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Id: biblio-1039044 Autor: Junqueira, Luis Otávio; Costa, Marcela Oliveira Legramanti da; Rando, Daniela Gonçales Galasse. Título: N-Myristoyltransferases as antileishmanial targets: a piggyback approach with benzoheterocyclic analogues Fonte: Braz. J. Pharm. Sci. (Online);55:e18087, 2019. graf. Idioma: en. Projeto: FAPESP. Resumo: Leishmaniasis is one of the neglected diseases that remain in need for pharmacological alternatives. In this context, N-Myristoyltransferases (NMT) arise as interesting targets to explore since they are involved in the co/post-translational processing of peptides which are responsible for host cell invasion. Studies that consider these enzymes as targets point out the potential of benzoheterocyclic compounds as inhibitors of Candida albicans's N-myristoyltransferase. Here we applied a combination of comparative binding site analysis and molecular docking studies based on a Piggyback approach in the search for new Leishmania major NMT ligands. Our results revealed that NMT enzymes from both pathogens present enough structural similarity to allow extrapolation of the knowledge available from C. albicans studies to develop new L. major NMT inhibitors. Molecular docking studies with benzoheterocyclic analogues indicate the potential of benzothiazole derivatives as L. major NMT ligands, giving rise to a completely new class of chemical compounds to be explored in the development of antileishmanial drugs. Descritores: Benzofuranos/farmacologia Leishmaniose/tratamento farmacológico Leishmania major -Candida albicans Enzimas/análise Tipo de Publ: Estudo Comparativo Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas

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Id: biblio-828186 Autor: Ellepola, Arjuna N. B; Samaranayake, L. P; Khan, Z. U. Título: Extracellular phospholipase production of oral Candida albicans isolates from smokers, diabetics, asthmatics, denture wearers and healthy individuals following brief exposure to polyene, echinocandin and azole antimycotics Fonte: Braz. j. microbiol;47(4):911-916, Oct.-Dec. 2016. tab. Idioma: en. Projeto: Kuwait University Research Grant. Resumo: Abstract Objective Candida albicans is the primary causative agent of oral candidosis, and one of its key virulent attributes is considered to be its ability to produce extracellular phospholipases that facilitate cellular invasion. Oral candidosis can be treated with polyenes, and azoles, and the more recently introduced echinocandins. However, once administered, the intraoral concentration of these drugs tend to be sub-therapeutic and rather transient due to factors such as the diluent effect of saliva and cleansing effect of the oral musculature. Hence, intra-orally, the pathogenic yeasts may undergo a brief exposure to antifungal drugs. We, therefore, evaluated the phospholipase production of oral C. albicans isolates following brief exposure to sub-therapeutic concentrations of the foregoing antifungals. Materials and methods Fifty C. albicans oral isolates obtained from smokers, diabetics, asthmatics using steroid inhalers, partial denture wearers and healthy individuals were exposed to sub-therapeutic concentrations of nystatin, amphotericin B, caspofungin, ketoconazole and fluconazole for one hour. Thereafter the drugs were removed and the phospholipase production was determined by a plate assay using an egg yolk-agar medium. Results The phospholipase production of these isolates was significantly suppressed with a percentage reduction of 10.65, 12.14, 11.45 and 6.40% following exposure to nystatin, amphotericin B, caspofungin and ketoconazole, respectively. This suppression was not significant following exposure to fluconazole. Conclusions Despite the sub-therapeutic, intra oral, bioavailability of polyenes, echinocandins and ketoconazole, they are likely to produce a persistent antifungal effect by suppressing phospholipase production, which is a key virulent attribute of this common pathogenic yeast. Descritores: Fosfolipases/biossíntese Candida albicans/efeitos dos fármacos Candida albicans/metabolismo Candidíase Bucal/microbiologia Candidíase Bucal/tratamento farmacológico Antifúngicos/farmacologia -Polienos/uso terapêutico Polienos/farmacologia Azóis/uso terapêutico Azóis/farmacologia Candida albicans/isolamento & purificação Candida albicans/patogenicidade Fumar Testes de Sensibilidade Microbiana Dentaduras Fatores de Virulência Diabetes Mellitus Ativação Enzimática Espaço Extracelular Equinocandinas/farmacologia Antifúngicos/uso terapêutico Limites: Seres Humanos Responsável: BR1.1 - BIREME

