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Id: biblio-1055405
Autor: Silva, Anna Carolina da; Queiroz, Alana Emilia Soares de França; Oliveira, João Tiago Correia; Medeiros, Erika Valente; Souza-Motta, Cristina Maria de; Moreira, Keila Aparecida.
Título: Antioxidant Activities of Chicken Egg White Hydrolysates Obtained by New Purified Protease of Aspergillus avenaceus URM 6706
Fonte: Braz. arch. biol. technol;62:e19180062, 2019. tab, graf.
Idioma: en.
Projeto: FACEPE; . CAPES.
Resumo: Abstract Protein hydrolysates originating from egg white have already been reported to be bioactive and, among their biological activities, possess the antioxidant property that protects the body from early ageing and diseases linked to oxidation. Therefore, the objective of this work was to evaluate the antioxidant activity of hydrolysates obtained by the hydrolysis of egg white from hen poultry. The protease produced by Aspergillus avenaceus URM 6706 was purified and subsequently applied to hydrolysate the egg white, and the degree of hydrolysis was verified during the protease exposure time (4-24 h). The hydrolysis was intensified over time of exposure to the protease. It was possible to detect the antioxidant activities of eliminating the 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical (ABTS•+) from 97% to 99% and 2,2-diphenyl-1-picrylhydrazyl (DPPH•) up to 27%, as well as the chelation of Cu2+ metal ions up to 62% and Fe2+ up to 54%. The elimination of ABTS•+ radical had a positive correlation with the degree of hydrolysis; however, all the other activities tested showed a negative correlation with the degree of hydrolysis. The results obtained suggest that the egg white of hen chicken represents a food source of animal origin with potential application in the functional food industry.
Descritores: Aspergillus
Quelantes
Clara de Ovo
-Peptídeo Hidrolases
Antioxidantes
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1290644
Autor: Feitosa, André de O; Dias, Amanda Cristina S; Ramos, Gisele da C; Bitencourt, Heriberto R; Siqueira, José Edson S; Marinho, Patrícia Santana B; Barison, Andersson; Ocampos, Fernanda M. M; Marinho, Adrey Moacir do R.
Título: Letalidad de citocalasina B y otros compuestos aislados del hongo Aspergillus spp. (Trichocomaceae) endófito de Bauhinia guianensis (Fabaceae) / Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae)
Fonte: Rev. argent. microbiol;48(3):259-263, set. 2016. ilus..
Idioma: en.
Resumo: Los hongos endofíticos son hongos que colonizan los tejidos internos de las plantas; varios compuestos biológicamente activos se han aislado a partir de estos hongos. Existen pocos estudios de compuestos aislados de hongos endófitos de plantas amazónicas. Por lo tanto, este estudio tuvo como objetivo el aislamiento y la identificación estructural de ergosterol (1), peróxido de ergosterol (2), mevalonolactona (3), citocalasina B (4) y citocalasina H (5) a partir de Aspergillus spp. EJC 04, un hongo endofítico de Bauhinia guianensis. La citocalasina B (4) y el derivado diacetato de citocalasina B (4a) mostraron una alta letalidad en el ensayo de Artemia salina. Esta es la primera aparición de citocalasinas en hongos endófitos amazónica de B. guianensis

Endophytic fungi are fungi that colonize internal tissues of plants; several biologically active compounds have been isolated from these fungi. There are few studies of compounds isolated from endophytic fungi of Amazon plants. Thus, this study aimed the isolation and structural identification of ergosterol (1), ergosterol peroxide (2), mevalonolactone (3), cytochalasin B (4) and cytochalasin H (5) from Aspergillus sp. EJC 04, an endophytic fungus from Bauhinia guianensis. The cytochalasin B (4) and the diacetate derivative of cytochalasin B (4a) showed high lethality in the brine shrimp assay. This is the first occurrence of cytochalasins in Amazonian endophytic fungi from B. guianensis
Descritores: Artemia/efeitos dos fármacos
Aspergillus/imunologia
Citocalasina B/isolamento & purificação
Citocalasina B/análise
Citocalasinas/isolamento & purificação
Bauhinia/microbiologia
Ergosterol/isolamento & purificação
Endófitos/patogenicidade
Tipo de Publ: Estudo de Avaliação
Estudo Observacional
Responsável: AR635.1 - FCVyS - Servicio de Información y Documentación


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Id: biblio-950731
Autor: Mahilrajan, Subajini; Nandakumar, Jeyarani; Kailayalingam, Robika; Manoharan, Nilushiny Aloysius; SriVijeindran, SriThayalan.
