Base de dados : LILACS
Pesquisa : B01.300.107.795.095 [Categoria DeCS]
Referências encontradas : 704 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 71 ir para página                         

  1 / 704 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: lil-746939
Autor: Lee Muñoz, Ximena; Cajas Cajas, Nataly; Gómez Carranza, Leyla; Vergara Núñez, Cristian; Ivankovic Silva, Mariana; Astorga Bustamante, Elizabeth.
Título: Ocurrencia de levaduras del género Candida y estomatitis protésica antes y después del tratamiento rehabilitador basado en prótesis removible / Occurrence of genus Candida yeast and prosthetic stomatitis before and after rehabilitation treatment based on removable prosthesis
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);8(1):31-37, 2015. ilus, tab.
Idioma: es.
Projeto: Universidad de Chile. Facultad de Odontología.
Resumo: El 63,2% de la población chilena mayor de 65 años utiliza prótesis removible. Cuando estas pierden funcionalidad pueden producirse lesiones en la mucosa oral, siendo la más prevalente la estomatitis protésica, proceso inflamatorio de la mucosa de soporte de diversa extensión y severidad, cuyo principal factor etiológico es la infección por Candida spp. El objetivo de esta investigación fue determinar la cantidad y las especies de levaduras del género Candida y su asociación con estomatitis protésica en portadores de prótesis removible antes y después del tratamiento rehabilitador. Se realizó un estudio descriptivo cuantitativo, n = 34, en ambos géneros, edad promedio de 69 años, portadores de prótesis removible no funcionales, con y sin estomatitis protésica. Para el recuento e identificación de levaduras del género Candida se tomaron muestras de saliva antes y después del tratamiento. Las variables fueron analizadas estadísticamente. Los resultados indicaron el diagnóstico de estomatitis protésica en el 55,9% de los sujetos, de los cuales tipo I = 29,4% y tipo II = 26,5%. Los recuentos de Candida spp. fueron mayores en aquellos con estomatitis protésica, tanto antes como después del tratamiento. Al instalar prótesis funcionales el recuento disminuyó significativamente, sin embargo permaneció alto en aquellos con estomatitis protésica diagnosticada previa al tratamiento rehabilitador. La especie identificada más frecuentemente fue Candida albicans.

Almost two-thirds (63.2%) of the Chilean population aged 65 and above use removable prosthesis. When they cease to be functional, injuries may occur in the oral mucosa, with denture stomatitis being the most prevalent. This is an inflammatory process of the supportive mucosa of varying extension and severity, with its main etiologic factor being infection by Candida spp. The aim of this investigation was to determine the quantity and species of yeast of the genus Candida and their association with denture stomatitis in carriers of removable prosthesis, before and after the rehabilitation treatment. A descriptive quantitative study was conducted on 34 patients, with a mean age of 69 years, and carriers of a non-functional removable prosthesis, with and without prosthetic stomatitis. Saliva samples were taken before and after the treatment for the counting and identification of genus Candida yeast. The variables were statistically analyzed. The results showed a diagnosis of prosthetic stomatitis in 55.9% of the subjects, of which 29.4% were Type I and 26.5% were Type II. The Candida sppcount was higher in the subjects with prosthetic stomatitis both before and after the treatment. The count decreased significantly after installing a functional prosthesis. However, it remained high in those with prosthetic stomatitis. The most frequently identified species was Candida albicans.
Descritores: Estomatite sob Prótese/microbiologia
Candida/isolamento & purificação
Prótese Parcial Removível/efeitos adversos
Prótese Parcial Removível/microbiologia
-Saliva/microbiologia
Epidemiologia Descritiva
Reabilitação Bucal/efeitos adversos
Limites: Seres Humanos
Masculino
Adulto
Responsável: CL1.1 - Biblioteca Central


  2 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-894841
Autor: Ferreira, Mariana C; Cantrell, Charles L; Wedge, David E; Gonçalves, Vívian N; Jacob, Melissa R; Khan, Shabana; Rosa, Carlos A; Rosa, Luiz H.
Título: Antimycobacterial and antimalarial activities of endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from Brazil
Fonte: Mem. Inst. Oswaldo Cruz;112(10):692-697, Oct. 2017. tab, graf.
Idioma: en.
Projeto: FAPEMIG; . CAPES; . FINEP; . NIH; . USDA.
Resumo: BACKGROUND Endophytic fungi, present mainly in the Ascomycota and Basidiomycota phyla, are associated with different plants and represent important producers of bioactive natural products. Brazil has a rich biodiversity of plant species, including those reported as being endemic. Among the endemic Brazilian plant species, Vellozia gigantea (Velloziaceae) is threatened by extinction and is a promising target to recover endophytic fungi. OBJECTIVE The present study focused on bioprospecting of bioactive compounds of the endophytic fungi associated with V. gigantea, an endemic, ancient, and endangered plant species that occurs only in the rupestrian grasslands of Brazil. METHODS The capability of 285 fungal isolates to produce antimicrobial and antimalarial activities was examined. Fungi were grown at solid-state fermentation to recover their crude extracts in dichloromethane. Bioactive extracts were analysed by chromatographic fractionation and NMR and displayed compounds with antimicrobial, antimycobacterial, and antimalarial activities. FINDINGS Five fungi produced antimicrobial and antimalarial compounds. Extracts of Diaporthe miriciae showed antifungal, antibacterial, and antimalarial activities; Trichoderma effusum displayed selective antibacterial activity against methicillin-resistant Staphylococcus aureus and Mycobacterium intracellulare; and three Penicillium species showed antibacterial activity. D. miriciae extract contained highly functionalised secondary metabolites, yielding the compound epoxycytochalasin H with high antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with an IC50 approximately 3.5-fold lower than that with chloroquine. MAIN CONCLUSION Our results indicate that V. gigantea may represent a microhabitat repository hotspot of potential fungi producers of bioactive compounds and suggest that endophytic fungal communities might be an important biological component contributing to the fitness of the plants living in the rupestrian grassland.
Descritores: Plasmodium/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Magnoliopsida/classificação
Magnoliopsida/microbiologia
Fungos Mitospóricos/efeitos dos fármacos
Bactérias Aeróbias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antimaláricos/isolamento & purificação
Antimaláricos/farmacologia
-Clima Tropical
Bioensaio
Candida/efeitos dos fármacos
Endófitos/química
Responsável: BR1.1 - BIREME


  3 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Rosalen, Pedro Luiz
Texto completo
Id: biblio-889473
Autor: Almeida, Carolina Medeiros de; Lima, Rennaly de Freitas; Costa, Tereza Karla Vieira Lopes da; Sousa, Ilza Maria de Oliveira; Cabral, Elaine Cristina; Basting, Rosanna Tarkany; Torre, Adriana Della; Cavalcanti, Yuri Wanderley; Rosalen, Pedro Luiz; Duarte, Marta Cristina Teixeira; Ruiz, Ana Lúcia Tasca Gois; Foglio, Mary Ann; Godoy, Gustavo Pina; Costa, Edja Maria Melo de Brito.
Título: Antifungal, antibiofilm, and antiproliferative activities of Guapira graciliflora Mart
Fonte: Braz. oral res. (Online);32:e41, 2018. tab, graf.
Idioma: en.
Projeto: CNPq/CAPES.
Resumo: Abstract: The aim of this study was to evaluate in vitro the antifungal, antibiofilm and antiproliferative activities of the extract from the leaves of Guapira graciliflora Mart. The phytochemical characterization of the extract was performed using electrospray ionization mass spectrometry (ESI-MS). The antimicrobial activity of the extract and its fractions was evaluated using the broth microdilution method against species of Candida. The inhibition of C. albicans biofilm was evaluated based on the number of colony-forming units (CFU) and metabolic activity (MTT). The antiproliferative activity of the extract and its fraction was evaluated in the presence of human tumor and non-tumor cells, and the cytotoxicity of the extract was determined on the RAW 264.7 macrophage line - both using the sulforhodamine B method. The phytochemical characterization indicated the presence of the flavonoids rutin and kaempferol. The extract and the methanol fraction exhibited moderate antifungal activity against C. albicans, C. krusei, and C. glabrata, and strong activity against C. dubliniensis. In the biofilms at 24 and 48 hours, the concentration of 12500 µg/mL of the extract was the most effective at reducing the number of CFU s/mL (44.4% and 42.9%, respectively) and the metabolic activity of C. albicans cells (34.6% and 52%, respectively). The extract and its fractions had no antiproliferative effect on the tumor lines tested, with mean activity (log GI50) equal to or greater than 1.71 µg/mL. Macrophage cell viability remained higher than 80% for concentrations of the extract of up to 62.5 µg/mL. G. graciliflora has flavonoids in its chemical composition and demonstrates potential antifungal and antibiofilm activity, with no evidence of a significant change in the viability of human tumor and non-tumor cell lines.
Descritores: Candida/efeitos dos fármacos
Extratos Vegetais/farmacologia
Biofilmes/efeitos dos fármacos
Nyctaginaceae/química
Proliferação Celular/efeitos dos fármacos
Antifúngicos/farmacologia
-Testes de Sensibilidade Microbiana
Sobrevivência Celular/efeitos dos fármacos
Biofilmes/crescimento & desenvolvimento
Dose Letal Mediana
Antifúngicos/isolamento & purificação
Responsável: BR1.1 - BIREME


  4 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-888713
Autor: Rossoni, Rodnei Dennis; Barros, Patrícia Pimentel de; Freire, Fernanda; Santos, Jéssica Diane dos; Jorge, Antonio Olavo Cardoso; Junqueira, Juliana Campos.
Título: Study of Microbial Interaction Formed by "Candida krusei" and "Candida glabrata": "In Vitro" and "In Vivo" Studies
Fonte: Braz. dent. j;28(6):669-674, Nov.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: Abstract Recently, the non-albicans Candida species have become recognized as an important source of infection and oral colonization by association of different species in a large number of immunosuppressed patients. The objective of this study was to evaluate the interactions between C. krusei and C. glabrata in biofilms formed in vitro and their ability to colonize the oral cavity of mouse model. Monospecies and mixed biofilms were developed of each strain, on 96-well microtiter plates for 48 h. These biofilms were analyzed by counting colony-forming units (CFU/mL) and by determining cell viability, using the XTT hydroxide colorimetric assay. For the in vivo study, twenty-four mice received topical applications of monospecie or mixed suspensions of each strain. After 48 h, yeasts were recovered from the mice and quantified by CFU/mL count. In the biofilm assays, the results for the CFU/mL count and the XTT assay showed that the two species studied were capable of forming high levels of in vitro monospecie biofilm. In mixed biofilm, the CFU of C. krusei increased (p=0.0001) and C. glabrata decreased (p=0.0001). The metabolic activity observed in XTT assay of mixed biofilm was significantly reduced compared with a single C. glabrata biofilm (p=0.0001). Agreeing with CFU in vitro count, C. glabrata CFU/mL values recovered from oral cavity of mice were statistically higher in the group with single infection (p=0.0001) than the group with mixed infection. We concluded that C. krusei inhibits C. glabrata and takes advantage to colonize the oral cavity and to form biofilms.

