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Id: biblio-1041461
Autor: Cabana, Ângela Leitzke; Mendes, Josiara Furtado; Klafke, Gabriel Baracy; Brandolt, Tchana Martinez; Melo, Aryse Martins; Meireles, Mário Carlos Araújo; Xavier, Melissa Orzechowski.
Título: Can Aspergillus fumigatus conidia cause false-positive results in the galactomannan enzyme immunoassay test?
Fonte: Rev. Soc. Bras. Med. Trop;51(3):387-389, Apr.-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: Several factors can cause false-positive results in the galactomannan (GM) test; however, others remain unknown. Presently, the impact of airborne contamination by Aspergillus conidia during enzyme-linked immunosorbent assay (ELISA) remains uninvestigated. METHODS: We studied 12 A. fumigatus isolates. Fungal conidia were serially diluted and tested for GM detection using the Platelia® Aspergillus enzyme immunoassay (EIA). RESULTS: The conidia concentration required for an EIA-positive result was 4.8 × 103 (median). CONCLUSIONS: This is the first study to evaluate the impact of environmental contamination on the Platelia® Aspergillus EIA assay. Only massive contamination can interfere with GM optical readings, suggesting that environmental contamination does not cause false-positive test results.
Descritores: Aspergillus fumigatus/isolamento & purificação
Esporos Fúngicos
Ensaio de Imunoadsorção Enzimática/efeitos adversos
Reações Falso-Positivas
Mananas
-Ensaio de Imunoadsorção Enzimática/métodos
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-839419
Autor: Dutta, Mainak; Jotdar, Arijit; Kundu, Sohag; Ghosh, Bhaskar; Mukhopadhyay, Subrata.
Título: Primary laryngeal aspergillosis in the immunocompetent state: a clinical update / Aspergilose laríngea primária no estado imunocompetente: atualização clínica
Fonte: Braz. j. otorhinolaryngol. (Impr.);83(2):228-234, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Descritores: Aspergilose/diagnóstico
Aspergillus fumigatus/isolamento & purificação
Doenças da Laringe/diagnóstico
Imunocompetência
-Aspergilose/tratamento farmacológico
Doenças da Laringe/microbiologia
Doenças da Laringe/tratamento farmacológico
Itraconazol/uso terapêutico
Antifúngicos/uso terapêutico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1131490
Autor: Zamboni, R; Alberti, T. S; Scheid, H. V; Venancio, F. R; Brunner, C. B; Martins, O. A; Raffi, M. B; Sallis, E. S. V.
Título: Outbreak of avian aspergillosis in colonial-bred chicks (Isa Brown) in southern Rio Grande do Sul - case report / [Surto de aspergilose aviária em pintainhas (Isa Brown) de criação colonial na região sul do Rio Grande do Sul - relato de caso]
Fonte: Arq. bras. med. vet. zootec. (Online);72(4):1363-1368, July-Aug. 2020. ilus.
Idioma: en.
Resumo: In this study we describe the epidemiology, clinical signs, and pathology of an outbreak of avian aspergillosis in alternative breeding in the southern region of Rio Grande do Sul, Brazil. Between the fifth and tenth day of life, 360 chicks from a flock of 4000 developed unspecific clinical signs and died. The birds were housed in a reused aviary litter, without previous treatment. In 11 six-day-old female ISA Brown chicks (Gallus gallus domesticus), necropsy revealed firm, yellowish-white, multinodular lesions extending from the pleura to the lung parenchyma. Histologically, a granulomatous, multifocal to coalescent pneumonia was observed. Granulomas were characterized by central necrosis, with heterophil and epithelioid macrophage infiltration and presence of countless Y-shaped intralesional septate hyphae morphologically compatible with Aspergillus spp. The diagnosis through isolation confirmed Aspergillus fumigatus. We highlight the importance of aspergillosis as a primary cause of diseases in the respiratory tract of young birds in alternative breeding. Measures to prevent aspergillosis mainly regarding the reuse of aviary litter are essential in poultry husbandry to prevent economic losses, reduce environmental contamination and mitigate the potential risk to public health.(AU)

Descrevem-se os aspectos epidemiológicos e patológicos de um surto de aspergilose aviária em criação alternativa na região sul do Rio Grande do Sul, Brasil. De um lote de 4000 pintainhas, entre o quinto e o 10º dia de vida, 360 aves apresentaram sinais clínicos inespecíficos e morreram. As aves foram alojadas em cama reutilizada do aviário, sem tratamento prévio. Na necropsia de 11 pintainhas (Gallus gallus domesticus), fêmeas, seis dias de idade da linhagem Isa Brown, foram observadas no pulmão lesões multinodulares, branco-amareladas e firmes, que se estendiam da pleura ao parênquima. Histologicamente foi observada pneumonia granulomatosa, multifocal a coalescente. Os granulomas eram caracterizados por necrose central, com infiltrado inflamatório de heterófilos, macrófagos, células epitelioides com presença de inúmeras hifas septadas intralesionais, semelhantes à letra "Y", morfologicamente compatíveis com Aspergillus spp. O diagnóstico foi confirmado pelo isolamento de Aspergillus fumigatus. Alerta-se para a importância da aspergilose como causa primária de afecções no trato respiratório de aves jovens em criações alternativas. Medidas preventivas relacionadas ao manejo dessas aves são indispensáveis principalmente quanto à reutilização da cama dos aviários, a fim de evitar perdas econômicas, reduzir a contaminação ambiental e o potencial risco à saúde pública.(AU)
Descritores: Aves Domésticas/microbiologia
Aspergilose/epidemiologia
Aspergillus fumigatus/isolamento & purificação
Galinhas/microbiologia
-Brasil
Limites: Animais
Tipo de Publ: Relatos de Casos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1145981
Autor: Savoldi, Thais Lorana; Glamoclija, Jasmina; Sokovic, Marina; Gonçalves, José Eduardo; Ruiz, Suelen Pereira; Linde, Giani Andrea; Gazim, Zilda Cristiani; Colauto, Nelson Barros.
Título: Actividad antimicrobiana del aceite esencial de hojas de Psidium cattleianum Afzel. ex Sabine / Antimicrobial activity of essential oil from Psidium cattleianum Afzel. ex Sabine leaves
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(6):614-627, 2020. tab.
Idioma: en.
Resumo: La búsqueda de fuentes naturales para controlar los microorganismos es de interés en la producción de alimentos. Este estudio evaluó la composición química y la actividad antimicrobiana del aceite esencial de las hojas de Psidium cattleianum. El aceite esencial se extrajo por hidrodestilación y se identificó por GC-MS. La clase predominante de compuestos fueron los sesquiterpenos (47,6%) y los principales fueron trans-ß-cariofileno (14,7%), 1,8-cineol (11,7%) y É£-muuroleno (5,6%). Actividad antimicrobiana se realizó mediante la técnica de microdilución contra ocho hongos y ocho bacterias. Concentración inhibitoria mínima varió de 0,17 a 11,25 mg mL-1 para hongos y de 1,40 a 16,87 mg mL-1 para bacterias. Principales actividades fueron contra hongos Aspergillus fumigatus (ATCC 1022), Aspergillus ochraceus (ATCC 12066), Aspergillus versicolor (ATCC 11730) y Trichoderma viride (IAM 5061), y bacterias Pseudomonas aeruginosa (ATCC 27853), Bacillus cereus (clinical isolate) y Staphylococcus aureus (ATCC 6538) con potencial para prevenir enfermedades transmitidas por alimentos.

The search for natural sources to control microorganisms is of interest in food production. This study evaluated the chemical composition and antimicrobial activity of the essential oil from Psidium cattleianum leaves. The essential oil was extracted by hydrodistillation, and identified by GC-MS. The predominant class of compounds was sesquiterpenes (47.6%) and the major compounds were trans-ß-caryophyllene (14.7%), 1,8-cineole (11.7%) and É£-muurolene (5.6%). The antimicrobial activity was carried out by microdillution technique against eight fungi and eight bacteria. The minimum inhibitory concentration ranged from 0.17 to 11.25 mg mL-1 for fungi, and from 1.40 to 16.87 mg mL-1 for bacteria. The highest activities were against fungi Aspergillus fumigatus (ATCC 1022), Aspergillus ochraceus (ATCC 12066), Aspergillus versicolor (ATCC 11730), and Trichoderma viride (IAM 5061), and bacteria Pseudomonas aeruginosa (ATCC 27853), Bacillus cereus (clinical isolate), and Staphylococcus aureus (ATCC 6538) with potential to prevent foodborne diseases.
