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Id: biblio-951607
Autor: Chicatto, J A; Rainert, K T; Gonçalves, M J; Helm, C V; Altmajer-Vaz, D; Tavares, L B B.
Título: Decolorization of textile industry wastewater in solid state fermentation with Peach-Palm (Bactris gasipaes) residue / Decoloração de águas residuais da indústria têxtil em fermentação de estado sólido com resíduo de Pupunha (Bactris gasipaes)
Fonte: Braz. j. biol;78(4):718-727, Nov. 2018. tab, graf.
Idioma: en.
Projeto: MCTI.
Resumo: Abstract In this work we have assessed the decolorization of textile effluents throughout their treatment in a solid-state fermentation (SSF) system. SSF assays were conducted with peach-palm (Bactris gasipaes) residue using the white rot fungus Ganoderma lucidum EF 31. The influence of the dye concentration and of the amounts of peach-palm residue and liquid phase on both the discoloration efficiency and enzyme production was studied. According to our results, independently of experimental conditions employed, laccase was the main ligninolytic enzyme produced by G. lucidum. The highest laccase activity was obtained at very low effluent concentrations, suggesting the existence of an inhibitory effect of higher concentrations on fungal metabolism. The highest percentage of color removal was reached when 10 grams of peach palm residue was moistened with 60 mL of the final effluent. In control tests carried out with the synthetic dye Remazol Brilliant Blue R (RBBR) decolorization efficiencies about 20% higher than that achieved with the industrial effluent were achieved. The adsorption of RBBR on peach-palm residue was also investigated. Equilibrium tests showed that the adsorption of this dye followed both Langmuir and Freundlich isotherms. Hence, our experimental results indicate that peach-palm residue is suitable substrate for both laccase production and color removal in industrial effluents.

Resumo Neste trabalho, avaliamos a descoloração de efluentes têxteis durante seu tratamento em um sistema de fermentação em estado sólido (SSF). Os ensaios foram conduzidos com resíduo de pupunha (Bactris gasipaes) utilizando o fungo de podridão branca Ganoderma lucidum EF 31. A influência da concentração de corante, as quantidades de resíduo e da fase líquida foram estudadas tanto na eficiência de descoloração como na produção de enzima. De acordo com os resultados, independentemente das condições experimentais utilizadas, a lacase foi a principal enzima ligninolítica produzida por G. lucidum. A atividade de lacase mais elevada foi obtida em baixas concentrações de efluentes, sugerindo um efeito inibitório no metabolismo fúngico. A maior remoção de cor foi obtida com 10 gramas de resíduo da pupunha e 60 mL do efluente final. Nos ensaios de controle realizados com o corante sintético RBBR, foram atingidos cerca de 20% mais descoloração do que os obtidos com o efluente industrial. A adsorção de RBBR no resíduo de pupunha também foi investigada. Os testes de equilíbrio mostraram que a adsorção deste corante seguiu as isotermas de Langmuir e Freundlich. Assim, os resultados experimentais indicam que o resíduo de pupunha é um substrato adequado tanto para a produção de lacase quanto para a remoção de cor em efluentes industriais.
Descritores: Indústria Têxtil/métodos
Biodegradação Ambiental
Reishi/enzimologia
Arecaceae/química
Lacase/química
Águas Residuárias/química
-Antraquinonas
Cor
Adsorção
Corantes/química
Fermentação
Responsável: BR1.1 - BIREME


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Id: biblio-1054694
Autor: Laçin, Nihat; İzol, Serhat Bozan; İpek, Fikret; Tuncer, Mehmet Cudi.
Título: Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats
Fonte: Acta cir. bras;34(9):e201900904, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. Methods: Wistar male rats (n = 30) were divided into 3 groups: 1) the control (defect) group (n = 10), 2) defect and graft group (n = 10), and 3) defect, graft, and G. lucidum treated group (n = 10). The G. lucidum was administered to the rats at 20 mL/kg per day via gastric lavage. Results: In the defect and graft group, osteonectin positive expression was observed in osteoblast and osteocyte cells at the periphery of the small bone trabeculae within the graft area. In the defect, graft, and G. lucidum treated group, osteonectin expression was positive in the osteoblast and osteocyte cells and positive osteonectin expression in new bone trabeculae. The expression of matrix metalloproteinase-9 (MMP-9) was positive in the inflammatory cells, fibroblast cells, and degenerated collagen fibril areas within the defect area. Conclusion: This study shows that, with its antioxidant and anti-inflammatory properties, G. Lucidum is an important factor in the treatment of calvarial bone defects.
Descritores: Crânio/cirurgia
Regeneração Óssea/efeitos dos fármacos
Transplante Ósseo
Reishi/química
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
-Crânio/efeitos dos fármacos
Imuno-Histoquímica
Osseointegração/efeitos dos fármacos
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-975722
Autor: Özevren, Hüseyin; Irtegün, Sevgi; Ekingen, Arzu; Tuncer, Mehmet Cudi; Gökalp-Özkorkmaz, Ebru; Deveci, Engin; Deveci, Senay.
Título: Immunoexpression of vascular endothelial growth factor, beta-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with Ganoderma lucidum / Inmunoexpresión del factor de crecimiento endotelial vascular, linfoma de células beta 2 y grupo de diferenciación 68 en tejido cerebeloso de ratas tratadas con Ganoderma lucidum
Fonte: Int. j. morphol;36(4):1453-1462, Dec. 2018. tab, graf.
Idioma: en.
Resumo: Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells and nerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant on cerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-brain injury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballar samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treated groups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic brain injury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cell accumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cells.

La lesión cerebral traumática (LCT) puede provocar hemorragias en todas las áreas del cráneo, lo que puede dañar las células y las conexiones nerviosas. Este estudio tuvo como objetivo investigar los efectos protectores de los polisacáridos de Ganoderma lucidum (GLPS) como antioxidante en los tejidos de las células del cerebelo después de la lesión cerebral traumática en ratas. Ratas Sprague Dawley fueron sometidas a TBI con un dispositivo de caída de peso usando un impacto de peso de 300 g-1 m. Se formaron los siguientes grupos: control, trauma y trauma + Ganoderma lucidum. Siete días después de la lesión cerebral, las ratas experimentales fueron decapitadas después de la administración intraperitoneal de ketamina HCL (0,15 ml / 100 g de peso corporal). Se tomaron muestras cerebrales para el examen histológico y para la determinación de niveles de malondialdehído (MDA) y glutatión (GSH) y actividad de mieloperoxidasa (MPO). Se observó una mejora significativa en las células y las estructuras vasculares de los grupos tratados con Ganoderma lucidum en comparación con los grupos no tratados. Durante el estudio se observó que Ganoderma lucidum puede tener un efecto sobre la progresión de la lesión cerebral traumática. La aplicación de Ganoderma lucidum puede afectar el desarrollo angiogénico en las células endoteliales de los vasos sanguíneos, disminuir la acumulación de células inflamatorias al afectar el mecanismo de las citocinas y puede crear células nerviosas apoptóticas y un mecanismo neuroprotector en las células gliales.
Descritores: Cerebelo/efeitos dos fármacos
Reishi/química
Lesões Encefálicas Traumáticas/patologia
Antioxidantes/farmacologia
-Polissacarídeos/farmacologia
Imuno-Histoquímica
Antígenos de Diferenciação Mielomonocítica
Antígenos CD
Cerebelo/metabolismo
Cerebelo/patologia
Western Blotting
Ratos Sprague-Dawley
Peroxidase/metabolismo
Fármacos Neuroprotetores
Proteínas Proto-Oncogênicas c-bcl-2
Fator A de Crescimento do Endotélio Vascular/metabolismo
Glutationa/análise
Malondialdeído/análise
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-893207
Autor: Ekinci, Aysun; Ozevren, Hüseyin; Bilgiç, Bülent Emre; Ekinci, Cenap; Deveci, Senay; Deveci, Engin.
Título: Neuroprotective effects of Ganoderma lucidum on spinal cord injury / Efectos neuroprotectores de Ganoderma lucidum en la lesión de la médula espinal 1
Fonte: Int. j. morphol;36(1):175-179, Mar. 2018. tab, graf.
Idioma: en.
Resumo: SUMMARY: Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.