Resumo Recentemente, as espécies não albicans tem se tornado uma importante fonte de infecção e de colonização oral pela associação de espécies em um grande número de pacientes imunossuprimidos. O objetivo desse estudo foi avaliar a interação entre C. krusei e C. glabrata em biofilmes formados in vitro e sua capacidade em colonizar a cavidade oral em modelo de camundongo. Biofilmes monoespécies e mistos foram formados em placas de 96 poços por 48 h. Esses biofilmes foram analisados pela contagem de UFC/mL e pela determinação da viabilidade celular, usando ensaio de XTT. Para o estudo in vivo, vinte e quatro camundongos receberam aplicações tópicas de suspensões monoespécies e mistas de cada espécie. Após 48 h, as leveduras foram recuperadas dos camundongos e quantificadas por UFC/mL. Nos ensaios de biofilme, os resultados da contagem de UFC/mL e do ensaio de XTT mostraram que as duas espécies estudadas foram capazes de formar grande quantidade de biofilme monoespécie in vitro. Nos biofilmes mistos, a UFC/mL de C. krusei aumentou (p=0,0001) e de C. glabrata diminuiu (p=0,0001). A atividade metabólica observada no ensaio de XTT nos biofilmes mistos foi significantemente reduzida comparada com o biofilme formado apenas de C. glabrata (p=0,0001). Concordado com as contagens in vitro, os valores de UFC/mL de C. glabrata recuperados da cavidade oral dos camundongos foram estatisticamente maior no grupo com infecção simples (p=0,0001) do que do grupo com infecção mista. Nós concluímos que C. krusei inibe C. glabrata e possui vantagem em colonizar a cavidade oral e formar biofilmes.
Descritores: Candida/fisiologia
-Especificidade da Espécie
Técnicas In Vitro
Candida/classificação
Contagem de Colônia Microbiana
Colorimetria
Biofilmes
Interações Microbianas
Limites: Camundongos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  5 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Machado, Alcyone Artioli
Texto completo
Id: biblio-842770
Autor: Lourenço, Alan Grupioni; Ribeiro, Ana Elisa Rodrigues Alves; Nakao, Cristiano; Motta, Ana Carolina Fragoso; Antonio, Luana Grupioni Lourenço; Machado, Alcyone Artioli; Komesu, Marilena Chinali.
Título: Oral Candida spp carriage and periodontal diseases in HIV-infected patients in Ribeirão Preto, Brazil
Fonte: Rev. Inst. Med. Trop. Säo Paulo;59:e29, 2017. tab, graf.
Idioma: en.
Projeto: National Counsel of Technological and Scientific Development.
Resumo: ABSTRACT The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp carriage in the oral cavity of HIV-infected patients compared to non-infected patients. Twenty-five patients not infected with HIV and 48 HIV-infected patients were classified according to periodontal conditions as being periodontal healthy or with periodontal disease. Candida spp carriage and classification were performed in oral rinse samples. Viral load and CD4+ T lymphocyte (CD4+L) counts were performed in blood samples from HIV-infected patients. No differences in Candida spp prevalence related to HIV status or periodontal condition were detected. However, Candida spp carriage was increased in periodontally affected HIV-infected patients when compared to periodontally healthy HIV-infected patients (p= 0.04). Periodontally healthy HIV-infected patients presented Candida spp carriage in similar levels as healthy or periodontally affected non-HIV-infected patients. Candida spp carriage was correlated with CD4+L counting in HIV-infected patients. We concluded that periodontal disease is associated with increased Candida spp carriage in HIV-infected patients and may be a predisposing factor to clinical manifestations of candidiasis.
Descritores: Doenças Periodontais/microbiologia
Candida/classificação
Candidíase Bucal/microbiologia
Infecções Oportunistas Relacionadas com a AIDS/microbiologia
-Doenças Periodontais/epidemiologia
Brasil/epidemiologia
Candida/isolamento & purificação
Candidíase Bucal/epidemiologia
Portador Sadio
Infecções Oportunistas Relacionadas com a AIDS/epidemiologia
Contagem de Linfócito CD4
Carga Viral
Boca/microbiologia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


