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Texto completo SciELO Brasil
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Id: lil-202014
Autor: Dent, L. A; Daly, C; Geddes, A; Cormie, J; Finlay, D. A; Bignold, L; Hagan, P; Parkhouse, R. M. E; Garate, T; Parsons, J; Mayrhofer, G.
Título: Immune responses of IL-5 transgenic mice to parasites and aeroallergens
Fonte: Mem. Inst. Oswaldo Cruz;92(supl.2):45-54, Dec. 1997. ilus, tab, graf.
Idioma: en.
Conferência: Apresentado em: New perspectives in eosinophils, Rio de Janeiro, 1996.
Resumo: Eosinophils have long been thought to be effectors of immunity to helminth but have also been implicated in the pathogenesis of asthma. Patterns of cytokine production in the host may influence the pathogenesis of these diseases by regulating the activities of eosinophils and other components of the immune response. Mice which constitutively over-express IL-5 have profound and life-long eosinophilia in a restricted number of tissues. Although eosinophils from IL-5 transgenics are funtionally competent for a number of parameters considered to be important in inflammation, untreated animals are overtly normal and free of disease. In addition, the responses of these animals when exposed to aeroallergens and helminth present a number of apparent paradoxes. Eosinophil accumulation in tissue adjacent to major airways is rapid and extensive in transgenics exposed to the aeroallergen, but even after treatment with antigen over many months these mice show no evidence of respiratory distress or pathology. Helminth-infected IL-5 transgenics and their non-transgenic littermates develop similar inflammatory responses at mucosal sites and are comparable for a number of T cell and antibody responses, but they differ considerably in their ability to clear some parasite species. The life-cycle of Nippostrongylus brasilensis is significantly inhibited in IL-5 transgenics, but that of Toxocara canis is not. Our results suggest that eosinophilia and/or over-expression of IL-5 may actually impair host resistance to Schistosoma mansoni and Trichinella spiralis. The pathogenesis of diseases in which eosinophils are involved may therefore be more complex than previously thought.
Descritores: Asma/imunologia
Camundongos Transgênicos/imunologia
Hipersensibilidade Respiratória/imunologia
Schistosoma mansoni/imunologia
Toxocara canis/imunologia
Trichinella spiralis/imunologia
Limites: Animais
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas

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Id: lil-92205
Autor: Giorgio, S; Haig, D. M.
Título: Identification T-cell reactive antigens in Nippostrongylus brasiliensis using a cell immunoblotting technique
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;23(6/7):573-6, 1990. ilus.
Idioma: en.
Conferência: Apresentado em: Annual Meeting of the Federaçäo de Sociedades de Biologia Experimental, 5, Ribeiräo Preto, Aug. 24-28, 1990.
Resumo: Antigens of the nematode Nippostrongylus brasiliensis were fractionated by SDS-PAGE under reducing conditions, transferred electrophoretically onto nitrocelluose and converted to antigen-bound nitrocellulose particles for use in vitro proliferation assays. Mesenteric lymph node cells from unfected rats were analyzed for reactivity against the fractionated antigens, revealing a range of different molecular weight antigens. Ian addition, when supernatants from these cultures were assyed for IL3, further reactive antigens wee detected. The results demonstrated that these approaches are useful for the identification of T-cell reactive components of a complex mixture of parasite antigens in helminth infections, where the cellular nature of protection is not well defined
Descritores: Antígenos de Helmintos/imunologia
Técnicas In Vitro
Infecções por Nematoides/imunologia
Linfócitos T/fisiologia
Ratos Wistar
Limites: Ratos
Responsável: BR26.1 - Biblioteca Central

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