RESUMEN: La lesión traumática de la médula espinal provoca disfunción retrasada y muerte neuronal. La función mitocondrial deteriorada, la generación de especies reactivas de oxígeno (ERO) y la peroxidación lipídica ocurren poco después de una lesión traumática de la médula espinal (LTE), mientras que la activación de moléculas compensatorias que neutralizan ERO ocurre posteriormente. El objetivo del presente estudio fue investigar el efecto neuroprotector de Ganoderma lucidum en un modelo de LTE en ratas. Con el fin de inducir LTE, se utilizó un método estándar de pérdida de peso que indujo una lesión moderadamente grave (100 g / cm de fuerza) a T10. A los animales lesionados se les administró 20 ml / kg de Ganoderma lucidum o solución salina, por sonda gástrica, 30 minutos después de la lesión. A los siete días después de la lesión, las ratas fueron eutanasiadas por decapitación. Se tomaron muestras de médula espinal para el examen histológico y para la determinación de los niveles de malondialdehído (MDA) y glutatión (GSH), y la actividad de mieloperoxidasa (MPO). LTE causó una disminución significativa en el contenido de GSH de la médula espinal, además de aumentos significativos en los niveles de MDA y la actividad de MPO. Por otro lado, el tratamiento con Ganoderma lucidum invirtió todos estos parámetros bioquímicos así como las alteraciones histopatológicas inducidas por LTE. El deterioro de las funciones neurológicas debidas a LTE mejoró con el tratamiento con meloxicam. El presente estudio sugiere que Ganoderma lucidum, reduce el estrés oxidativo inducido por LTE y ejerce la neuroprotección mediante la inhibición de la peroxidación de los lípidos y agotamiento del GSH.
Descritores: Fármacos Neuroprotetores/administração & dosagem
Reishi/química
Traumatismos da Medula Espinal/tratamento farmacológico
-Glutationa/análise
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Malondialdeído/análise
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/efeitos dos fármacos
Ratos Sprague-Dawley
Traumatismos da Medula Espinal/patologia
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-893094
Autor: Özevren, Hüseyin; Deveci, Engin.
Título: Protective effects of Ganoderma lucidum on the changes made in the retinal damage induced by traumatic head injury / Efectos protectores de Ganoderma lucidum sobre los cambios producidos en el daño retinal inducido por lesión traumática en la cabeza
Fonte: Int. j. morphol;35(3):1063-1068, Sept. 2017. ilus.
Idioma: en.
Resumo: Head trauma affects the optic nerve visual function and visual acuity. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. The protective effect of Ganoderma lucidum was evaluated on the damage to the retina of the rats. Sprague-Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weight-height impact. Thirty rats were divided into three groups as group 1 control, 2 group trauma, 3 group trauma+Gonoderma lucidum (20 mL/kg per day via gastric gavage) Ganoderma lucidum was administered for 7 days after trauma.All rats were decapitated 5 days after the induction of trauma, and the protective effects of Ganoderma lucidum in retina were evaluated by histological, immunohistochemical and biochemical analyses. The antioxidant effect of Ganoderma lucidum on the cellular degeneration extracellular matrix and retinal barrier in retina after head trauma was investigated.

El traumatismo craneal afecta al nervio óptico en relación a su función y la agudeza visual. Se estudiaron los diversos efectos bioquímicos, histológicos e inmunohistoquímicos en la retina producidos por una lesión y trauma a la cabeza. En esta investigación se evaluó el efecto protector de Gonaderin lucidum sobre el daño a la retina de ratas. Ratas Sprague-Dawley fueron sometidas a una lesión cerebral traumática con un dispositivo de caída de peso usando un impacto de 300 g-1 m de peso-altura. Treinta ratas se dividieron en tres grupos: grupo 1, de control; grupo 2, trauma; grupo 3, de trauma + Gonoderma lucidum (20 ml / kg día, a través de una sonda gástrica). Ganoderma lucidum se administró durante 7 días después del trauma. Todas las ratas fueron decapitadas 5 días después. La inducción del trauma y los efectos protectores de Ganoderma lucidum en la retina fueron evaluados mediante análisis histológicos, inmunohistoquímicos y bioquímicos. Se investigó el efecto antioxidante de Ganoderma lucidum sobre la degeneración celular en la matriz extracelular y la barrera retiniana en la retina después del traumatismo craneal.
Descritores: Antioxidantes/administração & dosagem
Traumatismos Craniocerebrais/patologia
Extratos Vegetais/administração & dosagem
Reishi/química
Doenças Retinianas/tratamento farmacológico
-Antioxidantes/metabolismo
Traumatismos Craniocerebrais/tratamento farmacológico
Imuno-Histoquímica
Extratos Vegetais/metabolismo
Ratos Sprague-Dawley
Doenças Retinianas/etiologia
Retina/patologia
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-734576
Autor: Kuhar, Francisco; Papinutti, Leandro.
Título: Optimization of laccase production by two strains of Ganoderma lucidum using phenolic and metallic inducers / Optimización de la producción de lacasa por dos cepas de Ganoderma lucidum utilizando inductores fenólicos y metálicos
Fonte: Rev. argent. microbiol;46(2):144-149, jun. 2014. tab, ilus, graf.
Idioma: en.
Resumo: Ganoderma lucidum (Curtis) P. Karst es un hongo causante de pudrición blanca, capaz de degradar la lignina de la madera y otros sustratos en los que crece. En este trabajo se evaluó la capacidad de dos cepas de esta especie de producir la enzima ligninolítica lacasa. Asimismo, se ensayó la inducción de esta enzima con diferentes compuestos fenólicos e iones metálicos, y se encontró que el ácido ferúlico y el cobre fueron los mejores inductores de la lacasa entre los agentes evaluados. También se encontró que los dos tipos de inductores (fenólicos y metálicos) producen distintos patrones electroforéticos de actividad lacasa. Las concentraciones óptimas de los inductores fueron establecidas mediante un diseño factorial. Se estimó la estabilidad térmica de la lacasa en un amplio rango de pH ácidos, y se comprobó que a pH más altos la enzima es más termoestable.