  6 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1026763
Autor: Rosanova, M T; Voto, C; Highton, E; Carnovale, S; Caracciolo, B; Tramonti, N; Lema, J; Álvarez, V; Villasboas, R M; Laborde, S; Basilico, H.
Título: Osteomielitis fúngica en niños quemados / Fungal osteomyelitis in burned children
Fonte: Med. infant;26(3):272-275, sept. 2019. Tab, ilus.
Idioma: es.
Resumo: Introducción: En pacientes pediátricos quemados la osteomielitis fúngica es una complicación infrecuente que conduce a una significativa morbilidad. La información en la literatura está limitada a unos escasos reportes de casos. Objetivo: Describir las características clínicas, epidemiológicas y de evolución de niños quemados con osteomielitis fúngica. Métodos: Se llevo a cabo un estudio retrospectivo y descriptivo de pacientes mayores de 1 mes y menores de 18 años quemados con osteomielitis fúngica internados en el hospital Juan P. Garrahan, un hospital terciario en Buenos Aires, Argentina. Resultados: entre enero del 2007 y enero del 2017, de 600 niños quemados, 9 pacientes presentaron diagnóstico confirmado de osteomielitis fúngica. La mediana de edad fue de 42.5 meses (RIC, 27-118 meses) y la mediana de superficie quemada fue de 33.5% (RIC, 18.5-58%). La osteomielitis fue diagnosticada con una mediana de 30 días luego de la quemadura. Las localizaciones más frecuentes de osteomielitis fueron los miembros superiores y a nivel de calota. Los microorganismos aislados a partir del cultivo de hueso fueron: Fusarium spp. en tres pacientes, Mucor spp. en un paciente; Trichosporon asahii en un paciente; Cándida albicans en dos pacientes y Candida parapsilosis en dos pacientes. En dos casos la infección fúngica fue asociada con aislamientos bacteriano concomitante. Todos los pacientes presentaron hallazgos histopatológicos compatibles con osteomielitis. La mediana de tiempo de tratamiento fue de 44.5 días (RIC, 34.5- 65.5 días). Seis pacientes (67%) presentaron secuela motora. Conclusión: La osteomielitis fúngica fue infrecuente Candida spp. y Fusarium spp. fueron los hongos más comúnmente identificados. La secuela funcional fue frecuente (AU)

Introduction: In pediatric burn patients fungal osteomyelitis is a rare complication that leads to significant morbidity. Data in the literature are limited to sporadic case reports. Objective: To describe the clinical and epidemiological features and outcome in burned children with fungal osteomyelitis. Methods: A retrospective descriptive study was conducted in burn patients older than 1 month and younger than 18 years admitted to Hospital Juan P. Garrahan, a tertiary hospital in Buenos Aires, Argentina. Results: Between January 2007 and January 2017, of 600 burned children, nine had a confirmed diagnosis of fungal osteomyelitis. Median age was 42.5 months (IQR, 27-118 months) and median burn surface was 33.5% (IQR, 18.5-58%). Osteomyelitis was diagnosed at a median of 30 days after the burn. The most common location of osteomyelitis were the upper limbs and skull. The microorganisms isolated form bone cultures were Fusarium spp. in three patients, Mucor spp. in one patient; Trichosporon asahii in one patient; Candida albicans in two patients; and Candida parapsilosis in two patients. In two cases the funal infection was associated with concomitant bacterial isolation. In all patients, the histopathological findings were compatible with osteomyelitis. Median duration of treatment was 44.5 days (IQR, 34.5-65.5 days). Six patients (67%) had motor sequelae. Conclusion: Fungal osteomyelitis is a rare disease. Candida spp. and Fusarium spp. were most frequently identified fungi. Functional sequelae were common (AU)
Descritores: Osteomielite/diagnóstico
Osteomielite/etiologia
Osteomielite/epidemiologia
Queimaduras/complicações
Micoses/microbiologia
-Candida/isolamento & purificação
Miose/tratamento farmacológico
Estudos Retrospectivos
Fusarium/isolamento & purificação
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Lactente
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR305.1 - SID - Servicio de Información y Documentación


  7 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1026420
Autor: Carnovale, S.
Título: Candida auris: un patógeno emergente y multiresistente / Candida auris: An emerging multiresistant pathogen
Fonte: Med. infant;26(3):326-326, sept. 2019.
Idioma: es.
Descritores: Candida/isolamento & purificação
Candida/efeitos dos fármacos
Farmacorresistência Fúngica
/uso terapêutico
FRUCTOSEDIPHOSPHATESABDOMEN/uso terapêutico
-Isolamento de Pacientes
Limites: Seres Humanos
Responsável: AR305.1 - SID - Servicio de Información y Documentación