Descritores: Psidium/química
Anti-Infecciosos
-Aspergillus
Aspergillus fumigatus
Trichoderma
Aspergillus ochraceus
Extratos Vegetais
Responsável: BR1.1 - BIREME


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ALVES, Sydney Hartz
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Id: biblio-951621
Autor: Denardi, Laura Bedin; Hoch Dalla-Lana, Bianca; Pantella Kunz de Jesus, Francielli; Bittencourt Severo, Cecília; Santurio, Janio Morais; Zanette, Régis Adriel; Alves, Sydney Hartz.
Título: In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil
Fonte: Braz. j. infect. dis;22(1):30-36, Jan.-feb. 2018. tab, graf.
Idioma: en.
Projeto: FAPERGS; . CNPq.
Resumo: ABSTRACT The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC > 2.0 mg/L). Voriconazole showed good activity against A. fumigatus and A. flavus strains, except for one clinical strain of A. fumigatus whose MIC was 4.0 mg/L. Posaconazole (≤0.25 mg/L) also showed appreciable activity against both species of Aspergillus, except for six A. fumigatus strains with relatively higher MICs (0.5 mg/L). The MICs for Amphotericin B ranged from 0.06 to 1.0 mg/L for A. fumigatus, but were much higher (0.5-8.0 mg/L) for A. flavus. Among the echinocandins, caspofungin showed a geometric mean of 0.078 and 0.113 against the clinical and environmental strains of A. flavus, respectively, but had elevated minimal effective concentrations (MECs) for seven of the A. fumigatus strains. Anidulafungin and micafungin exhibited considerable activity against both A. fumigatus and A. flavus isolates, except for one environmental isolate of A. fumigatus that showed an MEC of 1 mg/L to micafungin. Our study proposes that a detailed investigation of the antifungal susceptibility of the genus Aspergillus from different regions of Brazil is necessary for establishing a response profile against the different classes of antifungal agents used in the treatment of aspergillosis.
Descritores: Aspergillus flavus/efeitos dos fármacos
Aspergillus fumigatus/efeitos dos fármacos
Antifúngicos/farmacologia
-Aspergillus flavus/isolamento & purificação
Aspergillus fumigatus/isolamento & purificação
Valores de Referência
Brasil
Testes de Sensibilidade Microbiana
Reação em Cadeia da Polimerase
Farmacorresistência Fúngica Múltipla
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-477890
Autor: Casquero C, José; Guevara R, Miriam; Urcia A, Flor; Navarro M, Alida; Linares F, Nancy; Acurio U, Vilma; Huamaní B, Luis; Espinoza E, Nelva; Sotomayor E, Alfredto; Somocurcio V, José; Fernández V, Eduardo; Asmat M, Percy; Hurtado A, Elizabeth; Cornejo C, Marco.
Título: Frecuencia de aspergiloma en pacientes con antecedente de tuberculosis, hemoptisis, radiografía anormal y baciloscopía negativa / Frequency of aspergilloma in patients with history of tuberculosis, hemoptysis, abnormal chest x-ray films and negative sputum smears
Fonte: Rev. peru. med. exp. salud publica;23(2):104-109, abr.-jun. 2006. tab.
Idioma: es.
Resumo: Objetivo: Determinar la frecuencia de aspergilomas en pacientes con antecedentes de tuberculosis pulmonar curada,hemoptisis, radiografía de tórax anormal y BK negativo. Materiales y métodos: Se enroló 28 pacientes entre diciembrede 2002 y septiembre de 2004 en el Hospital Nacional Hipólito Unanue de Lima y Hospital Belén de Trujillo. A los pacientesevaluados en el Hospital Belén se les solicitó tres muestras de esputo, seriadas y consecutivas, mientras que lospacientes evaluados en el Hospital Nacional Hipólito Unanue y que fueron sometidos a cirugía de tórax, se les colectóuna porción de la pieza quirúrgica tisular pulmonar. Ambas muestras biológicas fueron cultivadas en agar sabourauddextrosa - cloramfenicol 0,05 por ciento e incubados a temperatura ambiente y 37 °C por 15 días. A todos los pacientes se lesextrajo 5 mL de sangre total para realizar la prueba de inmunodifusión contra Aspergillus sp. Resultados: La frecuenciade aspergiloma fue de 43 por ciento (12/28). Se identificó por cultivo Aspergillus fumigatus en cinco casos, Aspergillus sp endos, A. niger en uno, A. flavus en uno y en dos casos positivos por serología no se logró aislar el hongo. En los dospacientes donde se identificó A. niger, no se detectó presencia de anticuerpos contra Aspergillus sp. En el HospitalBelén la frecuencia de aspergiloma fue 39 por ciento (7/18) y en el Hospital Hipólito Unanue 50 por ciento (5/10). Conclusiones: Lafrecuencia de aspergiloma en los 28 pacientes investigados en ambos hospitales fue de 43 por ciento y el principal agenteetiológico fue A. fumigatus.

