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Pesquisa : A18.024 [Categoria DeCS]
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Id: biblio-950753
Autor: Zeb, Anwar; Sadiq, Abdul; Ullah, Farhat; Ahmad, Sajjad; Ayaz, Muhammad.
Título: Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus
Fonte: Biol. Res;47:1-6, 2014. tab.
Idioma: en.
Resumo: BACKGROUND: Isodon rugosus is used traditionally in the management of hypertension, rheumatism, tooth-ache and pyrexia. Present study was arranged to investigate I. rugosus for phytoconstituents, phytotoxic and cytotoxic activities to explore its toxicological, pharmacological potentials and to rationalize its ethnomedicinal uses. Briefly, qualitative phytochemical analysis of the plant extracts were carried out for the existence of alkaloids, flavonoids, saponins, oils, glycosides, anthraquinones, terpenoids, sterols and tannins. Plant crude methanolic extract (Ir.Cr), its subsequent fractions; n-hexane (Ir.Hex), chloroform (Ir.Chf), ethyl acetate (Ir.EtAc), aqueous (Ir.Aq) and saponins (Ir.Sp) in different concentrations were tested for phytotoxic and cytotoxic activities using radish seeds and brine shrimps (Artemia salina) respectively. The phytotoxic activity was determined by percent root length inhibition (RLI) and percent seeds germination inhibition (SGI) while the cytotoxicity was obtained with percent lethality of the brine shrimps. RESULTS: Ir.Cr was tested positive for the presence of alkaloids, glycosides, flavonoids, oils, terpenoids, saponins, tannins and anthraquinones. Among different fractions Ir.Sp, Ir.Chf, Ir.EtAc, and Ir.Cr were most effective causing 93.55, 89.32, 81.32 and 58.68% inhibition of seeds in phytotoxicity assay, with IC50 values of 0.1, 0.1, 0.1 and 52 µg/ml respectively. Similarly, among all the tested samples, Ir.Sp exhibited the highest phytotoxic effect causing 91.33% root length inhibition with IC50 of 0.1 µg/ml. Ir.Sp and Ir.Chf were most effective against brine shrimps showing 92.23 and 76.67% lethality with LC50 values of 10 and 12 µg/ml respectively. CONCLUSIONS: It may be inferred from the current investigations that I. rugosus contains different secondary metabolites and is a potential source for the isolation of natural anticancer and herbicidal drug molecules. Different fractions exhibited phytotoxic and cytotoxic activities, thus providing pharmacological basis for ethnomedicinal uses of this plant.
Descritores: Saponinas/análise
Extratos Vegetais/farmacologia
Isodon/química
Fitoterapia
-Artemia/efeitos dos fármacos
Taninos/análise
Terpenos/análise
Flavonoides/análise
Óleos Vegetais/análise
Clorofórmio
Antraquinonas/análise
Raízes de Plantas/crescimento & desenvolvimento
Citotoxinas
Componentes Aéreos da Planta/química
Metanol
Alcaloides/análise
Glicosídeos/análise
Hexanos
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950772
Autor: Zeb, Anwar; Sadiq, Abdul; Ullah, Farhat; Ahmad, Sajjad; Ayaz, Muhammad.