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Id: biblio-1039047 Autor: Kaskatepe, Banu; Yilmaz, Betul Sever; Acikara, Ozlem Bahadir; Iscan, Gulcin Saltan; Vlainic, Josipa; Kosalec, Ivan. Título: Antifungal activity of some Sternbergia taxa: effects on germ tube and biofilm formation Fonte: Braz. J. Pharm. Sci. (Online);55:e17200, 2019. tab, graf. Idioma: en. Resumo: Natural products are rapidly becoming the primary sources of novel antimicrobial agents, as resistance to existing antimicrobial agents is increasing. Apart from determining the antimicrobial activity of natural products, it is also important to understand their effects on the virulence factors of microorganisms. This study aimed to determine the antimicrobial activity of Sternbergia species prevalent in Turkey and investigate their role in the inhibition of germination tube and biofilm formation, both of which are known to be important virulence factors of Candida albicans. The antimicrobial activities of the plant extracts were evaluated using bore-plate and broth microdilution method. The extracts' capacity to inhibit the formation of the germ-tube was also evaluated. The findings of our study revealed that Sternbergia lutea, Sternbergia vernalis possessed antimicrobial activities, with MIC values ranging between 0.048 mg/mL and 0.39 mg/mL. The highest antimicrobial activity was observed against Candida dubliniensis (0.048 mg/mL). While evaluating the inhibition of fungal germination activities, S. vernalis extract (at a concentration of 0.09 mg/mL) was found to be the most effective against C. albicans ATCC 90028 strain. The results also indicated that S. vernalis extracts at sub-MIC levels inhibited germ tube formation and modulated the tail-length of germinated cells, both of which are important virulence factors of C. albicans. Furthermore, the inhibition of biofilm-formation was also investigated, and it was found that two Sternbergia spp. extracts at or below MIC levels inhibited biofilm formation. Descritores: Biofilmes/efeitos dos fármacos Amaryllidaceae/classificação Anti-Infecciosos/análise -Candida albicans Extratos Vegetais/efeitos adversos Fatores de Virulência Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas

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Id: lil-510775 Autor: Sanabria, R; Samudio, M; Fariña, N; Laspina, F; Ortellado de Canese, J; Arbizu Ledesma, G; Laconich Romero, M; Rodríguez, H. Título: Identificación de especies de candida aisladas de pacientes ambulatorios, hospitalizados, e inmunocomprometidos en Paraguay / Identification of candida species isolated from ambulatory, hospitalized and immune-depressed patients in Paraguay Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);2(2):45-49, dic. 2006. tab. Idioma: es. Resumo: Objetivo: Identificar las especies de candida aisladas de varias muestras clínicas. Métodos: Seaislaron 310 cepas de Candida spp de pacientes internados (n=133), ambulatorios (n=134) einmunocomprometidos (n=43) que concurrieron a cuatro centros médicos en Asunción, desde enerodel 2004 a octubre del 2005. Para la identificación de especies, las colonias fueron cultivadas enplacas de CHROMagar Candida® e incubadas a 35º por 18-24 horas. Aquellas colonias que nopudieron ser identificadas por el método cromogénico fueron identificadas con el microsistema deidentificación API candida (Biomérieux). Resultados: De las 310 cepas estudiadas, 188 (60,6%)correspondió a C. albicans, 79 (25,5%) a C. tropicalis, 33 (10,6%) a C. glabrata, 8 (2,6%) a C.krusei, y 2 (0,7%) a C. parapsilosis. C. albicans fue la especie más frecuentemente aislada tantoen las muestras de origen comunitario como en los pacientes inmunocomprometidos, 81% y 58%,respectivamente. Sin embargo, en las muestras hospitalarias especies de C. tropicalis fueron másfrecuente que C. albicans (47% y 41%, respectivamente). Conclusión: Las especies de candida noalbicans predominaron en las muestras hospitalarias por lo que su tipificación rutinaria deberíahacerse en forma rutinaria Descritores: Candida albicans Responsável: PY3.1 - Biblioteca