Objective: To determine the frequency of aspergilloma in patients with history of cured pulmonary tuberculosis, hemoptysis, abnormal chest X-ray films, and negative sputum smears for acid-fast bacilli. Materials and methods: 28 patients were enrolled between December 2002 and September 2004 in Hipolito Unanue National Hospital in Lima and Belen Hospital in Trujillo. Patients from Belen Hospital had three serial and consecutive sputum samples taken, while those patients from Hipolito Unanue Hospital who underwent thoracic surgery had a portion of the surgical specimen collected. Both biological samples were cultured in Sabouraud dextrose agar – 0,05% chloramphenicol, and they were incubated at room temperature and at 37° C for 15 days. All patients had a 5-mL blood sample taken in order to perform immunodifusion tests for Aspergillus sp. Results: The frequency of aspergilloma was 43%) (12/28). Aspergillus fumigatus was identified in cultures in five cases, Aspergillus sp. was identified in two cases, A. niger in one, A. flavus in one, and in two cases reported as positive for serological tests the fungus could not be isolated. In the two patients in whom A. niger was identified, no presence of antibodies against Aspergillus sp. was detected. In Belen Hospital the frequency of aspergilloma was 39% (7/18), and in Hipolito Unanue Hospital it was 50% (5/10). Conclusions: Aspergilloma frequency in 28 patients studied in both hospitals was 43%, and the main etiological agent was A. fumigatus.
Descritores: Aspergillus flavus
Aspergillus fumigatus
Aspergillus niger
Técnicas de Cultura
Responsável: PE14.1 - Biblioteca de la Sede Central


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Id: biblio-1087465
Autor: Sepúlveda, Leonardo; Laredo-Alcalá, Elan; Buenrostro-Figueroa, José Juan; Ascacio-Valdés, Juan Alberto; Genisheva, Zlatina; Aguilar, Cristobal; Teixeira, José.
Título: Ellagic acid production using polyphenols from orange peel waste by submerged fermentation
Fonte: Electron. j. biotechnol;43:1-7, Jan. 2020. tab, graf.
Idioma: en.
Projeto: Portuguese Foundation for Science and Technology (FCT); . BioTecNorte operation; . Zlatina Genisheva wish to thank to FCT.
Resumo: Background: Biotechnological processes are part of modern industry as well as stricter environmental requirements. The need to reduce production costs and pollution demands for alternatives that involve the integral use of agro-industrial waste to produce bioactive compounds. The citrus industry generates large amounts of wastes due to the destruction of the fruits by microorganisms and insects together with the large amounts of orange waste generated during the production of juice and for sale fresh. The aim of this study was used orange wastes rich in polyphenolic compounds can be used as source carbon of Aspergillus fumigatus MUM 1603 to generate high added value compounds, for example, ellagic acid and other molecules of polyphenolic origin through submerged fermentation system. Results: The orange peel waste had a high concentration of polyphenols, 28% being condensed, 27% ellagitannins, 25% flavonoids and 20% gallotannins. The major polyphenolic compounds were catechin, EA and quercetin. The conditions, using an experimental design of central compounds, that allow the production of the maximum concentration of EA (18.68 mg/g) were found to be: temperature 30°C, inoculum 2 × 107 (spores/g) and orange peel polyphenols 6.2 (g/L). Conclusion: The submerged fermentation process is an effective methodology for the biotransformation of molecules present in orange waste to obtain high value-added as ellagic acid that can be used as powerful antioxidants, antibacterial and other applications.
Descritores: Gerenciamento de Resíduos
Citrus sinensis/química
Ácido Elágico
-Aspergillus fumigatus
Resíduos/análise
Flavonoides/análise
Biotecnologia/métodos
Taninos Hidrolisáveis/análise
Fermentação
Polifenóis/análise
Compostos Fitoquímicos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-564002
Autor: Casquero, José; Urcia, Flor; Sánchez, Elizabeth.
Título: Antígenos nativos de aspergillus fumigatus con utilidad para el inmunodiagnóstico de aspergiloma / Native antigen of aspergillus fumigatus with useful for immunodiagnosis of aspergilloma
Fonte: Rev. peru. med. exp. salud publica;26(2):182-186, abr.-jun. 2009. tab, ilus.
Idioma: es.
Resumo: Con el objetivo de evaluar la utilidad de los antígenos nativos de cepas autóctonas de Aspergillus fumigatus para el inmunodiagnóstico de aspergiloma, se desarrolló un estudio empleando dos cepas de ese hongo, aisladas de pacientes con diagnóstico de aspergiloma (533 y 554), los cuales fueron confrontados con sueros controles comerciales de A. fumigatus, A. flavus, A. niger, Candida, Coccidioides, Histoplasma y Paracoccidioides mediante la prueba de inmunodifusión, asimismo, se evaluaron frente a 28 sueros de pacientes con sospecha de aspergiloma. Además, se realizó la caracterización de los componentes proteicos de los antígenos nativos con la técnica de SDS-PAGE y se confrontaron con diez sueros de pacientes con aspergiloma, paracoccidioidomicosis, histoplasmosis, proteína C reactiva e hidatidosis y suero de persona sana por inmunoblot. Se encontró una buena concordancia (kappa 0,92) entre los antígenos 533 y 554, y algo menor de éstos con el antígeno comercial para A. fumigatus (kappa 0,73 y 0,81 para el 553 y 554; respectivamente). La banda de 97 kDa reaccionó sólo con sueros de pacientes con aspergiloma siendo inmunodominante.

In order to evaluate the usefulness of native antigens of autochthonous strains of Aspergillus fumigatus for immunodiagnosis of aspergilloma, We was conducted a study using two strains of this fungus, isolated from patients with aspergilloma (533 and 554), which were confronted with commercial control serum of A. fumigatus, A. flavus, A. niger, Candida, Coccidioides, Histoplasma and Paracoccidioides by immunodiffusion test, moreover, we evaluated 28 serum samplesfrom patients with suspected aspergilloma. We also performed the characterization of the protein components of native antigens using the technique of SDS-PAGE and were confronted with ten serum samples from patients with aspergilloma,paracoccidioidomycosis, histoplasmosis, C-reactive protein and hydatidosis, also healthy person serum by immunoblot.Good agreement (kappa 0.92) was found between antigens 533 and 554 and somewhat less than those with commercial antigen A. fumigatus (kappa 0.73 and 0.81 for the 533 and 554, respectively). The band of 97 kDa reacted only with sera from patients with aspergilloma being immunodominant.
Descritores: Antígenos
Aspergillus fumigatus
Imunodifusão
Testes Imunológicos
Limites: Humanos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-575439
Autor: Arroyo Sánchez, Gisel; Gayoso Cervantes, Oscar; Rojas Vilca, José Luis.
Título: Aspergilosis broncopulmonar alérgica en pacientes con asma no controlada: serie de casos / Pulmonary aspergillosis-allergic patients with uncontrolled asthma: number of cases
Fonte: Enfer. tórax (Lima);54(1):24-31, ene.-jun. 2010. ilus, tab.
Idioma: es.
Resumo: Introducción: el asma es una enfermedad crónica con alta morbilidad a nivel mundial. La Aspergilosis broncopulmonar alérgica (ABPA) es un desorden alérgico causado por hipersensibilidad al Aspergillues fumigatus, y en estadios avanzados produce gran deterioro de la estructura y función pulmonar. Objetivo: describir, por primera vez en el país, las caractetísticas clínicas, radiológicas e inmunológicas de pacientes con Aspergilosis broncopulmonar alérgica (ABPA). Pacientes y método: pacientes ambulatorios con asma que fueron diagnosticados de ABPA entre el 2007 y 2009, en un Hospital general y una clínica privada (Lima, Perú). El estudio es observacional de tipo serie de casos. Resultados: encontramos 6 pacientes que fueron diagnosticados de ABPA 4 de sexo femenino, entre 7 y45 años de edad, 5 en estadio III. Conclusiones: se evidencia la presencia de ABPA en nuestro país y el 100 por ciento de los casos encontrados fueron diagnosticados en estadios avanzados de la enfermedad.

Asthma is a chronic disease with high morbidity worldwide. Allergic bronchopulmonary Aspergilosis (ABPA) is an allergic disorder caused by hypersensivity to Aspergillus fumigates. In advanced stages causes great damage to the lung structure and function. Objective: to describe for the first time in our country the clinical, radiological and immunological features from patients with ABPA. Patients and methods: outpatients with Asthma and ABPA who were diagnosed between 2007 and 2009, in a General Hospital and a Medical Center (Lima-Peru). This is an observational and case series study. Results: we found 6 patients who were diagnosed with ABPA, 4 females, aged between 7 y 45 years old and 5 of them in stage III. Conclusions: we found the presence of ABPA in our environment and 100 per cent of the cases found were diagnosed in advanced stages of the disease.
Descritores: Asma
Aspergillus fumigatus
Aspergilose Broncopulmonar Alérgica
-Epidemiologia Descritiva
Estudos Observacionais como Assunto
Peru
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Texto completo SciELO Brasil
Texto completo
Id: biblio-1098449
Autor: Spanamberg, Andréia; Ravazzolo, Ana Paula; Denardi, Laura B; Hartz, Sydney A; Santurio, Janio M; Driemeier, David; Ferreiro, Laerte.
Título: Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs / Perfil de suscetibilidade antifúngica de isolados de Aspergillus fumigatus provenientes de pulmões de aves
Fonte: Pesqui. vet. bras = Braz. j. vet. res;40(2):102-106, Feb. 2020. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Susceptibility testing is essential to inform the correct management of Aspergillus infections. In this study we present antifungal susceptibility profile of A. fumigatus isolates recovered from lungs of birds with and without aspergillosis. Fifty three isolates were tested for their antifungal susceptibility to voriconazole (VRC), itraconazole (ITZ), amphotericin (AMB) and caspofungin (CSP) using the M38-A2 broth microdilution reference method. Five isolates were resistant to more than one antifungal drug (CSP + AMB, VRC + ITZ and AMB + ITZ). Fifteen (28%) isolates with susceptible increased exposure (I) to ITZ were sensible to VRC. Resistance to AMB (>2µg/mL) was observed in only four isolates. Eleven (21%) A. fumigatus present resistance to ITZ (13%) and VRC (8%). Fungal isolation from respiratory samples has been regarded as being of limited usefulness in the ante mortem diagnosis of aspergillosis in birds. However, the results suggest that the detection and antifungal susceptibility profile may be helpful for monitoring of therapy for avian species and where antifungal resistance might be emerging and what conditions are associated to the event.(AU)

Os testes de suscetibilidade são essenciais para informar o correto manejo das infecções por Aspergillus. Neste estudo apresentamos o perfil antifúngico de isolados de A. fumigatus provenientes de pulmões de aves com e sem aspergilose. Cinqüenta e três isolados foram testados quanto à susceptibilidade antifúngica ao voriconazol (VRC), itraconazol (ITZ), anfotericina B (AMB) e caspofungina (CSP) pelo método de referência de microdiluição do caldo M38-A2. Cinco isolados foram resistentes a mais de um antifúngico (CSP + AMB, VRC + ITZ e AMB + ITZ). Quinze (28%) isolados suscetíveis - com exposição aumentada (I) ao ITZ foram sensíveis ao VRC. A resistência ao AMB (>2µg/mL) foi observada em apenas quatro isolados. Onze (21%) A. fumigatus apresentaram resistência a ITZ (13%) e VRC (8%). O isolamento de fungos de amostras respiratórias tem sido considerado de utilidade limitada no diagnóstico ante mortem de aspergilose em aves. No entanto, os resultados sugerem que a detecção e o perfil de suscetibilidade a antifúngicos podem ser úteis para o monitoramento da terapia de espécies aviárias, assim como a emergência da resistência antifúngica e quais condições podem estar associadas ao evento.(AU)
Descritores: Doenças das Aves Domésticas
Aspergilose/tratamento farmacológico
Aspergilose/veterinária
Aspergillus fumigatus/isolamento & purificação
Aspergillus fumigatus/efeitos dos fármacos
Galinhas
Farmacorresistência Fúngica/efeitos dos fármacos
Antifúngicos/uso terapêutico
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



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