  8 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1025898
Autor: Gupta, Veenu; Malhotra, Anchal; Chhina, Deepinder; Singh, Akashdeep.
Título: Identificación de las especies de Candida en las infecciones sanguíneas / Characterization of Candida species in blood stream infections
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);22(8):719-726, dic.-mar. 2018. tab., graf..
Idioma: es.
Resumo: Introducción: La candidemia se convirtió en una infección importante del torrente sanguíneo que se asocia frecuentemente con índices elevados de mortalidad y morbilidad. Las especies de Candida generan del 70% al 80% de las infecciones micóticas invasivas del torrente sanguíneo y son la cuarta causa más frecuente de infecciones hospitalarias del torrente sanguíneo. La identificación de las especies de Candida es importante, ya que las especies no albicans son cada vez más numerosas y resistentes a las drogas antimicóticas. El objetivo del estudio fue aislar e identificar diferentes especies de Candida asociadas con candidemia y analizar su patrón de susceptibilidad a los antimicóticos. Materiales y métodos: Los pacientes con sospecha de infecciones del torrente sanguíneo (ITS) fueron reclutados durante un período de un año para el estudio prospectivo. Se analizaron las características demográficas, la duración de la internación y los factores de riesgo asociados y la evolución clínica. El análisis de las muestras de sangre tuvo lugar mediante el sistema automatizado BacTAlert. La identificación y la susceptibilidad antimicótica de las levaduras fueron realizadas mediante el uso de dispositivo VITEK-2. Resultados: Las especies de Candida fueron aisladas en 30 de los 3146 cultivos recibidos (0.9%). La mayoría de los casos de candidemia tuvieron lugar en hombres (66%). Los factores de riesgo más frecuentes fueron el uso de antibióticos de amplio espectro, la vía central y la ventilación mecánica. Entre las levaduras aisladas, las especies de Candida no albicans fueron predominantes (60%), en comparación con la especie C. albicans (40%). La especie albicans presentó una susceptibilidad del 100% a los azoles y la anfotericina, en tanto que las especies no albicans fueron resistentes. De los 30 pacientes mencionados, 5 fallecieron. Conclusión: La prevalencia de Candida no albicans fue mayor en comparación con la prevalencia de Candida albicans. Las especies no albicans fueron más resistentes a los antimicóticos. En consecuencia, los pacientes internados deberían ser evaluados para identificar la candidemia.

Introduction: Candidemia has become an important bloodstream infection that is frequently associated with high rates of mortality and morbidity. Candida species account for 70-80% of invasive bloodstream fungal infections and represent the fourth most common nosocomial bloodstream infections. The identification of Candida species is important as the number of non albicans Candida species is increasing and they are becoming more resistant to antifungal drugs. The aim of the study was to isolate and identify various Candida species associated with candidemia and to study their antifungal susceptibility pattern. Materials and methods: Patients suspected of having BSI were enrolled on a one-year prospective study. Patient's demographic details, duration of hospital stay, associated risk factors and outcome were studied. Blood samples were analyzed by BacTAlert automated system. Identification and antifungal susceptibility testing of yeasts was done using VITEK-2 compact system. Results: Of 3146 blood cultures received, Candida species were isolated in 30 samples (0.9%). The majority of candidemia cases were in males (66%). The most common risk factors were use of broad spectrum antibiotics, central line and mechanical ventilation. Among the yeast isolates, non albicans Candida species were predominant (60%) compared to C. albicans (40%). Candida albicans showed 100% susceptibility to azoles and amphotericin whereas non albicans Candida species showed resistance. Of these 30 patients, 5 patients died. Conclusion: Prevalence of non albicans Candida was greater than C. albicans and cases were more resistant to antifungal drugs. Therefore surveillance for candidemia should be carried out in hospitalized patients.
Descritores: Candida
Candida albicans
Fungos Mitospóricos
Candidemia
Antifúngicos
Limites: Seres Humanos
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


  9 / 704 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Rode, Sigmar de Mello
Texto completo
Texto completo
Id: biblio-966755
Autor: Rode, Sigmar de Mello; Jóias, Renata Pilli; Oliveira, Jonatas Rafael de; Mattos, Maria Fernanda; Jorge, Antônio Olavo Cardoso; Silva, Michelle Perreluppi; Seixas, Ellen Cristina Libonati.
Título: Assessment of Candida SPP. proliferation in occlusal and palatal splints / Avaliação da proliferação Candida SPP. em placas oclusais e palatais
Fonte: Biosci. j. (Online);34(2):525-533, mar./apr. 2018. ilus, tab.
Idioma: en.
Resumo: Candida species inhabit the oral cavity of all individuals who wear complete denture and whose material is the same as that used in splints. Assess the growth of C. albicans in occlusal and palatal splints used for treatment of TMD so that the potential risks of oral microbiota can be assessed. The growth of Candida spp. was assessed in the saliva of 27 individuals wearing splints for treatment of TMD. They were divided into two groups: G1 (n = 14), individuals wearing occlusal splint; and G2 (n = 13), individuals wearing palatal splint. Saliva samples were collected during placement of the splints (T1) and after 4 months (T2), being stored in PBS (10 mL) after 60-second rinses. It was observed that patients wearing occlusal splints (G1) had an increase of 0.648 CFU/mL (Log 10), with statistically significant differences (P = 0.043) for C. albicans (42.33%), C. glabrata (5.52%), C. krusei (41.72%) and C. tropicalis (10.43%). In the group of patients wearing palatal splints (G2), there was a decrease of 0.101 CFU/mL (Log 10), was observed with (P = 0.964) only the presence of C. albicans. The results suggest that growth of Candida species was greater in patients wearing occlusal splints compared to those wearing palatal ones as the presence of different yeast species was found in the former.

Espécies de Candida habitam a cavidade oral de 60-100% de indivíduos usuários de prótese total, cujo material é o mesmo utilizado em placas miorrelaxante. Avaliar o crescimento de C. albicans. em placas relaxantes musculares oclusais e palatais, usadas para o tratamento de DTM, na intenção de verificar riscos em potencial à microbiota bucal. Avaliou-se o crescimento de Candida spp. na saliva de 27 indivíduos, usuários de placa miorrelaxante, em tratamento para DTM no ICT-UNESP. Os indivíduos foram divididos em dois grupos: G1(n=14) ­ placa com recobrimento oclusal; e G2 (n=13) ­ sem recobrimento. As coletas foram com PBS (10mL), em bochechos por 60seg, na instalação das placas (T1) e após 4 meses (T2). Observou-se que pacientes usuários da placa miorrelaxante com recobrimento oclusal (grupo G1) apresentaram aumento de 0,648 UFC/mL (Log10) com diferença estatisticamente significante (p=0,043) analisando-se 42,33% C. albicans, 5,52% C. glabrata, 41,72% C. krusei e 10,43% C. tropicalis. No grupo de pacientes que utilizaram a placa sem recobrimento (grupo G2), observou-se diminuição de 0,101 UFC/mL (Log10) com (p=0,954) apresentando apenas C. albicans. Os resultados sugerem que os pacientes que fizeram uso de placa miorrelaxante com recobrimento oclusal apresentaram maior crescimento de Candida spp. em relação aos usuários de placa sem recobrimento, verificando-se a presença de diferentes espécies da levedura.
Descritores: Candida
Contagem de Colônia Microbiana
-Higiene Bucal
Candidíase Bucal
Placas Oclusais
Prótese Dentária
Responsável: BR396.1 - Biblioteca Central