Título: Screening the antifungal activity of essential oils against decay fungi from palmyrah leaf handicrafts
Fonte: Biol. Res;47:1-5, 2014. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: The whitish tender leaves of Palmyrah are used for making handicrafts. The problem with these articles is discolouration with time and become more brittle due to fungal attack. This could be prevented by some protective coating. Instead of expensive and harmful chemicals we decided to test natural plant essential oils to control fungal attack. Palmyrah leaf article decay fungi were isolated from two different sites of Jaffna peninsula. In this investigation Antifungal Activity of different plant essential oils from neem (Azadirachta indica), castor (Ricinus communis), citronella (Cymbopogon sp) and camphor (Cinnamomum camphora) obtained from local market have been evaluated against isolated fungi. For screening of Antifungal activity, tests and controls were set to determine minimum inhibitory concentration (MIC) and Percentage of Growth Inhibition. RESULTS: Morphologically three different types of Palmyrah leaf decay fungi were isolated and characterized asAspergillus niger, Aspergillus flavus and Penicillium sp. Neem and castor oils have recorded no significant (0.05 > P) antifungal activity while citronella and camphor oils showed significantly different antifungal activity compared with control. Camphor oil and Citronella oil showed 100, 58.13% of average growth inhibition for A. niger. 96.38, 51.32% for A.flavus and 84.99, 72.76% forPenicillium sp respectively. Camphor oil showed highest percentage of growth inhibition at lowest minimum inhibitory concentration compared with citronella oil. Camphor oil was found to be highly antifungal and most effective against A niger, and A. flavus, compared with Penicillium sp and gave 100 percentage of growth inhibitions at 5, 1 and 15 ml/dl minimum inhibitory concentration respectively. CONCLUSION: Significantly higher broad-spectrum of antifungal activity was observed in camphor oil than other tested oils because it showed highest percentage of growth inhibition at lowest inhibitory concentration. Therefore it could be used for the development of new environmental friendly antifungal agent for the preservation of leafy handicrafts. Further formulation, field experiments are necessary to achieve this target.
Descritores: Penicillium/efeitos dos fármacos
Aspergillus/efeitos dos fármacos
Óleos Vegetais/farmacologia
Óleos Voláteis/farmacologia
Arecaceae/microbiologia
Inibidores do Crescimento/farmacologia
Antifúngicos/farmacologia
-Penicillium/isolamento & purificação
Penicillium/crescimento & desenvolvimento
Aspergillus/isolamento & purificação
Aspergillus/crescimento & desenvolvimento
Aspergillus flavus/isolamento & purificação
Aspergillus flavus/crescimento & desenvolvimento
Aspergillus flavus/efeitos dos fármacos
Aspergillus niger/isolamento & purificação
Aspergillus niger/crescimento & desenvolvimento
Aspergillus niger/efeitos dos fármacos
Ricinus/química
Testes de Sensibilidade Microbiana/métodos
Cinnamomum camphora/química
Azadirachta/química
Cymbopogon/química
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950732
Autor: Kabir, Md Golam; Rahman, Md Monsor; Ahmed, Nazim Uddin; Fakruddin, Md; Islam, Saiful; Mazumdar, Reaz Mohammad.
Título: Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root
Fonte: Biol. Res;47:1-12, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: This study was subjected to investigate different pharmacological properties of ethanol extract ofSolena amplexicaulis root. RESULTS: The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 µg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500 - 3000 µg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed. CONCLUSION: Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.
Descritores: Extratos Vegetais/farmacologia
Sequestradores de Radicais Livres/farmacologia
Raízes de Plantas/química
Cucurbitaceae/química
Analgésicos/farmacologia
Anti-Infecciosos/farmacologia
-Artemia/efeitos dos fármacos
Aspergillus/efeitos dos fármacos
Saccharomyces cerevisiae/efeitos dos fármacos
Shigella/efeitos dos fármacos
Bacillus/efeitos dos fármacos
Extratos Vegetais/química
Peroxidação de Lipídeos/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Quelantes/farmacologia
Substâncias Redutoras/farmacologia
Fibrinolíticos/farmacologia
Hipoglicemiantes/farmacologia
Dose Letal Mediana
Anti-Inflamatórios/farmacologia
Antibacterianos/farmacologia
Antifúngicos/farmacologia
Antioxidantes/farmacologia
Limites: Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Silva, Maria do Rosário Rodrigues
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Id: biblio-842812
Autor: Camplesi Junior, Milton; Silva, Hildene Meneses; Arantes, Adriano Moraes; Costa, Carolina Rodrigues; Ataides, Fábio Silvestre; Silva, Thaisa Cristina; Reis, Maysa de Paula Costa dos; Silva, Maria do Rosário Rodrigues.
Título: Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital
Fonte: Rev. Soc. Bras. Med. Trop;50(1):80-85, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT INTRODUCTION: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. METHODS: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. RESULTS: Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. CONCLUSIONS: Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely.
Descritores: Infecções Fúngicas Invasivas/microbiologia
Doenças Hematológicas/microbiologia
-Aspergillus/isolamento & purificação
Aspergillus/efeitos dos fármacos
Acremonium/isolamento & purificação
Acremonium/efeitos dos fármacos
Candida/isolamento & purificação
Candida/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Prevalência
Sensibilidade e Especificidade
Hospedeiro Imunocomprometido
Infecções Fúngicas Invasivas/diagnóstico
Fusarium/isolamento & purificação
Fusarium/efeitos dos fármacos
Mananas/sangue
Pessoa de Meia-Idade
Antifúngicos/farmacologia
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1132169
Autor: Rosa-Garzon, Nathalia Gonsales da; Siqueira, Ana Claudia Rodrigues de; Hirano, Viviane Naomi; Rodrigues, André; Pessela, Benevides Costa; Cabral, Hamilton.
Título: Amino Acid Supplementation Improves the Production of Extracellular Peptidases by Aspergillus Section Flavi and their Ionic Immobilization
Fonte: Braz. arch. biol. technol;63:e20190127, 2020. graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo; . Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Resumo: Abstract Bioprocess studies have been highlighted due to the importance of physiological processes and industrial applications of enzymes. The potential of peptidase production from Aspergillus section Flavi using different amino acids as a supplemental nitrogen source was investigated. A production profile revealed that amino acids had positive effects on peptidase production when compared to the control without amino acids. Optimal production (100 U/mL) was obtained with Arginine amino acid in 96 h of fermentation. Extracellular peptidase from Aspergillus section Flavi was identified in submerged bioprocesses by in situ activity. Biochemical studies revealed that the maximum activities of the enzyme extract were obtained at pH 6.5 and a temperature of 55°C. The inhibition by EDTA and PMSF suggests the presence of more than one peptidase while the Ni2+ and Cu2+ had a negative influence on the enzyme activity. When the crude extract was reversibly immobilized on ionic supports, DEAE-Agarose and MANAE-Agarose the derivative showed different profiles of thermal and pH stabilities. Hence, this study revealed the basic properties and biochemical characteristics that allowed the production improvement of this class of enzyme. Moreover, with known properties stabilization and immobilization process is required to further explore its biotechnological capacities.
Descritores: Peptídeo Hidrolases/biossíntese
Aspergillus/enzimologia
Aminoácidos/administração & dosagem
-Arginina
Sefarose
Inibidores Enzimáticos
Responsável: BR1.1 - BIREME


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Id: biblio-1132186
Autor: Souza, Patrícia Nirlane da Costa; Tavares, Dérica Gonçalves; Souza, Cláudia Regina Fernandes; Martinez, Marcelo Luis Lombardi; Oliveira, Wanderley Pereira; Guimarães, Luís Henrique Souza; Cardoso, Patrícia Gomes.
Título: Spray Drying of Coloring Extracts Produced by Fungi Isolated from Brazilian Caves
Fonte: Braz. arch. biol. technol;63:e20190024, 2020. tab, graf.
Idioma: en.
Projeto: National Council of Scientific and Technological Development; . Foundation of Research Support of Minas Gerais State; . State of São Paulo Research Foundation.
Resumo: Abstract Pigments produced by submerged fermentation of three filamentous fungi isolated from Brazilian caves, namely Aspergillus keveii, Penicillium flavigenum, and Epicoccum nigrum, were submitted to spray drying in presence of the adjuvants maltodextrin, modified starch or gum arabic. Yellow fine powders with low moisture content and water activity, and high color retention (> 70%) were successfully generated with a high product recovery ratio (> 50%), independently of the adjuvant used. The dried products have enhanced stability and potential to might be used as a natural colorant in food and pharmaceutical applications.
Descritores: Pigmentos Biológicos/biossíntese
Amido/biossíntese
Fungos/metabolismo
Goma Arábica
Maltose/biossíntese
-Aspergillus
Brasil
Cavernas/microbiologia
Fungos/classificação
Maltose/análogos & derivados
Modelos Teóricos
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-742543
Autor: Alvarez, Eduardo.
Título: Utilidad de la prueba Aspergillus-LFD para el diagnóstico de aspergilosis: primera experiencia en Chile / Utility of Aspergillus-LFD: first experience in Chile
Fonte: Rev. chil. infectol;32(1):117-119, feb. 2015. tab.
Idioma: es.
Resumo: Introduction: Invasive fungal diseases (IFD) by filamentous fungi are a common cause of morbidity and mortality in immunocompromised patients, especially those with myeloid leukemia. In 2011 a protocol for the rapid diagnosis of IFD by filamentous fungi was implemented in Valparaiso Region. Objectives: To describe cases of IFD by filamentous fungi of the Valparaíso Region, since the implementation of rapid diagnosis and to compare results with the period 2004-2009. Materials and Method: Descriptive and prospective study conducted in two public hospitals: Carlos van Buren at Valparaiso and Gustavo Fricke at Viña del Mar. We selected patients with a diagnosis of filamentous fungal diseases considering the EORTC/MSG criteria. Demographics, underlying diseases, risk factors for EFI, galactomannan (GM) results in blood and bronchoalveolar lavage, cultures and biopsies, treatment and overall lethality rates at 30 days were registered. Results: Eighteen patients were detected, 6 with proven and 12 probable IFD. Nine were diagnosed by GM, 8 by culture and two with both methods. In cases which the agent (9/18) was isolated from Rhizopus oryzae was the most frequent. When comparing overall lethality with the period 2004-2009, there was a reduction of 47.8%, which was statistically significant. Conclusions: Compared to data previously published in the region, demographic and comorbidities of patients with IFD caused by filamentous fungi are similar, however the currently rapid diagnosis protocol has improved survival of patients and lethality experienced overall decrease.

Introducción: la enfermedad fúngica invasora (EFI) por hongos filamentosos es una causa frecuente de morbilidad y mortalidad en pacientes inmunocomprometidos, en especial en aquellos con leucemia mieloide. En el 2011 se implementó en la Región de Valparaíso un protocolo de diagnóstico rápido de la EFI por hongos filamentosos. Objetivos: describir los casos de EFI por hongos filamentosos de la Región de Valparaíso, desde la implementación del diagnóstico rápido y compararlos con el período 2004-2009. Materiales y Método: Estudio descriptivo y prospectivo realizado en los hospitales públicos Carlos van Buren de Valparaíso y Gustavo Fricke de Viña del Mar. Se seleccionaron aquellos pacientes con diagnóstico de EFI por hongos filamentosos considerando los criterios EORTC/MSG. Se obtuvieron datos demográficos, enfermedad de base, factores de riesgo para EFI, resultados de galactomanano (GM), cultivos y biopsias, tratamiento y letalidad global a 30 días. Resultados: Se identificaron 18 pacientes, seis con EFI probadas y 12 probables. Nueve fueron diagnosticados con galactomanano, ocho con cultivos y uno con los dos métodos. En los casos en que se aisló el agente (9/18), Rhizopus oryzae fue el más frecuente. Al comparar la letalidad global con la del período 2004-2009, hubo una reducción de 47,8%, la cual fue estadísticamente significativa. Conclusiones: En relación a lo publicado anteriormente en la región, se conservan las características demográficas y de co-morbilidad de los pacientes con EFI por hongos filamentosos; sin embargo, la introducción del nuevo protocolo de diagnóstico rápido se asoció a una disminución en la letalidad global.
Descritores: Aspergilose/diagnóstico
Kit de Reagentes para Diagnóstico
Aspergillus/isolamento & purificação
Cromatografia de Afinidade/instrumentação
Técnicas Imunoenzimáticas/instrumentação
Mananas/análise
-Kit de Reagentes para Diagnóstico/economia
Fatores de Tempo
Biomarcadores/sangue
Chile
Cromatografia de Afinidade/economia
Técnicas Imunoenzimáticas/economia
Sensibilidade e Especificidade
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-978072
Autor: Delama, Ignacio; Legarraga, Paulette; González, Tamara; García, Patricia; Rabagliati, Ricardo.
Título: Evaluación del Aspergillus lateral flow device para el diagnóstico de aspergilosis invasora, experiencia en un hospital universitario / Evaluation of the lateral flow Aspergillus assay for the diagnosis of invasive aspergillosis, experience in a university hospital
Fonte: Rev. chil. infectol;35(5):574-579, 2018. tab, graf.
Idioma: es.
Resumo: Resumen Introducción: El diagnóstico de aspergilosis invasora (AI) se realiza mediante criterios clínicos y microbiológicos los que incluyen marcadores séricos. Recientemente, el test inmunocromatográfico Aspergillus lateral flow device (LFD), ha sido evaluado como método para diagnóstico de AI. Objetivo: Evaluar el desempeño de este test para el diagnóstico de AI. Material y Método: Estudio transversal en que se evaluaron muestras de suero y lavado bronco-alveolar (LBA) procesadas para galactomanano provenientes de pacientes adultos con sospecha de AI, atendidos en el Hospital Clínico de Red de Salud UCCHRISTUS. Resultados: Se procesó un total de 142 muestras de 98 pacientes, correspondientes a AI probada 5,6%, AI probable 41,5%, AI posible 12,7% y ausencia de AI 40,1%. Al confrontar los resultados con las categorías diagnósticas según criterios EORTC/MSG se obtuvo una sensibilidad y especificidad de LFD para diagnóstico de AI de 70,9 y 53,5% para muestras de suero y 83,3 y 38,5% para muestras de LBA. La concordancia entre galactomanano y LFD fue de 62,4% (54,1-69,9) con un índice Kappa de 0,202 (0,03682-0,3669). Conclusiones: Aspergillus LFD presentó una adecuada sensibilidad; sin embargo, la especificidad fue baja por lo que un resultado positivo requiere ser confirmado.

Background: The incidence of invasive aspergillosis is increasing. Its diagnosis is based on clinical and microbiological criteria which include the determination of serological markers such as galactomannan. Recently, the Aspergillus lateral flow device, an inmunocromatograph assay has been described for its diagnosis. Aim: To evaluate the performance of the lateral flow device for the diagnosis of invasive aspergillosis (IA) in adult patients. Material and Method: In this cross-sectional study, frozen samples that had been previously evaluated for galactomannan from patients classified with proven/probable/possible or no AI according to the EORTC/MSG criteria were selected. Results: A total of 142 samples from 98 patients were processed, corresponding to proven AI 5.6%, probable IA 41.5%, possible IA 12.7% and no-IA 40.1%. The sensitivity and specificity of the Aspergillus lateral flow was 70.9% and 53.5% for serum samples and 83.3% and 38.5% for BAL samples. The concordance between the galactomannan and Aspergillus lateral flow was 62.4% (54.1 - 69.9) with a Kappa index of 0.202 (0.03682 - 0.3669). Conclusions: We observed a good sensitivity but low specificity, a positive result need a confirmatory test.
Descritores: Aspergilose/diagnóstico
Aspergillus/genética
Aspergillus/imunologia
DNA Fúngico/análise
Líquido da Lavagem Broncoalveolar/microbiologia
Mananas/análise
-Estudos Transversais
Cromatografia de Afinidade/métodos
Sensibilidade e Especificidade
Hospitais Universitários
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1136888
Autor: Santana, Monique Freire; Pivoto, Guilherme; Alexandre, Márcia A. Araujo; Baía-da-Silva, Djane Clarys; Borba, Mayla Gabriela da Silva; Val, Fernando Almeida; Brito-Sousa, Jose Diego; Melo, Gisely Cardoso; Monteiro, Wuelton Marcelo; Souza, João Vicente Braga; Pinheiro, Silviane Bezerra; Ferreira, Luiz Carlos Lima; Naveca, Felipe Gomes; Nascimento, Valdinete Alves; Corado, André Lima Guerra; Hajjar, Ludhmila Abrahão; Silva Neto, João Ricardo; Siva, George Alan Villarouco; Pasqualotto, Alessandro C; Lacerda, Marcus Vinícius Guimarães.
Título: Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management
Fonte: Rev. Soc. Bras. Med. Trop;53:e20200401, 2020. graf.
Idioma: en.
Resumo: Abstract We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
Descritores: Pneumonia Viral/patologia
Aspergillus/isolamento & purificação
Infecções por Coronavirus/patologia
Aspergilose Pulmonar Invasiva/patologia
Betacoronavirus
-Pneumonia Viral/complicações
Aspergillus/genética
Autopsia
Evolução Fatal
Infecções por Coronavirus
Infecções por Coronavirus/complicações
Aspergilose Pulmonar Invasiva/complicações
Pandemias
Pulmão/microbiologia
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde