y progresión de esta enfermedad. Objetivos: Resumir los conocimientos actuales de la relación sistema inmune-síndromes mielodisplásicos, enfatizando en las células inmunes del microambiente de la médula ósea y su importancia en la clínica de la enfermedad. Métodos: Se realizó investigación bibliográfica-documental acerca del tema. Se consultaron las bases de datos Scielo y Pubmed. Conclusiones: La comprensión de la función dual que ejerce el sistema inmune en los síndromes mielodisplásicos, constituye un desafío y son necesarios estudios clínicos rigurosos para poder establecer el valor de la manipulación del sistema inmune como una forma posible de tratamiento de esta enfermedad(AU)

Introduction: Myelodysplastic syndromes (MDS) constitute a heterogeneous group of acquired clonal hematological disorders that affect the stem cell. These are characterized morphologically and clinically by: ineffective hematopoiesis, progressive peripheral cytopenia, dysplasia in one or more cell lineages, in most of cases and evolutionary tendency to acute leukemia. Recent advances in understanding the genetic and molecular mechanisms of MDS have revealed the association between immunological alterations and recurrent mutations. Cells of the innate and adaptive immune response, as well as various soluble mediators released by them, can establish a protective antitumor response or, on the contrary, induce events of chronic inflammation that favor the promotion and progression of this disease. Objective: To summarize the current knowledge of the immune system-MDS relationship, emphasizing the immune cells of the bone marrow microenvironment and their importance in the clinic of the disease. Methods: A bibliographic-documentary research was carried out on the subject. The Scielo and Pubmed databases were consulted. Conclusions: Understanding the dual role of the immune system in MDS constitutes a challenge and rigorous clinical studies are necessary to establish the value of manipulating the immune system as a possible form of treatment of this disease(AU)
Descritores: Células-Tronco
Síndromes Mielodisplásicas/complicações
Leucemia
Imunidade Adaptativa
Hematopoese/genética
Sistema Imunitário/fisiopatologia
-Inflamação/diagnóstico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1001076
Autor: Ponce de León, Patricia; Lamagni, Ernesto; Ivancovich, Juan José; Bottai, Hebe.
Título: Efecto de Trichinella spiralis y de Trichinella patagoniensis n.sp. sobre la desialización / Effect of Trichinella spiralis and Trichinella patagoniensis n.sp. on desialization
Fonte: Acta bioquím. clín. latinoam;53(1):37-42, mar. 2019. graf, tab.
Idioma: es.
Resumo: El ácido siálico tiene importantes funciones biológicas, muchas de las cuales determinan su participación en la respuesta inmune. El objetivo del trabajo fue comparar el efecto de Trichinella spiralis y Trichinella patagoniensis n.sp. sobre la desialización eritrocitaria. Se trabajó con 10 concentrados de larvas musculares de T. spiralis y 10 de T. patagoniensis de la misma concentración larval. Se realizó el tratamiento incubando el sedimento de eritrocitos frescos con igual volumen de concentrado larval (37 ºC), tomando muestra a los 30, 60 y 90 minutos. Los controles fueron incubados de la misma forma con solución salina. Se aplicó el método de Titulación de la Agregación por Polibrene y se determinó el CexpST. Los resultados mostraron que el valor medio del CexpST en los eritrocitos tratados con T. spiralis fue significativamente menor que en los glóbulos tratados con T. patagoniensis, para todos los tiempos estudiados. El aumento del tiempo de tratamiento también disminuyó significativamente el valor medio del CexpST para las dos especies. Éste fue significativamente menor a los 90 minutos de incubación que a los 60 minutos y éstos a su vez menores que a los 30 minutos. Se concluye que T. spiralis provocó mayor desialización eritrocitaria que T. patagoniensis en las condiciones experimentales estudiadas.

Sialic acid has important biological functions, many of which determine its participation in the immune response. The objective of this paper was to compare the effect of Trichinella spiralis and Trichinella patagoniensis n.sp. on erythrocyte desialization. Work was performed on 10 larval concentrates of muscle larvae of T. spiralis and 10 of T. patagoniensis of the same larval concentration. The treatment was carried out incubating the sediment of fresh erythrocytes with an equal volume of larval concentrate (37 °C), taking samples at 30, 60 and 90 minutes. The controls were incubated in the same way treated with saline solution. Titration of aggregation by Polybrene Method was applied and the CexpST was determined. The results showed that the mean value of CexpST in erythrocytes with T. spiralis was significantly lower than in the globules treated with T. patagoniensis, for all the studied times. The increase in treatment time also significantly decreased the mean value of CexpST for the two species, being significantly lower at 90 minutes of incubation than at 60 minutes and these in turn lower than at 30 minutes. It is concluded that T. spiralis caused greater erythrocyte desialization than T. patagoniensis in the experimental conditions studied.

O ácido siálico tem importantes funções biológicas, muitas das quais determinam sua participação na resposta imune. O objetivo foi comparar o efeito de Trichinella spiralis e Trichinella patagoniensis n.sp. sobre a dessialização eritrocitária. Trabalhou-se com 10 concentrados de larvas musculares de T. spiralis e 10 de T. patagoniensis da mesma concentração larval. Realizou-se o tratamento incubando o sedimento de eritrócitos frescos com igual volume de concentrado larval (37 ºC), tomando amostra aos 30, 60 e 90 minutos. Os controles foram incubados da mesma forma com solução salina. Foi aplicado o método de Titulação da Agregação por Polibrene e se determinouo CexpST. Os resultados mostraram que o valor médio do CexpST nos eritrócitos Tratados com T. spiralis foi significativamente menor que nos glóbulos tratados com T. patagoniensis, para todos os tempos estudados. O aumento do tempo de tratamento também diminuiu significativamente o valor médio do CexpST para as duas espécies, sendo significativamente menor aos 90 minutos de incubação que aos 60 minutos e eles por sua vez menores que aos 30 minutos. Conclui-se que T. spiralis provocou maior dessialização eritrocitária que T. patagoniensis nas condições experimentais estudadas.
Descritores: Trichinella
Trichinella spiralis
-Ácidos Siálicos
Glóbulos
Ácido N-Acetilneuramínico
Alergia e Imunologia
Eritrócitos
Solução Salina
Brometo de Hexadimetrina
Sistema Imunitário
Larva
Métodos
Tipo de Publ: Relatório Técnico
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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