  10 / 704 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-774727
Autor: Wanderley, Bruno Rocha; Maquiné, Gustavo Ávila; Wanderley, Patrícia Varotto; Albuquerque, Janaina Rocha de; Jezini, Deborah Laredo.
Título: Cândida esofágica em paciente diabético tipo 2 ? relato de caso / Esophageal candidiasis in type 2 diabetic patients ? case report
Fonte: Rev. Soc. Bras. Clín. Méd;13(3), dez. 2015. ilus.
Idioma: pt.
Resumo: A cândida sp. são fungos comensais dos seres humanos e consideradasflora normal do trato gastrointestinal e genitourinário.Entretanto alterações na imunidade do hospedeiro podem culminarem infecção por estes fungos, definida como candidíase.Uma causa importante do desequilíbrio imunológico são asdoençasendócrinas, principalmente o Diabetes tipo 2. Pacientesdiabéticos estão mais propensos a desenvolver formas infecciosasde candidíase, destacando o comprometimento esofágicoque muitas vezes, não é diagnosticado. O objetivo deste estudofoi relatar um caso de paciente diabético tipo 2 com processoinfeccioso importante à esclarecer decorrente de extensa cândidíaseesofágica. Paciente masculino, 55 anos, procedente deItacoatiara-AM, tabagista de longa data. Após história prévia deinternação hospitalar para tratamento de Diabetes tipo 2 descompensadae piomiosite de coxa esquerda, evoluiu com asteniainsidiosa, anorexia, mal-estar e febre diária (38,5 ºC), intermitente,vespertina, sendo diagnosticado e tratado para infecçãodo trato urinário, sem melhora. Após piora do quadro, acrescidode disfagia para sólidos e perda ponderal, foi re-internado paraelucidaçãodiagnóstica. Durante a investigação apurou-se sangueoculto nas fezes positivo, seguida de endoscopia digestivaalta mostrando várias placas elevadas esbranquiçadas linearese confluentes ocupando todo o trajeto do esôfago, compatívelcom candidíase esofágica grau III de KODSI. As sorologias paraHIV e Hepatites B e C, foram negativas. A biopsia revelou esofagiteaguda erosiva. Devemos estar atentos à possibilidade de infecção por cândida, em especial, o comprometimento esofágico,nos pacientes diabéticos descompensados que apresentemfatores de risco associados a sinais e sintomas da doença e/ouinfecciosos, sem foco definido.(AU)

Candida sp. are commensal fungi of humans and are considerednormal flora of the gastrointestinal and genitourinary tracts.However, changes in the host immunity may lead to infection bythese fungi, defined as candidiasis. A major cause of the imbalanceare immune endocrine diseases, especially type 2 diabetesmellitus. Diabetic patients are more likely to develop infectiousforms of candidiasis, in particular the esophageal involvementthat often goes undiagnosed. The aim of this study was to reporta case of a type 2 diabetic patient with an infectious processwhich is important to clarify the result of extensive esophagealcandidiasis. Male patient, 55 years, coming from Itacoatiara-AM,a longtime smoker. After a history of hospitalization for treatmentof decompensated diabetes mellitus type 2 and pyomyositis of theleft thigh, it progressed with insidious asthenia, anorexia, malaiseand intermittent evening daily fever (38.5 °C), he was diagnosedand treated for urinary tract infection with no improvement.After the condition worsened, followed by dysphagia for solidsand weight loss, he was re-admitted for diagnosis. During theinvestigation it was found positive fecal occult blood, upperendoscopy showed multiple elevated confluent whitish linearplaques occupying the entire course of the esophagus, esophagealcandidiasis compatible with grade III KODSI. Serology forHIV and Hepatitis B and C were negative. The biopsy revealed acute erosive esophagitis. We must be alert to the possibility ofinfection by Candida, in particular, esophageal involvement inpatients presenting decompensated diabetic risk factors associatedwith signs and symptoms of disease and/or infections, without adefined focus.(AU)
Descritores: Candidíase/etiologia
Diabetes Mellitus Tipo 2/patologia
Esofagite/tratamento farmacológico
-Candida/isolamento & purificação
Fluconazol/uso terapêutico
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



página 1 de 71 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde