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Id: biblio-892251
Autor: ZHANG, Liying; WANG, Fabao; REN, Xiubao.
Título: Inhibitory effect of Dendrobium officinale polysaccharide on human gastric cancer cell xenografts in nude mice
Fonte: Food Sci. Technol (SBCTA, Impr.) = Cienc. tecnol. aliment;38(1):78-83, Jan.-Mar. 2018. tab.
Idioma: en.
Resumo: Abstract This study investigated the inhibitory effect of Dendrobium officinale polysaccharide (DOPA) on human gastric cancer cell SGC-7901 xenografts in nude mice. The nude mice with SGC-7901 xenografts were randomly divided into model, 5-fluorouracil (5-Fu), low-dose DOPA, middle-dose DOPA and high-dose DOPA group. The later four groups were intragastrically administrated with 100, 200 and 400 mg·kg-1·day-1 DOPA, 400 mg·kg-1·day-1 5-Fu and normal saline, respectively. After treatment for 20 days, the tumor inhibition rate of in high-dose DOPA group was basically equivalent to 5-Fu group. Compared with 5-Fu, DOPA had no obvious toxic side effect on spleen or thymus indexes, routine blood indexes or liver and kidney functions of nude mice. Compared with model group, the serum tumor necrosis factor-α and interleukin-2 levels in middle- and high-dose DOPA group were significantly increased (P < 0.05), Bax protein expression was significantly increased (P < 0.05), and Bcl-2 protein expression was significantly decreased (P < 0.05). DOPA can inhibit the growth of SGC-7901 cell xenografts in nude mice. The mechanism may be related to its increase of serum TNF-α and IL-2 levels, up-regulation of Bax protein expression and down-regulation of Bcl-2 protein expression.
Descritores: Neoplasias Gástricas
Ensaios Antitumorais Modelo de Xenoenxerto
-Plantas Medicinais
Polissacarídeos
Neoplasias Gástricas/terapia
Dendrobium
Xenoenxertos
Camundongos Nus
Limites: Seres Humanos
Animais
Camundongos
Responsável: BR25.1 - Biblioteca


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Id: biblio-892237
Autor: LIU, Aixue; ZHENG, Ruinian; YANG, Fan; HUANG, Li; ZHANG, Lingyan; ZHANG, Jiren.
Título: Effects of curcumin on growth of human cervical cancer xenograft in nude mice and underlying mechanism
Fonte: Food Sci. Technol (SBCTA, Impr.) = Cienc. tecnol. aliment;38(1):106-111, Jan.-Mar. 2018. tab, graf.
Idioma: en.
Resumo: Abstract The present study investigated the effects of curcumin (Cur) on growth of human cervical cancer xenograft in nude mice and underlying mechanism. The nude mice modeled with human cervical cancer HeLa cell xenograft were treated with normal saline (control), 3 mg/kg Cisplatin, 50, 100 and 200 mg/kg Cur, respectively. The animal body weight and growth of tumor were measured. The expressions of Bax, Bcl-2, p53, p21, HIF-1α, VEGF and MIF protein in tumor tissue were determined. Results showed that, after treatment for 20 days, the tumor mass and tumor volume in 100 and 200 mg/kg Cur group were significantly lower than control group (P < 0.05). The expressions of Bax, p53 and p21 protein in tumor tissue in 200 mg/kg Cur group were significantly higher than control group (P < 0.05), and the expressions of Bcl-2, HIF-1α, VEGF and MIF protein in tumor tissue in 200 mg/kg Cur group were significantly lower than control group (P < 0.05). Cur can inhibit the growth of HeLa cell xenograft in nude mice. The possible mechanism may be related to its up-regulation of Bax, p53 and p21 protein expression in tumor tissue, and down-regulation of Bcl-2, HIF-1α, VEGF and MIF protein expression.
Descritores: Neoplasias do Colo do Útero
Curcumina
Xenoenxertos
-Plantas Medicinais
Ensaios Antitumorais Modelo de Xenoenxerto
Polifenóis
Camundongos Nus
Limites: Seres Humanos
Animais
Feminino
Camundongos
Responsável: BR25.1 - Biblioteca


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Id: biblio-889068
Autor: Jiao, Yang; Wu, Yan; Du, Dong.
Título: Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(4):e6867, 2018. graf.
Idioma: en.
Projeto: Innovative Research Program; . Science and Technology Program.