Título: Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus
Fonte: Biol. Res;47:1-10, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Based on the ethnomedicinal uses and the effective outcomes of natural products in various diseases, this study was designed to evaluate Isodon rugosus as possible remedy in oxidative stress, alzheimer's and other neurodegenerative diseases. Acetylecholinestrase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of crude methanolic extract (Ir.Cr), resultant fractions (n-hexane (Ir.Hex), chloroform (Ir.Cf), ethyl acetate (Ir.EtAc), aqueous (Ir.Aq)), flavonoids (Ir.Flv) and crude saponins (Ir.Sp) of I. rugosus were investigated using Ellman's spectrophotometric method. Antioxidant potential of I. rugosus was determined using DPPH, H2O2 and ABTS free radicals scavenging assays. Total phenolic and flavonoids contents of plant extracts were determined and expressed in mg GAE/g dry weight and mg RTE/g of dry sample respectively. RESULTS: Among different fractions Ir.Flv and Ir.Cf exhibited highest inhibitory activity against AChE (87.44 ± 0.51, 83.73 ± 0.64%) and BChE (82.53 ± 0.71, 88.55 ± 0.77%) enzymes at 1 mg/ml with IC50 values of 45, 50 for AChE and 40, 70 µg/ml for BChE respectively. Activity of these fractions were comparable to galanthamine causing 96.00 ± 0.30 and 88.61 ± 0.43% inhibition of AChE and BChE at 1 mg/ml concentration with IC50 values of 20 and 47 µg/ml respectively. In antioxidant assays, Ir.Flv, Ir.Cf, and Ir.EtAc demonstrated highest radicals scavenging activities in DPPH and H2O2 assays which were comparable to ascorbic acid. Ir.Flv was found most potent with IC50 of 19 and 24 µg/ml against DPPH and H2O2 radicals respectively. Whereas antioxidant activates of plant samples against ABTS free radicals was moderate. Ir.Cf, Ir.EtAc and Ir.Cr showed high phenolic and flavonoid contents and concentrations of these compounds in different fractions correlated well to their antioxidant and anticholinestrase activities. CONCLUSION: It may be inferred from the current investigations that the Ir.Sp, Ir.Flv and various fractions of I. rugosus are good sources of anticholinesterase and antioxidant compounds. Different fractions can be subjected to activity guided isolation of bioactive compounds effective in neurological disorders.
Descritores: Saponinas/análise
Flavonoides/análise
Extratos Vegetais/química
Inibidores da Colinesterase/análise
Isodon/química
Antioxidantes/análise
-Picratos/metabolismo
Acetilcolinesterase/efeitos dos fármacos
Saponinas/isolamento & purificação
Espectrofotometria/métodos
Ácidos Sulfônicos/metabolismo
Flavonoides/isolamento & purificação
Compostos de Bifenilo/metabolismo
Butirilcolinesterase/efeitos dos fármacos
Clorofórmio
Sequestradores de Radicais Livres/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Concentração Inibidora 50
Isodon/classificação
Isodon/enzimologia
Componentes Aéreos da Planta/química
Misturas Complexas
Metanol
Benzotiazóis/metabolismo
Radicais Livres/análise
Hexanos
Peróxido de Hidrogênio/metabolismo
Medicina Tradicional
Acetatos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950792
Autor: Águila, Luis; Ruedlinger, Jenny; Mansilla, Karina; Ordenes, José; Salvatici, Raúl; Campos, Rui Ribeiro de; Romero, Fernando.
Título: Relaxant effects of a hydroalcoholic extract of Ruta graveolens on isolated rat tracheal rings
Fonte: Biol. Res;48:1-6, 2015. graf, tab.
Idioma: en.
Projeto: CONICYT. FONDEF.
Resumo: BACKGROUND: Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among others. We evaluated the trachea-relaxant effects of hydroalcoholic extract of R. graveolens against potassium chloride (KCl)- and carbachol-induced contraction of rat tracheal rings in an isolated organ bath. RESULTS: The results showed that the airway smooth muscle contraction induced by the depolarizing agent (KCl) and cholinergic agonist (carbachol) was markedly reduced by R. graveolens in a concentration-dependent manner, with maximum values of 109 ± 7.9 % and 118 ± 2.6 %, respectively (changes in tension expressed as positive percentages of change in proportion to maximum contraction), at the concentration of 45 µg/mL (half-maximal inhibitory concentration IC50: 35.5 µg/mL and 27.8 µg/mL for KCl- and carbachol-induced contraction, respectively). Additionally, the presence of R. graveolens produced rightward parallel displacement of carbachol dose-response curves and reduced over 35 % of the maximum smooth muscle contraction. CONCLUSIONS: The hydroalcoholic extract of R. graveolens exhibited relaxant activity on rat tracheal rings. The results suggest that the trachea-relaxant effect is mediated by a non-competitive antagonistic mechanism. More detailed studies are needed to identify the target of the inhibition, and to determine more precisely the pharmacological mechanisms involved in the observed biological effects.