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Id: biblio-884960 Autor: Duarte, Cynthia; Soilán, Ana María. Título: Detección de Chlamydia trachomatis, esporos micóticos y Trichomonas vaginalis en mujeres en edad fértil que acuden a los Hospitales San Pablo y Regional de San Lorenzo / Chlamydia trachomatis, fungal spores and Trichomonas vaginalis detection of childbearing age women who attend to San Pablo Hospital and Regional of San Lorenzo Fonte: Rev. Nac. (Itauguá);3(2):36-42, dic. 2011. Idioma: es. Resumo: Introducción: Las infecciones vulvo-cérvico-vaginales constituyen la causa más común por la que las mujeres en edad fértil acuden al Ginecólogo. Los agentes etiológicos involucrados incluyen a Chlamydia trachomatis, Trichomonas vaginalis, Cándida albicans, entre otros. La sospecha de vulvo-cervico-vaginitis debe orientar a la realización de estudios de secreción vaginal y muestreo endocervical a fin de detectar el agente causal, establecer un tratamiento específico y disminuir la prevalencia de los mismos así como las complicaciones. Objetivos: Determinar la prevalencia de esporos micóticos, Trichomonas vaginalis y Chlamydia trachomatis en mujeres en edad fértil. Materiales y Métodos: Estudio observacional, descriptivo, de corte transversal y prospectivo, con cuestionario realizado a mujeres en edad fértil que acudieron a los hospitales Materno Infantil San Pablo y Regional de San Lorenzo entre los meses de diciembre de 2010 a febrero de 2011. Resultados: De las 148 pacientes estudiadas, se observó una prevalencia de 27,7% de esporos micóticos, 2% de Trichomonas vaginalis y 4,1% de Chlamydia trachomatis. De las pacientes estudiadas, la mayoría tenían entre 25 a 29 años (26%). Conclusión:La prevalencia de esporos micóticos fue 27,7%, Trichomonas vaginalis 2% y Chlamydia trachomatis 4,1%. Introduction: the vulvo cervicovaginal infections are the most common reason that women of childbearing age go to the gynecologist. The ethiological agents involved are Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, among others. The suspicion of cervico-vulvo-vaginitis should guide the studies of vaginal discharge and endocervical sampling to detect the causative agent, to stablish specific treatment and reduce the prevalence of these infections and the complications. Objective: to determine the prevalence of fungal spores, Trichomonas vaginalis and Chlamydia trachomatis in women of childbearing age. Materials and Methods: observational, descriptive, cross-sectional and prospective study performed in women of childbearing age who attended the San Pablo Hospital and Regional of San Lorenzo between the months of December 2010 to February 2011. Results: 148 patients were studied, there was a 27.7% prevalence of fungal spores, 2% Trichomonas vaginalis and 4.1% Chlamydia trachomatis. Of the patients studied, most were between 25 to 29 years (26%). Conclusion: the prevalence of fungal spores was 27.7%, Trichomonas vaginalis 2% and Chlamydia trachomatis 4.1%. Descritores: Vaginite por Trichomonas/epidemiologia Candidíase Vulvovaginal/epidemiologia Infecções por Chlamydia/epidemiologia -Trichomonas vaginalis/crescimento & desenvolvimento Candida albicans/crescimento & desenvolvimento Chlamydia trachomatis/crescimento & desenvolvimento Prevalência Estudos Transversais Estudos Prospectivos Limites: Seres Humanos Feminino Adolescente Adulto Meia-Idade Tipo de Publ: Estudo Observacional Responsável: PY92.1 - Biblioteca

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Id: biblio-884769 Autor: Gill, Gilberto. Título: Infecciones fúngicas en un Servicio de Terapia Intensiva de Adultos de un hospital especializado / Fungal infections in Intensive Care Service of a specialized hospital Adults Fonte: Rev. Nac. (Itauguá);7(2):07-14, dic 2015. Idioma: es. Resumo: RESUMEN Introducción: las infecciones fúngicas son frecuentes en las Unidades de Terapia Intensiva, debida a múltiples factores predisponentes. Objetivos: determinar la prevalencia de infecciones fúngicas y las características clínicas de los pacientes afectados. Metodología: estudio observacional, descriptivo, retrospectivo, realizado en pacientes adultos internados en el Servicio de Terapia Intensiva del Hospital Nacional (Itauguá, Paraguay) en el año 2013. Resultados: fueron incluidos 1034 pacientes, encontrándose 85 con infección por hongos (prevalencia 8,22%). Las especies más frecuentemente aisladas fueron: Cándida spp. (51,76%), C. tropicalis (27,06%) y C. albicans (14,12%). Las comorbilidades más frecuentes fueron hipertensión arterial (91,76%), diabetes mellitus (44,71%) y obesidad (28,24%). Los sitios de aislamientos predominantes fueron el urocultivo (51,76%), hemocultivo (22,35%) y secreción traqueal (21,18%). Hubo 26 óbitos (30,59%). Los factores asociados al óbito fueron los score APACHE y SOFA elevados. Conclusiones: la prevalencia de infecciones fúngicas fue 8,22%, con predominio de Cándida spp. La mortalidad fue 30,59%. ABSTRACT Introduction: fungal infections are common in intensive care units due to multiple risk factors. Objectives: To determine the prevalence of fungal infections and clinical characteristics of affected patients. Methodology: observational, descriptive and retrospective study, conducted in adult patients admitted to the Intensive Care Service of the National Hospital (Itauguá, Paraguay) in 2013. Results: 1034 patients were included, been 85 with patients affected fungal infection (prevalence 8, 22%). The most frequently isolated species were: Candida spp. (51.76%), C. tropicalis (27.06%) and C. albicans (14.12%). The most common comorbidities were hypertension (91.76%), diabetes mellitus (44.71%) and obesity (28.24%). Predominant sites of isolation were urine culture (51.76%), blood culture (22.35%) and tracheal secretion (21.18%). There were 26 deaths (30.59%). Factors associated with death were the high APACHE score and SOFA. Conclusions: The prevalence of fungal infections were 8.22%, with a predominance of Candida spp. Mortality was 30.59%. Descritores: Candida albicans Candidíase Invasiva/mortalidade Candidíase Invasiva/sangue Unidades de Terapia Intensiva -Comorbidade Contenção de Riscos Biológicos Limites: Adulto Meia-Idade Idoso Tipo de Publ: Estudo Observacional Responsável: PY92.1 - Biblioteca

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Id: biblio-1017969 Autor: Centuríon, María Gloria; Medina, Dorita; Alborno, Rose Marie; Laspina, Florntina; Amarilla, María Angela; Fariña, Norma; Ruiz, Antonia; Vergara, Juana; Paredes, María Elena. Título: Estudio etiológico de infección de secrecion endocervical en un grupo de alto riesgo (prostistutas) / Study on the etiology of infections of endocervical secretions in a high risk group (prostitutes). Fonte: Asunción; EFACIM; 1991. 227-232 p. tab. Idioma: es. Resumo: In order to determine the incidence and the etiology of the sexually trasnmitted diseaes (STD) 500 women, belonging to a high risk group (prostitutes), were studied from August, 1989 to Octuber 1990, and bacteriological and mycological studied were performed. Also, a questionnaire comprising detailed sexual behavior were rendered. High incidence of Gardnerella vaginalis (41.4 percent), Neisseria gonorrhoeae (12.2 percent), Trichomonas vaginalis (10.2 percent) and Candida albicans (10 percent) were found, in contrast with the low level found for Lactobacillus sp. The questinnaire revealed very low utilization of contraceptives as well as condom employement Descritores: Candida albicans Doenças Sexualmente Transmissíveis Lactobacillus Neisseria gonorrhoeae Trichomonas vaginalis Responsável: PY2.1 - Centro de Documentación PY3.1 SR 616.9363 An78a 1991

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Id: biblio-1017968 Autor: Medina, Dorita; Centurión, María Gloria; Alborno, Rose Marie; Fariña, Norma; Balmaceda, María Angela; Ruiz, Antonia. Título: Estudio de prevalencia de algunos agentes etiológicos de enfermedades de transmición sexual en mujeres de alto riesgo (prostitutas) / Study on the prevalence of some ethiological agents of sexually transmitted disease in women at high risk (prostitutes). Fonte: Asunción; EFACIM; 1991. 223-236 p. tab. Idioma: es. Resumo: The prevalence of Candida albicans, Neisseria Gonorrhoeae, and trichomonas vaginalis as some of the most important agents of sexually transmditted disease (STD), were studied in 100 women, belonging to a high risk group (protitues). Also a questionnaire were provided, in order to determine the potential risk of transmission of STD at the time of the survey. The prevalence of the infection by Candida albicans in the genital tract were 7 percent, and 8 percent and 10 percent for Neisseria gonorrhoeae and Trichomonas vaginalis, respectively. In some cases, inappropriate sexual behavior, as well as high number of sexual contacts with different clients, were detected Descritores: Candida albicans Doenças Sexualmente Transmissíveis/prevenção & controle Neisseria gonorrhoeae Trichomonas vaginalis Responsável: PY2.1 - Centro de Documentación PY3.1 SR 616.9363 An78a 1991

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Id: biblio-1017751 Autor: Soilán, A. Título: Frecuencia de candidiasis vaginal en embarazadas del Hospital Nacional de Itauguá / Vaginal frecuency of candidiasis in pregnancy women of the National Hospital of Itauguá Fonte: Rev. Nac. (Itauguá);1(1):19-24, 2009. Idioma: es. Resumo: La infección vaginal por Candida spp , frecuente durante la gestación, la mayoría de los casos de pacientes sanas su probable repercusión motiva la realización de este trabajo para conocer la frecuencia de candidiasis vaginal en embarazadas que acuden a la consulta hospitalaria y su sensibiblidad con los antifúngicos. Se estudiaron 91 embarazadas que acudieron que acudieron al Consultorio Prenatal en el Hospital Nacional desde marzo a julio del 2008. En la población estudiada de mujeres embarazadas se aisló el 21 % de las muestras de levaduras, siendo en su mayoría Candida Albicans y con más frecuencia en las que cursaban el tercer trimestre gestacional. Se encontró amplia sensibilidad a los antifúngicos y resistencia, en las que se aislaron C. Glabrata... Descritores: Antifúngicos Candida albicans Candidíase Candidíase Vulvovaginal Complicações Infecciosas na Gravidez/diagnóstico Complicações Infecciosas na Gravidez/epidemiologia -Paraguai/epidemiologia Limites: Feminino Gravidez Responsável: PY92.1 - Biblioteca

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Id: biblio-838197 Autor: Ozdemir, Abdurrahman A; Oral, Tugce K; Varol, Aydin. Título: Endocarditis micótica en un recién nacido de extremadamente bajo peso al nacer: A propósito de un caso / Fungal endocarditis in an extremely low birth weight infant: Case report Fonte: Arch. argent. pediatr;114(2):e117-e120, abr. 2016. ilus. Idioma: en; es. Resumo: Las tasas de supervivencia de los recién nacidos prematuros se han incrementado gracias a los avances tecnológicos y los conocimientos en constante evolución, aunque la sepsis de aparición tardía es más frecuente debido a los períodos prolongados de hospitalización de estos niños. Presentamos el caso de un recién nacido prematuro de extremadamente bajo peso al nacer hospitalizado con síndrome de dificultad respiratoria, enterocolitis necrosante y sepsis fúngica con endocarditis por Candida albicans. Se le administró tratamiento antimicótico hasta que se resolvió la vegetación fúngica. La sepsis y la endocarditis de origen micótico podrían ser una causa de morbilidad significativa en los recién nacidos prematuros. En este artículo revisamos las publicaciones científicas recientes acerca de los factores de riesgo, el diagnóstico, el tratamiento y la prevención de la sepsis fúngica en estos neonatos de alto riesgo. Survival rates of premature infants have increased with developing technology and evolving knowledge but late-onset sepsis is more frequent due to prolonged hospitalization periods of these infants. We report the case of an extremely low birth weight premature infant who was admitted with respiratory distress syndrome, developed necrotizing enterocolitis and fungal sepsis with endocarditis by Candida albicans. He was treated with antifungal therapy until fungal vegetation resolved. Fungal sepsis and endocarditis may be an important morbidity in preterm infants; we review the recent literature about the risk factors, diagnosis, treatment and prevention of fungal sepsis in these high risk infants. Descritores: Candida albicans Recém-Nascido Prematuro Sepse/complicações Sepse/microbiologia Enterocolite Necrosante/complicações Enterocolite Necrosante/microbiologia Endocardite/complicações Endocardite/microbiologia Recém-Nascido de Peso Extremamente Baixo ao Nascer Micoses Limites: Seres Humanos Masculino Recém-Nascido Tipo de Publ: Relatos de Casos Responsável: AR94.1 - Centro de Información Pediatrica

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