Resumo: Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Flow cytometry and TUNEL assay were used to measure cell apoptosis. Quantitative real-time PCR and western blotting assays were used to determine mRNA and protein expression levels. Xenograft experiment was performed to determine the in vivo anti-tumor effect of polydatin. Immunostaining was performed to analyze the expression of caspase-3 and Ki-67. Our results showed that polydatin inhibited cell proliferation in a concentration-dependent and time-dependent manner in the HCC cell lines. Polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, Bax, and down-regulating the protein expression of Bcl-2. In addition, polydatin treatment had an inhibitory effect on cell proliferation, invasion and migration in HCC cell lines. Polydatin treatment also suppressed the Wnt/beta-catenin signaling activities in HCC cells. Polydatin treatment significantly reduced tumor growth in nude mice inoculated with HepG2 cells, suppressed the expression of Ki-67, and increased caspase-3 expression and TUNEL activity. Our data indicated the important role of polydatin for the suppression of HCC progression.
Descritores: Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Glucosídeos/farmacologia
Neoplasias Hepáticas Experimentais/tratamento farmacológico
Estilbenos/farmacologia
-Western Blotting
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Medicamentos de Ervas Chinesas
Citometria de Fluxo
Neoplasias Hepáticas Experimentais/patologia
Camundongos Endogâmicos BALB C
Camundongos Nus
Invasividade Neoplásica
Reação em Cadeia da Polimerase em Tempo Real
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Id: lil-767042
Autor: Delgado-Enciso, Iván; Soriano-Hernández, Alejandro D.; Rodriguez-Hernandez, Alejandrina; Galvan-Salazar, Héctor R.; Montes-Galindo, Daniel A.; Martinez-Martinez, Rafael; Valdez-Velazquez, Laura L.; Gonzalez-Alvarez, Rafael; Espinoza-Gómez, Francisco; Newton-Sanchez, Oscar A.; Lara-Esqueda, Agustín; Guzman-Esquivel, Jose.
Título: Histological changes caused by meclofenamic acid in androgen independent prostate cancer tumors: evaluation in a mouse model
Fonte: Int. braz. j. urol;41(5):1002-1007, Sept.-Oct. 2015. tab, graf.
Idioma: en.
Projeto: Fondo Mixto CONACYT-Gobierno de Colima.
Resumo: ABSTRACT Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5) or saline solution (control group, n=5) was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms), an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.
Descritores: Antineoplásicos/farmacologia
Inibidores de Ciclo-Oxigenase/farmacologia
Ácido Meclofenâmico/farmacologia
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
Neoplasias de Próstata Resistentes à Castração/patologia
-Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Modelos Animais de Doenças
Fibrose
Imuno-Histoquímica
Camundongos Nus
Invasividade Neoplásica
Neovascularização Patológica/tratamento farmacológico
Próstata/efeitos dos fármacos
Próstata/patologia
Neoplasias de Próstata Resistentes à Castração/química
Reprodutibilidade dos Testes
Limites: Animais
Seres Humanos
Masculino
Tipo de Publ: Estudos de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-761602
Autor: Carlesso, F.N.; Fuscaldi, L.L.; Araújo, R.S.; Teixeira, C.S.; Oliveira, M.C.; Fernandes, S.O.A.; Cassali, G.D.; Reis, D.C.; Barros, A.L.B.; Cardoso, V.N..
Título: Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(10):923-928, Oct. 2015. ilus.
Idioma: en.
Resumo: Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using99mTc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that99mTc-HYNIC-βAla-Bombesin(7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that99mTc-HYNIC-βAla-Bombesin(7-14)may be useful for the detection of pancreatic adenocarcinoma.
Descritores: Adenocarcinoma
Bombesina/análogos & derivados
Compostos de Organotecnécio/farmacocinética
Neoplasias Pancreáticas
-Adenocarcinoma/patologia
Bombesina/farmacocinética
Linhagem Celular Tumoral
Peptídeo Liberador de Gastrina/análogos & derivados
Xenoenxertos/patologia
Xenoenxertos
Camundongos Nus
Músculos
Neoplasias Pancreáticas/patologia
Fragmentos de Peptídeos/farmacocinética
Limites: Animais
Seres Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-751375
Autor: Lee, Dong-Kyu; Kang, Min-Hyeok; Lee, Tae-Sik; Oh, Jae-Seop.
