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Id: biblio-1017986
Autor: Ferreira, María Elena; Schinini, Alicia.
Título: Hemocultivos en monos cebus apella experimentalmente infectados con Trypanosoma cruzi y tratado con espirogermanium / Hemoculture in Cebus apella monkeys experimentally infected with Trypanosoma cruzi and treated with spirogermanium.
Fonte: Asunción; EFACIM; 1991. 85-88 p. tab.
Idioma: es.
Resumo: twelve cebus apella monkeys experimentally infected with 3 x 10 sobre 5 T. cruzi trypomastigotes Y strain, and treated with different doses of Spirogermanium and Nifurtimox during the acute phase of the infection, were subjected to hemoculture in order to test the sensitivity of this methd in comparsson to direct parasitemia through hemoconcentration. The 75 percent of positive results obtained with hemocutive shows a high sensitivity when compared with direct parasitemia, which did not yield any positive. This makes hemoculture suitable for long term evaluation of potential trypanocide drugs
Descritores: Haplorrinos
Trypanosoma cruzi
-Paraguai
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1991


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Id: biblio-1017982
Autor: Inchausti, Alba; Schinini, Alicia.
Título: Infección experimental de monos Cebus apella con Trypanosoma cruzi: Datos preliminares de parasitemia / Experimental infection of Cebus apella monkeys with Trypanosoma cruzi. Preliminary data on parasitemia.
Fonte: Asunción; EFACIM; 1991. 112-116 p. tab.
Idioma: es.
Resumo: Three Cabus apella monkeys were infected with 3.5 x 10 sobre 5 cells of Trypanosoma cruzi Y strian in order to evaluate the parasitemia and to study the behavior of the parasites in the mammalian host for a one-year period. The parasitemia was determined by hemoconcentraction. In the there monkeys, circulating parasites were detected in blood one week after infection. Parasitemia persisted in two monkeys one year after infection, but not continuously. Cyclic peaks of parasitemia were not detected
Descritores: Haplorrinos
Parasitemia
Trypanosoma cruzi
-Paraguai
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1991


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Id: biblio-1017981
Autor: Saito, Susumu; Schinini, Alicia; Fujita, Osamu.
Título: Examem poe el método MGL de la parasitosis intestinal en monos Cebus apella / Examination of intastinal parasitosis in Cebus apella monkeys by the MGL method.
Fonte: Asunción; EFACIM; 1991. 117-120 p. ilus.
Idioma: es.
Resumo: Feces from 64 Cebus apella monkeys were examined by the MGL method. The monkeys have been kept in captivity at IICS. Larvae resembling those of Strongyloides were found in 25 percent of the animals, eggs resembling thosse of Strongyloide in 39 percent of the animals and eggs resembling those of Cestode in 1.6 percent of them
Descritores: Enteropatias Parasitárias
Haplorrinos
-Paraguai
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1991


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Id: biblio-1017970
Autor: Cabello, Agueda; Cabral, Margarita; Picagua, Estela; Schinini, Alicia; Yamashita, Takao; Sendo, Fujiro.
Título: Precencia de receptores de células rojas sangínea de cabral en células mononucleares de mono Cebus apella / Presence of receptorst to sheep red blood cells in mononucleares cells from Cebus apella monkeys.
Fonte: Asunción; EFACIM; 1991. 219-226 p. tab.
Idioma: es.
Resumo: The configuration of E Rosettes with sheep red blood cells and the expression of the epitope detected for the monoclonal antibody anti-CD2 was detected in mononuclear cells from 9 Cebus apella monkeys. Nine human controls were employed, and also the results demostrated the existence of inhibition in the formation of rosettes when anti-CD2 antiboides were used to a maximumdilution of 1/1000
Descritores: Haplorrinos
Primatas
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1991


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Id: biblio-1017964
Autor: Rovira, María Teresa; Ruiz, Julio C.; Encarnación, Filomeno.
Título: Factores ambientales que afectan el comportamiento de primates en habitad especiales / Environmental factors affecting the behavior of primates in special habitats.
Fonte: Asunción; EFACIM; 1991. 255-261 p.
Idioma: es.
Resumo: It was observed the effects of captivity on the reproductive competence of monkeys, to measure the degree of adaptation to a confined situation. These observation were made on Cebus, Aotus, and Saimiri monkeys, from two different monkeys colonies, facing a project of establishment a breeding monkey colony at the IICS. It was observed the behavior of the monkeys concerning the aggressivness against the other monkeys in the cage and themselves, the organization of social groups, and its hierarchy. It was evidenced the importance of the tryning of the staff dealing with the monkeys, as factor influencing the behavior of the animals. It was observed the importance of the organization of the colony, concerning the surroundings of the cages, ventilation, room temperature, illumination, presence of personnel, location of other cages, as factors exerting a strong influence in the behavior of the monkeys
Descritores: Haplorrinos
Saimiri
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1991


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Fotocópia
Texto completo
Id: lil-233897
Autor: Kohn, André Fábio; Araújo, Luiz Jurandir S.
Título: Testes preliminares de um modelo reduzido da rede neuronal da meula envolvida em controle motor / Preliminary tests the a reduced neuronal model of spinal cord network involved in motor control
Fonte: In: Schiabel, Homero; Slaets, Annie France Frère; Costa, Luciano da Fontoura; Baffa Filho, Oswaldo; Marques, Paulo Mazzoncini de Azevedo. Anais do III Fórum Nacional de Ciência e Tecnologia em Saúde. Säo Carlos, s.n, 1996. p.618-618, graf.
Idioma: pt.
Conferência: Apresentado em: Fórum Nacional de Ciência e Tecnologia em Saúde, 3 e Congresso Brasileiro de Engenharia Biomédica, 15 e Congresso Brasileiro de Físicos em Medicina , 6 e Congresso Brasileiro de Informática em Saúde, 5 e Encontro Brasileiro de Proteçäo Radiológica, Campos do Jordäo, 13-17 out. 1996.
Resumo: Um modelo reduzido da rede neuronal da medula espinhal foi simulado. Constatou-se que certas discrepâncias entre as simulações e dados experimentais podem ser eliminadas com modificações na proposta original do modelo.
Descritores: Medula Espinal
Eletrodos/estatística & dados numéricos
Rede Nervosa
Axônios
-Haplorrinos
Mamíferos
Neurônios Motores
Limites: Seres Humanos
Animais
Gatos
Responsável: BR1.1 - BIREME
BR1.1/3012.89


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Id: lil-790893
Autor: Neves Filho, Hernando Borges; Carvalho Neto, Marcus Bentes de; Barros, Romariz da Silva; Costa, Juliane Rufino da.
Título: Insight em macacos-prego (Sapajus spp) com diferentes contextos de treino das habilidades pré-requisitos / Insight in Capuchin-monkeys (Sapajus spp) with different contexts of training of prerequisite abilities
Fonte: Interaçao psicol = Interação psicol. (Online) = Interaçao psicol. (Impr.);18(3):333-350, set.-dez.2014. ilus, tab.
Idioma: pt.
Resumo: Insight, na Psicologia Experimental, indica, tradicionalmente, a resolução súbita e espontânea de um determinado problema. O presente estudo verificou a ocorrência de resolução súbita em macacos-prego (Sapajus spp.) a partir do treino de habilidades pré-requisitos de uma tarefa. Adicionalmente o estudo avaliou se a manipulação do local de treino altera a topografia de solução do problema. Dois sujeitos foram treinados a: a) encaixar objetos e b) pescar objetos fora do alcance utilizando uma ferramenta. O treino das duas habilidades se deu de forma independente e em diferentes contextos. A tarefa final consistiiu em pescar um alimento fora do alcance encaixando um par de ferramentas nunca antes manuseado. Os dois sujeitos resolveram a tarefa, entretanto, nenhum apresentou um desempenho tipicamente de insight, na medida em que as resoluções foram pouco fluidas, com pausas entre suas etapas, e aparentemente sem direcionamento. Discute-se o papel do treino das habilidades pré-requisitos em ambientes diferenciados como um fator que dificulta a resolução da tarefa

Insight, in Experimental Psychology, traditionally refers a sudden and spontaneous solution of a specific problem. The present study aims to verify the occurrence of sudden problem resolution in capuchin monkeys (Sapajus spp.) based on explicit training of two pre-requisite repertoires. Additionally, we examined if the manipulation of the context of training alters the topography of the problem solution response. Two subjects were trained to: a) join objects, and b) to rake objects with a tool. The training of the two repertoires was independent and was carried out in different contexts. The final task consists in raking a piece of food with a joinable tool that was never seen before. The two subjects solved the task, but the topography of solution was not clearly compatible with insight interpretation. The solutions had pauses between steps, and the behavior was not goal directed. The negative effects of different contexts for the training of the pre-requisite repertoires are discussed
Descritores: Haplorrinos/psicologia
Resolução de Problemas
Limites: Animais
Masculino
Responsável: BR628.1 - Biblioteca Central


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Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-769827
Autor: Souza, Nicolli Bellotti de; Aguiar, Anna Caroline Campos; Oliveira, Alane Cabral de; Top, Siden; Pigeon, Pascal; Jaouen, Gérard; Goulart, Marilia Oliveira Fonseca; Krettli, Antoniana Ursine.
Título: Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
Fonte: Mem. Inst. Oswaldo Cruz;110(8):981-988, Dec. 2015. tab, graf.
Idioma: en.
Projeto: MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT; . MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT; . FAPEMIG; . ANR.
Resumo: This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.
Descritores: Antimaláricos/farmacologia
Complexos de Coordenação/síntese química
Compostos Ferrosos/farmacologia
Compostos Organometálicos/farmacologia
Plasmodium falciparum/efeitos dos fármacos
Rutênio/farmacologia
-Antimaláricos/síntese química
Linhagem Celular
Cromatografia em Camada Delgada
Complexos de Coordenação/farmacologia
Citotoxinas/farmacologia
Compostos Ferrosos/síntese química
Haplorrinos
/parasitologia
HEP GTEMEFOS CELLS/parasitologia
Técnicas In Vitro
INHIBITORY CONCENTRATION ACADEMIES AND INSTITUTES
Compostos Organometálicos/síntese química
Rutênio/química
Tamoxifeno/química
Limites: Animais
Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
Texto completo
Id: lil-733237
Autor: Pimentel, Raquel; Skewes-Ramm, Ronald; Moya, José.
Título: Chikungunya en la República Dominicana: lecciones aprendidas en los primeros seis meses / Chikungunya in the Dominican Republic: lessons learned in the first six months
Fonte: Rev. panam. salud pública = Pan am. j. public health;36(5):336-341, nov. 2014. graf, tab.
Idioma: es.
Resumo: La epidemia de chikungunya en la República Dominicana se inició en febrero de 2014. En los primeros seis meses se registraron 429 421 casos, que representaron 65% de todos los notificados a la Organización Panamericana de la Salud por 33 países y territorios de la Región de las Américas. Esta epidemia se ha transmitido con rapidez en dicho país y ha demandado una intensa respuesta intersectorial, que ha liderado el Ministerio de Salud Pública y, especialmente, el Sistema Nacional de Vigilancia Epidemiológica y la red de los servicios de salud. Considerando que afectará a miles de personas, el objetivo de este artículo es describir las actuaciones realizadas y compartir los resultados y las lecciones aprendidas durante estos primeros meses con los ministerios de salud y los profesionales de los países de la Región para ayudarles a preparar una respuesta adecuada para afrontarla de forma efectiva y eficiente.