Ganoderma lucidum (Curtis) P. Karst is a white rot fungus that is able to degrade the lignin component in wood. The ability of two strains of this species to produce the ligninolytic enzyme laccase was assessed. After the evaluation of induction with heavy metals and phenolic compounds, it was found that among the tested substances, copper and ferulic acid are the best laccase inducers. It was also observed that the two types of inducers (phenolic and metallic) produce different electrophoretic patterns of laccase activity. Optimized concentrations of inducers were obtained through a factorial design and the thermal stability of optimized supernatants was studied at a wide range of acidic pH. We found that the enzyme is more thermostable at higher pH values.
Descritores: Lacase/biossíntese
Reishi/efeitos dos fármacos
Reishi/metabolismo
-Ácidos Cumáricos
Cobre/farmacologia
Manganês/farmacologia
Fenóis/farmacologia
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: lil-723139
Autor: Jiang, Yun-Gang; Wang, Chu-Yan; Jin, Chao; Jia, Jun-Qiang; Guo, Xijie; Zhang, Guo-Zheng; Gui, Zhong-Zheng.
Título: Improved 1-Deoxynojirimycin (DNJ) production in mulberry leaves fermented by microorganism
Fonte: Braz. j. microbiol;45(2):721-729, Apr.-June 2014. ilus, graf, tab.
Idioma: en.
Resumo: DNJ, an inhibitor of α-glucosidase, is used to suppress the elevation of postprandial hyperglycemia. In this study, we focus on screening an appropriate microorganism for performing fermentation to improve DNJ content in mulberry leaf. Results showed that Ganoderma lucidum was selected from 8 species and shown to be the most effective in improvement of DNJ production from mulberry leaves through fermentation. Based on single factor and three factor influence level tests by following the Plackett-Burman design, the optimum extraction yield was analyzed by response surface methodology (RSM). The extracted DNJ was determined by reverse-phase high performance liquid chromatograph equipped with fluorescence detector (HPLC-FD). The results of RSM showed that the optimal condition for mulberry fermentation was defined as pH 6.97, potassium nitrate content 0.81% and inoculums volume 2 mL. The extraction efficiency reached to 0.548% in maximum which is 2.74 fold of those in mulberry leaf.
Descritores: 1-Desoxinojirimicina/isolamento & purificação
1-Desoxinojirimicina/metabolismo
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/metabolismo
Morus/metabolismo
Reishi/metabolismo
-Biotecnologia/métodos
Cromatografia Líquida de Alta Pressão
Meios de Cultura/química
Fermentação
Concentração de Íons de Hidrogênio
Folhas de Planta/metabolismo
Reishi/crescimento & desenvolvimento
Tecnologia Farmacêutica/métodos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-676896
Autor: Zárate-Chaves, Carlos Andrés; Romero-Rodríguez, María Camila; Niño-Arias, Fabián Camilo; Robles-Camargo, Jorge; Linares-Linares, Melva; Rodríguez-Bocanegra, María Ximena; Gutiérrez-Rojas, Ivonne.
Título: Optimizing a culture medium for biomass and phenolic compounds production using Ganoderma lucidum
Fonte: Braz. j. microbiol;44(1):215-223, 2013. ilus, tab.
Idioma: en.
Projeto: Universidad Javeriana.
Resumo: The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum. The culture was optimized in two stages; a Plackett-Burman design was used in the first one for identifying key components in the medium and a central composite design was used in the second one for optimizing their concentration. Both responses (biomass and phenolic compounds) were simultaneously optimized by the latter methodology regarding desirability, and the optimal concentrations obtained were 50.00 g/L sucrose, 13.29 g/L yeast extract and 2.99 g/L olive oil. Maximum biomass production identified in these optimal conditions was 9.5 g/L and that for phenolic compounds was 0.0452 g/L, this being 100% better than that obtained in the media usually used in the laboratory. Similar patterns regarding chemical characterization and biological activity towards Aspergillus sp., from both fruiting body and mycelium-derived secondary metabolites and extracts obtained in the proposed medium were observed. It was shown that such statistical methodologies are useful for optimizing fermentation and, in the specific case of G. lucidum, optimizing processes for its production and its metabolites in submerged culture as an alternative to traditional culture.
Descritores: Biomassa
Compostos Fenólicos/análise
Meios de Cultura/análise
Micélio/isolamento & purificação
Reishi/isolamento & purificação
-Metodologia
Otimização
Técnicas
Tipo de Publ: Estudo de Avaliação
Responsável: BR32.1 - Serviço de Biblioteca e Informação Biomédica


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Id: lil-644463
Autor: Yuan, Baojing; Chi, Xiaoyan; Zhang, Rijun.
Título: Optimization of exopolysaccharides production from a novel strain of Ganoderma lucidum CAU5501 in submerged culture
Fonte: Braz. j. microbiol;43(2):490-497, Apr.-June 2012. graf, tab.
Idioma: en.
Projeto: State Key Laboratory of Animal Nutrition.
Resumo: This study aimed at optimizing the medium of a new Ganoderma lucidum strain CAU5501 to enhance the yield of exopolysaccharides (EPS) and mycelial growth. Firstly, the suitable level of glucose, magnesium, phosphate and C/N ratio was determined by single factor experiment. Subsequently, the optimum concentrations of these medium components were investigated using the orthogonal matrix method. The results indicated that the higher levels of EPS were correlated with the level of cell growth when glucose concentration was studied (data no show). The optimum medium for EPS yield was found to be 70 g/l glucose, 5 C/N ratio, 2.5 g/l KH2PO4, 0.75 g/l MgSO4·7H2O, and for mycelial growth was 50 g/l glucose, 5 C/N ratio, 1.5 g/l KH2PO4, 0.5 g/l MgSO4·7H2O. When cultivated in the obtained optimal media in 3 L shake flask, compared to the basal medium, the EPS yield increased markedly from 1.003 to 1.723 g/l, and the mycelium formation was also markedly improved from 2.028 to 7.235 g/l. Results obtained in this study are beneficial to further study for enhancing the production of Ganoderma lucidum polysaccharides in large scale commercialized production.
Descritores: Fosfatos/análise
Fosfatos/isolamento & purificação
Glucose/análise
Glucose/isolamento & purificação
Micélio/crescimento & desenvolvimento
Polissacarídeos/análise
Polissacarídeos/isolamento & purificação
Reishi/enzimologia
Reishi/isolamento & purificação
-Ativação Enzimática
Métodos
Otimização
Responsável: BR32.1 - Serviço de Biblioteca e Informação Biomédica


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Id: lil-619902
Autor: Camargo, Marcela R; Kaneno, Ramon.
Título: Antitumor properties of ganoderma lucidum polysaccharidesand terpenoids: [review]
Fonte: ARBS annu. rev. biomed. sci;13(n.esp):1-8, 2011. tab.
Idioma: en.
Resumo: Ganoderma lucidum is an edible medicinal mushroom withimmunomodulatory and antitumor properties, which are mainly attributed to polysaccharides and triterpenesthat can be isolated from mycelia, fruiting bodies and spores. G. lucidum has been used in a powdered form, asa medicinal beverage and a nutraceutical food (usually dried). In the present review we report some historicalfacts and the experimental evidence that polysaccharides and triterpenes obtained from this mushroom presentpotential antitumor activity. Direct effects on tumor cells include induction of apoptosis and interference in thecell cycle, whereas indirect effects are based on the modulation of immune response, usually impaired bycancer cells. Data indicate that G. lucidum can be used as a complementary tool for treatment of cancerpatients.
Descritores: Agaricales/imunologia
Fatores Imunológicos
Neoplasias/terapia
Polissacarídeos/isolamento & purificação
Polissacarídeos/uso terapêutico
Reishi
Triterpenos/isolamento & purificação
Triterpenos/uso terapêutico
Tipo de Publ: Revisão
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação



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