Título: Relationships among the Y balance test, Berg Balance Scale, and lower limb strength in middle-aged and older females
Fonte: Braz. j. phys. ther. (Impr.) = Rev. bras. fisioter;19(3):227-234, May-Jun/2015. tab, graf.
Idioma: en.
Resumo: Background: Older females have less dynamic postural control and muscle strength than do middle-aged females. Aging-related strength losses may limit balancing performance. Objective: The purpose of this study was to investigate the ability of the Y Balance Test (YBT) and lower limb strength to discriminate between females in 2 age groups, the relationship between YBT distance and the Berg Balance Scale (BBS), and the degree to which performance on YBT distance is related to lower limb strength in middle-aged and older females. Method: The 40 healthy, independently active females were divided into 2 groups: older and middle-aged. The participants underwent measurements of YBT distance using the YBT, maximal muscular strength of the lower limbs using a handheld dynamometer, and the BBS. Results: The YBT distance in 3 directions and lower limb muscle strength for both lower limbs were significantly lower in the older adults than in the middle-aged group. A moderate correlation but insignificant correlation was found between the YBT composite distance and the BBS score. In the older females, YBT distance was significantly positively correlated with strength of the knee flexor and hip abductor. In the middle-aged group, YBT distance was significantly positively correlated with strength of the knee flexor and hip extensor. Conclusions: Performance on the YBT was influenced by the strength of lower limb. We suggested that YBT can be used to alternative as a measurement of dynamic balance. Proper training programs for older people could include not only strengthening exercises but also YBT performance to improve balance. .
Descritores: Adrenomedulina/metabolismo
Neoplasias Colorretais/genética
Neoplasias Colorretais/metabolismo
Proteínas Proto-Oncogênicas/genética
Proteínas ras/genética
-Linhagem Celular Tumoral
Hipóxia Celular/fisiologia
Imuno-Histoquímica
Camundongos Nus
Análise de Sequência com Séries de Oligonucleotídeos
Microambiente Tumoral/fisiologia
Ensaios Antitumorais Modelo de Xenoenxerto
Limites: Animais
Feminino
Seres Humanos
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-748280
Autor: Silva, Fernando Marcuz; Queiroz, Elaine Cristina Silveira de; Navarro-Rodriguez, Tomás; Barbuti, Ricardo Correa; Mattar, Rejane; Iriya, Kiyoshi; Lee, Jin Hwa; Eisig, Jaime Natan.
Título: Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers
Fonte: Clinics;70(5):318-321, 05/2015. tab.
Idioma: en.
Resumo: OBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to clarithromycin. In our country, the eradication rate by intention to treat with this regimen is 83%. In Brazil, a commercially available regimen for bacterial eradication that uses levofloxacin and amoxicillin with lansoprazole is available; however, its efficacy is not known. Considering that such a treatment may be an alternative to the classic regimen, we aimed to verify its efficacy in H. pylori eradication. METHODS: Patients with peptic ulcer disease infected with H. pylori who had not received prior treatment were treated with the following regimen: 30 mg lansoprazole bid, 1,000 mg amoxicillin bid and 500 mg levofloxacin, once a day for 7 days. RESULTS: A total of 66 patients were evaluated. The patients’ mean age was 52 years, and women comprised 55% of the sample. Duodenal ulcers were present in 50% of cases, and gastric ulcers were present in 30%. The eradication rate was 74% per protocol and 73% by intention to treat. Adverse effects were reported by 49 patients (74%) and were mild to moderate, with a prevalence of diarrhea complaints. CONCLUSIONS: Triple therapy comprising lansoprazole, amoxicillin and levofloxacin for 7 days for the eradication of H. pylori in Brazilian peptic ulcer patients showed a lower efficacy than that of the classic triple regimen. .
Descritores: Imobilização/instrumentação
Imobilização/veterinária
Imagem Multimodal/veterinária
Neoplasias/diagnóstico
Tomografia por Emissão de Pósitrons
Tomografia Computadorizada por Raios X
-Imobilização/métodos
Camundongos Nus
Imagem Multimodal/métodos
Reprodutibilidade dos Testes
Radioisótopos de Sódio
Limites: Animais
Camundongos
Tipo de Publ: Estudo Comparativo
Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-747179
Autor: Acosta, Aline Marques; Lima, Maria Alice Dias da Silva.
Título: Frequent users of emergency services: associated factors and reasons for seeking care / Usuários frequentes de serviço de emergência: fatores associados e motivos de busca por atendimento / Usuarios frecuentes de servicios de emergencia: factores asociados y motivos de la búsqueda de atención
Fonte: Rev. latinoam. enferm;23(2):337-344, Feb-Apr/2015. tab, graf.
Idioma: en.
Resumo: Aim: to identify the profile of frequent users of emergency services, to verify the associated factors and to analyze the reasons for the frequent use of the services. METHOD: An explanatory sequential type mixed method was adopted. Quantitative data were collected from the electronic medical records, with a sample of 385 users attended four or more times in an emergency service, during the year 2011. Qualitative data were collected through semi-structured interviews with 18 users, intentionally selected from the results of the quantitative stage. Quantitative data were analyzed using descriptive and inferential statistics and qualitative data using thematic analysis. RESULTS: It was found that 42.9% were elderly, 84.9% had chronic diseases, 63.5% were classified as urgent, 42.1% stayed for more than 24 hours in the service and 46.5% were discharged. Scheduled follow-up appointment, risk classification, length of stay and outcome were factors associated with frequent use. The reasons for seeking the services were mainly related to the exacerbation of chronic diseases, to easier access and concentration of technology, to the bond, and to the scheduled appointments. CONCLUSIONS: The results contribute to comprehending the repeated use of emergency services and provide additional data to plan alternatives to reduce frequent use. .

OBJETIVO: identificar o perfil de usuários frequentes de serviço de emergência, verificar fatores associados e analisar os motivos para utilização frequente do serviço. MÉTODO: adotou-se método misto, do tipo sequencial explanatório. Os dados quantitativos foram coletados em registros de prontuários eletrônicos, com amostra de 385 usuários, atendidos quatro vezes ou mais em um serviço de emergência, durante o ano de 2011. Os dados qualitativos foram obtidos por meio de entrevistas semiestruturadas, com 18 usuários, selecionados intencionalmente a partir dos resultados da etapa quantitativa. Os dados quantitativos foram analisados com estatística descritiva e inferencial e os qualitativos com análise temática. RESULTADOS: identificou-se que 42,9% eram idosos, 84,9% tinham doenças crônicas, 63,5% foram classificados como urgentes, 42,1% permaneceram mais de 24 horas no serviço e 46,5% tiveram alta. Os fatores associados à utilização frequente são retorno agendado, classificação de risco, tempo de permanência e desfecho. Os motivos da busca pelo serviço são relacionados, principalmente, à agudização de doenças crônicas, maior facilidade de acesso, concentração de tecnologia, vínculo e retornos agendados. CONCLUSÕES: os resultados contribuem para compreensão do uso repetido de serviços de emergência e oferecem subsídios para planejamento de alternativas para redução da utilização frequente. .

OBJETIVO: identificar el perfil de usuarios frecuentes de servicios de emergencia, verificar los factores asociados y analizar los motivos para utilización frecuente de ese servicio. MÉTODO: se adoptó un método mixto del tipo secuencial explicativo. Los datos cuantitativos fueron recolectados en registros de fichas electrónicas, con muestra de 385 usuarios atendidos cuatro veces o más, en un servicio de emergencia, durante el año de 2011. Los datos cualitativos fueron obtenidos por medio de entrevistas semiestructuradas con 18 usuarios, seleccionados intencionalmente a partir de los resultados de la etapa cuantitativa. Los datos cuantitativos fueron analizados con estadística descriptiva e inferencial y los cualitativos con análisis temático. RESULTADOS: se identificó que 42,9% eran ancianos, 84,9% tenían enfermedades crónicas, 63,5% fueron clasificados como urgentes, 42,1% permanecieron más de 24 horas en el servicio y 46,5% tuvieron alta para el domicilio. El retorno programado, la clasificación de riesgo, el tiempo de permanencia y el resultado, son factores asociados a la utilización frecuente. Los motivos de la búsqueda por el servicio son relacionados, principalmente a: la agudización de enfermedades crónicas, la mayor facilidad de acceso y concentración de tecnología, los vínculos, y a los retornos programados. CONCLUSIONES: los resultados contribuyen para la comprensión del uso repetido de servicios de emergencia y ofrecen informaciones para planificar alternativas para reducción de la utilización frecuente. .
Descritores: Carcinoma Pulmonar de Células não Pequenas/terapia
Dieta Cetogênica
Neoplasias Pulmonares/terapia
Estresse Oxidativo
-Linhagem Celular Tumoral
Terapia Combinada
Carcinoma Pulmonar de Células não Pequenas/metabolismo
Fracionamento de Dose
Cetonas/metabolismo
Peroxidação de Lipídeos
Neoplasias Pulmonares/metabolismo
Camundongos Nus
Antígeno Nuclear de Célula em Proliferação/metabolismo
Tolerância a Radiação
Ensaios Antitumorais Modelo de Xenoenxerto
Limites: Seres Humanos
Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Responsável: BR1.1 - BIREME


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Id: lil-747176
Autor: Fiorati, Regina Celia; Elui, Valeria Meirelles Carril.
Título: Social determinants of health, inequality and social inclusion among people with disabilities / Determinantes sociais da saúde, iniquidades e inclusão social entre pessoas com deficiência / Determinantes sociales de la salud, iniquidades e inclusión social entre personas con deficiencia
Fonte: Rev. latinoam. enferm;23(2):329-336, Feb-Apr/2015. graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: OBJECTIVE: to analyze the socio-familial and community inclusion and social participation of people with disabilities, as well as their inclusion in occupations in daily life. METHOD: qualitative study with data collected through open interviews concerning the participants' life histories and systematic observation. The sample was composed of ten individuals with acquired or congenital disabilities living in the region covered by a Family Health Center. The social conception of disability was the theoretical framework used. Data were analyzed according to an interpretative reconstructive approach based on Habermas' Theory of Communicative Action. RESULTS: the results show that the socio-familial and community inclusion of the study participants is conditioned to the social determinants of health and present high levels of social inequality expressed by difficult access to PHC and rehabilitation services, work and income, education, culture, transportation and social participation. CONCLUSION: there is a need to develop community-centered care programs in cooperation with PHC services aiming to cope with poverty and improve social inclusion. .

OBJETIVO: analisar a inclusão sociofamiliar e comunitária e a participação social de pessoas com deficiência, bem como sua inserção em ocupações na vida cotidiana. MÉTODO: estudo qualitativo, com coleta de dados por meio de entrevistas abertas sobre história de vida e observação sistemática. A amostra foi composta por dez pessoas com deficiência, adquirida ou congênita, moradoras de região adstrita a um Núcleo de Saúde da Família. O referencial teórico foi a concepção social da deficiência. Os dados foram analisados segundo abordagem interpretativa reconstrutiva, fundamentada no referencial da Teoria da Ação Comunicativa de Habermas. RESULTADOS: os resultados evidenciaram que a inclusão sociofamiliar e comunitária dos sujeitos do estudo condiciona-se a determinantes sociais da saúde, apresentando índices de iniquidades sociais, expressos pela dificuldade de acesso a serviços de Atenção Primária à Saúde e de reabilitação, trabalho e renda, educação, cultura, transporte e participação social. CONCLUSÃO: conclui-se a necessidade da elaboração de programas de atenção centrados na comunidade, voltados ao enfrentamento da pobreza e à inclusão social, em articulação com serviços de Atenção Primaria à Saúde. .

OBJETIVO: analizar la inclusión social familiar y comunitaria, y la participación social de personas con deficiencia, así como su inserción en ocupaciones en la vida cotidiana. MÉTODO: estudio cualitativo, con recolección de datos por medio de entrevistas abiertas sobre historia de vida y por observación sistemática. La muestra estuvo compuesta por diez personas con deficiencia, adquirida o congénita, habitantes de una región adscrita a un Núcleo de Salud de la Familia. El referencial teórico fue la concepción social de la deficiencia. Los datos fueron analizados según abordaje interpretativo reconstructivo, fundamentado en el referencial de la Teoría de la Acción Comunicativa de Habermas. RESULTADOS: los resultados evidenciaron que la inclusión social familiar y comunitaria de los sujetos del estudio se condiciona a determinantes sociales de la salud, presentando índices de iniquidades sociales, expresados por la dificultad de acceso a servicios de Atención Primaria de la Salud y de rehabilitación, trabajo y renta, educación, cultura, transporte y participación social. CONCLUSIÓN: se concluye que existe la necesidad de elaborar programas de atención centrados en la comunidad, dirigidos al enfrentamiento de la pobreza y a la inclusión social, en articulación con servicios de Atención Primaria a la Salud. .
Descritores: Antineoplásicos/farmacologia
Proteínas de Choque Térmico HSP90/metabolismo
Lactonas/farmacologia
/tratamento farmacológico
NEUROFIBROMATOSIS TEMEFOS/tratamento farmacológico
Oximas/farmacologia
-Linhagem Celular Tumoral
Proliferação Celular
Proteínas de Choque Térmico HSP90/antagonistas & inibidores
Camundongos Nus
Camundongos Transgênicos
/metabolismo
NEUROFIBROMATOSIS TEMEFOS/metabolismo
Proteólise
Transcriptoma/efeitos dos fármacos
Ensaios Antitumorais Modelo de Xenoenxerto
Limites: Seres Humanos
Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-745851
Autor: Cardoso, Mauricio de Almeida; Saraiva, Patrícia Pinto; Maltagliati, Liliana Ávila; Rhoden, Fernando Kleinübing; Costa, Carla Cristina Alvarenga; Normando, David; Capelozza Filho, Leopoldino.
Título: Alterations in plaque accumulation and gingival inflammation promoted by treatment with self-ligating and conventional orthodontic brackets
Fonte: Dental press j. orthod. (Impr.);20(2):35-41, Mar-Apr/2015. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: The aim of the present study was to evaluate, comparatively, the periodontal response during orthodontic treatment performed with self-ligating and conventional brackets. METHODS: Sixteen Caucasian individuals of both sexes, aged between 12 and 16 years old and in permanent dentition were selected. Eight individuals were treated with conventional brackets installed on the lower dental arch and self-ligating brackets on the upper arch. Another eight individuals received self-ligating brackets in the lower arch and conventional brackets in the upper arch. The subjects received material and instructions for oral hygiene. Visible plaque index (VPI), gingival bleeding index (GBI) and clinical attachment level (CAL) were evaluated just after installation of orthodontic appliances, and 30, 60 and 180 days later. Mann-Whitney test was used to compare differences between groups (self-ligating and conventional), two-way ANOVA followed by Tukey's test was used to assess CAL at each site of each tooth. Significance level was set at 5%. RESULTS: No significant changes were found with regard to the assessed parameters (VPI, GBI and CAL) in either one of the systems. CONCLUSION: No significant changes were found with regard to the periodontal response to orthodontic treatment for the variables assessed and between subjects receiving passive self-ligating and conventional brackets. All individuals had received oral hygiene instructions and had their periodontal conditions monitored. .

OBJETIVO: o objetivo do presente estudo foi avaliar, comparativamente, a resposta periodontal durante o tratamento ortodôntico realizado com braquetes autoligáveis e convencionais. MÉTODOS: dezesseis indivíduos, leucodermas, em dentição permanente, de ambos os sexos, com idades de 12 a 16 anos, foram selecionados. Oito foram tratados com braquetes convencionais instalados na arcada inferior, e braquetes autoligáveis na arcada superior. Os outros oito indivíduos receberam braquetes autoligáveis na arcada inferior e braquetes convencionais na arcada superior. Os pacientes receberam materiais e instruções sobre higiene bucal. O índice de placa visível (IPV), o índice de sangramento gengival (ISG) e o nível de inserção clínica (NIC) foram avaliados logo após a instalação do aparelho e 30, 60 e 180 dias mais tarde. Para comparar as diferenças entre os grupos (braquetes autoligáveis e convencionais), foi utilizado o teste Mann-Whitney; para analisar o NIC em cada local de cada dente, foi utilizada a análise de variância de duas vias, seguida do teste de Tukey, com nível de significância a 5%. RESULTADOS: não houve alteração significativa nos parâmetros avaliados (IPV, ISG e NIC), em nenhum dos dois sistemas. CONCLUSÃO: a resposta periodontal ao tratamento ortodôntico não apresentou diferenças significativas, para nenhuma das variáveis analisadas, entre os indivíduos tratados com braquetes autoligáveis passivos e braquetes convencionais, os quais receberam instruções quanto à adequada higienização bucal e foram submetidos ao monitoramento das condições periodontais. .
Descritores: Transportador de Glucose Tipo 1/metabolismo
Neoplasias/metabolismo
-Ilhas de CpG
Metilação de DNA
Regulação Neoplásica da Expressão Gênica
Glicólise
Transportador de Glucose Tipo 1/genética
Camundongos Nus
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Neoplasias/genética
Oxigênio/metabolismo
Regiões Promotoras Genéticas
Proteólise
Limites: Animais
Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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