The chikungunya epidemic in the Dominican Republic began in February 2014. During the first six months 429 421 cases were recorded, representing 65% of all those notified to the Pan American Health Organization by 33 countries and territories of the Region of the Americas. This epidemic has spread quickly in the Dominican Republic, requiring a focused intersectoral response, led by the Ministry of Public Health and involving major efforts by the National Epidemiological System and the health services network. Given that the virus will affect thousands of people, this article seeks to describe the actions that have already been carried out, and to share the results and lessons learned during these first months with health ministries and professionals in the countries of the Region, in order to assist them to prepare an appropriate response to confront the epidemic effectively and efficiently.
Descritores: Núcleo Celular/metabolismo
Citoplasma/metabolismo
Proteínas de Choque Térmico HSP90/metabolismo
Receptores de Glucocorticoides/metabolismo
-Linhagem Celular
Dexametasona/farmacologia
Haplorrinos
Rim
Neoplasias Hepáticas Experimentais
Molibdênio/farmacologia
Receptores de Glucocorticoides/genética
Transfecção
Células Tumorais Cultivadas
Limites: Animais
Ratos
Tipo de Publ: Research Support, U.S. Gov't, P.H.S.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-702069
Autor: Loria-Cervera, Elsy Nalleli; Andrade-Narvaez, Fernando Jose.
Título: Animal models frr the study of leishmaniasis immunolggy / Modelos animales para el estudio de la inmunologia de la leishmaniosis
Fonte: Rev. Inst. Med. Trop. Säo Paulo;56(1):1-11, Jan-Feb/2014.
Idioma: en.
Resumo: Leishmaniasis remains a major public health problem worldwide and is classified as Category I by the TDR/WHO, mainly due to the absence of control. Many experimental models like rodents, dogs and monkeys have been developed, each with specific features, in order to characterize the immune response to Leishmania species, but none reproduces the pathology observed in human disease. Conflicting data may arise in part because different parasite strains or species are being examined, different tissue targets (mice footpad, ear, or base of tail) are being infected, and different numbers (“low” 1×102 and “high” 1×106) of metacyclic promastigotes have been inoculated. Recently, new approaches have been proposed to provide more meaningful data regarding the host response and pathogenesis that parallels human disease. The use of sand fly saliva and low numbers of parasites in experimental infections has led to mimic natural transmission and find new molecules and immune mechanisms which should be considered when designing vaccines and control strategies. Moreover, the use of wild rodents as experimental models has been proposed as a good alternative for studying the host-pathogen relationships and for testing candidate vaccines. To date, using natural reservoirs to study Leishmania infection has been challenging because immunologic reagents for use in wild rodents are lacking. This review discusses the principal immunological findings against Leishmania infection in different animal models highlighting the importance of using experimental conditions similar to natural transmission and reservoir species as experimental models to study the immunopathology of the disease.

Las leishmaniosis siguen siendo un importante problema de salud pública a nivel mundial y se clasifican como categoría I por el programa TDR/WHO, debido principalmente a la ausencia de control. Muchos modelos experimentales tales como roedores, perros y monos han sido desarrollados, cada uno con características específicas, para caracterizar la respuesta inmune a las diferentes especies de Leishmania, sin embargo ninguno reproduce la patología observada en la enfermedad humana. La diversidad en los resultados obtenidos podría deberse en parte a que diferentes cepas de parásitos o especies están siendo examinadas, diferentes tejidos (cojinete plantar, oreja o base de la cola) han sido infectados y diferente número (“bajo” 1×102 y “alto” 1×106) de promastigotes metacíclicos han sido inoculados. Recientemente, nuevos enfoques han sido propuestos con el fin de obtener datos más significativos en cuanto a la respuesta inmune del huésped y a la patogénesis, de tal forma que reproduzcan lo que ocurre en la enfermedad humana. El uso de la saliva del insecto y de un número de parásitos menor en las infecciones experimentales ha permitido reproducir la transmisión natural, identificar nuevas moléculas, así como mecanismos inmunes que deberían ser considerados en el diseño de vacunas y estrategias de control. Adicionalmente, se ha propuesto como una buena alternativa el uso de roedores silvestres como modelos experimentales tanto para el estudio de las relaciones huésped-patógeno como para probar nuevas vacunas. A la fecha, el uso de reservorios naturales para estudiar la infección por Leishmania ha sido un reto, debido a la carencia de reactivos inmunológicos para uso en roedores silvestres. Esta revisión describe los principales hallazgos inmunológicos ante la infección por Leishmania, en los diferentes modelos animales, destacando la importancia del uso de condiciones experimentales similares a la transmisión natural y de reservorios como modelos experimentales para el estudio de la inmunopatología de la enfermedad.
Descritores: Modelos Animais de Doenças
Leishmania/imunologia
Leishmaniose/imunologia
-Haplorrinos
Leishmaniose/parasitologia
Roedores
Limites: Animais
Cricetinae
Cães
Camundongos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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