Descritores: Parassimpatolíticos/farmacologia
Traqueia/efeitos dos fármacos
Extratos Vegetais/farmacologia
Ruta/química
Músculo Liso/efeitos dos fármacos
Fármacos Neuromusculares Despolarizantes/farmacologia
-Cloreto de Potássio/farmacologia
Furocumarinas/análise
Quercetina/análise
Rutina/análise
Traqueia/cirurgia
Técnicas In Vitro
Carbacol/farmacologia
Extratos Vegetais/química
Cromatografia Líquida
Ratos Sprague-Dawley
Colinérgicos/farmacologia
Concentração Inibidora 50
Componentes Aéreos da Planta/química
Contração Muscular/efeitos dos fármacos
Tono Muscular/efeitos dos fármacos
Limites: Animais
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1132224
Autor: Ramachandran, Reshmi Geetha; Radhakrishnan, Rajalakshmi.
Título: Anatomical Characterization of Nine Taxa of Genus Acmella Rich. (Toothache Plant) in India
Fonte: Braz. arch. biol. technol;63:e20190083, 2020. tab, graf.
Idioma: en.
Projeto: Kerala State Council for Science, Technology and Environment.
Resumo: Abstract The present study is aimed for anatomical characterization of nine taxa of Acmella to supplement data specifically for its current sectional classification and species circumscriptions. Anatomical characterization of this genus is little explored. This study focuses on internal structure of leaves, petioles, peduncles, stems, roots and cell inclusions to determine its taxonomic importance. In stem anatomy the number of hypodermal collenchymatous layers and the arrangement of parenchymatous cortex together place an important role in the identification of Acmella. Root anatomy was similar in all the examined taxa except in the arrangement of xylem vessels. In A. tetralobata xylem vessels arranged in pentarch fashion while rest of the species possess tetrarch arrangement. Several cellular inclusions such as calcium oxalate crystals and oil bodies were observed. The petioles were crescent shaped having bifacial surfaces with both surfaces pubescent. Peduncles possess ridges and furrows in its outline. The leaves are dorsi ventral and possess single layered epidermal cells covered with cuticle having anomocytic, anisocytic and diacytic types of stomata in both adaxial and abaxial surfaces. The present study provides a tool for the microscopic identification of the genus.
Descritores: Spilanthes oleracea/classificação
Raízes de Plantas/anatomia & histologia
Componentes Aéreos da Planta/anatomia & histologia
Responsável: BR1.1 - BIREME


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Id: biblio-950867
Autor: Hwan-Hee, Jang; Su-Yeon, Cho; Mi-Ju, Kim; Jung-Bong, Kim; Sung-Hyen, Lee; Mee-Young, Lee; Young-Min, Lee.
Título: Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
Fonte: Biol. Res;49:1-11, 2016. ilus, graf.
Idioma: en.
Projeto: National Institute of Agricultural Science of Rural Development Administration.
Resumo: BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone CONCLUSIONS: Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthma
Descritores: Asma/tratamento farmacológico
Medicamentos de Ervas Chinesas/farmacologia
Antiasmáticos/farmacologia
Anti-Inflamatórios/farmacologia
-Asma/induzido quimicamente
Ensaio de Imunoadsorção Enzimática
Células Cultivadas
Ovalbumina
Lipopolissacarídeos/farmacologia
Reprodutibilidade dos Testes
Citocinas/análise
Citocinas/efeitos dos fármacos
Componentes Aéreos da Planta/química
Modelos Animais de Doenças
Etanol/farmacologia
Reação em Cadeia da Polimerase em Tempo Real
Células RAW 264.7
Pulmão/efeitos dos fármacos
Pulmão/fisiologia
Camundongos Endogâmicos BALB C
Óxido Nítrico/análise
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Estudo de Avaliação
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-828100
Autor: Habermann, E; Imatomi, M; Pontes, F C; Gualtieri, S C J.
Título: Antioxidant activity and phenol content of extracts of bark, stems, and young and mature leaves from Blepharocalyx salicifolius (Kunth) O. Berg / Atividade antioxidante e teor de polifenóis de extratos de cascas (súber), caule, folhas jovens e folhas maduras de Blepharocalyx salicifolius (Kunth) O. Berg (Murta)
Fonte: Braz. j. biol;76(4):898-904, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Phenolic compounds are a group of plant secondary metabolites known to have a variety of bioactivities, including the ability to function as antioxidants. Because of the side effects of the use of synthetic substances, the search for natural and less toxic compounds has increased significantly. This study was designed to evaluate the antioxidant activity and phenol content of hexane, ethyl acetate, and aqueous extracts of the bark (suber) and stems as well as the young and mature leaves of Blepharocalyx salicifolius. The extracts were obtained by extraction with organic solvents and subsequent fractionation by chromatographic partition coefficient. Preliminary tests for the presence of antioxidants were performed using bioautography in thin-layer chromatography. The antioxidant activity of the extracts was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the phenol content of the extracts was quantified using the Folin-Ciocalteu technique. The results showed that 9 of the 12 extracts evaluated displayed very strong antioxidant activity and three displayed moderate activity. Aqueous extracts of the young leaves and bark and the ethyl acetate extract of the young leaves showed the highest levels of antioxidant activity and total phenolic content (TPC). A correlation was observed between TPC and antioxidant activity index (AAI) with a correlation coefficient (r2) of 0.7999. Thus, the high phenol content of B. salicifolius extracts and its correlation with antioxidant activity provide substrates for further studies.

Resumo Os polifenóis são um grupo de metabólitos secundários vegetais que possuem uma variedade de bioatividades conhecidas, dentre elas a capacidade de funcionar como antioxidantes. Devido aos efeitos colaterais do uso excessivo de substâncias sintéticas, a busca por compostos naturais e menos tóxicos têm aumentado significativamente. Esse estudo teve por objetivo avaliar a atividade antioxidante e o teor de polifenóis dos extratos hexânicos, acetato de etila e aquosos de cascas (súber), caules, folhas jovens e folhas maduras de Blepharocalyx salicifolius. Os extratos foram obtidos por meio de extração com solventes orgânicos e subsequente fracionamento em cromatografia por coeficiente de partição. Testes preliminares da presença de compostos com atividade antioxidante foram realizados por meio de bioautografia em cromatografia de camada delgada. Os extratos foram submetidos ao teste da capacidade sequestrante do radical 2,2-difenil-1-picrilhidrazil (DPPH) para quantificação da atividade antioxidante e submetidos ao teste com o reagente de Folin-Ciocalteu para quantificação dos polifenóis. Os resultados mostraram que dos 12 extratos avaliados, 9 apresentaram atividade antioxidante muito forte e 3 atividade moderada. Os extratos aquosos de folhas jovens e cascas e o extrato acetato de etila de folhas jovens apresentaram os maiores índices de atividade antioxidante e teor de polifenóis (TPC). A correlação entre TPC e o índice de atividade antioxidante (AAI) observada foi de r2 = 0,7999. Dessa forma, ficou evidenciado o elevado teor de polifenóis e sua correlação com a atividade antioxidante nos extratos de B. salicifolius, fornecendo subsídios para novos estudos.
Descritores: Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Myrtaceae
Componentes Aéreos da Planta/química
Antioxidantes/análise
-Oxirredução/efeitos dos fármacos
Picratos
Compostos de Bifenilo
Brasil
Responsável: BR1.1 - BIREME


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Id: biblio-974415
Autor: Puertas-Mejía, Miguel Angel; Gutierrez-Villegas, María Isabel; Mejía-Giraldo, Juan Camilo; Winkler, Robert; Rojano, Benjamín.
Título: In vitro UV absorption properties and radical scavenging capacity of Morella parvifolia (Benth. ) Parra-Os. extracts
Fonte: Braz. J. Pharm. Sci. (Online);54(3):e17498, 2018. tab, graf.
Idioma: en.
Resumo: The goal of this research was to identify major compounds of the aerial parts of M. parvifolia (Benth.) Parra-Os., that could enhance its possible application as additive in dermocosmetic products, as well as evaluate the antioxidant properties. The extracts agreed with the broad-spectrum UVB/UVA absorption detected and could act as broad-spectrum sunscreens, covering the UVA and UVB range. Methanolic extracts showed an important antiradical capacity (0.46 and 0.47 g/µmol DPPH), TPC (37.58 and 51.41mg GAE/g DS) and TAC (1.12 and 3.31 mg C3GE/g DS) in fruits and leaves, respectively. M. parvifolia could be considered as a prospective source of natural UV-radiation absorbers with antioxidant capacity. Although the results have clearly demonstrated the potential photoprotection capacity, more studies are needed to enhance its application as an additive in pharmaceutical and medicinal formulations.
Descritores: Raios Ultravioleta/efeitos adversos
Extratos Vegetais
Myricaceae/classificação
Absorção
-Protetores Solares/efeitos adversos
Técnicas In Vitro/instrumentação
Componentes Aéreos da Planta
Aditivos em Cosméticos
Antioxidantes
Responsável: BR1.1 - BIREME


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Id: biblio-974406
Autor: Merino, Francis José Zortéa; Ribas, Daniele Felipe; Silva, Cristiane Bezerra da; Duarte, Ana Flávia Schvabe; Paula, Cristiane da Silva; Oliveira, Maislian de; Dias, Josiane de Fátima Gaspari; Miguel, Marilis Dallarmi; Miguel, Obdulio Gomes.
Título: A study of the phytotoxic effects of the aerial parts of Senecio westermanii Dusén (Asteraceae) on Lactuca sativa L. and Allium cepa L. seeds
Fonte: Braz. J. Pharm. Sci. (Online);54(3):e17135, 2018. graf.
Idioma: en.
Resumo: The objective of this study was to evaluate the effects of the ethanolic crude extracts and fractions of the species Senecio westermanii Dusén on Lactuca sativa L. (lettuce) and Allium cepa L. (onion) seeds. We assessed the germination, growth, root respiration and photosynthesis of the target species in Petri dishes (9.0 cm diameter) containing filter paper n°6. The study was conducted using 50 seeds per plate and held in 4 replicates per concentration of each sample. In the germination there was an inhibitory effect of fractions hexane (FH) and chloroform (FCl) at concentrations of 500 and 1000 µg/mL. There was a reduction in the radicle growth of lettuce by 14 to 24% and a reduction of hypocotilum by 14 to 28%. As for the radicle of the onion was up 74% reduction to the FCl and the coleoptile was 24 and 45% reduction for FH and FCl, respectively. Inhibitory effects in the root respiration of lettuce were detected in all the samples analyzed, with results ranging from 16 to 83%. For the seeds of A. cepa, there was an encouragement for the FCl and ethyl acetate fractions (FAE), with results ranging from 94 to 142% and 76 to 150%, respectively. With regard to the photosynthesis of L. sativa, there was no significant difference between the control, and as for the A. cepa, there was a strain in inhibition concentrations of 250 and 500 µg/mL, which ranged from 27 to 68%. The samples of S. westermanii caused changes in the target species and thus can be used as a natural herbicide.
Descritores: Sementes/crescimento & desenvolvimento
Extratos Vegetais/efeitos adversos
Alface/crescimento & desenvolvimento
Asteraceae/efeitos adversos
Cebolas/crescimento & desenvolvimento
Componentes Aéreos da Planta
-Senécio/classificação
Alelopatia/fisiologia
Responsável: BR1.1 - BIREME


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Id: biblio-974397
Autor: Zhang, Xiaochao; Yang, Renhua; Long, Jiang; He, Bo; Zhang, Yue; Fu, Ting; Shen, Zhiqiang; Chen, Peng.
Título: A novel effect of geraniin on OPG/RANKL signaling in osteoblasts
Fonte: Braz. J. Pharm. Sci. (Online);54(3):e17567, 2018. graf.
Idioma: en.
Resumo: In this study, the effects of geraniin on osteoprotegerin/receptor activator of nuclear factor-κB ligand(OPG/RANKL) in regulating the proliferation of osteoblasts and suppression of osteoclast-like cells (OLC) in OLC-osteoblast co-cultured system in vitro were investigated. Osteoblasts were cultured and identified with alkaline phosphatase (ALP), gomori stain, and mineralized nodule stain. OLCs were isolated from long bones of Sprague-Dawley (SD) rats and identified with tartrate-resistant acid phosphatase(TRAP) stain. Methyl thiazolyl tetrazolium assay was used to examine the proliferation of osteoblasts, and immunocytochemistry and in situ hybridization to analyze the expression OPG/RANKL in osteoblasts co-cultured with osteoclasts under the action of geraniin, respectively. Geraniin could regulate the proliferation of osteoblasts MC3T3-E1, decrease the number of OLC in OLC-osteoblast co-cultured system, and inhibit the bone resorption areas and resorption pits of OLC in vitro experiments. Geraniin could promote the mRNA and protein expression levels of OPG and suppress those of RANKL in osteoblasts. These results indicate that geraniin has a promoting effect on the proliferation of osteoblasts and an inhibitory effect on the osteoclastic bone-resorption through regulating OPG/RANKL signaling pathway in OLC-OB co-cultured system.
Descritores: Ligante RANK/classificação
Osteoprotegerina/efeitos adversos
-Osteoblastos
Phyllanthus/classificação
Componentes Aéreos da Planta
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR1.1 - BIREME


  10 / 41 LILACS  
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Id: biblio-889387
Autor: Gharachorloo, Maryam; Honarvar, Masoud; Mardani, Shima.
Título: Chemical compositions and antioxidant activity of Heracleum persicum essential oil
Fonte: Braz. J. Pharm. Sci. (Online);53(3):e00260, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT In this study essential oil of the aerial parts of Heracleum persicum a spice widely used in Iran was isolated by conventional hydrodistillation (HD) and microwave-assisted hydrodistillation (MAHD) techniques. The extraction yield was determined and the chemical compositions of essential oils were identified by the application of gas chromatography/mass spectrometry (GC/MS). The antioxidant activity was determined by two different methods: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and oven test methods. Although the main compounds of essential oils by the both extraction methods were similar, the essential oil extracted by HD with lower extraction efficiency showed more diverse compounds. The evaluation of antioxidant activity of the essential oil measured by delay in sunflower oil oxidation indicated that the antioxidant activity was dependent on the concentration which increased when higher concentrations of the essential oils were applied. The results of DPPH radical assay also indicated that the percentage of inhibition increased with increasing of essential oil concentration and IC50 value for essential oil extracted by MAHD method was obtained 1.25 mg/mL. Therefore the Heracleum persicum essential oil might be recommended for use as a flavoring agent and a source of natural antioxidants in functional foods, formulation of the supplements and in medicinal due to numerous pharmacological activities.
Descritores: Óleos Voláteis/análise
Heracleum/efeitos adversos
Heracleum/química
Antioxidantes/análise
-Componentes Aéreos da Planta/classificação
Estufas para Plantas/métodos
Oxidação
Óleo de Girassol/efeitos adversos
Cromatografia Gasosa-Espectrometria de Massas/instrumentação
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas



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